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https://www.readbyqxmd.com/read/29458749/efficacy-of-ferric-carboxymaltose-fcm-500-mg-dose-for-the-treatment-of-restless-legs-syndrome
#1
Yong Won Cho, Richard P Allen, Christopher J Earley
INTRODUCTION: There have been four randomized, placebo-controlled, double-blinded studies of intravenous (IV) iron in Restless Legs Syndrome (RLS), all of which delivered a final total dose of 1000 mg of iron. The purpose of this study was to evaluate effects of a lesser total dose (500 mg of iron). METHODS: Subjects with idiopathic RLS were enrolled in a randomized, double-blinded, placebo-controlled study. Subjects received either 500 mg ferric carboxymaltose (FCM) or placebo as a single infusion (Phase I)...
February 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29458704/evaluation-of-cardiovascular-risk-factors-and-restless-legs-syndrome-in-women-and-men-a-preliminary-population-based-study-in-china
#2
Yuqiong Liu, Gangqiong Liu, Ling Li, Jing Yang, Shengli Ma
STUDY OBJECTIVES: Many studies have investigated the association between restless legs syndrome (RLS) and cardiovascular risk factors, leading to conflicting results. Therefore, the aim of the current study was to determine whether RLS is associated with cardiovascular risk factors and disease. METHODS: This cross-sectional study included 5,324 consecutive subjects who visited the Physical Examination Center of The First Affiliated Hospital of Zhengzhou University for their yearly routine physical examination...
February 13, 2018: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29456298/reactive-lesions-of-oral-cavity-a-retrospective-study-of-659-cases
#3
REVIEW
Biji Babu, Kaveri Hallikeri
Objective: This study reviews, analyzes, and compares the demographic data, histopathological features and discusses the treatment and prognosis of reactive lesions (RLs). Materials and Methods: Retrospective study was performed on the departmental archives from July 2006 to July 2016 (total 5000 cases) comprising of 659 cases of RLs of the oral cavity. The recorded data included age, gender, size, site, duration, habits, etiology, histopathological diagnosis, treatment, and prognosis...
July 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29444659/right-to-left-shunt-and-subclinical-ischemic-brain-lesions-in-chinese-migraineurs-a-multicentre-mri-study
#4
Xiao-Han Jiang, Si-Bo Wang, Qian Tian, Chi Zhong, Guan-Ling Zhang, Ya-Jie Li, Pan Lin, Yong You, Rong Guo, Ying-Hua Cui, Ying-Qi Xing
BACKGROUND: Migraine is considered as a risk factor for subclinical brain ischemic lesions, and right-to-left shunt (RLS) is more common among migraineurs. This cross-sectional study assessed the association of RLS with the increased prevalence of subclinical ischemic brain lesions in migraineurs. METHODS: We enrolled 334 migraineurs from a multicentre study from June 2015 to August 2016. Participants were all evaluated using contrast-enhanced transcranial Doppler, magnetic resonance imaging (MRI), and completed a questionnaire covering demographics, the main risk factors of vascular disease, and migraine status...
February 14, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29442943/ultrasensitive-detection-of-protein-based-on-graphene-quantum-dots-with-resonance-light-scattering-technique
#5
Chunxia Wu, Xing Song, Zelin Song, Zijuan He, Jun Dai
In this paper, a simple, label-free and ultrasensitive resonance light scattering (RLS) method for ultratrace protein detection was investigated using graphene quantum dots (GQDs) as probes. Due to the electrostatic interaction between GQDs and protein, the RLS intensity was gradually enhanced as the protein was added into the GQDs solution. Through a series of optimization experiments, the optimal detection conditions of the GQDs solution were as follows: pH = 7.4, 2 M ion concentration and 60 μM GQDs. Under the optimized conditions, the linear correlation between the GQDs and the concentration of protein was observed from 10 μM to 60 μM with the correlation coefficient (R2) of 0...
