keyword
https://read.qxmd.com/read/38443007/myotonic-dystrophy-type-1-dm1-clinical-characteristics-and-disease-progression-in-a-large-cohort
#21
JOURNAL ARTICLE
Tanushree Chawla, Nishanth Reddy, Rahul Jankar, Seena Vengalil, Kiran Polavarapu, Gautham Arunachal, Veeramani Preethish-Kumar, Saraswati Nashi, Mainak Bardhan, Jamuna Rajeshwaran, Mohammad Afsar, Manjusha Warrier, Priya T Thomas, Kandavel Thennarasu, Atchayaram Nalini
BACKGROUND: DM1 is a multisystem disorder caused by expansion of a CTG triplet repeat in the 3' non-coding region of DMPK. Neuropsychological consequences and sleep abnormalities are important associations in DM1. OBJECTIVE: To describe the clinical phenotype, disease progression and characterize the sleep alterations and cognitive abnormalities in a sub-set of patients. MATERIALS AND METHODS: A retrospective study on 120 genetically confirmed DM1 cases...
January 1, 2024: Neurology India
https://read.qxmd.com/read/38442614/investigating-the-binding-interaction-of-quinoline-yellow-with-bovine-serum-albumin-and-anti-amyloidogenic-behavior-of-ferulic-acid-on-qy-induced-bsa-fibrils
#22
JOURNAL ARTICLE
Maham Fatima, Faisal Nabi, Rizwan Hasan Khan, Aabgeena Naeem
Protein aggregation induces profound changes in the structure along with the conformation of the protein, and is responsible for the pathogenesis of a number of neurodegenerative conditions such as Huntington's, Creutzfeldt-Jacob, Type II diabetes mellitus, Alzheimer's, etc. Numerous multi-spectroscopic approaches and in-silico experiments were utilized to investigate BSA's biomolecular interaction and aggregation in the presence of quinoline yellow. The present research investigation evaluated the interaction of BSA with the food colorant (QY) at two different pH (7...
February 25, 2024: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://read.qxmd.com/read/38434213/isolated-right-ventricular-hypoplasia-associated-with-cyanotic-atrial-septal-defect-a-case-report
#23
Sakiko Gohbara, Yasuhide Mochizuki, Takanari Fujii, Hideshi Tomita, Toshiro Shinke
BACKGROUND: Hypoxaemia in isolated right ventricular (RV) hypoplasia (IRVH) is primarily caused by a right-to-left shunt (RLS) at the atrial level, such as an atrial septal defect (ASD). When considering closure of the RLS, it should be closed only after ensuring that it will not cause right-sided heart failure (HF). CASE SUMMARY: A 21-year-old woman had been experiencing shortness of breath during exertion since childhood. Transthoracic and transoesophageal echocardiography revealed an ASD with bidirectional shunting, and microbubble test revealed a marked RLS...
March 2024: European Heart Journal. Case Reports
https://read.qxmd.com/read/38431536/methotrexate-for-drug-repurposing-as-an-anti-aggregatory-agent-to-mercuric-treated-%C3%AE-chymotrypsinogen-a
#24
JOURNAL ARTICLE
Neha Kausar Ansari, Amaan Rais, Aabgeena Naeem
Protein aggregation is related to numerous pathological conditions like Alzheimer's and Parkinson's disease. In our study, we have shown that an already existing FDA-approved drug; methotrexate (MTX) can be reprofiled on preformed α-chymotrypsinogen A (α-Cgn A) aggregates. The zymogen showed formation of aggregates upon interaction with mercuric ions, with increasing concentration of Hg2 Cl2 (0-150 µM). The hike in ThT and ANS fluorescence concomitant with blue shift, bathochromic shift and the hyperchromic effect in the CR absorbance, RLS and turbidity measurements, substantiate the zymogen β-rich aggregate formation...
March 2, 2024: Protein Journal
https://read.qxmd.com/read/38427272/prognostic-value-of-visual-and-quantitative-cmr-regional-myocardial-function-in-patients-with-suspected-myocarditis
#25
JOURNAL ARTICLE
Benedikt Bernhard, Philippe Joss, Noah Greisser, Anselm W Stark, Jonathan Schütze, Isaac Shiri, Yasaman Safarkhanlo, Kady Fischer, Dominik P Guensch, Jessica A M Bastiaansen, Maryam Pavlicek, Dominik C Benz, Raymond Y Kwong, Christoph Gräni
According to updated Lake-Louise Criteria, impaired regional myocardial function serves as a supportive criterion in diagnosing myocarditis. This study aimed to assess visual regional wall motional abnormalities (RWMA) and novel quantitative regional longitudinal peak strain (RLS) for risk stratification in the clinical setting of myocarditis. In patients undergoing CMR and meeting clinical criteria for suspected myocarditis global longitudinal strain (GLS), late gadolinium enhancement (LGE), RWMA and RLS were assessed in the anterior, septal, inferior, and lateral regions and correlated to the occurrence of major adverse cardiac events (MACE), including heart failure hospitalization, sustained ventricular tachycardia, recurrent myocarditis, and all-cause death...
