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Thomas von Arx, Simone Fm Janner, Stefan Hänni, Michael M Bornstein
The successful outcome of apical surgery is usually defined by absence of clinical signs and symptoms and resolution of previous periapical radiolucencies. However, little attention is given to soft tissue scarring. The present study evaluated the severity of gingival and mucosal scarring 1 year following apical surgery of 52 teeth. Clinical pictures taken at the 1-year examination were rated by three observers using specific scarring scores. The overall repeatability of the two scores was high (85.3%), whereas the overall reproducibility was relatively low (44...
November 2016: International Journal of Periodontics & Restorative Dentistry
Sarenur Gokben, Huseyin Onay, Sanem Yilmaz, Tahir Atik, Gul Serdaroglu, Hande Tekin, Ferda Ozkinay
We investigated the genetic background of early-onset epileptic encephalopathy (EE) using targeted next generation sequencing analysis. Thirty sporadic or familial cases associated with early-onset EE were included. An early-onset EE gene panel including sixteen genes (ARX, CDKL5, CNTNAP2, FOLR1, FOXG1, LAMC3, MBD5, MECP2, NTNG1, PCDH19, PNKP, SCN1A, SCN1B, SCN2A, STXBP1, KCNQ2) was constituted. Nine definite and three potential causal mutations in 30 cases (40 %) were identified. All mutations presented heterozygously except one...
October 12, 2016: Acta Neurologica Belgica
K Hurtikova, G von Arx, N Fichter, H Gerding
No abstract text is available yet for this article.
April 2016: Klinische Monatsblätter Für Augenheilkunde
Fabian Prasser, Raffael Bild, Klaus A Kuhn
Data sharing plays an important role in modern biomedical research. Due to the inherent sensitivity of health data, patient privacy must be protected. De-identification means to transform a dataset in such a way that it becomes extremely difficult for an attacker to link its records to identified individuals. This can be achieved with different types of data transformations. As transformation impacts the information content of a dataset, it is important to balance an increase in privacy with a decrease in data quality...
2016: Studies in Health Technology and Informatics
Sheng Zhao, Bin Liu, Bei-Bei Zhan, Wei-Dong Zhang, Bing-Feng Shi
Ni(II)-catalyzed ortho-arylation of aromatic and heteroaromatic carboxamides with triethoxy(aryl)silanes assisted by a removable bidentate auxiliary is reported. This transformation features a broad substrate scope, good functional group tolerance, and compatibility with heterocyclic substrates. Compared to the well-established Ni(II)-catalyzed C-H arylation with ArX or aryliodonium salts via oxidative addition, this reaction proceeded via a fluoride-promoted transmetalation.
September 16, 2016: Organic Letters
Weihua Yue, Weiqiu Cheng, Zhaorui Liu, Yi Tang, Tianlan Lu, Dai Zhang, Muni Tang, Yueqin Huang
Literatures have suggested that not only genetic but also environmental factors, interactively accounted for susceptibility of obsessive-compulsive disorder (OCD). DNA methylation may regulate expression of genes as the heritable epigenetic modification. The examination for genome-wide DNA methylation was performed on blood samples from 65 patients with OCD, as well as 96 healthy control subjects. The DNA methylation was examined at over 485,000 CpG sites using the Illumina Infinium Human Methylation450 BeadChip...
2016: Scientific Reports
Priska Hagmann-von Arx, Sakari Lemola, Alexander Grob
Numerous intelligence tests are available to psychological diagnosticians to assess children's intelligence, but whether they yield comparable test results has been little studied. We examined test scores of 206 typically developing children aged 6 to 11 years on five German intelligence tests (Reynolds Intellectual Assessment Scales; Snijders Oomen Nonverbal Intelligence Test; Intelligence and Development Scales; Wechsler Intelligence Scale for Children, 4th edition; Culture Fair Intelligence Test Scale 2), which were individually administered...
August 5, 2016: Assessment
Sofie Sylvest Nielsen, Gitte Lund Christensen, Jens Juul Holst, Nils Billestrup
Increased expression of bone morphogenetic proteins (BMPs) in several tissues is associated with inflammation and type 2 diabetes mellitus. BMP2 and BMP4 mRNA expression is increased in pancreatic islets from db/db mice and β-cell proliferation and function are inhibited by BMP4. The effect of BMPs on α-cells is currently unknown. Here, we investigate the effects of BMP4 on mouse and human α-cells in vitro. The effects of BMP4 on α-cell proliferation and function were investigated in islets isolated from male mice and from human donors, and in α-TC1-6 cells...
