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https://www.readbyqxmd.com/read/28445539/restless-legs-syndrome-and-cardiovascular-diseases-a-case-control-study
#1
Marion Cholley-Roulleau, Sofiene Chenini, Séverine Béziat, Lily Guiraud, Isabelle Jaussent, Yves Dauvilliers
OBJECTIVE: The association between restless legs syndrome (RLS), cardiovascular diseases (CVD) and hypertension is inconsistent. This case-control study examined i) the association between primary RLS, CVD and hypertension by taking into account many potential confounders and ii) the influence of RLS duration, severity and treatment, sleep and depressive symptoms on CVD and hypertension in primary RLS. METHODS: A standardized questionnaire to assess the RLS phenotype, history of CVD and hypertension, sleep and depressive symptoms, drug intake and demographic/clinical features was sent to the France-Ekbom Patients Association members...
2017: PloS One
https://www.readbyqxmd.com/read/28441282/magnetic-field-reference-levels-for-arbitrary-periodic-waveforms-for-prevention-of-peripheral-nerve-stimulation
#2
Gregory B Gajda, Stephen H Bly
Guidelines for prevention of peripheral nerve stimulation from exposure to low frequency magnetic fields have been developed by standard-setting bodies. Exposure limits or reference levels (RLs) are typically set in terms of the maximum root-mean-square amplitude of a sinusoidal waveform; however, environmental flux densities are often periodic, non-sinusoidal waveforms. This work presents a procedure for deriving RLs for any generalized periodic waveform using the empirical nerve-stimulation threshold data obtained from human volunteer MRI experiments...
June 2017: Health Physics
https://www.readbyqxmd.com/read/28431637/transcranial-color-coded-sonography-of-vertebral-artery-for-diagnosis-of-right-to-left-shunts
#3
Teppei Komatsu, Yuka Terasawa, Ayumi Arai, Kenichi Sakuta, Hidetaka Mitsumura, Yasuyuki Iguchi
BACKGROUND: It is unknown whether contrast transcranial color-coded sonography of vertebral artery monitoring via the foramen magnum window (cTCCS-VA) is useful to detect right-to-left shunt (RLS). We investigated whether cTCCS-VA can be proposed as an alternative to middle cerebral artery monitoring via the temporal bone window (cTCCS-MCA) for RLS detection, as compared with contrast transesophageal echocardiography (cTEE). METHODS: We evaluated 112 patients with ischemic stroke or transient ischemic attack...
May 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28425489/meis1-variant-as-a-determinant-of-autonomic-imbalance-in-restless-legs-syndrome
#4
Jérôme Thireau, Charlotte Farah, Nicolas Molinari, Fabrice Bouilloux, Lucas Torreilles, Juliane Winkelmann, Sabine Scholz, Sylvain Richard, Yves Dauvilliers, Frédéric Marmigère
Restless Legs Syndrome (RLS) is a genetically complex neurological disorder in which overlapping genetic risk factors may contribute to the diversity and heterogeneity of the symptoms. The main goal of the study was to investigate, through analysis of heart rate variability (HRV), whether in RLS patients the MEIS1 polymorphism at risk influences the sympathovagal regulation in different sleep stages. Sixty-four RLS patients with periodic leg movement index above 15 per hour, and 38 controls underwent one night of video-polysomnographic recording...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28425083/restless-legs-syndrome-willis-ekbom-disease-prevalence-in-beta-thalassemia-patients
#5
Euthimia Dimitriadou, Christoforos D Giannaki, Maria Tsekoura, Ioannis Stefanidis, Georgios M Hadjigeorgiou, Eleftherios Lavdas, Christina Karatzaferi, Giorgos K Sakkas
PURPOSE: Both beta thalassemia and restless legs syndrome (RLS) patients share some common pathophysiological characteristics related to iron handling. In the present study, the aim was to explore the prevalence of RLS as well as to explore potential association between the syndrome and various quality of life-related parameters in a sample of beta thalassemia patients. METHODS: One hundred fourteen (age 40 ± 11 yr, 59 M/55F) beta thalassemia patients participated in this cross-sectional descriptive study...
