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https://www.readbyqxmd.com/read/29332155/prevalence-of-the-pfdhfr-and-pfdhps-mutations-among-asymptomatic-pregnant-women-in-southeast-nigeria
#1
Ekpereonne Esu, Costanza Tacoli, Prabhanjan Gai, Nicole Berens-Riha, Michael Pritsch, Thomas Loescher, Martin Meremikwu
Sulfadoxine-pyrimethamine (SP) is the recommended drug for intermittent preventive treatment of malaria in pregnancy in most of sub-Saharan Africa. Resistance to SP is related to mutations in the dhfr and dhps gene of Plasmodium falciparum. This study determined the prevalence of Pfdhfr and Pfdhps polymorphisms found in asymptomatic pregnant women attending antenatal care in Calabar, Nigeria. From October 2013 to November 2014, asymptomatic pregnant women attending antenatal care clinics were enrolled after obtaining informed consent...
January 13, 2018: Parasitology Research
https://www.readbyqxmd.com/read/29332150/ectoparasite-activity-during-incubation-increases-microbial-growth-on-avian-eggs
#2
G Tomás, D Martín-Gálvez, C Ruiz-Castellano, M Ruiz-Rodríguez, J M Peralta-Sánchez, M Martín-Vivaldi, J J Soler
While direct detrimental effects of parasites on hosts are relatively well documented, other more subtle but potentially important effects of parasitism are yet unexplored. Biological activity of ectoparasites, apart from skin injuries and blood-feeding, often results in blood remains, or parasite faeces that accumulate and modify the host environment. In this way, ectoparasite activities and remains may increase nutrient availability that may favour colonization and growth of microorganisms including potential pathogens...
January 13, 2018: Microbial Ecology
https://www.readbyqxmd.com/read/29331367/molecular-characterization-and-differential-expression-analysis-of-interleukin-1%C3%AE-from-ovis-aries
#3
Yi-Ming Shui, Shi-Ying Lu, Xing Guo, Xi-Lin Liu, Bao-Quan Fu, Pan Hu, Lin-Lin Qu, Nan-Nan Liu, Yan-Song Li, Lu-Lu Wang, Fei-Fei Zhai, Dan-Di Ju, Zeng-Shan Liu, Yu Zhou, Hong-Lin Ren
The interleukin-1 family is an important component of the innate immune system and plays an important role in regulating immune responses on the invasion of intracellular parasites in the acquired immune system. Interleukin 1β (IL-1β) is one of the members of the IL-1 family that predominantly activates downstream signaling pathways to play immunological functions of stimulating T and B lymphocyte activation and promoting the various syntheses of inflammatory substances in conjunction with other cytokines...
January 10, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29331279/dynamics-of-spatiotemporal-distribution-of-schistosomiasis-in-hubei-province-china
#4
Yan-Yan Chen, Jian-Bing Liu, Yong Jiang, Guo Li, Xiao-Wei Shan, Juan Zhang, Shun-Xiang Cai, Xi-Bao Huang
Schistosomiasis caused by parasitic flatworms of blood flukes, remains a major public health concern in China. The significant progress in controlling schistosomiasis in China over the past decades has resulted in the remarkable reduction in the prevalence and intensity of Schistosoma japonicum infection to an extremely low level. Therefore, the elimination of schistosomiasis has been promoted by the Chinese national government. Hubei Province is the major endemic area, that is, along the middle and low reaches of the Yangtze River in the lake and marshland regions of southern China...
January 10, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29331278/impact-of-treatment-with-a-protein-tyrosine-kinase-inhibitor-genistein-on-acute-and-chronic-experimental-schistosoma-mansoni-infection
#5
Maysa Mohamed Kamel Sobhy, Soheir Sayed Mahmoud, Shaimaa Helmy El-Sayed, Enas Mohamed Ali Rizk, Amira Raafat, Mohamed Sherif Ismail Negm
Schistosomiasis mansoni is considered one of the most common fibrotic diseases resulting from inflammation and deposition of fibrous tissue around parasitic eggs trapped in the liver, causing morbidity and mortality. Chemotherapy against schistosomiasis is largely dependent on Praziquantel (PZQ). Yet, the huge administration of it in endemic areas and its incompetence towards the immature stages have raised serious alarms against the development of drug resistance. Few drugs are directed to reverse schistosomal liver fibrosis, particularly at the chronic and advanced stages of the disease...
