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https://www.readbyqxmd.com/read/27916275/artemisinins-target-gabaa-receptor-signaling-and-impair-%C3%AE-cell-identity
#1
Jin Li, Tamara Casteels, Thomas Frogne, Camilla Ingvorsen, Christian Honoré, Monica Courtney, Kilian V M Huber, Nicole Schmitner, Robin A Kimmel, Roman A Romanov, Caterina Sturtzel, Charles-Hugues Lardeau, Johanna Klughammer, Matthias Farlik, Sara Sdelci, Andhira Vieira, Fabio Avolio, François Briand, Igor Baburin, Peter Májek, Florian M Pauler, Thomas Penz, Alexey Stukalov, Manuela Gridling, Katja Parapatics, Charlotte Barbieux, Ekaterine Berishvili, Andreas Spittler, Jacques Colinge, Keiryn L Bennett, Steffen Hering, Thierry Sulpice, Christoph Bock, Martin Distel, Tibor Harkany, Dirk Meyer, Giulio Superti-Furga, Patrick Collombat, Jacob Hecksher-Sørensen, Stefan Kubicek
Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of regenerative medicine. One promising approach is transdifferentiation of developmentally related pancreatic cell types, including glucagon-producing α cells. In a genetic model, loss of the master regulatory transcription factor Arx is sufficient to induce the conversion of α cells to functional β-like cells. Here, we identify artemisinins as small molecules that functionally repress Arx by causing its translocation to the cytoplasm...
November 30, 2016: Cell
https://www.readbyqxmd.com/read/27867266/a-new-antifungal-isocoumarin-from-the-endophytic-fungus-trichoderma-sp-09-of-myoporum-bontioides-a-gray
#2
Wensheng Li, Jiaxin Xu, Fenqi Li, Li Xu, Chunyuan Li
BACKGROUND: Myoporum bontioides A. Gray is a commonly used medicinal plant in China. Recently, the chemical and bioactive investigations to the endophytic fungi of this plant have led to several new compounds with antimicrobial and cytotoxic activities. To find out more active molecules, the metabolites of an endophytic fungus, Trichoderma sp. 09 from the root of Myoporum bontioides were investigated. MATERIALS AND METHODS: The metabolites were isolated by column chromatography on silica gel, and their structures were elucidated on the basis of spectroscopic analysis[one-dimensional (1D), two-dimensional (2D)-nuclear magnetic resonance (NMR), Mass spectrometry (MS)], and by comparison with the published data...
October 2016: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/27864883/neuronal-sources-of-hedgehog-modulate-neurogenesis-in-the-adult-planarian-brain
#3
Ko W Currie, Alyssa M Molinaro, Bret J Pearson
The asexual freshwater planarian is a constitutive adult, whose central nervous system (CNS) is in a state of constant homeostatic neurogenesis. However, very little is known about the extrinsic signals that act on planarian stem cells to modulate rates of neurogenesis. We have identified two planarian homeobox transcription factors, Smed-nkx2.1 and Smed-arx, which are required for the maintenance of cholinergic, GABAergic, and octopaminergic neurons in the planarian CNS. These very same neurons also produce the planarian hedgehog ligand (Smed-hh), which appears to communicate with brain-adjacent stem cells to promote normal levels of neurogenesis...
November 19, 2016: ELife
https://www.readbyqxmd.com/read/27846270/measurement-invariance-and-latent-mean-differences-in-the-reynolds-intellectual-assessment-scales-rias-does-the-german-version-of-the-rias-allow-a-valid-assessment-of-individuals-with-a-migration-background
#4
Jasmin T Gygi, Elodie Fux, Alexander Grob, Priska Hagmann-von Arx
This study examined measurement invariance and latent mean differences in the German version of the Reynolds Intellectual Assessment Scales (RIAS) for 316 individuals with a migration background (defined as speaking German as a second language) and 316 sex- and age-matched natives. The RIAS measures general intelligence (single-factor structure) and its two components, verbal and nonverbal intelligence (two-factor structure). Results of a multi-group confirmatory factor analysis showed scalar invariance for the two-factor and partial scalar invariance for the single-factor structure...
