keyword
MENU ▼
Read by QxMD icon Read
search

Acral melanoma

keyword
https://www.readbyqxmd.com/read/28737763/melanoma-subtypes-demonstrate-distinct-pd-l1-expression-profiles
#1
Genevieve J Kaunitz, Tricia R Cottrell, Mohammed Lilo, Valliammai Muthappan, Jessica Esandrio, Sneha Berry, Haiying Xu, Aleksandra Ogurtsova, Robert A Anders, Alexander H Fischer, Stefan Kraft, Meg R Gerstenblith, Cheryl L Thompson, Kord Honda, Jonathan D Cuda, Charles G Eberhart, James T Handa, Evan J Lipson, Janis M Taube
PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic and predictive biomarker in patients with cutaneous melanoma, a finding closely related to its adaptive (IFN-γ-mediated) mechanism of expression. Approximately 35% of cutaneous melanomas express PD-L1, however, the expression patterns, levels, and prevalence in rarer melanoma subtypes are not well described. We performed immunohistochemistry for PD-L1 and CD8 on 200 formalin-fixed paraffin-embedded specimens from patients with acral (n=16), mucosal (n=36), uveal (n=103), and chronic sun-damaged (CSD) (n=45) melanomas (24 lentigo maligna, 13 'mixed' desmoplastic, and 8 'pure' desmoplastic melanomas)...
July 24, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28724272/patients-characteristics-histopathological-findings-and-tumor-stage-in-different-types-of-malignant-melanoma-a-retrospective-multicenter-study
#2
Ali-Mohammad Farahmand, Amir-Hoshang Ehsani, Mojtaba Mirzaei, Maryam Mohsenian, Alireza Ghanadan
Cutaneous malignant melanoma (CMM) is currently the most fatal of skin cancers accounting for 50000 deaths annually. Five distinct melanomas are described histopathologically: superficial spreading, lentigo maligna, nodular, acral lentiginous and mucosal melanoma. The aim of this study was to investigate the characteristics of patients with various types of malignant melanoma and evaluate histopathological findings. In this retrospective study, we obtained our data from the records of 111 patients with melanoma...
May 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28723771/malignant-melanoma-misdiagnosed-as-diabetic-foot-ulcer-a-case-report
#3
Wei Gao, Dawei Chen, Xingwu Ran
RATIONALE: Acral lentiginous melanoma (AML) does not exhibit the classic signs of malignant melanoma. ALM is frequently misdiagnosed because of its unusual sites and atypical clinical morphologies, which lead to poor prognosis. PATIENT CONCERNS: A female patient aged 78 years was presented to our center with two ulcers on her right foot. Diabetic foot ulcer was considered as the primary diagnosis. The ulcers failed to improve after 2 weeks' therapy. DIAGNOSES: An incisional biopsy of the lesion revealed malignant melanoma...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28720667/mapk-pathway-and-tert-promoter-gene-mutation-pattern-and-its-prognostic-value-in-melanoma-patients%C3%AF-a-retrospective-study-of-2793-cases
#4
Xue Bai, Yan Kong, Zhihong Chi, Xinan Sheng, Chuanliang Cui, Xuan Wang, Lili Mao, Bixia Tang, Siming Li, Bin Lian, Xieqiao Yan, Li Zhou, Jie Dai, Jun Guo, Lu Si
Ethnic differences are conspicuous in melanoma. This study is to obtain a comprehensive view of a genomic landscape and a better understanding of the correlations of gene mutation status with clinicopathological characteristics and disease prognosis in Asian population.<br /><br />Experimental Design: 2793 melanoma patient samples were retrospectively collected and analyzed for mutations in C-KIT, BRAF, NRAS, and PDGFRA coding regions and TERT promoter region by Sanger sequencing. Mutations were correlated to clinicopathological features and overall survival...
July 18, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28717212/a-clinicopathological-analysis-of-153-acral-melanomas-and-the-relevance-of-mechanical-stress
#5
Yi-Shuan Sheen, Yi-Hua Liao, Ming-Hsien Lin, Jau-Shiuh Chen, Jau-Yu Liau, Yu-Ju Tseng, Chih-Hung Lee, Yih-Leong Chang, Chia-Yu Chu
The pathogenesis of melanomas emerging in plantar surfaces remains unclear; however, mechanical stress has been reported to increase the formation of melanomas. In this study, we conducted a multicenter retrospective analysis of 153 acral melanomas diagnosed between 2000 and 2015 in Taiwan. The male-to-female ratio of the patients in question was 1:1.28, and the mean age at diagnosis was 68 years. We examined whether melanomas which developed in different areas of the patients' soles differed in their associations with various clinicopathological characteristics and survival...
