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https://www.readbyqxmd.com/read/29221785/attention-deficit-hyperactivity-disorder-symptom-severity-and-sleep-problems-in-adult-participants-of-the-netherlands-sleep-registry
#1
Suzan W N Vogel, Denise Bijlenga, Jeroen S Benjamins, Aartjan T F Beekman, J J Sandra Kooij, Eus J W Van Someren
BACKGROUND: We examined whether current overall attention deficit hyperactivity disorder (ADHD), inattention, or hyperactivity symptom severities are associated with the current presence and persistent history of sleep problems. METHODS: N = 942 participants of the Netherlands Sleep Registry filled out online several validated questionnaires. Regression analyses were performed to assess the association between (1) current overall ADHD symptom severity and the current presence of sleep problems, (2) current ADHD symptom-severity groups and the persistent history of sleep problems, and (3) current inattention or hyperactivity symptom severities and the current presence of sleep problems...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29221778/long-term-treatment-with-dopamine-d3-receptor-agonists-induces-a-behavioral-switch-that-can-be-rescued-by-blocking-the-dopamine-d1-receptor
#2
Mai-Lynne Dinkins, Perrine Lallemand, Stefan Clemens
Restless legs syndrome (RLS) is commonly treated with the dopamine agonists pramipexole, and rotigotine, which target the inhibitory dopamine receptor subtype D3R. While initially highly effective, these compounds lose their efficacy in treating RLS over time, and long-term therapy regularly leads to a worsening of the symptoms (augmentation). This dopamine agonist-induced augmentation has become a prime concern in the treatment of RLS, and while alternate therapies are being proposed, the mechanisms leading to augmentation remain opaque...
December 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29209397/individuals-with-restless-legs-syndrome-tend-to-have-severe-depressive-symptoms-findings-from-a-community-based-cohort-study
#3
Chul-Hyun Cho, Leen Kim, Heon-Jeong Lee
Restless legs syndrome (RLS) is a sensorimotor neurological disturbance causing physical and psychological distress. Here, we investigated the severity and effect of depressive symptoms in RLS among a Korean cohort population. Depressive symptoms were more prevalent in the RLS group than in the non-RLS group [≥mild depression: odds ratio (OR)=1.95, p<0.001; ≥ moderate depression: OR=6.15, p<0.001; and ≥severe depression: OR=56.54, p<0.001], with a predominant proportion of severe depression (97%) in the RLS group...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29209388/a-genome-wide-association-study-identifies-utrn-gene-polymorphism-for-restless-legs-syndrome-in-a-korean-population
#4
Chul-Hyun Cho, Ji-Hye Choi, Seung-Gul Kang, Ho-Kyoung Yoon, Young-Min Park, Joung-Ho Moon, Ki-Young Jung, Jin-Kyu Han, Hong-Bum Shin, Hyun Ji Noh, Yong Seo Koo, Leen Kim, Hyun Goo Woo, Heon-Jeong Lee
Objective: Restless legs syndrome (RLS) is a highly heritable and common neurological sensorimotor disease disturbing sleep. The objective of study was to investigate significant gene for RLS by performing GWA and replication study in a Korean population. Methods: We performed a GWA study for RLS symptom group (n=325) and non-RLS group (n=2,603) from the Korea Genome Epidemiology Study. We subsequently performed a replication study in RLS and normal controls (227 RLS and 229 controls) to confirm the present GWA study findings as well as previous GWA study results...
November 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29207973/identifying-models-of-hiv-care-and-treatment-service-delivery-in-tanzania-uganda-and-zambia-using-cluster-analysis-and-delphi-survey
#5
Sharon Tsui, Julie A Denison, Caitlin E Kennedy, Larry W Chang, Olivier Koole, Kwasi Torpey, Eric Van Praag, Jason Farley, Nathan Ford, Leine Stuart, Fred Wabwire-Mangen
BACKGROUND: Organization of HIV care and treatment services, including clinic staffing and services, may shape clinical and financial outcomes, yet there has been little attempt to describe different models of HIV care in sub-Saharan Africa (SSA). Information about the relative benefits and drawbacks of different models could inform the scale-up of antiretroviral therapy (ART) and associated services in resource-limited settings (RLS), especially in light of expanded client populations with country adoption of WHO's test and treat recommendation...