2016: PloS One
https://www.readbyqxmd.com/read/27808504/a-comparative-analysis-on-the-effector-role-of-redox-partner-binding-in-bacterial-p450s
#5
Dipanwita Batabyal, Ariel Lewis-Ballester, Syun-Ru Yeh, Thomas L Poulos
The camphor monooxygenase, cytochrome P450cam, exhibits a strict requirement for its own redox partner, putidaredoxin (Pdx), a two iron-sulfur ferredoxin. The closest homolog to P450cam is CYP101D1 which is structurally very similar, uses a similar redox partner, and exhibits nearly identical enzymatic properties in the monooxygenation of camphor to give the same single 5-exo-hydroxy camphor product. However, CYP101D1 does not strictly require its own ferredoxin (Arx) for activity since Pdx can support CYP101D1 catalysis but Arx cannot support P450cam catalysis...
November 3, 2016: Biochemistry
https://www.readbyqxmd.com/read/27798861/antiangiogenic-therapy-in-pancreatic-neuroendocrine-tumors
#6
REVIEW
Monica Capozzi, Claudia VON Arx, Chiara DE Divitiis, Alessandro Ottaiano, Fabiana Tatangelo, Giovanni Maria Romano, Salvatore Tafuto
In recent years, many progresses have been pursued in the management of advanced pancreatic neuroendocrine tumor (pNET); most of them were prompted by increasing knowledge of biology of these neoplasms, including the identification of promising biological targets for therapy. PNETs belong to a group of rare neoplastic diseases. They originate from neuroendocrine system cells and are very heterogeneous regarding anatomic localization and aggressiveness. Recently, many efforts have been particularly focused on the identification of pathologic pathways and innovative drugs in order to treat patients with unresectable, metastatic disease, in progressive well-differentiated pNETs...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27798109/embryonic-forebrain-transcriptome-of-mice-with-polyalanine-expansion-mutations-in-the-arx-homeobox-gene
#7
Tessa Mattiske, Kristie Lee, Jozef Gecz, Gaelle Friocourt, Cheryl Shoubridge
The Aristaless related homeobox (ARX) gene encodes a paired-type homeodomain transcription factor with critical roles in embryonic development. Mutations in ARX give rise to intellectual disability (ID), epilepsy and brain malformation syndromes. To capture the genetics and molecular disruptions that underpin the ARX-associated clinical phenotypes, we undertook a transcriptome wide RNASeq approach to analyse developing (12.5 dpc) telencephalon of mice modelling two recurrent polyalanine expansion mutations with different phenotypic severities in the ARX gene...
October 25, 2016: Human Molecular Genetics
https://www.readbyqxmd.com/read/27781032/genetic-basis-of-brain-malformations
#8
REVIEW
Elena Parrini, Valerio Conti, William B Dobyns, Renzo Guerrini
Malformations of cortical development (MCD) represent a major cause of developmental disabilities, severe epilepsy, and reproductive disadvantage. Genes that have been associated to MCD are mainly involved in cell proliferation and specification, neuronal migration, and late cortical organization. Lissencephaly-pachygyria-severe band heterotopia are diffuse neuronal migration disorders causing severe global neurological impairment. Abnormalities of the LIS1, DCX, ARX, RELN, VLDLR, ACTB, ACTG1, TUBG1, KIF5C, KIF2A, and CDK5 genes have been associated with these malformations...
September 2016: Molecular Syndromology
https://www.readbyqxmd.com/read/27779377/comprehensive-analysis-of-a-novel-ketoreductase-for-pentangular-polyphenol-biosynthesis
#9
Timothy R Valentic, David R Jackson, Sean F Brady, Shiou-Chuan Sheryl Tsai
Arixanthomycins are pentangular polyphenols (PP) with potent antiproliferative activities that were discovered through the heterologous expression of environmental DNA-derived gene clusters. The biosynthesis of arixanthomycin and other PPs is unusual, because it requires several novel type II polyketide synthase (PKS) enzymes for its complete maturation. Most type II PKSs contain a ketoreductase (KR) that mediates the C7-C12 first ring cyclization and C9-reduction. In contrast, based on previous studies of product analysis and genome mining, the arixanthomycin (ARX) gene cluster like harbors a C11-reducing ketoreductase (ARX 27), a C9-C14 first-ring aromatase/cyclase (ARX 19), and an unprecedented C-17 and C-19 reducing KR (ARX 21)...
