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https://www.readbyqxmd.com/read/28985375/rapid-monoterpene-induction-promotes-the-susceptibility-of-a-novel-host-pine-to-mountain-pine-beetle-colonization-but-not-to-beetle-vectored-fungi
#1
Jonathan A Cale, Marlena Muskens, Ahmed Najar, Guncha Ishangulyyeva, Altaf Hussain, Sanat S Kanekar, Jennifer G Klutsch, Spencer Taft, Nadir Erbilgin, Jörg-Peter Schnitzler
Chemical induction can drive tree susceptibility to and host range expansions of attacking insects and fungi. Recently, mountain pine beetle (Dendroctonus ponderosae Hopkins; MPB) has expanded its host range from its historic host lodgepole pine (Pinus contorta var. latifolia Douglas ex Loudon) to jack pine (Pinus banksiana Lamb) in western Canada. Beetle success in jack pine forests likely depends upon the suitability of tree chemistry to MPB and its symbiotic phytopathogenic fungi. In particular, how rapid induced defenses of jack pine affect MPB colonization and the beetle's symbionts is unknown...
July 17, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28970231/the-terminal-nerve-plays-a-prominent-role-in-gnrh-1-neuronal-migration-independent-from-proper-olfactory-and-vomeronasal-connections-to-the-olfactory-bulbs
#2
Ed Zandro M Taroc, Aparna Prasad, Jennifer M Lin, Paolo E Forni
Gonadotropin-releasing hormone-1 (GnRH-1) neurons (GnRH-1 ns) migrate from the developing olfactory pit into the hypothalamus during embryonic development. Migration of the GnRH-1 neurons is required for mammalian reproduction as these cells control release of gonadotropins from the anterior pituitary gland. Disturbances in GnRH-1 ns migration, GnRH-1 synthesis, secretion or signaling lead to varying degrees of hypogonadotropic hypogonadism (HH), which impairs pubertal onset and fertility. HH associated with congenital olfactory defects is clinically defined as Kallmann Syndrome (KS)...
October 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28965696/gene-expression-profiles-of-ovarian-low-grade-serous-carcinoma-resemble-those-of-fallopian-tube-epithelium
#3
Chunping Qiu, Nan Lu, Xiao Wang, Qing Zhang, Cunzhong Yuan, Shi Yan, Samina Dongol, Yingwei Li, Xiaomei Sun, Chenggong Sun, Zhiwei Zhang, Wenxin Zheng, Beihua Kong
OBJECTIVE: The cell of origin of ovarian low-grade serous carcinoma (LGSC) remains unclarified. Our recent morphologic and immunophenotypic study suggests that most LGSCs may be derived from the fallopian tube. The purpose of the current study was to gain further insight into the origin of LGSC at the molecular level. METHODS: RNA-seq analysis was performed on a total of 31 tissue samples including LGSC (n=6), serous borderline tumors (SBT, n=6), fallopian tube epithelia (FTE, n=5), ovarian surface epithelia (OSE, n=4), and human peritoneal mesothelia (HPM, n=4)...
September 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28953922/germline-and-somatic-mutations-in-cortical-malformations-molecular-defects-in-argentinean-patients-with-neuronal-migration-disorders
#4
Dolores González-Morón, Sebastián Vishnopolska, Damián Consalvo, Nancy Medina, Marcelo Marti, Marta Córdoba, Cecilia Vazquez-Dusefante, Santiago Claverie, Sergio Alejandro Rodríguez-Quiroga, Patricia Vega, Walter Silva, Silvia Kochen, Marcelo Andrés Kauffman
Neuronal migration disorders are a clinically and genetically heterogeneous group of malformations of cortical development, frequently responsible for severe disability. Despite the increasing knowledge of the molecular mechanisms underlying this group of diseases, their genetic diagnosis remains unattainable in a high proportion of cases. Here, we present the results of 38 patients with lissencephaly, periventricular heterotopia and subcortical band heterotopia from Argentina. We performed Sanger and Next Generation Sequencing (NGS) of DCX, FLNA and ARX and searched for copy number variations by MLPA in PAFAH1B1, DCX, POMT1, and POMGNT1...
