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https://www.readbyqxmd.com/read/28729849/nerve-decompression-and-restless-legs-syndrome-a-retrospective-analysis
#1
James C Anderson, Megan L Fritz, John-Michael Benson, Brian L Tracy
INTRODUCTION: Restless legs syndrome (RLS) is a prevalent sleep disorder affecting quality of life and is often comorbid with other neurological diseases, including peripheral neuropathy. The mechanisms related to RLS symptoms remain unclear, and treatment options are often aimed at symptom relief rather than etiology. RLS may present in distinct phenotypes often described as "primary" vs. "secondary" RLS. Secondary RLS is often associated with peripheral neuropathy. Nerve decompression surgery of the common and superficial fibular nerves is used to treat peripheral neuropathy...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28728619/restless-genital-syndrome-differential-diagnosis-and-treatment-with-pramipexole
#2
Emilia Sforza, David Hupin, Frédéric Roche
Restless genital syndrome refers to excessive and persistent sensations of genital and clitoral arousal with the absence of conscious feeling of sexual desire. These sensations have been linked to symptoms of restless legs syndrome (RLS) or an overactive bladder. Restless genital syndrome may be related to small fiber sensory neuropathy of the dorsal nerve of the clitoris, so it more frequently occurs in women. The association with RLS suggests a possible dopaminergic mechanism. We report a case of a 74-year-old woman who presented restless genital symptoms every night in association with RLS symptoms...
July 14, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28721446/rhamnolipids-enhance-in-vivo-oral-bioavailability-of-poorly-absorbed-molecules
#3
El-Sayed Khafagy, Mona F El-Azab, Mohamed E H ElSayed
PURPOSE: This report describes the effect of rhamnolipids (RLs) on the tight junctions (TJ) of the intestinal epithelium using the rat in-situ closed loop model. METHODS: We investigated the transport of 5 (6)-carboxyfluorescein (CF) and fluorescein isothiocyanate-labeled dextrans with average molecular weights of 4.4 and 10 kDa (FD-4 and FD-10) when co-administered with different concentrations of RLs. Lactate dehydrogenase (LDH) leakage assay and histopathological examination of treated intestinal loops were used to assess potential toxicity of RLs...
July 18, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28704560/performance-characteristics-of-finger-stick-dried-blood-spots-dbs-on-the-determination-of-human-immunodeficiency-virus-hiv-treatment-failure-in-a-pediatric-population-in-mozambique
#4
Joy Chang, Amina de Sousa, Jennifer Sabatier, Mariamo Assane, Guoqing Zhang, Dulce Bila, Paula Vaz, Charity Alfredo, Loide Cossa, Nilesh Bhatt, Emilia H Koumans, Chunfu Yang, Emilia Rivadeneira, Ilesh Jani, James C Houston
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this study collected 717 DBS and paired plasma samples from children receiving ART ≥1 year in Mozambique and compared the performance of DBS using Abbott's VL test with a paired plasma sample using Roche's VL test...
2017: PloS One
https://www.readbyqxmd.com/read/28699332/prevalence-of-restless-legs-syndrome-in-migraine-patients-a-case-control-study-analysis-of-risk-factors-for-restless-legs-syndrome-in-migraine-patients
#5
Mariarosaria Valente, Francesco Janes, Valentina Russo, Augusto Fontana, Alessia Travanut, Martina Sommaro, Giessica Canal, Carolina Gentile, Gian Luigi Gigli
BACKGROUND: Restless legs syndrome (RLS) is a sensorimotor disorder. It can be idiopathic, associated to other diseases or to pharmacologic treatments. RLS has been reported to occur more frequently in migraine patients, but a clear pathogenetic link seems still under debate. We aimed to evaluate RLS prevalence in migraine, impact on sleep quality and the main clinical determinants of this association. METHODS: Migraine patients and age- and sex-matched controls were enrolled from 1(st) January 2011 to 30(th) December 2012...
July 2017: Headache
https://www.readbyqxmd.com/read/28695622/sleep-disturbance-by-pramipexole-is-modified-by-meis1-in-mice
#6
Aaro V Salminen, Barbara Schormair, Cornelia Flachskamm, Miguel Torres, Bertram Müller-Myhsok, Mayumi Kimura, Juliane Winkelmann
Meis homeobox 1 (Meis1) is a transcription factor functioning in the development of the nervous system and the cardiovascular system. Both common and rare variants within the gene have been associated with restless legs syndrome (RLS), while its association with symptoms of insomnia has also been discovered recently. RLS is associated with sleep disturbances, and while Meis1 haploinsufficiency is one of the most promising strategies for an RLS animal model, sleep phenotyping of Meis1 knockout mice has never been conducted...