January 10, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29330527/aquaglyceroporin-pbaqp-is-required-for-efficient-progression-through-the-liver-stage-of-plasmodium-infection
#6
Dominique Promeneur, Godfree Mlambo, Peter Agre, Isabelle Coppens
The discovery of aquaglyceroporins (AQP) has highlighted a new mechanism of membrane solute transport that may hold therapeutic potential for controlling parasitic infections, including malaria. Plasmodium parasites express a single AQP at the plasma membrane that functions as a channel for water, nutrients and waste into and out cells. We previously demonstrated that Plasmodium berghei targeted for PbAQP deletion are deficient in glycerol import and less virulent than wild-type parasites during the blood developmental stage...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330449/lithium-chloride-effectively-kills-the-honey-bee-parasite-varroa-destructor-by-a-systemic-mode-of-action
#7
Bettina Ziegelmann, Elisabeth Abele, Stefan Hannus, Michaela Beitzinger, Stefan Berg, Peter Rosenkranz
Honey bees are increasingly important in the pollination of crops and wild plants. Recent reports of the weakening and periodical high losses of managed honey bee colonies have alarmed beekeeper, farmers and scientists. Infestations with the ectoparasitic mite Varroa destructor in combination with its associated viruses have been identified as a crucial driver of these health problems. Although yearly treatments are required to prevent collapses of honey bee colonies, the number of effective acaricides is small and no new active compounds have been registered in the past 25 years...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330436/blood-transcriptomics-of-captive-forest-musk-deer-moschus-berezovskii-and-possible-associations-with-the-immune-response-to-abscesses
#8
Xiaoning Sun, Ruibo Cai, Xuelin Jin, Aaron B A Shafer, Xiaolong Hu, Shuang Yang, Yimeng Li, Lei Qi, Shuqiang Liu, Defu Hu
Forest musk deer (Moschus berezovskii; FMD) are both economically valuable and highly endangered. A problem for FMD captive breeding programs has been the susceptibility of FMD to abscesses. To investigate the mechanisms of abscess development in FMD, the blood transcriptomes of three purulent and three healthy individuals were generated. A total of ~39.68 Gb bases were generated using Illumina HiSeq 4000 sequencing technology and 77,752 unigenes were identified after assembling. All the unigenes were annotated, with 63,531 (81...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29329982/gongylonema-pulchrum-infection-in-the-human-oral-cavity-a-case-report-and-literature-review
#9
REVIEW
Liu Xiaodan, Wang Zhensheng, Han Ying, Liu Hongwei, Jin Jianqiu, Zhou Peiru, Su Sha, Yan Zhimin
Gongylonema infection is a zoonotic disease occurring throughout the world and is mainly caused by consumption of contaminated water and raw food. Adult Gongylonema worms can exist as parasites in the human body for up to 10 years and cause symptoms of local irritation in the oral cavity, esophagus, and pharynx. Herein, we report a rare case in which live Gongylonema pulchrum was detected and extracted from the oral cavity of a woman. The pathogen was confirmed as G. pulchrum on the basis of microscopic examination and morphologic analysis...
December 8, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29329749/assessment-of-the-diagnostic-performance-of-four-methods-for-the-detection-of-giardia-duodenalis-in-fecal-samples-from-human-canine-and-feline-carriers
#10
Flávia Fernandes de Mendonça Uchôa, Adriana Pittella Sudré, Sabrina Destri Emmerick Campos, Nádia Regina Pereira Almosny
Enteric parasitic diseases including giardiasis are of public health concern. Different methods are available for the diagnosis of this parasitic infection in fecal samples such as the identification of protozoan cysts and trophozoites by light microscopy, detection of specific antigens by ELISA, and amplification of DNA fragments by PCR. The present study aimed at assessing the performance of four laboratory tests for the detection of Giardia duodenalis in fecal specimens from three different host species with a previous diagnosis of giardiasis; canine, feline and human patients provided new stool samples to be retested for Giardia before initiating treatment with antiprotozoal drugs...
