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https://www.readbyqxmd.com/read/28320456/thiolation-of-arabinoxylan-and-its-application-in-the-fabrication-of-controlled-release-mucoadhesive-oral-films
#1
Muhammad Hanif, Muhammad Zaman
BACKGROUND: Mucoadhesion is an important property that helps oral drug delivery system to remain attached with buccal mucosa and hence to improve the delivery of the drug. The current study was designed to achieve the thiol modification of Arabinoxylan (ARX) and to develop a mucoadhesive oral film for the improved delivery of tizanidine hydrochloride (TZN HCl). METHOD: Synthesis of thiolated arabinoxylan (TARX) was accomplished by esterification of ARX with thioglycolic acid (TGA)...
March 20, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28298263/a-proof-of-principle-simulation-for-closed-loop-control-based-on-preexisting-experimental-thalamic-dbs-enhanced-instrumental-learning
#2
Ching-Fu Wang, Shih-Hung Yang, Sheng-Huang Lin, Po-Chuan Chen, Yu-Chun Lo, Han-Chi Pan, Hsin-Yi Lai, Lun-De Liao, Hui-Ching Lin, Hsu-Yan Chen, Wei-Chen Huang, Wun-Jhu Huang, You-Yin Chen
Deep brain stimulation (DBS) has been applied as an effective therapy for treating Parkinson's disease or essential tremor. Several open-loop DBS control strategies have been developed for clinical experiments, but they are limited by short battery life and inefficient therapy. Therefore, many closed-loop DBS control systems have been designed to tackle these problems by automatically adjusting the stimulation parameters via feedback from neural signals, which has been reported to reduce the power consumption...
February 24, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28280739/a-miso-arx-based-method-for-single-trial-evoked-potential-extraction
#3
Nannan Yu, Lingling Wu, Dexuan Zou, Ying Chen, Hanbing Lu
In this paper, we propose a novel method for solving the single-trial evoked potential (EP) estimation problem. In this method, the single-trial EP is considered as a complex containing many components, which may originate from different functional brain sites; these components can be distinguished according to their respective latencies and amplitudes and are extracted simultaneously by multiple-input single-output autoregressive modeling with exogenous input (MISO-ARX). The extraction process is performed in three stages: first, we use a reference EP as a template and decompose it into a set of components, which serve as subtemplates for the remaining steps...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28269727/mr-conditional-safety-assessment-of-implanted-medical-devices-advantages-of-computational-human-phantoms
#4
James E Brown, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx
Until recently, patients with active implantable medical devices (AIMDs) have been contraindicated for magnetic resonance imaging (MRI). Current efforts to demonstrate safety of these devices separate the interaction of the device and MRI into several hazards. For several of these hazards, computational human phantoms (CHPs) are used to provide conservative conditions for a risk-based analysis. This use of CHPs for the identification of conservative conditions provides a substantial benefit to the assessment of MR conditional safety over experimental techniques, as the evaluation of millions of test cases is possible in simulation, but impractical (due to economic constraints) and, in some cases, unethical for an experimental effort...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28269350/saw-lc-coupled-resonator-wideband-vco-for-medical-telemetry
#5
Madhav Venkateswaran, Mark Hillig, James E Brown, Paul J Stadnik, Jeffrey A Von Arx, Brian Sutton, Larry J Stotts
Wireless links with implantable devices can help in real-time monitoring of symptoms, irregularities, implanted device efficacy and their reconfiguration. We present the design of a low-power wideband voltage controlled oscillator (VCO) to facilitate implantable wireless telemetry. A coupled SAW-LC resonator design combines high Q and spectral purity of a SAW element and tunability of an LC-tank. The designed 2.7 MHz bandwidth VCO is suitable for full duplex communication protocols in the MedRadio band with frequency agility and higher duty cycles, in conformance with FCC regulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268423/dynamic-cerebral-autoregulation-in-young-athletes-following-concussion
#6
Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis
The purpose of this study was to examine cerebral autoregulation (CA) in young athletes experiencing concussion. The subjects were monitored and repeatedly tested 72 hours, 2 weeks and 1 month post-injury. Mean arterial blood pressure (MABP), end-tidal partial pressure of carbon dioxide (PETCO2) and cerebral blood flow velocity (CBFV) in the middle and posterior cerebral arteries were monitored during mental activation paradigms. In order to characterize CA we employed autoregressive models with exogenous inputs (ARX) and impulse response models based on the Laguerre expansion technique (LET)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28258660/pure-optic-ataxia-and-visual-hemiagnosia-extending-the-dual-visual-hypothesis
#7
Jurka R Meichtry, Dario Cazzoli, Silvia Chaves, Sebastian von Arx, Tobias Pflugshaupt, Roger Kalla, Claudio L Bassetti, Klemens Gutbrod, René M Müri
Goodale and Milner's two visual system hypothesis is an influential model for the understanding of the primate visual system. Lesions of either the ventral (occipito-temporal) or the dorsal (occipito-parietal) stream produce distinct and dissociated syndromes in humans: visual agnosia is typical for ventral damage, whereas optic ataxia (OA) for dorsal damage. We studied the case of a 59-year-old left-handed woman with a circumscribed lesion around the left posterior occipital sulcus, extending to the underlying white matter...