April 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28424977/restless-legs-syndrome-and-tension-type-headache-a-population-based-study
#6
Pil-Wook Chung, Soo-Jin Cho, Won-Joo Kim, Kwang Ik Yang, Chang-Ho Yun, Min Kyung Chu
BACKGROUND: Recent studies have shown a significant association between restless legs syndrome (RLS) and primary headache disorders. Nevertheless, information regarding the association between tension-type headache (TTH) and RLS is limited. This study aimed to investigate the association between RLS and TTH in a population-based sample. METHODS: We selected a stratified random population sample of Koreans aged 19-69 years and assessed them using a semi-structured interview designed to identify RLS, headache type, and clinical characteristics of TTH...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28421356/the-technology-acceptance-model-for-resource-limited-settings-tam-rls-a-novel-framework-for-mobile-health-interventions-targeted-to-low-literacy-end-users-in-resource-limited-settings
#7
Jeffrey I Campbell, Isaac Aturinda, Evans Mwesigwa, Bridget Burns, Data Santorino, Jessica E Haberer, David R Bangsberg, Richard J Holden, Norma C Ware, Mark J Siedner
Although mobile health (mHealth) technologies have shown promise in improving clinical care in resource-limited settings (RLS), they are infrequently brought to scale. One limitation to the success of many mHealth interventions is inattention to end-user acceptability, which is an important predictor of technology adoption. We conducted in-depth interviews with 43 people living with HIV in rural Uganda who had participated in a clinical trial of a short messaging system (SMS)-based intervention designed to prompt return to clinic after an abnormal laboratory test...
April 18, 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/28417178/highly-sensitive-and-selective-determination-of-hydrogen-sulfide-by-resonance-light-scattering-technique-based-on-silver-nanoparticles
#8
Yangfang Kuang, Shu Chen, Yunfei Long
We have developed a green approach to prepare DNA-templated silver nanoparticles (Ag-NPs) from the direct reaction between Ag(+) and ascorbic acid in the presence of DNA and sodium hydroxide. The Ag-NPs showed strong resonance light scattering (RLS) intensity property. Then, the interaction between hydrogen sulfide (H2S) and Ag-NPs was studied by measuring their RLS spectra. The results showed that there is a strong interaction between Ag-NPs and H2S, which resulted in a decrease in the size of Ag-NPs and a decrease in the RLS intensity of the Ag-NPs solution at the wavelength of 467 nm...
April 17, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28393990/-restless-legs-syndrome-long-term-follow-up-of-a-series-of-patients
#9
Marcelo Miranda C, Lorena Hudson A
BACKGROUND: Restless legs syndrome (RLS) affects 10% of the general population. AIM: To analyze a series of patients with a minimum follow-up period of four years, treated during an interval of 14 years. MATERIAL AND METHODS: Retrospective analysis of medical records of 200 patients assessed and followed by the authors at a private outpatient clinic. RESULTS: Fifty patients aged 25 to 90 years (34 females), who had a mean follow-up of 6,3 years (range 4-14 years), were selected...
December 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/28391285/while-isolated-periodic-limb-movement-disorder-significantly-impacts-sleep-depth-and-efficiency-co-morbid-restless-leg-syndrome-mainly-exacerbates-perceived-sleep-quality
#10
Florent-Xavier Hardy De Buisseret, Olivier Mairesse, Johan Newell, Paul Verbanck, Daniel Neu
BACKGROUND: Restless leg syndrome (RLS) and periodic limb movement (PLM) disorder (PLMD) can affect sleep quality and interfere with daytime functioning. Whether the co-morbidity of RLS further worsens daytime symptoms, sleep architecture and quality in patients with PLMs, is not yet fully clarified. METHODS: Sleep (polysomnography) and daytime symptoms of 47 drug-free patients, assigned to isolated PLMD or co-morbid RLS subgroups, were compared to controls in a retrospective cohort-study (n = 501)...