October 25, 2016: ACS Chemical Biology
https://www.readbyqxmd.com/read/27740642/scarring-of-soft-tissues-following-apical-surgery-visual-assessment-of-outcomes-one-year-after-intervention-using-the-bern-and-manchester-scores
#10
Thomas von Arx, Simone Fm Janner, Stefan Hänni, Michael M Bornstein
The successful outcome of apical surgery is usually defined by absence of clinical signs and symptoms and resolution of previous periapical radiolucencies. However, little attention is given to soft tissue scarring. The present study evaluated the severity of gingival and mucosal scarring 1 year following apical surgery of 52 teeth. Clinical pictures taken at the 1-year examination were rated by three observers using specific scarring scores. The overall repeatability of the two scores was high (85.3%), whereas the overall reproducibility was relatively low (44...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27734276/targeted-next-generation-sequencing-the-diagnostic-value-in-early-onset-epileptic-encephalopathy
#11
Sarenur Gokben, Huseyin Onay, Sanem Yilmaz, Tahir Atik, Gul Serdaroglu, Hande Tekin, Ferda Ozkinay
We investigated the genetic background of early-onset epileptic encephalopathy (EE) using targeted next generation sequencing analysis. Thirty sporadic or familial cases associated with early-onset EE were included. An early-onset EE gene panel including sixteen genes (ARX, CDKL5, CNTNAP2, FOLR1, FOXG1, LAMC3, MBD5, MECP2, NTNG1, PCDH19, PNKP, SCN1A, SCN1B, SCN2A, STXBP1, KCNQ2) was constituted. Nine definite and three potential causal mutations in 30 cases (40 %) were identified. All mutations presented heterozygously except one...
October 12, 2016: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/27626649/radiation-retinopathy-15-years-after-orbital-irradiation-for-thyroid-orbitopathy
#12
K Hurtikova, G von Arx, N Fichter, H Gerding
No abstract text is available yet for this article.
April 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27577394/a-generic-method-for-assessing-the-quality-of-de-identified-health-data
#13
Fabian Prasser, Raffael Bild, Klaus A Kuhn
Data sharing plays an important role in modern biomedical research. Due to the inherent sensitivity of health data, patient privacy must be protected. De-identification means to transform a dataset in such a way that it becomes extremely difficult for an attacker to link its records to identified individuals. This can be achieved with different types of data transformations. As transformation impacts the information content of a dataset, it is important to balance an increase in privacy with a decrease in data quality...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27571141/nickel-catalyzed-ortho-arylation-of-unactivated-hetero-aryl-c-h-bonds-with-arylsilanes-using-a-removable-auxiliary
#14
Sheng Zhao, Bin Liu, Bei-Bei Zhan, Wei-Dong Zhang, Bing-Feng Shi
Ni(II)-catalyzed ortho-arylation of aromatic and heteroaromatic carboxamides with triethoxy(aryl)silanes assisted by a removable bidentate auxiliary is reported. This transformation features a broad substrate scope, good functional group tolerance, and compatibility with heterocyclic substrates. Compared to the well-established Ni(II)-catalyzed C-H arylation with ArX or aryliodonium salts via oxidative addition, this reaction proceeded via a fluoride-promoted transmetalation.