2017: PloS One
https://www.readbyqxmd.com/read/28931935/alpha-tc1-and-beta-tc-6-genomic-profiling-uncovers-both-shared-and-distinct-transcriptional-regulatory-features-with-their-primary-islet-counterparts
#5
Nathan Lawlor, Ahrim Youn, Romy Kursawe, Duygu Ucar, Michael L Stitzel
Alpha TC1 (αTC1) and Beta-TC-6 (βTC6) mouse islet cell lines are cellular models of islet (dys)function and type 2 diabetes (T2D). However, genomic characteristics of these cells, and their similarities to primary islet alpha and beta cells, are undefined. Here, we report the epigenomic (ATAC-seq) and transcriptomic (RNA-seq) landscapes of αTC1 and βTC6 cells. Each cell type exhibits hallmarks of its primary islet cell counterpart including cell-specific expression of beta (e.g., Pdx1) and alpha (e.g., Arx) cell transcription factors (TFs), and enrichment of binding motifs for these TFs in αTC1/βTC6 cis-regulatory elements...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28929231/patent-nasopalatine-ducts-an-update-of-the-literature-and-a-series-of-new-cases
#6
REVIEW
Th von Arx, M Schaffner, M M Bornstein
PURPOSE: The objective of this review is to present an update and summary of clinical findings of cases with a patent nasopalatine duct (NPD) reported in the literature from 1881 to 2016. METHODS: Previous articles and reviews about patent NPDs were studied and copies of all original publications were obtained for data verification. Furthermore, a literature search was conducted. In addition, the study sample was complemented with four cases recently seen in our institution...
September 19, 2017: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/28924486/expression-of-transcription-factors-in-men1-associated-pancreatic-neuroendocrine-tumors
#7
Yasutaka Takeda, Yukihiro Fujita, Kentaro Sakai, Tomoe Abe, Tomonobu Nakamura, Tsuyoshi Yanagimachi, Hidemitsu Sakagami, Jun Honjo, Atsuko Abiko, Yuichi Makino, Masakazu Haneda
MEN1-associated pancreatic neuroendocrine tumors (pNETs) may potentially express distinct hormones, but the mechanism has not been elucidated. Transcription factors such as MafA and Pdx1 have been identified to lead to beta cell differentiation, while Arx and Brn4 to alpha cell differentiation in developing pancreas. We hypothesized those transcription factors are important to produce specific hormones in pNETs, similarly to developing pancreas, and examined the expression of transcription factors in a case of MEN1 who showed immunohistological coexistence of several hormone-producing pNETs including insulinoma...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28920140/frequency-location-and-association-with-dental-pathology-of-mucous-retention-cysts-in-the-maxillary-sinus-a-radiographic-study-using-cone-beam-computed-tomography-cbct
#8
Andy Wai Kan Yeung, Ray Tanaka, Pek-Lan Khong, Thomas von Arx, Michael M Bornstein
OBJECTIVES: The purpose of the present study was to evaluate the frequency, locations, and dimensions of mucous retention cysts of the maxillary sinus and analyze potential associated dental pathology. MATERIALS AND METHODS: A total of 156 cone beam computed tomography (CBCT) scans were included in the analysis, resulting in an evaluation of 310 maxillary sinuses. The presence of mucous retention cysts (MRC) manifesting as dome-shaped radiopacities in the sinus was diagnosed...
September 17, 2017: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28851506/swiss-epilepsy-center-zurich-switzerland
#9
Martin Bieri, Ian Mothersill, Priska von Arx, Jörg Wehr
No abstract text is available yet for this article.
August 26, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28817424/impact-of-simulator-based-training-in-focused-transesophageal-echocardiography-a-randomized-controlled-trial
#10
RANDOMIZED CONTROLLED TRIAL
Andreas Bloch, Robert von Arx, Reto Etter, David Berger, Heiko Kaiser, Armando Lenz, Tobias M Merz
BACKGROUND: The aim of the study was to determine if training in transesophageal echocardiography (TEE) using a TEE simulator improves the ability of novice operators to perform and interpret a focused critical care TEE. METHODS: In this prospective, randomized, controlled study with blinded outcome assessment, 44 intensive care unit trainees were randomly assigned to a control group receiving 4 hours of lecture-based training only, or an intervention group which was additionally trained for 4 hours using a TEE simulator...