October 2016: Endocrinology
Vivianne Chappuis, Yeliz Cavusoglu, Daniel Buser, Thomas von Arx
BACKGROUND: The use of autogenous block grafts harvested from intraoral donor sites has proven to be effective for the reconstruction of horizontal bone defects. PURPOSE: The objective of this study was to analyze implant success and the rate of block graft resorption 10 years after ridge augmentation to elucidate contributing factors influencing graft maintenance. MATERIALS AND METHODS: A staged horizontal block graft augmentation was performed in 52 implant sites exhibiting severe horizontal bone atrophy using autogenous block grafts protected by DBBM and collagen membranes...
July 31, 2016: Clinical Implant Dentistry and related Research
Natalie Maurer, Nadine Perkinson-Gloor, Tobias Stalder, Priska Hagmann-von Arx, Serge Brand, Edith Holsboer-Trachsler, Sven Wellmann, Alexander Grob, Peter Weber, Sakari Lemola
Very preterm birth involves increased stress for the child, which may lead to programming of the hypothalamic-pituitary-adrenal (HPA) axis activity and poor sleep in later life. Moreover, there is evidence for a relationship between HPA axis activity and sleep. However, research with objective sleep measures in very preterm children during school-age is rare. Eighty-five healthy children born very preterm (<32nd gestational week) and 91 full-term children aged 7-12 years were recruited for the present study...
October 2016: Psychoneuroendocrinology
Thomas von Arx
The objective of apical surgery is to retain teeth with persistent apical pathosis following orthograde root canal treatment if endodontic non-surgical revision is difficult or associated with risks, or is even declined by the patient. Since the most frequent cause of recurrent apical disease is bacterial reinfection from the (remaining) root canal system, the bacteria-tight root-end filling is the most important step in apical surgery. In the early 1990s, mineral trioxide aggregate (MTA) was developed at the Loma Linda University in California/USA...
2016: Swiss Dental Journal
Georg von Arx, Alan Crivellaro, Angela L Prendin, Katarina Čufar, Marco Carrer
Quantitative wood anatomy analyzes the variability of xylem anatomical features in trees, shrubs, and herbaceous species to address research questions related to plant functioning, growth, and environment. Among the more frequently considered anatomical features are lumen dimensions and wall thickness of conducting cells, fibers, and several ray properties. The structural properties of each xylem anatomical feature are mostly fixed once they are formed, and define to a large extent its functionality, including transport and storage of water, nutrients, sugars, and hormones, and providing mechanical support...
2016: Frontiers in Plant Science
Denise de Jong, Sigal Kaufmann-Ezra, Jurka R Meichtry, Sebastian von Arx, Dario Cazzoli, Klemens Gutbrod, René M Müri
UNLABELLED: Hemianopic reading impairment is a consequence of a visual field defect to either the right or the left side and is characterized by an increased reading time and reduced reading performance. Depending on the side of the visual field defect, reading will be affected differently: Patients suffering from a visual field defect to the right side have noticeable difficulties in reading fluently with slowing. Patients suffering from a visual field defect to the left usually struggle to find the beginning of a line and read more fluently...
December 2016: Journal of Clinical and Experimental Neuropsychology
Zhenhai Liu, Fei Wang, Weizhi Wang, Yanhua Luo
The aim of this study was to calculate the median effective concentration (EC50) of remifentanil (Rem) for the inhibition of laryngoscope-induced cardiovascular responses, and to observe its effects on the cardiovascular system and stress system. The study included 20 patients, who underwent time-scheduled vocal cord polyp resection with monitoring of heart rate (HR), mean blood pressure (MBP) and auditory evoked potential (AEP)-based A-line ARX Index (AAI). The Rem concentration was initially 5 ng/ml in the first patient, and the concentration selected for each subsequent patient was calculated from the previous case on the basis of whether or not cardiovascular reactions occurred...