January 9, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29329629/estimates-of-repeatability-and-correlations-of-hemoparasites-infection-levels-for-cattle-reared-in-endemic-areas-for-rhipicephalus-microplus
#11
Rodrigo Giglioti, Henrique Nunes de Oliveira, Talita Barban Bilhassi, Amanda Izeli Portilho, Cintia Hiromi Okino, Cintia Righetti Marcondes, Marcia Cristina de Sena Oliveira
Rhipicephalus microplus is a vector of cattle tick fever, a disease caused by the protozoans Babesia bovisand B. bigemina, and also anaplasmosis, produced by the Rickettsiales Anaplasma marginale. These tick-borne pathogens cause considerable losses to Brazilian livestock breeders and represent an obstacle to the expanded use of taurine breeds due to their higher sensitivity to ticks and hemoparasites compared to zebu breeds. Differences in the susceptibility to hemoparasites were also verified within breeds, suggesting that may be possible to select a most resistant phenotype...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329627/comparative-efficacy-of-curcumin-and-paromomycin-against-cryptosporidium-parvum-infection-in-a-balb-c-model
#12
Mohammad Asadpour, Fatemeh Namazi, Seyed Mostafa Razavi, Saeed Nazifi
Cryptosporidium is a ubiquitous protozoan parasite causing gastrointestinal disorder in various hosts worldwide. The disease is self-limiting in the immunocompetent but life-threatening in immunodeficient individuals. Investigations to find an effective drug for the complete elimination of the Cryptosporidium infection are ongoing and urgently needed. The current study was undertaken to examine the anti-cryptosporidial efficacy of curcumin in experimentally infected mice compared with that of paromomycin. Oocysts were isolated from a pre-weaned dairy calf and identified as Cryptosporidium parvum using a nested- polymerase chain reaction (PCR) on Small subunit ribosomal ribonucleic acid (SSU rRNA) gene and sequencing analysis...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329626/applicability-of-flotac%C3%A2-technique-in-recovering-equine-strongyle-larvae-in-the-pasture-a-comparison-study
#13
Ingrid Carla do Nascimento Ramos, Rafael Antonio do Nascimento Ramos, Victor Fernando de Santana Lima, Alessio Giannelli, Irma Yaneth Torres López, Leucio Câmara Alves
The FLOTAC® technique represents a highly sensitive method for the isolation of oocysts, eggs, and larvae of parasites in faeces. This assay could be used for detecting free-living stages of nematodes in the pasture but no attempt has been assessed so far. Therefore, the performance of FLOTAC® technique for isolating infective larvae of nematodes in the environment was investigated and compared with the spontaneous sedimentation (SST) and centrifugal sedimentation (CST) techniques. The study was conducted in a horse farm located in northeastern Brazil, where the occurrence of strongyle larvae had been previously reported...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329625/immune-development-and-performance-characteristics-of-romney-sheep-selected-for-either-resistance-or-resilience-to-gastrointestinal-nematodes
#14
A W Greer, J L McKenzie, R W McAnulty, J F Huntley, T N McNeilly
Immunological and performance characteristics were explored in Romney sheep from lines selected for either resistance or resilience to parasite infection. At a mean 78 days-of-age, twin lambs from a line selected for resistance (RT) and lambs from a line selected for resilience (RL) were infected with the intestinal nematode Trichostrongylus colubriformis for 100 days (I) while their twin remained as an uninfected control (C). Compared with RL, RT animals had lower levels of circulating CD4+ T-cells (P = 0...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329624/apparent-prevalence-of-and-risk-factors-for-infection-with-ostertagia-ostertagi-fasciola-hepatica-and-dictyocaulus-viviparus-in-swiss-dairy-herds
#15
C F Frey, R Eicher, K Raue, C Strube, M Bodmer, B Hentrich, B Gottstein, N Marreros
Infections with helminth parasites can negatively affect performance of dairy cows. Knowledge on infection intensity, spatial distributions and risk factors are key to develop targeted treatment strategies. Canada and most EU countries have conducted large investigations, but respective data for Switzerland were missing. We now performed a bulk tank milk serosurvey for Ostertagia ostertagi, Fasciola hepatica, and Dictyocaulus viviparus on a total of 1036 voluntarily participating dairy herds that were sampled at confinement periods, i...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329623/parasite-control-strategies-used-by-equine-owners-in-the-united-states-a-national-survey