July 11, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28682991/the-effect-of-cold-dialysis-in-motor-and-sensory-symptoms-of-rls-wed-occurring-during-hemodialysis-a-double-blind-study
#7
Giorgos K Sakkas, Evaggelia Tsaknaki, Clara S Rosa, Christoforos D Giannaki, Argyro A Krase, Eleftherios Lavdas, Georgios M Hadjigeorgiou, Ioannis Stefanidis, Christina Karatzaferi
Restless legs syndrome/Willis-Ekbom disease (RLS/WED) is a common sensorimotory disorder affecting almost 30% of hemodialysis (HD) patients. RLS/WED induces discomfort during rest hours, and its symptoms have also been observed during HD sessions. Anecdotal reports suggest that cooling the dialysate solution during dialysis could help patients overcome those symptoms and improve restlessness. The aim of this double-blind study was to assess whether a reduction of the dialysate temperature by 1°C could reduce motor and sensory symptoms of RLS/WED occurring during HD...
July 4, 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28670126/prognostic-value-of-restless-legs-syndrome-in-hemodialysis-patients-a-systematic-review-and-meta-analysis
#8
Jing Li, Tao Zhang, Qingmiao Shao
BACKGROUND: Previous studies have revealed that restless legs syndrome (RLS) not only is frequently prevalent in dialysis patients but also increases the risk of death in dialysis patients, especially in hemodialysis (HD) patients. However, inconsistent results also still exist, having attracted confusion and discussion. Owing to mixed and inconclusive results, we conducted to perform the comprehensive meta-analysis to evaluate the potential prognostic value of RLS in HD patients. MATERIALS AND METHODS: We conducted a systematic literature search using electronic databases (PubMed, Ovid, Embase and Web of Science) to identify relevant studies reporting on all-cause mortality and cardiovascular (CV) events in HD patients suffering from RLS...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28669082/accompanying-migrainous-features-in-pediatric-migraine-patients-with-restless-legs-syndrome
#9
Melis Sohtaoğlu Sevindik, Seden Demirci, Baki Göksan, Aynur Özge, Feray Karaali Savrun, Hatice Onur, Veli Yıldırım, Ismail Simsek, Harika Ozhan, Derya Uludüz
The present study aimed to examine the frequency of restless legs syndrome (RLS) in pediatric patients with migraine and tension-type headache (TTH) and to investigate accompanying migrainous symptoms, sleep characteristics, as well as levels of serum ferritin between the pediatric migraine patients with RLS and those without RLS. We included 65 consecutive patients diagnosed with migraine, 20 patients with TTH, and 97 headache-free children in our study. Demographic, clinical, and laboratory data were noted...
July 1, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28668731/determination-of-thorium-iv-using-isophthalaldehyde-tetrapyrrole-as-probe-by-resonance-light-scattering-second-order-scattering-and-frequency-doubling-scattering-spectra
#10
Jiao Wang, Jinhua Xue, Xilin Xiao, Li Xu, Min Jiang, Pengcheng Peng, Lifu Liao
The coordination reaction of thorium (IV) with a ditopic bidentate ligand to form supramolecular polymer was studied by resonance light scattering (RLS) spectra, second-order scattering (SOS) spectra and frequency-doubling scattering (FDS) spectra, respectively. The ditopic bidentate ligand is isophthalaldehyde-tetrapyrrole (IPTP). It was synthesized through a condensation reaction of isophthalaldehyde with pyrrole. The formation of supramolecular polymer results in remarkable intensity enhancements of the three light scattering signals...