April 8, 2017: European Neurology
https://www.readbyqxmd.com/read/28384297/right-to-left-shunt-detection-using-contrast-enhanced-transcranial-doppler-a-comparison-of-provocation-maneuvers-between-coughing-and-a-modified-valsalva-maneuver
#11
Si-Bo Wang, Xiao-Cong Wang, Yan Ma, Kang-Ding Liu, Ying-Qi Xing
Contrast-enhanced transcranial Doppler (c-TCD) has been used to detect right-to-left shunts (RLS) because it is highly sensitive and cost-effective. The use of provocation maneuvers, such as physiologic maneuvers (e.g., coughing) and the Valsalva maneuver (VM) to transiently increase right atrial pressure and induce RLS increases the sensitivity of RLS detection. In this study, we sought to determine whether coughing is as effective as the VM in aiding the detection of RLS. We evaluated 162 subjects for RLS, using c-TCD under three different conditions: (i) resting state, (ii) coughing, and (iii) modified VM (m-VM), which involved blowing into a tube connected to a sphygmomanometer at 40 mmHg for 10 s...
2017: PloS One
https://www.readbyqxmd.com/read/28383438/safety-and-efficacy-of-cardi-o-fix-occluder-for-percutaneous-closure-of-a-patent-foramen-ovale-a-single-center-prospective-study
#12
Enfa Zhao, Wenjuan Liu, Yushun Zhang, Gesheng Cheng, Yajuan Du, Lu He, Xingye Wang, Xumei He
BACKGROUND: Amplatzer occluder and Cardio-O-fix occluder are currently used in percutaneous closure of patent foramen ovale. However, there is still a lack of relevant reports comparison the differences between them. The aim of this study was to evaluate the short-term and mid-term safety and efficacy of the Cardi-O-fix occluder in preventing recurrent cerebrovascular events in patients with a patent foramen ovale (PFO). METHODS: We enrolled 246 patients (105 men) with a PFO from May 30, 2013 to March 30, 2015 in this single-center prospective study...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28380045/haste-makes-waste-decision-making-in-patients-with-restless-legs-syndrome-with-and-without-augmentation
#13
Beatrice Heim, Marie-Theres Pertl, Ambra Stefani, Margarete Delazer, Anna Heidbreder, Laura Zamarian, Elisabeth Brandauer, Klaus Seppi, Birgit Högl, Werner Poewe, Atbin Djamshidian
OBJECTIVES: To investigate decision making in patients with primary restless legs syndrome (RLS) with and without augmentation treated with dopaminergic medication. METHODS: A total of 64 non-demented RLS patients treated with dopaminergic medication with and without augmentation were included in this study. We used an information sampling task to assess how much evidence participants gather before making a decision. Performance was compared to the results of 21 healthy controls...
2017: PloS One
https://www.readbyqxmd.com/read/28378384/short-interval-leg-movements-during-sleep-entail-greater-cardiac-activation-than-periodic-leg-movements-during-sleep-in-restless-legs-syndrome-patients
#14
Raffaele Ferri, Francesco Rundo, Alessandro Silvani, Marco Zucconi, Debora Aricò, Oliviero Bruni, Bartolo Lanuzza, Luigi Ferini-Strambi, Mauro Manconi
Periodic leg movements during sleep (PLMS) are sequences of ≥4 motor events with intermovement intervals (IMI) of 10-90 s. PLMS are a supportive diagnostic criterion for restless legs syndrome (RLS) and entail cardiac activation, particularly when associated with arousal. RLS patients also over-express short-interval leg movements during sleep (SILMS), which have IMI <10 s and are organized mainly in sequences of two movements (doublets). We tested whether the cardiac activation associated with SILMS doublets differs from that associated with PLMS in a sample of 25 RLS patients...
April 4, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28375243/autostereoscopic-3d-display-with-high-brightness-and-low-crosstalk
#15
Guo-Jiao Lv, Bai-Chuan Zhao, Fei Wu, Wu-Xiang Zhao, Ya-Zhi Yang, Qiong-Hua Wang
An autostereoscopic 3D display with high brightness and low crosstalk is proposed. This display consists of a liquid crystal display (LCD) panel, a reflective light source (RLS), and a parallax barrier or lenticular lens. The RLS behind the LCD panel consists of a light source, a light guide plate, and a reflection cavity. The RLS can make light reflect continuously in the reflection cavity and exit from the slits on the cavity surface. The widths of these slits are narrower than those of the subpixels, so they can provide a low aperture ratio, which is helpful in obtaining low crosstalk...