March 4, 2017: Journal of Neuropsychology
https://www.readbyqxmd.com/read/28229599/palladium-catalyzed-arylcarboxylation-of-propargylic-alcohols-with-co2-and-aryl-halides-access-to-functionalized-%C3%AE-alkylidene-cyclic-carbonates
#8
Song Sun, Bingbing Wang, Ning Gu, Jin-Tao Yu, Jiang Cheng
A palladium-catalyzed, three-component reaction between propargylic alcohols, CO2, and aryl halides was developed whereby a sequential carboxylation, trans-oxopalladation of the C≡C bond by an ArPdX species, and a reductive elimination procedure afforded a series of functionalized α-alkylidene cyclic carbonates in moderate to excellent yields. Notably, the configuration of these tetrasubstituted olefins was dominated by the trans-oxopalladation step where the aryl group derived from ArX is located trans to the oxygen attached in the double bond...
February 23, 2017: Organic Letters
https://www.readbyqxmd.com/read/28228521/clustered-brachiopod-hox-genes-are-not-expressed-collinearly-and-are-associated-with-lophotrochozoan-novelties
#9
Sabrina M Schiemann, José M Martín-Durán, Aina Børve, Bruno C Vellutini, Yale J Passamaneck, Andreas Hejnol
Temporal collinearity is often considered the main force preserving Hox gene clusters in animal genomes. Studies that combine genomic and gene expression data are scarce, however, particularly in invertebrates like the Lophotrochozoa. As a result, the temporal collinearity hypothesis is currently built on poorly supported foundations. Here we characterize the complement, cluster, and expression of Hox genes in two brachiopod species, Terebratalia transversa and Novocrania anomalaT. transversa has a split cluster with 10 genes (lab, pb, Hox3, Dfd, Scr, Lox5, Antp, Lox4, Post2, and Post1), whereas N...
