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https://www.readbyqxmd.com/read/29435241/interannual-variations-in-needle-and-sapwood-traits-of-pinus-edulis-branches-under-an-experimental-drought
#1
Marceau Guérin, Dario Martin-Benito, Georg von Arx, Laia Andreu-Hayles, Kevin L Griffin, Rayann Hamdan, Nate G McDowell, Robert Muscarella, William Pockman, Pierre Gentine
In the southwestern USA, recent large-scale die-offs of conifers raise the question of their resilience and mortality under droughts. To date, little is known about the interannual structural response to droughts. We hypothesized that piñon pines (Pinus edulis) respond to drought by reducing the drop of leaf water potential in branches from year to year through needle morphological adjustments. We tested our hypothesis using a 7-year experiment in central New Mexico with three watering treatments (irrigated, normal, and rain exclusion)...
February 2018: Ecology and Evolution
https://www.readbyqxmd.com/read/29409750/modeling-individual-differences-a-case-study-of-the-application-of-system-identification-for-personalizing-a-physical-activity-intervention
#2
Sayali S Phatak, Mohammad T Freigoun, César A Martín, Daniel E Rivera, Elizabeth V Korinek, Marc A Adams, Matthew P Buman, Predrag Klasnja, Eric B Hekler
BACKGROUND: Control systems engineering methods, particularly, system identification (system ID), offer an idiographic (i.e., person-specific) approach to develop dynamic models of physical activity (PA) that can be used to personalize interventions in a systematic, scalable way. The purpose of this work is to: 1) apply system ID to develop individual dynamical models of PA (steps/day measured using Fitbit Zip) in the context of a goal setting and positive reinforcement intervention informed by Social Cognitive Theory; and 2) compare insights on potential tailoring variables (i...
January 31, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29378833/mafb-is-critical-for-glucagon-production-and-secretion-in-mouse-pancreatic-%C3%AE-cells-in-vivo
#3
Megumi C Katoh, Yunshin Jung, Chioma M Ugbama, Miki Shimbo, Akihiro Kuno, Walaa A Basha, Takashi Kudo, Hisashi Oishi, Satoru Takahashi
The MafB transcription factor is expressed in pancreatic α- and β-cells during development but becomes exclusive to α-cells in adult rodents. Mafb-null (Mafb-/- ) mice were reported to reduce α- and β-cell numbers throughout embryonic development. To further analyze postnatal function of MafB in the pancreas, we generated endocrine cell-specific (MafbΔEndo ) and tamoxifen-dependent (MafbΔTAM ) Mafb knockout mice. MafbΔEndo mice exhibited reduced population of insulin+ and glucagon+ cells at postnatal day 0 but recovered the insulin+ cell population by 8 weeks of age...
January 29, 2018: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29358049/ultraconserved-enhancers-are-required-for-normal-development
#4
Diane E Dickel, Athena R Ypsilanti, Ramón Pla, Yiwen Zhu, Iros Barozzi, Brandon J Mannion, Yupar S Khin, Yoko Fukuda-Yuzawa, Ingrid Plajzer-Frick, Catherine S Pickle, Elizabeth A Lee, Anne N Harrington, Quan T Pham, Tyler H Garvin, Momoe Kato, Marco Osterwalder, Jennifer A Akiyama, Veena Afzal, John L R Rubenstein, Len A Pennacchio, Axel Visel
Non-coding "ultraconserved" regions containing hundreds of consecutive bases of perfect sequence conservation across mammalian genomes can function as distant-acting enhancers. However, initial deletion studies in mice revealed that loss of such extraordinarily constrained sequences had no immediate impact on viability. Here, we show that ultraconserved enhancers are required for normal development. Focusing on some of the longest ultraconserved sites genome wide, located near the essential neuronal transcription factor Arx, we used genome editing to create an expanded series of knockout mice lacking individual or combinations of ultraconserved enhancers...
January 10, 2018: Cell
https://www.readbyqxmd.com/read/29343471/infantile-onset-hand-dystonia-with-intellectual-disability-clues-to-arx-mutations
#5
David P Breen, Saadet Mercimek-Andrews, Anthony E Lang
No abstract text is available yet for this article.