June 27, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28664035/neurophysiological-mechanisms-of-circadian-cognitive-control-in-rls-patients-an-eeg-source-localization-study
#11
Rui Zhang, Moritz D Brandt, Wiebke Schrempf, Christian Beste, Ann-Kathrin Stock
The circadian variation of sensory and motor symptoms with increasing severity in the evening and at night is a key diagnostic feature/symptom of the restless legs syndrome (RLS). Even though many neurological diseases have shown a strong nexus between motor and cognitive symptoms, it has remained unclear whether cognitive performance of RLS patients declines in the evening and which neurophysiological mechanisms are affected by the circadian variation. In the current study, we examined daytime effects (morning vs...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28661967/predictors-of-virological-failure-on-first-line-antiretroviral-therapy-among-children-in-a-referral-pediatric-center-in-cameroon
#12
Anne Esther Njom Nlend, Annie Nga Motaze, Suzie Tetang Ndiang, Joseph Fokam
BACKGROUND: Suboptimal response to antiretroviral therapy (ART) is common among children living with HIV (CHIV) in resource-limited settings (RLS). We sought to assess virological failure (VF), time for switching to second-line regimens, and factors associated with VF in CLHIV receiving first-line ART in Cameroon. METHODS: An observational cohort-study was conducted in 375 CLHIV initiating a first-line ART and treated for ≥6months at the National Social Insurance Fund Hospital in Yaoundé-Cameroon, from 2009-2013...
June 28, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28649608/distribution-and-impact-on-quality-of-life-of-the-pain-modalities-assessed-by-the-king-s-parkinson-s-disease-pain-scale
#13
Pablo Martinez-Martin, Jose Manuel Rojo-Abuin, Alexandra Rizos, Carmen Rodriguez-Blazquez, Claudia Trenkwalder, Lauren Perkins, Anna Sauerbier, Per Odin, Angelo Antonini, Kallol Ray Chaudhuri
In Parkinson's disease, pain is a prevalent and complex symptom of diverse origin. King's Parkinson's disease pain scale, assesses different pain syndromes, thus allowing exploration of its differential prevalence and influence on the health-related quality of life of patients. Post hoc study 178 patients and 83 matched controls participating in the King's Parkinson's disease pain scale validation study were used. For determining the respective distribution, King's Parkinson's disease pain scale items and domains scores = 0 meant absence and ≥1 presence of the symptom...
2017: NPJ Parkinson's Disease
https://www.readbyqxmd.com/read/28647269/quantum-chemical-investigation-on-photodegradation-mechanisms-of-sulfamethoxypyridazine-with-dissolved-inorganic-matter-and-hydroxyl-radical
#14
Shaheen Shah, Ce Hao
Sulfamethoxypyridazine (SMP) is one of the commonly used sulfonamide antibiotics (SAs). SAs are mainly studied to undergo triplet-sensitized photodegradation in water under natural sunlight with other coexisting aquatic environmental organic pollutants. In this work, SMP was selected as a representative of SAs. We studied the mechanisms of triplet-sensitized photodegradation of SMP and the influence of selected dissolved inorganic matter, i.e., anions (Br(-), Cl(-), and NO3(-)) and cations ions (Ca(2+), Mg(2+), and Zn(2+)) on SMP photodegradation mechanism by quantum chemical methods...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28645892/meis1-effects-on-motor-phenotypes-and-the-sensorimotor-system-in-mice
#15
Aaro V Salminen, Lillian Garrett, Barbara Schormair, Jan Rozman, Florian Giesert, Kristina M Niedermeier, Lore Becker, Birgit Rathkolb, Ildikó Rácz, Martin Klingenspor, Thomas Klopstock, Eckhard Wolf, Andreas Zimmer, Valérie Gailus-Durner, Miguel Torres, Helmut Fuchs, Martin Hrabě de Angelis, Wolfgang Wurst, Sabine M Hölter, Juliane Winkelmann
MEIS1 is a developmental transcription factor linked to restless legs syndrome (RLS) in genome-wide association studies. RLS is a movement disorder leading to severe sleep reduction and with significant impact on the quality-of-life of patients. In genome-wide association studies, MEIS1 has consistently been the gene with the highest effect size and functional studies suggest a disease-relevant downregulation. Therefore, haploinsufficiency of Meis1 could be the most potential system for modeling RLS in animals...
June 23, 2017: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/28643901/ferric-carboxymaltose-in-patients-with-restless-legs-syndrome-and-nonanemic-iron-deficiency-a-randomized-trial
#16
Claudia Trenkwalder, Juliane Winkelmann, Wolfgang Oertel, Garth Virgin, Bernard Roubert, Anna Mezzacasa
BACKGROUND: Compromised iron status is important in restless legs syndrome pathophysiology. We compared the efficacy and tolerability of ferric carboxymaltose (single intravenous dose) versus placebo for restless legs syndrome treatment in iron-deficient nonanemic patients. METHODS: Patients with moderate to severe restless legs syndrome and serum ferritin < 75 μg/L (or serum ferritin 75-300 μg/L and transferrin saturation < 20%) were randomized to ferric carboxymaltose (1000 mg iron) or placebo...