March 1, 2024: International Journal of Cardiovascular Imaging
https://read.qxmd.com/read/38424131/sleep-disorders-in-parkinson-s-disease-an-early-and-multiple-problem
#26
JOURNAL ARTICLE
Pauline Dodet, Marion Houot, Smaranda Leu-Semenescu, Jean-Christophe Corvol, Stéphane Lehéricy, Graziella Mangone, Marie Vidailhet, Emmanuel Roze, Isabelle Arnulf
In Parkinson's disease (PD), it remains unclear whether sleep disorders including insomnia, REM sleep behavior disorder (RBD), excessive daytime sleepiness (EDS), restless legs syndrome (RLS) and sleep-disordered breathing (SDB), are isolated or combined, interact with each other and are associated with clinical factors. We sought to determine the prevalence and combinations of the main sleep disorders, and their clinical and polysomnographic associations in early stage PD. Sleep disorders were systematically diagnosed after medical interview and video-polysomnography in 162 participants with early stage PD and 58 healthy controls from the baseline of the longitudinal ICEBERG cohort...
February 29, 2024: NPJ Parkinson's Disease
https://read.qxmd.com/read/38419934/prevalence-and-clinical-correlates-of-restless-legs-syndrome-in-psychiatric-patients-a-cross-sectional-study-from-north-india
#27
JOURNAL ARTICLE
Jitender Aneja, Jawahar Singh, Bharat Udey
BACKGROUND: Restless legs syndrome (RLS) is a neuro-sensorimotor disorder which is scarcely researched and is commonly missed in routine psychiatry practice. AIM: To evaluate the prevalence of RLS and its correlates in patients with anxiety, depression, and somatoform disorders. METHODS: A cross-sectional single-center study was undertaken in patients aged 18-65 years suffering from ICD-10 (International Statistical Classification of Diseases-10th edition) diagnosis of anxiety, depressive, and somatoform disorders...
January 2024: Indian Journal of Psychiatry
https://read.qxmd.com/read/38415485/assessment-of-the-characteristics-of-patent-foramen-ovale-associated-with-cryptogenic-stroke
#28
JOURNAL ARTICLE
Hong Pu, Qing Zhang, Jing Wu, Yuan Zhang, Yaxi Zhao, Ling Li
OBJECTIVE: This study aims to comprehensively assess the characteristics of patent foramen ovale (PFO) in relation to Cryptogenic Strok (CS) by utilizing transesophageal echocardiography (TEE) and contrast transthoracic echocardiography (c-TTE) and to identify high-risk factors associated with PFO-related CS. BACKGROUND: Transcatheter PFO closure has demonstrated its effectiveness in preventing PFO-related CS. Therefore, understanding the specific structural attributes of PFO associated with CS is imperative...
February 26, 2024: Current medical imaging
https://read.qxmd.com/read/38412438/amplatzer-or-figulla-flex-ii-occluder-a-comparative-study-of-outcomes-after-transcatheter-patent-foramen-ovale-closure
#29
JOURNAL ARTICLE
Stefan Toggweiler, Federico Moccetti, Nina Conrad, Lucca Loretz, Mehdi Madanchi, Matthias Bossard, Adrian Attiger-Toller, Florim Cuculi, Mathias Wolfrum
OBJECTIVES: Percutaneous closure of a patent foramen ovale (PFO) for the prevention of recurrent paradoxical thromboembolic events has been shown to be safe and effective in randomized controlled trials. However, it remains uncertain if differences in the structure and design of the occluder devices impact the outcomes. The aim of this study was to compare results of percutaneous PFO closure using 2 widely used double-disc occluders. METHODS: Consecutive patients who underwent percutaneous PFO closure with the Abbott Amplatzer occluder (APO) or the Occlutech Figulla-Flex-II occluder (OPO) at the Heart Center Lucerne between February 2017 and December 2022 were included in a registry...