January 17, 2018: Neurology
https://www.readbyqxmd.com/read/29329457/a-novel-application-of-rnase-h2-dependent-quantitative-pcr-for-detection-and-quantification-of-grosmannia-clavigera-a-mountain-pine-beetle-fungal-symbiont-in-environmental-samples
#6
Chandra H McAllister, Colleen E Fortier, Kate R St Onge, Bianca M Sacchi, Meaghan J Nawrot, Troy Locke, Janice E K Cooke
Mountain pine beetle (Dendroctonus ponderosae Hopkins; MPB) is an economically and ecologically important pest of pine species in western North America. Mountain pine beetles form complex multipartite relationships with microbial partners, including the ophiostomoid fungi Grosmannia clavigera (Robinson-Jeffrey and Davidson) Zipfel, de Beer and Wingfield, Ophiostoma montium (Rumbold) von Arx, Grosmannia aurea (Robinson-Jeffrey and Davidson) Zipfel, de Beer and Wingfield, Leptographium longiclavatum (Lee, Kim, and Breuil) and Leptographium terebrantis (Barras and Perry)...
January 10, 2018: Tree Physiology
https://www.readbyqxmd.com/read/29326366/highly-proliferative-alpha-cell-related-islet-endocrine-cells-in-human-pancreata
#7
Carol J Lam, Aaron R Cox, Daniel R Jacobson, Matthew M Rankin, Jake A Kushner
The proliferative response of non-β islet endocrine cells in response to type 1 diabetes (T1D) remains undefined. We quantified islet endocrine cell proliferation in a large collection of non-diabetic control and T1D human pancreata across a wide range of ages. Surprisingly, islet endocrine cells with abundant proliferation were present in many adolescent and young adult T1D pancreata. But, the proliferative islet endocrine cells were also present in similar abundance within control samples. We queried the proliferating islet cells with antisera against various islet hormones...
January 11, 2018: Diabetes
https://www.readbyqxmd.com/read/29302192/identification-of-epigenetically-altered-genes-and-potential-gene-targets-in-melanoma-using-bioinformatic-methods
#8
Honghao Duan, Ke Jiang, Dengke Wei, Lijun Zhang, Deliang Cheng, Min Lv, Yuben Xu, Aimin He
This study aimed to analyze epigenetically and genetically altered genes in melanoma to get a better understanding of the molecular circuitry of melanoma and identify potential gene targets for the treatment of melanoma. The microarray data of GSE31879, including mRNA expression profiles (seven melanoma and four melanocyte samples) and DNA methylation profiles (seven melanoma and five melanocyte samples), were downloaded from the Gene Expression Omnibus database. Differentially expressed genes (DEGs) and differentially methylated positions (DMPs) were screened using the linear models for microarray data (limma) package in melanoma compared with melanocyte samples...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29287189/human-epidermal-growth-factor-receptor-2-dual-blockade-with-trastuzumab-and-pertuzumab-in-real-life-italian-clinical-practice-versus-the-cleopatra-trial-results
#9
Sabino De Placido, Mario Giuliano, Francesco Schettini, Claudia Von Arx, Giuseppe Buono, Ferdinando Riccardi, Daniela Cianniello, Roberta Caputo, Fabio Puglisi, Marta Bonotto, Alessandra Fabi, Domenico Bilancia, Mariangela Ciccarese, Vito Lorusso, Andrea Michelotti, Dario Bruzzese, Bianca Maria Veneziani, Mariavittoria Locci, Michelino De Laurentiis, Grazia Arpino
OBJECTIVES: Given their inclusion and exclusion criteria, randomized clinical trials (RCT) might not include a population that truly mirrors real life (RL). This raises concerns about the applicability of RCT results in clinical practice. We evaluated the efficacy of anti-HER2 treatment with pertuzumab combined with trastuzumab and a taxane as first-line treatment for HER2-positive metastatic breast cancer in a RL setting, and compared the safety results obtained in our population versus the experimental cohort of the CLEOPATRA RCT, which led to the approval of this therapy...