December 6, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29205982/spasticity-or-periodic-limb-movements
#6
Jonathan Levy, Sarah Hartley, Elsa Mauruc-Soubirac, Antoine Leotard, Frederic Lofaso, Maria-Antonia Quera-Salva, Djamel Bensmail
BACKGROUND: Spasticity and spasms are distressing features of the upper motor neuron syndrome (UMNS) following spinal cord injuries (SCI) or multiple sclerosis (MS), and have common therapeutic implications. Despite an increase of antispastic drugs and strategies, sometimes up to the surgical implant of intrathecal baclofen pump, some patients still complain of disabling spasms, which poses diagnostic and therapeutic challenges. Although clinically similar, flexor spasms due to pyramidal tract disruption must be clearly differentiated from periodic limb movements (PLM), often accompanying restless leg syndrome (RLS) and occurring during sleep...
December 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29198453/effects-of-rotigotine-on-clinical-symptoms-quality-of-life-and-sleep-hygiene-adequacy-in-haemodialysis-associated-restless-legs-syndrome
#7
Vicent Esteve, Jose Carneiro, Gabriel Salazar, Mónica Pou, Irati Tapia, Miquel Fulquet, Verónica Duarte, Anna Saurina, Fátima Moreno, Manel Ramírez de Arellano
BACKGROUND: Restless legs syndrome (RLS) is a neurological disorder characterised by bothersome symptoms associated with impaired quality of life and sleep hygiene. Rotigotine is a novel therapeutic alternative, although few studies have been published in patients on haemodialysis (HD) with RLS treated with rotigotine. OBJECTIVES: 1.- To establish the prevalence of RLS in our HD unit. 2.- To evaluate the efficacy and safety profile of rotigotine and its effect on symptoms, quality of life and sleep hygiene in our HD population with RLS...
November 30, 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29198293/comparison-of-subjective-sleep-quality-of-long-term-residents-at-low-and-high-altitudes-saraha-study
#8
Ravi Gupta, Jan Ulfberg, Richard P Allen, Deepak Goel
STUDY OBJECTIVES: To study the effect of altitude on subjective sleep quality in populations living at high and low altitudes after excluding cases of restless legs syndrome (RLS). METHODS: This population-based study was conducted at three different altitudes (400 m, 1,900-2,000 m, and 3,200 m above sea level). All consenting subjects available from random stratified sampling in the Himalayan and sub-Himalayan regions of India were included in the study (ages 18 to 84 years)...
November 29, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29190387/chronic-hyperandrogenemia-in-the-presence-and-absence-of-a-western-style-diet-impairs-ovarian-and-uterine-structure-function-in-young-adult-rhesus-monkeys
#9
Cecily V Bishop, Emily C Mishler, Diana L Takahashi, Taylor E Reiter, Kise R Bond, Cadence A True, Ov D Slayden, Richard L Stouffer
STUDY QUESTION: Does chronic hyperandrogenemia beginning at menarche, in the absence and presence of a western-style diet (WSD), alter ovarian and uterine structure-function in young adult rhesus monkeys? SUMMARY ANSWER: Phenotypic alterations in ovarian and uterine structure/function were induced by exogenous testosterone (T), and compounded in the presence of a WSD (T+WSD). WHAT IS KNOWN ALREADY: Hyperandrogenemia is a well-established component of PCOS and is observed in adolescent girls, indicating a potential pubertal onset of disease symptoms...
November 28, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29182925/to-reveal-the-nature-of-interactions-of-human-hemoglobin-with-gold-nanoparticles-having-two-different-morphologies-sphere-and-star-shaped-by-using-various-spectroscopic-techniques
#10
Madhurima Chakraborty, Somnath Paul, Ishani Mitra, Munmun Bardhan, Mridul Bose, Abhijit Saha, Tapan Ganguly
The nature of interactions between heme protein human hemoglobin (HHb) and gold nanoparticles of two different morphologies that is GNP (spherical) and GNS (star-shaped) have been investigated by using UV-vis absorption, steady state fluorescence, synchronous fluorescence, resonance light scattering (RLS), time resolved fluorescence, FT-IR, and circular dichroism (CD) techniques under physiological condition of pH ~7 at ambient and different temperatures. Analysis of the steady state fluorescence quenching of HHb in aqueous solution in the presence of GNP and GNS suggests that the nature of the quenching is of static type...