September 16, 2016: Organic Letters
https://www.readbyqxmd.com/read/27527274/genome-wide-dna-methylation-analysis-in-obsessive-compulsive-disorder-patients
#15
Weihua Yue, Weiqiu Cheng, Zhaorui Liu, Yi Tang, Tianlan Lu, Dai Zhang, Muni Tang, Yueqin Huang
Literatures have suggested that not only genetic but also environmental factors, interactively accounted for susceptibility of obsessive-compulsive disorder (OCD). DNA methylation may regulate expression of genes as the heritable epigenetic modification. The examination for genome-wide DNA methylation was performed on blood samples from 65 patients with OCD, as well as 96 healthy control subjects. The DNA methylation was examined at over 485,000 CpG sites using the Illumina Infinium Human Methylation450 BeadChip...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27497247/does-iq-iq-comparability-of-intelligence-test-scores-in-typically-developing-children
#16
Priska Hagmann-von Arx, Sakari Lemola, Alexander Grob
Numerous intelligence tests are available to psychological diagnosticians to assess children's intelligence, but whether they yield comparable test results has been little studied. We examined test scores of 206 typically developing children aged 6 to 11 years on five German intelligence tests (Reynolds Intellectual Assessment Scales; Snijders Oomen Nonverbal Intelligence Test; Intelligence and Development Scales; Wechsler Intelligence Scale for Children, 4th edition; Culture Fair Intelligence Test Scale 2), which were individually administered...
August 5, 2016: Assessment
https://www.readbyqxmd.com/read/27479530/regulation-of-pancreatic-%C3%AE-cell-function-and-proliferation-by-bone-morphogenetic-protein-4-bmp4-in-vitro
#17
Sofie Sylvest Nielsen, Gitte Lund Christensen, Jens Juul Holst, Nils Billestrup
Increased expression of bone morphogenetic proteins (BMPs) in several tissues is associated with inflammation and type 2 diabetes mellitus. BMP2 and BMP4 mRNA expression is increased in pancreatic islets from db/db mice and β-cell proliferation and function are inhibited by BMP4. The effect of BMPs on α-cells is currently unknown. Here, we investigate the effects of BMP4 on mouse and human α-cells in vitro. The effects of BMP4 on α-cell proliferation and function were investigated in islets isolated from male mice and from human donors, and in α-TC1-6 cells...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27476677/lateral-ridge-augmentation-using-autogenous-block-grafts-and-guided-bone-regeneration-a-10-year-prospective-case-series-study
#18
Vivianne Chappuis, Yeliz Cavusoglu, Daniel Buser, Thomas von Arx
BACKGROUND: The use of autogenous block grafts harvested from intraoral donor sites has proven to be effective for the reconstruction of horizontal bone defects. PURPOSE: The objective of this study was to analyze implant success and the rate of block graft resorption 10 years after ridge augmentation to elucidate contributing factors influencing graft maintenance. MATERIALS AND METHODS: A staged horizontal block graft augmentation was performed in 52 implant sites exhibiting severe horizontal bone atrophy using autogenous block grafts protected by DBBM and collagen membranes...
July 31, 2016: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/27434634/salivary-and-hair-glucocorticoids-and-sleep-in-very-preterm-children-during-school-age
#19
Natalie Maurer, Nadine Perkinson-Gloor, Tobias Stalder, Priska Hagmann-von Arx, Serge Brand, Edith Holsboer-Trachsler, Sven Wellmann, Alexander Grob, Peter Weber, Sakari Lemola
Very preterm birth involves increased stress for the child, which may lead to programming of the hypothalamic-pituitary-adrenal (HPA) axis activity and poor sleep in later life. Moreover, there is evidence for a relationship between HPA axis activity and sleep. However, research with objective sleep measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7-12 years were recruited for the present study...
October 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27377433/-mineral-trioxide-aggregate-mta-a-success-story-in-apical-surgery
#20
REVIEW
Thomas von Arx
The objective of apical surgery is to retain teeth with persistent apical pathosis following orthograde root canal treatment if endodontic non-surgical revision is difficult or associated with risks, or is even declined by the patient. Since the most frequent cause of recurrent apical disease is bacterial reinfection from the (remaining) root canal system, the bacteria-tight root-end filling is the most important step in apical surgery. In the early 1990s, mineral trioxide aggregate (MTA) was developed at the Loma Linda University in California/USA...
2016: Swiss Dental Journal
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