March 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28227991/mr-conditional-safety-assessment-of-implanted-medical-devices-advantages-of-computational-human-phantoms
#10
James E Brown, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx, James E Brown, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx, James E Brown
Until recently, patients with active implantable medical devices (AIMDs) have been contraindicated for magnetic resonance imaging (MRI). Current efforts to demonstrate safety of these devices separate the interaction of the device and MRI into several hazards. For several of these hazards, computational human phantoms (CHPs) are used to provide conservative conditions for a risk-based analysis. This use of CHPs for the identification of conservative conditions provides a substantial benefit to the assessment of MR conditional safety over experimental techniques, as the evaluation of millions of test cases is possible in simulation, but impractical (due to economic constraints) and, in some cases, unethical for an experimental effort...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227592/saw-lc-coupled-resonator-wideband-vco-for-medical-telemetry
#11
Madhav Venkateswaran, Mark Hillig, James E Brown, Paul J Stadnik, Jeffrey A Von Arx, Brian Sutton, Larry J Stotts, Madhav Venkateswaran, Mark Hillig, James E Brown, Paul J Stadnik, Jeffrey A Von Arx, Brian Sutton, Larry J Stotts, Mark Hillig, Jeffrey A Von Arx, Madhav Venkateswaran, Brian Sutton, James E Brown, Paul J Stadnik, Larry J Stotts
Wireless links with implantable devices can help in real-time monitoring of symptoms, irregularities, implanted device efficacy and their reconfiguration. We present the design of a low-power wideband voltage controlled oscillator (VCO) to facilitate implantable wireless telemetry. A coupled SAW-LC resonator design combines high Q and spectral purity of a SAW element and tunability of an LC-tank. The designed 2.7 MHz bandwidth VCO is suitable for full duplex communication protocols in the MedRadio band with frequency agility and higher duty cycles, in conformance with FCC regulations...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226593/dynamic-cerebral-autoregulation-in-young-athletes-following-concussion
#12
Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis, Kyriaki Kostoglou, Alexander D Wright, Jonathan D Smirl, Kelsey Bryk, Paul van Donkelaar, Georgios D Mitsis, Paul van Donkelaar, Alexander D Wright, Kyriaki Kostoglou, Jonathan D Smirl, Kelsey Bryk, Georgios D Mitsis
The purpose of this study was to examine cerebral autoregulation (CA) in young athletes experiencing concussion. The subjects were monitored and repeatedly tested 72 hours, 2 weeks and 1 month post-injury. Mean arterial blood pressure (MABP), end-tidal partial pressure of carbon dioxide (PETCO2) and cerebral blood flow velocity (CBFV) in the middle and posterior cerebral arteries were monitored during mental activation paradigms. In order to characterize CA we employed autoregressive models with exogenous inputs (ARX) and impulse response models based on the Laguerre expansion technique (LET)...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28215845/converting-adult-pancreatic-islet-%C3%AE-cells-into-%C3%AE-cells-by-targeting-both-dnmt1-and-arx
#13
Harini Chakravarthy, Xueying Gu, Martin Enge, Xiaoqing Dai, Yong Wang, Nicolas Damond, Carolina Downie, Kathy Liu, Jing Wang, Yuan Xing, Simona Chera, Fabrizio Thorel, Stephen Quake, Jose Oberholzer, Patrick E MacDonald, Pedro L Herrera, Seung K Kim
Insulin-producing pancreatic β cells in mice can slowly regenerate from glucagon-producing α cells in settings like β cell loss, but the basis of this conversion is unknown. Moreover, it remains unclear if this intra-islet cell conversion is relevant to diseases like type 1 diabetes (T1D). We show that the α cell regulators Aristaless-related homeobox (Arx) and DNA methyltransferase 1 (Dnmt1) maintain α cell identity in mice. Within 3 months of Dnmt1 and Arx loss, lineage tracing and single-cell RNA sequencing revealed extensive α cell conversion into progeny resembling native β cells...
March 7, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28176220/does-early-response-to-intravenous-glucocorticoids-predict-the-final-outcome-in-patients-with-moderate-to-severe-and-active-graves-orbitopathy
#14
L Bartalena, G Veronesi, G E Krassas, W M Wiersinga, C Marcocci, M Marinò, M Salvi, C Daumerie, C Bournaud, M Stahl, L Sassi, C Azzolini, K G Boboridis, M P Mourits, M R Soeters, L Baldeschi, M Nardi, N Currò, A Boschi, M Bernard, G von Arx, P Perros, G J Kahaly
PURPOSE: Intravenous glucocorticoids (ivGCs) given as 12-weekly infusions are the first-line treatment for moderate-to-severe and active Graves' orbitopathy (GO), but they are not always effective. In this study, we evaluated whether response at 6 weeks correlated with outcomes at 12 (end of intervention) and 24 (follow-up) weeks, particularly in patients initially unresponsive. METHODS: Our database (Bartalena et al. J Clin Endocrinol Metab 97:4454-4463, 10), comprising 159 patients given three different cumulative doses of methylprednisolone (2...