June 23, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28642611/engineered-newcastle-disease-virus-expressing-the-f-and-g-proteins-of-ampv-c-confers-protection-against-challenges-in-turkeys
#17
Haixia Hu, Jason P Roth, Laszlo Zsak, Qingzhong Yu
Avian metapneumovirus (AMPV) infects the respiratory and reproductive tracts of domestic poultry, resulting in substantial economic losses for producers. Live attenuated vaccines appear to be the most effective in countries where the disease is prevalent. However, reversion to virulence has been demonstrated in several studies. Therefore, the development of a stable and safe next generation vaccine against the AMPV disease is needed. In the present study, we generated a recombinant Newcastle disease virus (NDV) vectoring the fusion (F) protein and glycoprotein (G) genes of AMPV subtype-C (AMPV-C) as a bivalent vaccine candidate using reverse genetics technology...
June 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28633715/restless-legs-syndrome-and-sleep-wake-disturbances-in-pregnancy
#18
Galit Levi Dunietz, Lynda D Lisabeth, Kerby Shedden, Q Afifa Shamim-Uzzaman, Alexandra S Bullough, Mark C Chames, Marc F Bowden, Louise M O'Brien
STUDY OBJECTIVES: To estimate the association of restless legs syndrome (RLS) and its frequency with sleep-wake disturbances in pregnancy. METHODS: A cohort of 1,563 women in their third trimester of pregnancy were recruited from prenatal clinics between March 2007 and December 2010. Demographic, pregnancy, and delivery data were extracted from medical records and sleep information was collected with questionnaires. To diagnose RLS, we used standardized criteria of RLS symptoms and frequency that were developed by the International Restless Legs Study Group...
July 15, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/28631766/-postural-effect-in-patients-with-patent-foramen-ovale-evaluation-of-right-to-left-shunt-with-transcranial-doppler-and-transthoracic-echocardiography-and-correlation-with-arterial-oxygen-saturation
#19
Stefano Lucreziotti, Chiara Debenedetti, Laura Massironi, Antonio Mantero, Fabiano Di Marco, Massimo Chessa, Stefano Carugo
BACKGROUND: Transcranial Doppler echocardiography and transthoracic echocardiography may detect with high accuracy right-to-left shunt (RLS) due to patent foramen ovale (PFO). However, a standardized diagnostic protocol has never been established. It has been suggested that standing or sitting positions may improve sensitivity of transcranial Doppler due to increased LRS in such positions. We aimed to test efficacy of the sitting position in addition to the supine position in the grading of RLS in patients with PFO...
June 2017: Giornale Italiano di Cardiologia
https://www.readbyqxmd.com/read/28627427/efficacy-and-safety-of-a-once-daily-single-tablet-regimen-of-tenofovir-lamivudine-and-efavirenz-assessed-at-144-weeks-among-antiretroviral-na%C3%A3-ve-and-experienced-hiv-1-infected-thai-adults
#20
Anchalee Avihingsanon, Wirach Maek-A-Nantawat, Sivaporn Gatechompol, Vorapot Sapsirisavat, Wanida Thiansanguankul, Jiratchaya Sophonphan, Narujakorn Thammajaruk, Sasiwimol Ubolyam, David M Burger, Kiat Ruxrungtham
OBJECTIVE: To assess the efficacy and safety of a new single-tablet regimen (STR) of tenofovir disoproxil fumarate (TDF) 300mg, lamivudine (3TC) 300mg, and efavirenz (EFV) 600mg in HIV-infected Thai patients. METHODS: This was a prospective study performed for 144 weeks among 51 treatment-naïve patients and 49 experienced patients on separate tablets of TDF, 3TC, and EFV with HIV RNA<50 copies/ml. CD4, HIV RNA, liver and renal function, and lipid profiles were assessed at baseline, weeks 12, 24, and 48, and then every 24 weeks...
June 13, 2017: International Journal of Infectious Diseases: IJID
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