November 22, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29179276/-analysis-of-contrast-echocardiography-for-detecting-right-to-left-shunt-in-adults-with-patent-foramen-ovale
#11
X J Kong, Q F Chai, K Guo, Y F Zhao, Y H Wang
Objective: To analyze the contrast echocardiography for detecting right to left shunt in adults with patent foramen ovale(PFO), and study the relationship between PFO and cryptogenic stroke. Methods: Clinical data of forty-six adults patients with PFO diagnosed by transesophageal echocardiography(TEE)from March, 2012 to March, 2017 were retrospectively collected, and the patients were divided to 3 groups according to the direction and brightness of the color Doppler shunts: obvious left-to-right shunt (OLRS, group A), weak left-to-right shunt(WLRS, group B), bi-directional shunt(BDS, group C)...
November 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29175807/obesity-is-a-strong-risk-factor-for-the-development-of-restless-legs-syndrome-and-poor-sleep-quality-in-children-and-adolescents
#12
Rıza Taner Baran, Müge Atar, Özgür Pirgon, Serkan Filiz, Meral Filiz
OBJECTIVE: Adult epidemiological studies have suggested that the rate of restless legs syndrome (RLS) in the general population may range from 5% to 15%. The aim of this study was to investigate the frequency of RLS in a community sample of obese adolescents aged 10-16 years and its association with sleep quality and health-related glucose metabolism markers. METHODS: The study group comprised 144 obese and overweight children aged 10-16 years [mean body mass index (BMI): 30...
November 24, 2017: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/29172258/dual-function-of-gold-nanoparticles-in-synergism-with-mitoxantrone-and-microwave-hyperthermia-against-melanoma-cells
#13
Ahmad Shanei, Ameneh Sazgarnia, Elham Dolat, Leila Hojaji-Najafabadi, Mohammadreza Sehhati, Milad Baradaran-Ghahfarokhi
Background: This study was performed to evaluate any synergetic effects of mitoxantrone (MX) and gold nanoparticles (GNPs) as dual therapeutic approach, along with microwave (MW) hyperthermia for melanoma cancer. Methods: Various tests were performed on the DFW melanoma cell line in the presence of MX and different concentrations of GNPs, with and without MW irradiation. MTT [3-(4,5-dimethylthiazol–2-yl)-2,5-iphenyltetrazolium bromide] assays were conducted to evaluate the effectiveness of the used therapeutic methods in terms of cell survival...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29172115/rls-patients-show-better-nocturnal-performance-in-the-simon-task-due-to-diminished-visuo-motor-priming
#14
Rui Zhang, Wiebke Schrempf, Moritz D Brandt, Moritz Mückschel, Christian Beste, Ann-Kathrin Stock
OBJECTIVE: The restless legs syndrome (RLS) is characterized by sensory-motor symptoms which usually occur predominantly at rest in the evening and at night. It is assumed that this circadian rhythm is caused by low dopamine levels in the evening. Yet, it has never been investigated whether RLS patients show diurnal variations in cognitive functions modulated by dopamine and what neurophysiological and functional neuroanatomical processes underlie such modulations. METHODS: We used a Simon task combined with EEG and source localization to investigate whether top-down response selection and/or automatic visuo-motor priming are subject to diurnal changes in RLS patients, as compared to matched healthy controls...
November 6, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29171915/targeting-hypersensitive-corticostriatal-terminals-in-restless-legs-syndrome
#15
Gabriel Yepes, Xavier Guitart, William Rea, Amy H Newman, Richard P Allen, Christopher J Earley, César Quiroz, Sergi Ferré
OBJECTIVE: The first aim was to demonstrate a previously hypothesized increased sensitivity of corticostriatal glutamatergic terminals in the rodent with brain iron deficiency (BID), a pathogenetic model of Restless Legs Syndrome (RLS). The second aim was to determine if these putative hypersensitive terminals could constitute a significant target for drugs effective in RLS, including dopamine agonists (pramipexole and ropinirole) and α2 δ ligands (gabapentin). METHODS: A recently introduced in vivo optogenetic-microdialysis approach was used, which allows the measurement of the extracellular concentration of glutamate upon local light-induced stimulation of corticostriatal glutamatergic terminals...