February 23, 2024: Journal of Invasive Cardiology
https://read.qxmd.com/read/38401112/patent-foramen-ovale-closure-for-migraineurs-with-massive-right-to-left-shunt-and-white-matter-lesions-an-exploration-on-curative-effects
#30
JOURNAL ARTICLE
Shuai Yan, Ning Wang, Huizhe Liu, Yunying Wei, Xin Liu, Luxuan Wang, Yuqing Huang, Meilin Lin
OBJECTIVE: This study aims to investigate the therapeutic efficacy of patent foramen ovale (PFO) closure in migraine patients with a massive right-to-left shunt (RLS) and white matter lesions (WMLs). METHODS: The research focused on migraine patients with a massive RLS who underwent PFO closure in our hospital from June 2020 to June 2021. The study included 51 patients without WMLs (control group, CG) and 27 patients with WMLs (observation group, OG). A 12-month postoperative follow-up survey was conducted to assess headache episodes (frequency and duration), evaluated using the Headache Impact Test-6 (HIT-6) and the Pain Intensity Visual Analog Scale (VAS)...
February 9, 2024: Alternative Therapies in Health and Medicine
https://read.qxmd.com/read/38376019/global-prevalence-of-restless-legs-syndrome-among-hemodialysis-patients-a-systematic-review-and-meta-analysis
#31
REVIEW
Xu-Hua Zhou, Yuan Liu, Xin-Rui Zhang, Cong Wang, Shan-Shan Liu, Yan Jiang
OBJECTIVES: Restless legs syndrome (RLS) is a common complaint in patients undergoing hemodialysis (HD). Despite the fact that the estimated prevalence of RLS among HD patients is widely reported, these results varied significantly in the relevant literature. Due to this limitation, the aim of this study was to determine the global prevalence of RLS among HD patients. METHODS: This systematic review was conducted and reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses 2020 statement...
January 2024: Brain and Behavior
https://read.qxmd.com/read/38369584/correction-to-restless-leg-syndrome-as-a-complication-of-primary-hyperparathyroidism-insights-from-a-retrospective-study
#32
Valeria Pozzilli, Stefano Toro, Gaia Tabacco, Anda Mihaela Naciu, Andrea Palermo, Vincenzo Di Lazzaro, Massimo Marano
No abstract text is available yet for this article.
February 19, 2024: Neurological Sciences
https://read.qxmd.com/read/38367361/coexistence-of-periodic-limb-movements-during-sleep-with-restless-legs-syndrome-and-its-association-with-hypertension-in-japanese-patients
#33
JOURNAL ARTICLE
Moeko Sato, Kentaro Matsui, Katsuji Nishimura, Yuichi Inoue
BACKGROUND: Caucasian patients with restless legs syndrome (RLS) frequently exhibit periodic limb movements during sleep (PLMS), which may increase the risk of hypertension. We evaluated the positivity rate of PLMS and factors associated with positivity in Japanese patients with RLS, and tested whether the complications of PLMS are associated with the presence of hypertension. METHODS: We retrospectively investigated polysomnographic data and the presence or absence of hypertension in patients with RLS...
February 13, 2024: Sleep Medicine
https://read.qxmd.com/read/38367359/restless-legs-syndrome-in-the-dominant-parkinson-s-side-related-to-subthalamic-deep-brain-stimulation
#34
JOURNAL ARTICLE
Lionel Tordjman, Ouhaïd Lagha-Boukbiza, Mathieu Anheim, Christine Tranchant, Patrice Bourgin, Elisabeth Ruppert
BACKGROUND: Restless legs syndrome (RLS) has an increased estimated prevalence in patients with Parkinson's disease (PS). RLS frequently mimics symptoms intrinsic to PD, such as motor restlessness, contributing to making its diagnosis challenging in this population. We report the case of a patient with new-onset RLS following subthalamic deep-brain stimulation (DBS-STN). We assessed symptoms using suggested immobilization test (SIT) with both DBS-STN activated and switched off. CASE DESCRIPTION: A 59-year-old man with idiopathic PD developed disabling RLS following DBS-STN at age 58, with PD onset at 50 manifesting as left arm tremor...
February 13, 2024: Sleep Medicine
https://read.qxmd.com/read/38359593/changes-in-time-structure-of-periodic-leg-movements-during-sleep-in-restless-legs-syndrome-effects-of-sex-and-age
#35
JOURNAL ARTICLE
Maria P Mogavero, Lourdes M DelRosso, Giuseppe Lanza, Bartolo Lanuzza, Oliviero Bruni, Luigi Ferini Strambi, Raffaele Ferri
BACKGROUND: The objective of this study was to check the hypothesis that in women with restless legs syndrome (RLS) different changes occur in periodic leg movements during sleep (PLMS) during the post-menopausal period (using >50 years as a proxy) than in men of the same age. METHODS: We recruited 36 untreated patients aged 18-50 years (19 men, median age 40 years, and 17 women, median age 37 years) while the remaining 67 were >50 years old (24 men, median age 66...