February 7, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28174645/a-novel-mutation-in-the-oar-domain-of-the-arx-gene
#15
Alejandra Tapie, Natalia Pi-Denis, Jorge Souto, Alejandra Vomero, Gabriel Peluffo, María Boidi, Martín Ciganda, Nicolás Curbelo, Victor Raggio, Leda Roche, Lucía Pastro
Mutations in ARX gene should be considered in patients with mental disability or/and epilepsy. It is an X-linked gene that has pleiotropic effects. Here, we report the case of a boy diagnosed with Ohtahara syndrome. We performed the molecular analysis of the gene and identified a new missense mutation.
February 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28154547/gait-in-children-with-attention-deficit-hyperactivity-disorder-in-a-dual-task-paradigm
#16
Olivia Manicolo, Alexander Grob, Priska Hagmann-von Arx
The aim was to examine gait in school-aged children with attention-deficit hyperactivity disorder (ADHD) and typically developing controls in a dual-task paradigm. Thirty children with ADHD (without or off medication) aged 7-13 years and 28 controls walked without an additional task (single-task walking) and while performing a concurrent cognitive or motor task (dual-task walking). Gait was assessed using GAITRite recordings of spatiotemporal and variability gait parameters. Compared to single-task walking, dual-tasking significantly altered walking performance of children with and without ADHD, whereby dual-task effects on gait were not different between the two groups...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28153982/diel-rhythms-and-sex-differences-in-the-locomotor-activity-of-hawkmoths
#17
Geoffrey T Broadhead, Trisha Basu, Martin von Arx, Robert A Raguso
Circadian patterns of activity are considered ubiquitous and adaptive, and are often invoked as a mechanism for temporal niche partitioning. Yet, comparisons of rhythmic behavior in related animal species are uncommon. This is particularly true of Lepidoptera (butterflies and moths), in which studies of whole-animal patterns of behavior are far outweighed by examinations of tissue-specific molecular clocks. Here, we used a comparative approach to examine the circadian patterns of flight behavior in Manduca sexta and Hyles lineata, two distantly related species of hawkmoth (Sphingidae)...
February 2, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28150386/an-emerging-female-phenotype-with-loss-of-function-mutations-in-the-aristaless-related-homeodomain-transcription-factor-arx
#18
Tessa Mattiske, Ching Moey, Lisenka E Vissers, Natalie Thorne, Peter Georgeson, Madhura Bakshi, Cheryl Shoubridge
The devastating clinical presentation of X-linked lissencephaly with abnormal genitalia (XLAG) is invariably caused by loss of function mutations in the Aristaless-related homeobox (ARX) gene. Mutations in this X-chromosome gene contribute to intellectual disability (ID) with co-morbidities including seizures and movement disorders such as dystonia in affected males. The detection of affected females with mutations in ARX is increasing. We present a family with multiple affected individuals, including two females...
February 1, 2017: Human Mutation
https://www.readbyqxmd.com/read/28134967/vertical-root-fractures-of-endodontically-treated-posterior-teeth-a-histologic-analysis-with-clinical-and-radiographic-correlates
#19
Thomas von Arx, Dieter Bosshardt
Vertical root fractures (VRFs) usually develop slowly, unnoticed by the patient until clinical signs and symptoms become apparent. In endodontically treated teeth, a VRF is a typical cause for extraction. The objective of the present study was the histologic analysis of VRFs in extracted, endodontically treated premolars and molars. In addition, clinical and radiographic findings of these VRF-affected teeth were retrospectively evaluated. Thirty extracted teeth with a clinically diagnosed VRF were embedded in methylmethacrylate...
2017: Swiss Dental Journal
https://www.readbyqxmd.com/read/28130220/how-does-climate-influence-xylem-morphogenesis-over-the-growing-season-insights-from-long-term-intra-ring-anatomy-in-picea-abies
#20
Daniele Castagneri, Patrick Fonti, Georg von Arx, Marco Carrer
BACKGROUND AND AIMS: During the growing season, the cambium of conifer trees produces successive rows of xylem cells, the tracheids, that sequentially pass through the phases of enlargement and secondary wall thickening before dying and becoming functional. Climate variability can strongly influence the kinetics of morphogenetic processes, eventually affecting tracheid shape and size. This study investigates xylem anatomical structure in the stem of Picea abies to retrospectively infer how, in the long term, climate affects the processes of cell enlargement and wall thickening...
January 27, 2017: Annals of Botany
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