November 24, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29169861/prevalence-of-restless-legs-syndrome-during-pregnancy-a-systematic-review-and-meta-analysis
#16
REVIEW
Si-Jing Chen, Le Shi, Yan-Ping Bao, Ye-Kun Sun, Xiao Lin, Jian-Yu Que, Michael V Vitiello, Yu-Xin Zhou, Yong-Qing Wang, Lin Lu
Pregnant women are more likely to be affected by restless legs syndrome (RLS) than the general population. Restless legs syndrome during pregnancy is associated with adverse maternal and fetal outcomes. Currently unknown is the worldwide and regional prevalence of RLS in pregnant women. We performed a meta-analysis to provide a full profile of the prevalence of RLS during pregnancy. A systematic search of the PubMed, Medline, EMBASE, and Web of Science databases was performed to identify studies that were published up to April 2017, followed by random-effects meta-analyses...
October 25, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29169540/retroperitoneoscopic-lumbar-sympathectomy-for-plantar-hyperhidrosis
#17
Sonia O Lima, Vanessa R de Santana, Daisy P Valido, Renata L B de Andrade, Leticia M Fontes, Victor Hugo O Leite, José M Neto, Jéssica M Santos, Lucas L Varjão, Francisco P Reis
OBJECTIVE: The objective of this study was to assess the reduction in quality of life (QoL) caused by the persistence of primary plantar hyperhidrosis (PPH) symptoms and the level of satisfaction in PPH patients after retroperitoneoscopic lumbar sympathectomy (RLS). The efficacy, safety, and procedure of bilateral RLS in both sexes are also described in this study. METHODS: This is a longitudinal study of consecutive patients who sought specific treatment from a private practitioner for severe PPH as classified on the Hyperhidrosis Disease Severity Scale (HDSS) from October 2005 to October 2014...
December 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29165968/restless-legs-syndrome-and-sleep-quality-in-patients-on-hemodialysis
#18
Özlem Örsal, Alaettin Ünsal, Güler Balcı-Alparslan, Pınar Duru
Restless legs syndrome (RLS) is a common health problem in patients on hemodialysis. This descriptive study was carried out with patients from a hemodialysis unit in the province of Eskişehir, Turkey. Of the 317 patients in the unit, 244 (77.0%) comprised the study group. RLS was assessed by diagnostic criteria defined by the International RLS Working Group, sleep quality by the Pittsburgh Sleep Quality Index, and depression by the Beck Depression Inventory. RLS was found in 15.6% of patients and was associated with depression and sleep quality...
March 2017: Nephrology Nursing Journal: Journal of the American Nephrology Nurses' Association
https://www.readbyqxmd.com/read/29155604/modelling-evolutionary-algorithms-with-stochastic-differential-equations
#19
Jorge Pérez Heredia
There has been renewed interest in modelling the behaviour of evolutionary algorithms (EAs) by more traditional mathematical objects, such as ordinary differential equations or Markov chains. The advantage is that the analysis becomes greatly facilitated due to the existence of well established methods. However, this typically comes at the cost of disregarding information about the process. Here, we introduce the use of stochastic differential equations (SDEs) for the study of EAs. SDEs can produce simple analytical results for the dynamics of stochastic processes, unlike Markov chains which can produce rigorous but unwieldy expressions about the dynamics...
November 20, 2017: Evolutionary Computation
https://www.readbyqxmd.com/read/29152680/restless-legs-syndrome-and-sleep-quality-among-adult-sickle-cell-disease-patients
#20
Siraj Omar Wali, Ibrahim AlQassas, Roah Merdad, Rajaa Alsaggaf, Fatin Al-Sayes
OBJECTIVE: The purpose of this study is to determine and compare the prevalence of restless legs syndrome (RLS) between adult patients with sickle cell disease (SCD) and non-SCD anemia. METHODS: This cross-sectional study was conducted from December 2013 to July 2014. Patients with SCD and non-SCD anemia were recruited from a hematology clinic at a large university hospital. Patients with secondary RLS were excluded. Data were collected on demographic features, clinical evaluations, laboratory tests, sleep quality using the Pittsburgh Sleep Quality Index, RLS symptoms using the International Restless Legs Syndrome Study Group Criteria, severity of RLS using the International Restless Leg Syndrome Rating Scale, and daytime sleepiness using the Epworth Sleepiness Scale...
November 19, 2017: Sleep & Breathing, Schlaf & Atmung
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