February 5, 2024: Sleep Medicine
https://read.qxmd.com/read/38357915/a-quantitative-review-of-competing-learning-slope-metrics-effects-of-age-sex-and-clinical-diagnosis
#36
JOURNAL ARTICLE
Robert J Spencer, Trevor F Williams, Victoria M Kordovski, Sarah D Patrick, Ketrin Lengu, Brian D Gradwohl, Dustin B Hammers
INTRODUCTION: In learning and memory tests that involve multiple presentations of the same material, learning slope refers to the degree to which examinees improve performances over successive learning trials. We aimed to quantitatively review the traditional raw learning slope (RLS), and the newly created learning ratio (LR) to understand the effects of demographic variables and clinical diagnoses on learning slope (e.g., limited improvement over multiple trials), and to develop demographically sensitive norms...
September 2023: Journal of Clinical and Experimental Neuropsychology
https://read.qxmd.com/read/38357105/restless-legs-syndrome-in-chronic-renal-failure-patients-on-dialysis
#37
JOURNAL ARTICLE
Carin Behrens van Tonder, Gina Joubert, Anand Moodley
BACKGROUND: Restless legs syndrome (RLS) occurs in patients with chronic renal failure (CRF). OBJECTIVES: To determine the prevalence and morbidity of RLS in CRF patients on dialysis. METHODS: This cross-sectional questionnaire-based study included 100 dialysis patients (50 on haemodialysis [HD]; 50 on peritoneal dialysis [PD]). A focused lower limb examination was done. Patients were classified with RLS when reporting uncomfortable feelings in their legs that improved with movement and worsened when resting and at night...
September 2023: African Health Sciences
https://read.qxmd.com/read/38356375/transcutaneous-electrical-nerve-stimulation-in-the-management-of-restless-legs-syndrome-symptoms-a-single-blind-parallel-group-clinical-study
#38
JOURNAL ARTICLE
Zeynep Selcan Şanli, Emine Aygül Ortaç, Hülya Binokay, Kübra Aktaş
The aim of this study was to investigate the additional effect of transcutaneous electrical nerve stimulation (TENS) on the control of the symptoms of restless legs syndrome (RLS). A total of 46 randomly selected patients diagnosed with RLS were divided into two groups in a single-blind study to either receive pramipexole (0.25 mg daily) plus 10 sessions of TENS or only pramipexole (0.25 mg daily) for 4 weeks. The severity of the symptoms was determined according to the International Restless Legs Syndrome Rating Scale (IRLSRS) and the Pittsburgh sleep quality index (PSQI) at the beginning of the treatment, post-treatment, and at an 8 week follow-up...
February 15, 2024: Journal of Sleep Research
https://read.qxmd.com/read/38355305/preferential-formation-of-z-rna-over-intercalated-motifs-in-long-noncoding-rna
#39
JOURNAL ARTICLE
Uditi Bhatt, Anne Cucchiarini, Yu Luo, Cameron W Evans, Jean-Louis Mergny, K Swaminathan Iyer, Nicole M Smith
Secondary structure is a principal determinant of lncRNA function, predominantly regarding scaffold formation and interfaces with target molecules. Noncanonical secondary structures that form in nucleic acids have known roles in regulating gene expression and include G-quadruplexes (G4s), intercalated-motifs (iMs), and R-loops (RLs). In this paper, we utilized computational tools G4-iM Grinder and QmRLFS-finder to predict the formation of each of these structures throughout the lncRNA transcriptome in comparison to protein-coding transcripts...
February 14, 2024: Genome Research
https://read.qxmd.com/read/38354484/is-minimally-invasive-surgical-approach-a-reasonable-option-in-apparent-early-stage-epithelial-ovarian-cancer-restaging-results-from-a-multicentric-retrospective-study
#40
JOURNAL ARTICLE
Navid Mokarram Dorri, Mathilde Del, Francesco Cannone, Manon Lefebvre, Cecile Loaec, Laura Sabiani, Camille Jauffret, Guillaume Blache, Gilles Houvenaeghel, Xavier Carcopino, Jean-Marc Classe, Fabrice Narducci, Alejandra Martinez, Eric Lambaudie
INTRODUCTION: To perform surgical staging of early stage ovarian cancer (EOC), conventional laparoscopy (LS) and robot-assisted laparoscopy (RLS) appear to be reliable procedures compared to open surgery. But oncologicals results with long-term follow up are limited in the literature. The objective of this study is to evaluate the surgical and long-term survival for patients managed by minimally invasive surgery (MIS). MATERIALS AND METHODS: We conducted a multicentric retrospective study in 6 institutions...
January 28, 2024: European Journal of Surgical Oncology
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