October 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28715316/virtual-humans-for-implantable-device-safety-assessment-in-mri-mitigating-magnetic-resonance-imaging-hazards-for-implanted-medical-devices
#11
James E Brown, Rui Qiang, Paul J Stadnik, Larry J Stotts, Jeffrey A Von Arx
Magnetic resonance imaging (MRI) is the preferred modality for soft tissue imaging because of its nonionizing radiation and lack of contrast agent. Due to interactions between the MR system and active implantable medical devices (AIMDs), patients with implants such as pacemakers are generally denied access to MRI, which presents a detriment to that population. It has been estimated that 50-75% of patients with a cardiac device were denied access to MRI scanning and, moreover, that 17% of pacemaker patients need an MRI within 12 months of implantation [1]...
July 2017: IEEE Pulse
https://www.readbyqxmd.com/read/28694108/increased-blood-pressure-variability-upon-standing-up-improves-reproducibility-of-cerebral-autoregulation-indices
#12
Adam Mahdi, Dragana Nikolic, Anthony A Birch, Mette S Olufsen, Ronney B Panerai, David M Simpson, Stephen J Payne
Dynamic cerebral autoregulation, that is the transient response of cerebral blood flow to changes in arterial blood pressure, is currently assessed using a variety of different time series methods and data collection protocols. In the continuing absence of a gold standard for the study of cerebral autoregulation it is unclear to what extent does the assessment depend on the choice of a computational method and protocol. We use continuous measurements of blood pressure and cerebral blood flow velocity in the middle cerebral artery from the cohorts of 18 normotensive subjects performing sit-to-stand manoeuvre...
July 7, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28681325/nonlinear-autoregressive-neural-networks-with-external-inputs-for-forecasting-of-typhoon-inundation-level
#13
Huei-Tau Ouyang
Accurate inundation level forecasting during typhoon invasion is crucial for organizing response actions such as the evacuation of people from areas that could potentially flood. This paper explores the ability of nonlinear autoregressive neural networks with exogenous inputs (NARX) to predict inundation levels induced by typhoons. Two types of NARX architecture were employed: series-parallel (NARX-S) and parallel (NARX-P). Based on cross-correlation analysis of rainfall and water-level data from historical typhoon records, 10 NARX models (five of each architecture type) were constructed...
August 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28636081/cell-size-and-wall-dimensions-drive-distinct-variability-of-earlywood-and-latewood-density-in-northern-hemisphere-conifers
#14
Jesper Björklund, Kristina Seftigen, Fritz Schweingruber, Patrick Fonti, Georg von Arx, Marina V Bryukhanova, Henri E Cuny, Marco Carrer, Daniele Castagneri, David C Frank
Interannual variability of wood density - an important plant functional trait and environmental proxy - in conifers is poorly understood. We therefore explored the anatomical basis of density. We hypothesized that earlywood density is determined by tracheid size and latewood density by wall dimensions, reflecting their different functional tasks. To determine general patterns of variability, density parameters from 27 species and 349 sites across the Northern Hemisphere were correlated to tree-ring width parameters and local climate...
June 21, 2017: New Phytologist
https://www.readbyqxmd.com/read/28634272/the-secreted-msp-domain-of-c-elegans-vapb-homolog-vpr-1-patterns-the-adult-striated-muscle-mitochondrial-reticulum-via-smn-1
#15
Jessica Schultz, Se-Jin Lee, Tim Cole, Hieu D Hoang, Jack Vibbert, Pauline A Cottee, Michael A Miller, Sung Min Han
The major sperm protein domain (MSPd) has an extracellular signaling function implicated in amyotrophic lateral sclerosis. Secreted MSPds derived from the C. elegans VAPB homolog VPR-1 promote mitochondrial localization to actin-rich I-bands in body wall muscle. Here we show that the nervous system and germ line are key MSPd secretion tissues. MSPd signals are transduced through the CLR-1 Lar-like tyrosine phosphatase receptor. We show that CLR-1 is expressed throughout the muscle plasma membrane, where it is accessible to MSPd within the pseudocoelomic fluid...