April 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29441041/altered-brain-functional-connectome-in-migraine-with-and-without-restless-legs-syndrome-a-resting-state-functional-mri-study
#6
Fu-Chi Yang, Kun-Hsien Chou, Ai-Ling Hsu, Jong-Ling Fuh, Jiing-Feng Lirng, Hung-Wen Kao, Ching-Po Lin, Shuu-Jiun Wang
Background: Migraine is frequently comorbid with restless legs syndrome (RLS), both displaying functional connectivity (FC) alterations in multiple brain networks, although the neurological basis of this association is unknown. Methods: We performed resting-state functional magnetic resonance imaging and network-wise analysis of FC in migraine patients with and without RLS and healthy controls (CRL). Network-based statistics (NBS) and composite FC matrix analyses were performed to identify the patterns of FC changes...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29440925/chronic-back-pain-cured-by-low-dose-levodopa-is-it-a-variant-of-restless-legs-syndrome
#7
Zhi-Fen Zeng, Yan-Ran Liang, Ying Chen, Xiu-Na Jing, Su-Dan Peng, En-Xiang Tao
Chronic back pain is one of the most common reasons for missed work and visits to the doctor. This report presents 2 interesting cases of chronic back pain that were effectively relieved by low-dose levodopa. These 2 patients showed no sign of anatomical problem of the spine or relative structures, but the discomforts on the back manifested some characteristics resembling those in restless legs syndrome (RLS), and one of them actually developed RLS after many years of back problem. We believe that this type of chronic back pain might be a variant of RLS, which we would like to call "restless back", and it can be effectively treated by dopaminergic drugs...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29435953/role-of-noncommunicable-diseases-ncds-in-resource-limited-settings-rls
#8
REVIEW
Mosepele Mosepele, Elizabeth Botsile
PURPOSE OF REVIEW: As access to effective antiretroviral therapy (ART) expands globally, a decline in AIDS-related morbidity and mortality has been complicated by rising rates of noncommunicable diseases (NCDs). This review provides a brief description of NCDs and existing gaps on knowledge about NCDs among HIV-infected adults mostly in Africa. RECENT FINDINGS: Recent reports show that one in every five persons living with HIV has a chronic illness, predominantly diabetes and/or hypertension, depression, and most of these conditions are either not diagnosed or not being managed...
February 12, 2018: Current HIV/AIDS Reports
https://www.readbyqxmd.com/read/29434568/restless-legs-syndrome-willis-ekbom-disease-is-prevalent-in-working-nurses-but-seems-not-to-be-associated-with-shift-work-schedules
#9
Siri Waage, Ståle Pallesen, Bente Elisabeth Moen, Bjørn Bjorvatn
Insomnia and excessive sleepiness are among the most commonly reported sleep problems related to shift work. Sleep-related movement disorders have, however, received far less attention in relation to such work schedules. The objective of this study was to investigate the association between different shift work schedules and the prevalence of Restless legs syndrome/Willis-Ekbom disease (RLS/WED) in a large sample of Norwegian nurses. Our hypothesis was that shift working nurses would report higher prevalence of RLS/WED compared to day workers...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29428170/fitness-and-retentive-force-of-cobalt-chromium-alloy-clasps-fabricated-with-repeated-laser-sintering-and-milling
#10
Mana Torii, Toyoki Nakata, Kazuya Takahashi, Noboru Kawamura, Hidemasa Shimpo, Chikahiro Ohkubo
PURPOSE: With computer-aided design and computer-aided manufacturing (CAD/CAM), the study was conducted to create a removable partial denture (RPD) framework using repeated laser sintering rather than milling and casting techniques. This study experimentally evaluated the CAM clasp and compared it to a conventional cast clasp. METHODS: After the tooth die was scanned, an Akers clasp was designed using CAD with and without 50μm of digital relief on the occlusal surface of the tooth die...