December 26, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29275192/detection-of-aristaless-related-homeobox-protein-in-ovarian-sex-cord-stromal-tumors
#10
Tamara Knific, Snježana Frković Grazio, Tea Lanišnik Rižner
OBJECTIVE: To examine the potential of ARX as a novel biomarker of ovarian endometriosis and other ovarian pathologies. METHODS: The mRNA level of ARX in ovarian endometriosis and normal endometrium samples was determined by real-time PCR, while the protein level was determined by Western blotting and immunohistochemical staining. Immunohistochemical analysis was performed on nearly 200 tissue samples of different ovarian pathologies. GraphPad Prism was used for statistical analysis...
December 21, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29245725/revision-of-the-i-hybobathus-i-i-arx-i-and-i-pelecinobaccha-i-i-summa-i-species-groups-diptera-syrphidae
#11
Gil Felipe Gonçalves Miranda
The morphologically similar Hybobathus arx and Pelecinobaccha summa species groups are revised and distinguished from each other. Four new species are described (H. avittatus sp. nov., H. luciane sp. nov., P. alia sp. nov. and P. impostor sp. nov.), and three new combinations (H. obsoletus comb. nov., H. persimilis comb. nov., and P. cubensis comb. nov.) and several synonimies are proposed: Baccha bivittata Curran = H. arx (Fluke), B. myrtella Hull and B. nectarina Hull = H. obsoletus (Curran), B. druida Hull = H...
October 24, 2017: Zootaxa
https://www.readbyqxmd.com/read/29234348/diurnal-transcriptome-and-gene-network-represented-through-sparse-modeling-in-brachypodium-distachyon
#12
Satoru Koda, Yoshihiko Onda, Hidetoshi Matsui, Kotaro Takahagi, Yukiko Yamaguchi-Uehara, Minami Shimizu, Komaki Inoue, Takuhiro Yoshida, Tetsuya Sakurai, Hiroshi Honda, Shinto Eguchi, Ryuei Nishii, Keiichi Mochida
We report the comprehensive identification of periodic genes and their network inference, based on a gene co-expression analysis and an Auto-Regressive eXogenous (ARX) model with a group smoothly clipped absolute deviation (SCAD) method using a time-series transcriptome dataset in a model grass, Brachypodium distachyon. To reveal the diurnal changes in the transcriptome in B. distachyon, we performed RNA-seq analysis of its leaves sampled through a diurnal cycle of over 48 h at 4 h intervals using three biological replications, and identified 3,621 periodic genes through our wavelet analysis...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29190809/molecular-diagnosis-of-patients-with-epilepsy-and-developmental-delay-using-a-customized-panel-of-epilepsy-genes
#13
Laura Ortega-Moreno, Beatriz G Giráldez, Victor Soto-Insuga, Rebeca Losada-Del Pozo, María Rodrigo-Moreno, Cristina Alarcón-Morcillo, Gema Sánchez-Martín, Esther Díaz-Gómez, Rosa Guerrero-López, José M Serratosa
Pediatric epilepsies are a group of disorders with a broad phenotypic spectrum that are associated with great genetic heterogeneity, thus making sequential single-gene testing an impractical basis for diagnostic strategy. The advent of next-generation sequencing has increased the success rate of epilepsy diagnosis, and targeted resequencing using genetic panels is the a most cost-effective choice. We report the results found in a group of 87 patients with epilepsy and developmental delay using targeted next generation sequencing (custom-designed Haloplex panel)...
2017: PloS One
https://www.readbyqxmd.com/read/29152528/x-linked-lissencephaly-with-absent-corpus-callosum-and-abnormal-genitalia-an-evolving-multisystem-syndrome-with-severe-congenital-intestinal-diarrhea-disease
#14
David Coman, Tom Fullston, Cheryl Shoubridge, Richard Leventer, Flora Wong, Simon Nazaretian, Ian Simpson, Josef Gecz, George McGillivray
X-linked lissencephaly with abnormal genitalia is a rare and devastating syndrome. The authors present an infant with a multisystem phenotype where the intestinal manifestations were as life limiting as the central nervous system features. Severe chronic diarrhea resulted in failure to thrive, dehydration, electrolyte derangements, long-term hospitalization, and prompted transition to palliative care. Other multisystem manifestations included megacolon, colitis, pancreatic insufficiency hypothalamic dysfunction, hypothyroidism, and hypophosphatasia...