July 2016: Experimental and Therapeutic Medicine
Tamar Chachua, Paola Di Grazia, Chian-Ru Chern, Meenu Johnkutty, Benjamin Hellman, Ho An Lau, Faariah Shakil, Margaret Daniel, Cezar Goletiani, Jana Velíšková, Libor Velíšek
OBJECTIVE: This study attempted to validate the effects of neonatal estradiol in ameliorating the spasms in the prenatally betamethasone-primed N-methyl-d-aspartate (NMDA) model of infantile spasms in rats as shown previously in a mouse Arx gene knock-in expansion model of infantile spasms. METHODS: Neonatal rats prenatally exposed to betamethasone (on day 15 of pregnancy) were treated with subcutaneous 40 ng/g estradiol benzoate (EB) between postnatal days (P)3-P10 or P0-P5...
August 2016: Epilepsia
Songlin Shi, Zongshan Li, Hao Wang, Georg von Arx, Yihe Lü, Xing Wu, Xiaochun Wang, Guohua Liu, Bojie Fu
Growth of herbaceous plants responds sensitively and rapidly to climate variability. Yet, little is known regarding how climate warming influences the growth of herbaceous plants, particularly in semi-arid sites. This contrasts with widely reported tree growth decline and even mortality in response to severe water deficits due to climate warming around the world. Here, we use the relatively novel approach of herb-chronology to analyze the correlation between climatic factors and annual ring width in the root xylem of two perennial forb species (Medicago sativa, Potentilla chinensis) in the Loess Plateau of China...
2016: Scientific Reports
Fabian Prasser, Florian Kohlmayer, Klaus A Kuhn
BACKGROUND: Data sharing is a central aspect of modern biomedical research. It is accompanied by significant privacy concerns and often data needs to be protected from re-identification. With methods of de-identification datasets can be transformed in such a way that it becomes extremely difficult to link their records to identified individuals. The most important challenge in this process is to find an adequate balance between an increase in privacy and a decrease in data quality. OBJECTIVES: Accurately measuring the risk of re-identification in a specific data sharing scenario is an important aspect of data de-identification...
August 5, 2016: Methods of Information in Medicine
Anna Lintunen, Teemu Paljakka, Tuula Jyske, Mikko Peltoniemi, Frank Sterck, Georg von Arx, Hervé Cochard, Paul Copini, Maria C Caldeira, Sylvain Delzon, Roman Gebauer, Leila Grönlund, Natasa Kiorapostolou, Silvia Lechthaler, Raquel Lobo-do-Vale, Richard L Peters, Giai Petit, Angela L Prendin, Yann Salmon, Kathy Steppe, Josef Urban, Sílvia Roig Juan, Elisabeth M R Robert, Teemu Hölttä
Phloem osmolality and its components are involved in basic cell metabolism, cell growth, and in various physiological processes including the ability of living cells to withstand drought and frost. Osmolality and sugar composition responses to environmental stresses have been extensively studied for leaves, but less for the secondary phloem of plant stems and branches. Leaf osmotic concentration and the share of pinitol and raffinose among soluble sugars increase with increasing drought or cold stress, and osmotic concentration is adjusted with osmoregulation...
2016: Frontiers in Plant Science
Maria J Lima, Kenneth R Muir, Hilary M Docherty, Neil W A McGowan, Shareen Forbes, Yves Heremans, Harry Heimberg, John Casey, Kevin Docherty
Transcription factor mediated lineage reprogramming of human pancreatic exocrine tissue could conceivably provide an unlimited supply of islets for transplantation in the treatment of diabetes. Exocrine tissue can be efficiently reprogrammed to islet-like cells using a cocktail of transcription factors: Pdx1, Ngn3, MafA and Pax4 in combination with growth factors. We show here that overexpression of exogenous Pax4 in combination with suppression of the endogenous transcription factor ARX considerably enhances the production of functional insulin-secreting β-like cells with concomitant suppression of α-cells...
2016: PloS One
Priska Hagmann-von Arx, Jasmin T Gygi, Rebekka Weidmann, Alexander Grob
This study examined the relation of fluid and crystallized intelligence with extrinsic (occupational skill level, income) and intrinsic (job satisfaction) career success as well as the incremental predictive validity of conscientiousness and its facets. Participants (N = 121) completed the Reynolds Intellectual Assessment Scales (RIAS), the Revised NEO Personality Inventory (NEO-PI-R), and reported their occupational skill level, income, and job satisfaction. Results revealed that crystallized intelligence was positively related to occupational skill level, but not to income...
2016: Frontiers in Psychology
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