April 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28373805/circadian-change-in-blink-reflex-recovery-in-restless-legs-syndrome
#16
Nurten Uzun, Ayşegül Gündüz, Derya Karadeniz, Meral E Kiziltan
INTRODUCTION: Restless legs syndrome (RLS) is associated with dysfunction of the dopaminergic systems in the pathways that specifically link the sensory input and motor output. Keeping in mind that clinical symptomatology in RLS and cerebrospinal fluid dopamine concentrations in healthy individuals show changes throughout the day, we hypothesized that excitability of the related pathways increases during the night in RLS, and in the present study, we aimed to analyze our hypothesis by the assessment of blink reflex (BR) recovery...
September 2016: Noro Psikiyatri Arsivi
https://www.readbyqxmd.com/read/28366342/pharmacokinetics-of-rotigotine-transdermal-system-in-adolescents-with-idiopathic-restless-legs-syndrome-willis-ekbom-disease
#17
Jan-Peer Elshoff, John Hudson, Daniel L Picchietti, Keith Ridel, Arthur S Walters, Kimberly Doggett, Kimberly Moran, Marga Oortgiesen, Francisco Ramirez, Erwin Schollmayer
OBJECTIVE: To investigate the pharmacokinetics (PK) of rotigotine transdermal system in adolescents with moderate-to-severe idiopathic restless legs syndrome (RLS). METHODS: This multicenter, open-label, dose-escalation study enrolled patients ≥13 to <18 years of age. Rotigotine transdermal patches were applied daily and up-titrated weekly: 0.5, 1, 2, 3 mg/24 h. Blood samples were collected on the final day of each dose step. Primary PK variables were the apparent total body clearance (CL/f; L/h) and volume of distribution at steady state (VSS/f; L) of unconjugated rotigotine for each dose step, calculated for the PK per-protocol set (PKPPS)...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28366320/bilateral-leg-movements-during-sleep-detailing-their-structure-and-features-in-normal-controls-and-in-patients-with-restless-legs-syndrome
#18
Raffaele Ferri, Mauro Manconi, Francesco Rundo, Marco Zucconi, Debora Aricò, Oliviero Bruni, Filomena I I Cosentino, Luigi Ferini-Strambi, Stephany Fulda
OBJECTIVE: The aim of this study was to analyze statistically the number of single leg movements (LMs) forming bilateral LMs during sleep, along with their combined duration, to eventually provide evidence-based data for the adjustment of the current scoring rules defining bilateral LMs. METHODS: Polysomnographic recordings of 111 untreated patients with RLS with a median age of 56.0 years, along with 42 normal controls with a mean age of 60.0 years, were included...
April 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28364505/association-of-restless-legs-syndrome-with-incident-parkinson-s-disease
#19
Szabolcs Szatmari, Daniel Bereczki, Katalin Fornadi, Kamyar Kalantar-Zadeh, Csaba P Kovesdy, Miklos Z Molnar
Study Objectives: The association between restless legs syndrome (RLS) and Parkinson's disease (PD) has been extensively studied with inconclusive results; therefore, we prospectively examined the associations of the presence of RLS with development of incident PD. Methods: From a nationally representative prospective cohort of almost 3.5 million US veterans (age: 60 ± 14 years, 93% male, median follow-up time of 7.8 years [interquartile range: 6.4-8.4 years]), we created a propensity-matched cohort of 100882 PD-free patients and examined the association between prevalent RLS and incident PD...
February 1, 2017: Sleep
https://www.readbyqxmd.com/read/28364468/intervening-leg-movements-disrupt-plms-sequences
#20
Kasidet Hiranniramol, Stephany Fulda, Patrick Skeba, Christopher J Earley, Richard P Allen
Study Objectives: Periodic leg movements during sleep (PLMS) occur within a subject as a series with a remarkably stable period defined by the intermovement interval (IMI). Sometimes a non-PLMS movement occurs intervening between two PLMS. PLMS scoring rules totally ignore these intervening leg movements (iLM). This implicitly assumes an iLM results from a process sufficiently independent from the periodic process producing PLMS that it does not affect the periodicity of the surrounding PLMS...
January 1, 2017: Sleep
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