January 2017: Child Neurology Open
https://www.readbyqxmd.com/read/29141310/-analysis-of-gene-mutation-of-early-onset-epileptic-spasm-with-unknown-reason
#15
X Yang, G Pan, W H Li, L M Zhang, B B Wu, H J Wang, P Zhang, S Z Zhou
Objective: To summarize the gene mutation of early onset epileptic spasm with unknown reason. Method: In this prospective study, data of patients with early onset epileptic spasm with unknown reason were collected from neurological department of Children's Hospital of Fudan University between March 2016 and December 2016. Patients with known disorders such as infection, metabolic, structural, immunological problems and known genetic mutations were excluded. Patients with genetic disease that can be diagnosed by clinical manifestations and phenotypic characteristics were also excluded...
November 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29140376/evaluating-maxillary-sinus-septa-using-cone-beam-computed-tomography-is-there-a-difference-in-frequency-and-type-between-the-dentate-and-edentulous-posterior-maxilla
#16
Martina Schriber, Thomas von Arx, Pedram Sendi, Reinhilde Jacobs, Valerie Ga Suter, Michael M Bornstein
PURPOSE: To analyze and compare the frequency, type, and location of maxillary sinus septa in patients with a dentate and an edentulous posterior maxilla using cone beam computed tomography (CBCT) imaging. MATERIALS AND METHODS: The study consisted of 100 maxillary sinuses: 50 from patients with a dentate and 50 from patients with an edentulous posterior maxilla. The aim was to assess the frequency, morphology, and location of maxillary sinus septa in axial, sagittal, and coronal CBCT images...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29107069/the-species-origin-of-the-cellular-microenvironment-influences-markers-of-beta-cell-fate-and-function-in-endoc-%C3%AE-h1-cells
#17
N Jeffery, S Richardson, C Beall, L W Harries
Interaction between islet cell subtypes and the extracellular matrix influences beta-cell function in mammals. The tissue architecture of rodent islets is very different to that of human islets; cell-to-cell communication and interaction with the extracellular matrix may vary between species. In this work, we have compared the responses of the human EndoC-βH1 cell line to non-human and human-derived growth matrices in terms of growth morphology, gene expression and glucose-stimulated insulin secretion (GSIS)...
October 26, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/29103923/artemether-does-not-turn-%C3%AE-cells-into-%C3%AE-cells
#18
Talitha van der Meulen, Sharon Lee, Els Noordeloos, Cynthia J Donaldson, Michael W Adams, Glyn M Noguchi, Alex M Mawla, Mark O Huising
Pancreatic α cells retain considerable plasticity and can, under the right circumstances, transdifferentiate into functionally mature β cells. In search of a targetable mechanistic basis, a recent paper suggested that the widely used anti-malaria drug artemether suppresses the α cell transcription factor Arx to promote transdifferentiation into β cells. However, key initial experiments in this paper were carried out in islet cell lines, and most subsequent validation experiments implied transdifferentiation without direct demonstration of α to β cell conversion...
November 1, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/29062978/interneuronopathies-and-their-role-in-early-life-epilepsies-and-neurodevelopmental-disorders
#19
Anna-Maria Katsarou, Solomon L Moshé, Aristea S Galanopoulou
GABAergic interneurons control the neural circuitry and network activity in the brain. The advances in genetics have identified genes that control the development, maturation and integration of GABAergic interneurons and implicated them in the pathogenesis of epileptic encephalopathies or neurodevelopmental disorders. For example, mutations of the Aristaless-Related homeobox X-linked gene (ARX) may result in defective GABAergic interneuronal migration in infants with epileptic encephalopathies like West syndrome (WS), Ohtahara syndrome or X-linked lissencephaly with abnormal genitalia (XLAG)...
September 2017: Epilepsia Open
https://www.readbyqxmd.com/read/29060096/assisting-people-with-nystagmus-through-image-stabilization-using-an-arx-model-to-overcome-processing-delays
#20
Stephan Polzer, Klaus Miesenberger
Pathological Nystagmus is characterized by an unintended and involuntary eye-movement, which tends to impact on visual acuity. Today only view therapies (for instance medication or surgeries) to treat nystagmus are at hand and the existing therapies only show partial improvement. Only general Assistive Technology (AT) solutions like glasses, screen magnifiers, speech output, display adaptation and concepts holders are at hand to support daily living. More specific ATs to reduce the impact of nystagmus are missing...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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