Michael I Lewis, Shelley Shapiro, Ronald J Oudiz, Mamoo Nakamura, Dael Geft, Yuri Matusov, Antoine Hage, Victor F Tapson, Timothy D Henry, Parisa Azizad, Rajan Saggar, James Mirocha, Oleg A Karpov, Jennifer E Van Eyk, Eduardo Marbán
BACKGROUND: Pulmonary Arterial Hypertension (PAH) is a progressive condition with no cure. Even with pharmacologic advances, survival remains poor. Lung pathology on PAH therapies still shows impressive occlusive arteriolar remodelling and plexiform lesions. Cardiosphere-derived cells (CDCs) are heart-derived progenitor cells exhibiting anti-inflammatory and immunomodulatory effects, are anti -fibrotic, anti-oxidative and anti-apoptotic to potentially impact several aspects of PAH pathobiology...
December 7, 2023: EBioMedicine