February 7, 2018: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29427229/diabetic-painful-neuropathy-and-restless-legs-syndrome-in-diabetes
#11
EDITORIAL
Sanjay Kalra, Anu Gupta
Restless legs syndrome (RLS) and diabetic painful neuropathy (DPN) are two distinct neurological conditions, which share many similarities. As RLS occurs frequently in persons with diabetes, the differential diagnosis and management of RLS and DPN may pose a clinical challenge. This communication describes the etiopathogenesis, clinical features, investigations, and treatment of both conditions. It highlights the similarities and differences between RLS and DPN, and helps the physician plan a rational clinical and therapeutic approach...
February 9, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29426514/application-of-polyacrylonitrile-nanofibers-decorated-with-magnetic-carbon-dots-as-a-resonance-light-scattering-sensor-to-determine-famotidine
#12
Somayeh Maleki, Tayyebeh Madrakian, Abbas Afkhami
In this study, a novel resonance light scattering (RLS) sensor was synthesized using polyacrylonitrile nanofibers decorated with magnetic carbon dots (MCDs@NFs) nanocomposite and applied for famotidine (FMD) determination. The MCDs@NFs nanocomposite was synthesized by combining electrospinning and a simple one-step hydrothermal method. Different methods were applied in order to characterize the MCDs@NFs nanocomposite such as: scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), Transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD)...
May 1, 2018: Talanta
https://www.readbyqxmd.com/read/29425576/evidence-based-and-consensus-clinical-practice-guidelines-for-the-iron-treatment-of-restless-legs-syndrome-willis-ekbom-disease-in-adults-and-children-an-irlssg-task-force-report
#13
Richard P Allen, Daniel L Picchietti, Michael Auerbach, Yong Won Cho, James R Connor, Christopher J Earley, Diego Garcia-Borreguero, Suresh Kotagal, Mauro Manconi, William Ondo, Jan Ulfberg, John W Winkelman
BACKGROUND: Brain iron deficiency has been implicated in the pathophysiology of RLS, and current RLS treatment guidelines recommend iron treatment when peripheral iron levels are low. In order to assess the evidence on the oral and intravenous (IV) iron treatment of RLS and periodic limb movement disorder (PLMD) in adults and children, the International Restless Legs Syndrome Study Group (IRLSSG) formed a task force to review these studies and provide evidence-based and consensus guidelines for the iron treatment of RLS in adults, and RLS and PLMD in children...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29425573/diurnal-variation-of-default-mode-network-in-patients-with-restless-legs-syndrome
#14
Jeonghun Ku, Yeong Seon Lee, Hyuk Won Chang, Christopher J Earley, Richard P Allen, Yong Won Cho
OBJECTIVE: Restless legs syndrome (RLS) patients compared to controls have been found to have abnormal patterns in the default mode network (DMN) in the morning when symptom threshold is the highest and symptoms are least likely to occur. If these morning abnormalities in DMN are pertinent to disease expression, then similar or further detectable differences may be expected on a nighttime assessment when RLS symptom threshold is at its lowest. The purpose of this study was to elucidate the potential neural mechanisms underlying the circadian aspect of RLS symptom expression by assessing diurnal changes in DMN...
January 2018: Sleep Medicine
https://www.readbyqxmd.com/read/29422930/haplotype-association-of-the-map2k5-gene-with-antipsychotics-induced-symptoms-of-restless-legs-syndrome-among-patients-with-schizophrenia
#15
Seung-Gul Kang, Yu Jin Lee, Young-Min Park, Leen Kim, Heon-Jeong Lee
Objective: Restless legs syndrome (RLS) is considered a genetic disease and, following a genome-wide association study conducted in 2007, the mitogen-activated protein kinase 5 (MAP2K5) gene has been regarded as the promising candidate gene for RLS. The present study investigated whether polymorphisms of MAP2K5 are associated with antipsychotics-induced RLS in schizophrenia. Methods: We assessed antipsychotics-induced RLS symptoms in 190 Korean schizophrenic patients using the diagnostic criteria of the International Restless Legs Syndrome Study Group...