#16
M K Nielsen, M A Branan, A M Wiedenheft, R Digianantonio, L P Garber, C A Kopral, A M Phillippi-Taylor, J L Traub-Dargatz
The widespread occurrence of anthelmintic resistance in equine parasites across the world has led to recommendations of fecal egg count-based parasite programs to reduce treatment intensity and thereby delay further development of resistance as much as possible. The most recent study describing equine parasite control in the United States was conducted 20 years ago, and little is known about current strategies employed. This study was part of the National Animal Health Monitoring Systems (NAHMS) Equine 2015 Study, and aimed to describe equine parasite control strategies in the U...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329622/prevalence-and-molecular-characterization-of-giardia-duodenalis-in-cattle-and-sheep-from-the-qinghai-tibetan-plateau-area-qtpa-northwestern-china
#17
Yingna Jian, Xueyong Zhang, Xiuping Li, Gabriele Karanis, Liqing Ma, Panagiotis Karanis
Giardia duodenalis is an important intestinal protozoan parasite with a wide range of hosts, including humans, livestock and wildlife. The purpose of this study was to determine the prevalence of G. duodenalis infections among cattle and sheep in the Qinghai-Tibetan Plateau Area (QTPA) and to assess the potential risk of the zoonotic transmission of this pathogen. A total of 454 stool specimens were collected and examined using the nested PCR method based on the G. duodenalis SSUrRNA gene fragment. Thirty-nine out of 389 cattle specimens examined were positive (10%) for the G...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329618/vaccination-against-fasciola-hepatica-using-cathepsin-l3-and-b3-proteases-delivered-alone-or-in-combination
#18
Agnieszka Wesołowska, Katarzyna Basałaj, Luke J Norbury, Alicja Sielicka, Halina Wędrychowicz, Anna Zawistowska-Deniziak
No licensed vaccine is currently available for prevention of Fasciola hepatica infections. However, considering the alarming increase in drug resistance, there is an urgent need for a safe and fully effective vaccine against fasciolosis. Here, we tested if cathepsins L (FhCL3-1, FhCL3-2) and B (FhCB3) secreted by juvenile liver flukes are viable vaccine targets when delivered alone or in combination in a rat model. Since control over the early immune response is crucial for parasite's establishment in its host, it was hypothesised that targeting fluke juvenile stages may prove beneficial...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329617/dna-detection-of-trypanosoma-evansi-diagnostic-validity-of-a-new-assay-based-on-loop-mediated-isothermal-amplification-lamp
#19
Qunbo Tong, Rui Chen, Qingming Kong, Julie Goossens, Magdalena Radwanska, Di Lou, Jianzu Ding, Bin Zheng, Yixiu Fu, Tianping Wang, Magez Stefan, Shaohong Lu
Trypanosoma evansi (T. evansi) is the most widely spread pathogenic trypanosome in the world. The control of trypanosomiasis depends on accurate diagnosis and effective treatment. Focusing on the presence of T. evansi in Asia, we developed a detection assay based on tracing phosphate ions (Pi) generated during LAMP targeting the variant surface glycoprotein (VSG) gene of Rode Trypanozoon antigenic type 1.2 (RoTat 1.2 VSG). The diagnostic potential as well as the use of the assay as a test-of-cure method after berenil treatment, was assessed in mice at different time points of infection...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29329599/gallbladder-ascariasis-in-kosovo-focus-on-ultrasound-and-conservative-therapy-a-case-series
#20
Vlora Ismaili-Jaha, Halim Toro, Lidvana Spahiu, Mehmedali Azemi, Teuta Hoxha-Kamberi, Muharrem Avdiu, Shqipe Spahiu-Konjusha, Luan Jaha
BACKGROUND: Ascaris lumbricoides is one of the most common intestinal infections in developing countries, including Kosovo. In contrast to migration to the bile duct, migration of the worm to the gallbladder, due to the narrow and tortuous nature of the cystic duct, is rare. When it does occur, it incites acalculous cholecystitis. CASE PRESENTATIONS: This case series describes a 16-month-old Albanian girl, a 22-month-old Albanian girl, a 4-year-old Albanian girl, and a 10-year-old Albanian boy...
January 13, 2018: Journal of Medical Case Reports
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