June 15, 2017: Development
https://www.readbyqxmd.com/read/28627419/arx-polyalanine-expansion-mutations-lead-to-migration-impediment-in-the-rostral-cortex-coupled-with-a-developmental-deficit-of-calbindin-positive-cortical-gabaergic-interneurons
#16
K Lee, K Ireland, M Bleeze, C Shoubridge
The Aristaless-related homeobox gene (ARX) is indispensable for interneuron development. Patients with ARX polyalanine expansion mutations of the first two tracts (namely PA1 and PA2) suffer from intellectual disability of varying severity, with seizures a frequent comorbidity. The impact of PA1 and PA2 mutations on the brain development is unknown, hindering the search for therapeutic interventions. Here, we characterized the disturbances to cortical interneuron development in mice modeling the two most common ARX polyalanine expansion mutations in human...
June 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28602636/extensive-phenotyping-of-two-arx-polyalanine-expansion-mutation-mouse-models-that-span-clinical-spectrum-of-intellectual-disability-and-epilepsy
#17
Matilda R Jackson, Kristie Lee, Tessa Mattiske, Emily J Jaehne, Ezgi Ozturk, Bernhard T Baune, Terence J O'Brien, Nigel Jones, Cheryl Shoubridge
The Aristaless-related homeobox gene (ARX) is a known intellectual disability (ID) gene that frequently presents with X-linked infantile spasm syndrome as a comorbidity. ID with epilepsy in children is a chronic and devastating disorder that has poor treatment options and disease outcomes. To gain a better understanding of the role that mutations in ARX play in ID and epilepsy, we investigate ARX patient mutations modelled in mice. Over half of all ARX mutations result from expansions of the first two polyalanine (PA1 and PA2 respectively) tracts...
September 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/28575521/sex-determines-xylem-anatomy-in-a-dioecious-conifer-hydraulic-consequences-in-a-drier-world
#18
José M Olano, Noelia González-Muñoz, Alberto Arzac, Vicente Rozas, Georg von Arx, Sylvain Delzon, Ana I García-Cervigón
Increased drought frequency and severity may reshape tree species distribution in arid environments. Dioecious tree species may be more sensitive to climate warming if sex-related vulnerability to drought occurs, since lower performance of one sex may drive differential stress tolerance, sex-related mortality rates and biased sex ratios. We explored the effect of sex and environment on branch hydraulic (hydraulic conductivity and vulnerability to embolism) and trunk anatomical traits in both sexes of the dioecious conifer Juniperus thurifera L...
June 1, 2017: Tree Physiology
https://www.readbyqxmd.com/read/28571755/new-methods-of-laguerre-pole-optimization-for-the-arx-model-expansion-on-laguerre-bases
#19
Tawfik Najeh, Abdelkader Mbarek, Kais Bouzrara, Lotfi Nabli, Hassani Messaoud
The ARX-Laguerre model is a very important reduced complexity representation of linear system. However a significant reduction of this model is subject to an optimal choice of both Laguerre poles. Therefore we propose in this paper two new methods to estimate, from input/output measurements, the optimal values of Laguerre poles of the ARX-Laguerre model. The first method is based on the Newton-Raphson's iterative technique where we prove that the gradient and the Hessian can be expressed analytically. The second method is based on Genetic Algorithms...
May 29, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28553981/initiation-in-photoredox-c-h-functionalization-reactions-is-dimsyl-anion-a-key-ingredient
#20
María E Budén, Javier I Bardagí, Marcelo Puiatti, Roberto A Rossi
Previous studies have reported the arylation of unactivated arenes with ArX, base (KO(t)Bu or NaO(t)Bu), and an organic additive at high temperatures. Recently, we showed that this reaction proceeds in the absence of additives at rt but employs UV-vis light. However, details of mechanisms that can use a photoinduced base-promoted homolytic aromatic substitution reaction (photo-BHAS) have remained elusive until now. This work examines different mechanistic routes of the essential electron-transfer step (ET) of this reaction in order to identify a possible path for the formation of 1-adamantyl radicals from 1-haloadamantanes (initiation step)...
June 6, 2017: Journal of Organic Chemistry
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