January 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29419360/the-prevalence-of-restless-legs-syndrome-and-its-relationship-with-demographic-characteristics-and-medical-disorders-in-postmenopausal-iranian-women
#16
Roghieh Bagheri, Parvin Abedi, Parvaneh Mousavi, Nasrin Azimi
This study was conducted to evaluate the prevalence of restless legs syndrome (RLS) and its relationship with demographic factors and medical disorders on 980 postmenopausal women. Data was gathered using a demographic questionnaire and the International Restless Legs Syndrome Scale. The prevalence of RLS was 16.02% (157/980). Women with poor economic status were 3.37 and 2.33 times more likely to have RLS than women with a good economic situation and moderate economic status (CI:2.041-5.579, P≤0.0001) and (CI: 1...
February 8, 2018: Health Care for Women International
https://www.readbyqxmd.com/read/29410740/crude-and-adjusted-prevalence-of-sleep-complaints-in-mexico-city
#17
Alejandro Jiménez-Genchi, Jorge Caraveo-Anduaga
OBJECTIVE: To estimate the crude prevalence rates of several sleep complaints and the prevalence for each one adjusted for the coexistence of symptoms in other sleep domains in a representative sample of adult individuals from Mexico City. METHODS: A probabilistic sample of 1933 adult individuals living in Mexico City was surveyed using fourteen questions of the Sleep Disorders Questionnaire to assess sleep-related symptoms and sleep complaints. Estimates of crude prevalence rates for each sleep disturbance and adjusted for a score ≥ the 80th...
July 2017: Sleep Science
https://www.readbyqxmd.com/read/29408974/the-impact-of-sleep-disorders-on-driving-safety-findings-from-the-shrp-2-naturalistic-driving-study
#18
Shu-Yuan Liu, Miguel A Perez, Nathan Lau
Study Objectives: This study investigated the association between driving safety and seven sleep disorders amongst 3,541 participants of the Second Strategic Highway Research Program (SHRP 2) naturalistic driving study. Methods: SHRP 2 collected naturalistic driving data from participants between 16 to 98 years old by instrumenting participants' vehicles. The analyses used logistic regression to determine the likelihood of crash/near-crash involvement, Poisson log-linear regression to assess crash/near-crash rate, and ordinal logistic regression to assess driver maneuver appropriateness and crash/near-crash severity...
February 2, 2018: Sleep
https://www.readbyqxmd.com/read/29404899/tox3-variants-are-involved-in-restless-legs-syndrome-and-parkinson-s-disease-with-opposite-effects
#19
Sadaf Mohtashami, Qin He, Jennifer A Ruskey, Sirui Zhou, Patrick A Dion, Richard P Allen, Christopher J Earley, Edward A Fon, Lan Xiong, Nicolas Dupre, Yves Dauvilliers, Guy A Rouleau, Ziv Gan-Or
Parkinson's disease (PD) and restless legs syndrome (RLS) may be clinically and/or etiologically related, yet this association is under debate. Single-nucleotide polymorphisms (SNPs) in the TOX3 gene locus were implicated in both RLS and PD genome-wide association studies (GWASs), suggesting a potential pleiotropy. Two case-control cohorts including 644 PD patients, 457 RLS patients, and 945 controls were genotyped for one known RLS-related SNP (rs3104767) and one PD-related SNP (rs4784226) in the TOX3 locus...
February 5, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29404269/the-prevalence-of-restless-leg-syndrome-among-pregnant-saudi-women
#20
Mohmd Khan, Noha Mobeireek, Yassar Al-Jahdali, Nujood Al-Dubyan, Anwar Ahmed, Majed Al-Gamedi, Abdullah Al-Harbi, Hamdan Al-Jahdali
Objectives: Restless legs syndrome (RLS) is common among pregnant women, but it has not been documented in pregnant Saudi Arabian women. The main purpose of this study was to estimate the extent of the prevalence of RLS and identify both the associated factors and the associated risk factors among pregnant Saudi women. Methods: A cross-sectional study was conducted among pregnant women visiting obstetric clinics at King Abdulaziz Medical City in Riyadh (KAMC-Riyadh) over the period from June 1 to November 1, 2014...
January 2018: Avicenna Journal of Medicine
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