July 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28710916/systemic-immune-inflammation-index-and-circulating-t-cell-immune-index-predict-outcomes-in-high-risk-acral-melanoma-patients-treated-with-high-dose-interferon
#6
Jiayi Yu, Xiaowen Wu, Huan Yu, Siming Li, LiLi Mao, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Jie Dai, Meng Ma, Huan Tang, Tianxiao Xu, Junya Yan, Yan Kong, Jun Guo
High-dose interferon alfa-2b (IFN-α-2b) improves the survival of patients with high-risk melanoma. We aimed to identify baseline peripheral blood biomarkers to predict the outcome of acral melanoma patients treated with IFN-α-2b. Pretreatment baseline parameters and clinical data were assessed in 226 patients with acral melanoma. Relapse-free survival (RFS) and overall survival (OS) were assessed using the Kaplan-Meier method, and multivariate Cox regression analyses were applied after adjusting for stage, lactate dehydrogenase (LDH), and ulceration...
July 12, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28707317/acral-lentiginous-melanoma-a-skin-cancer-with-unfavourable-prognostic-features-a-study-of-the-german-central-malignant-melanoma-registry-cmmr-in-2050-patients
#7
Y Teramoto, U Keim, A Gesierich, G Schuler, E Fiedler, T Tüting, C Ulrich, U Wollina, J C Hassel, R Gutzmer, S Goerdt, C Zouboulis, U Leiter, T K Eigentler, C Garbe
BACKGROUND: Acral lentiginous melanoma (ALM) is one of the four major subtypes in cutaneous melanoma (CM). Although ALM has a poorer prognosis than other CM subtypes, the prognostic factors of ALM have been verified only in small-sized cohorts because of the low incidence of ALM worldwide. OBJECTIVES: To investigate clinical characteristics of ALM and to evaluate their prognostic values based on a large dataset from the Central Malignant Melanoma Registry (CMMR) of the German Dermatologic Society...
July 14, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28692464/melanocytes-pattern-in-the-normal-nail-with-special-reference-to-nail-bed-melanocytes
#8
Christophe Perrin, Jean-F Michiels, Julien Boyer, Damien Ambrosetti
Previous studies of the density of melanocytes in the normal nail bed have had conflicting results. This is unfortunate because knowing the normal values might help the difficult distinction between a benign subungual melanotic macule and an early melanoma in situ. Five specimens of normal nail unit were analyzed. On hematoxylin and eosin-stained sections the melanocytes were undetectable. We defined the melanocyte count (MC) as the number of melanocytes per 1-mm stretch of nail epithelium. The mean MC for nail matrix was 6...
June 19, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28691466/oral-melanoma-with-osteocartilagineous-differentiation-a-case-report-and-literature-review
#9
M L Pallotta, G A Beltramini, L Moneghini, R Monteverdi, A B Giannì, F J Silvestre, A Baj
Osteocartilagineous differentiation within malignant melanoma is a rare occurrence with several implications for diagnosis. Most of the reported cases have occurred in acral lentiginous malignant melanomas. In this paper, the authors describe the clinical, morphological, immunohistochemical features and surgical treatment of a case of primary oral mucosal melanoma with osteocartilaginous differentiation and they review the existing literature. The clinical history of a 67-year-old man affected of oral malignant melanoma was described from the first presentation to the second recurrence...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28678766/prognostic-role-of-systemic-immune-inflammation-index-in-solid-tumors-a-systematic-review-and-meta-analysis
#10
Jie-Hui Zhong, Dan-Hui Huang, Zi-Yu Chen
BACKGROUND: Inflammation may play an important role in cancer progression, and a higher systemic immune-inflammation index (SII) has been reported to be a poor prognostic marker in several malignancies. However, the results of published studies are inconsistent. MATERIALS AND METHODS: A systematic review of databases was conducted to search for publications regarding the association between blood SII and clinical outcome in solid tumors with a date up to February 12, 2017...
June 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28654767/melanoma-metastasis-to-the-mandible-case-report-and-comprehensive-literature-review
#11
Peter D Cervenka, Leonel Perez, Daniel E Perez, Bradley Jones
With the incidence of melanoma increasing yearly, there is a need for heightened awareness of its metastatic potential and for screening with appropriate referral for identification of pre-metastatic lesions. Melanoma has a 16- to 25-month period to metastasize from a localized disease to one with a median survival no longer than 12 months once metastasis occurs. Nearly one third of oral metastases are found to be the first indication of occult malignancy from a distant site. This report describes the case of a 54-year-old woman with a longstanding undiagnosed acral lentiginous melanoma with metastasis to the maxillofacial region...
June 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28598449/clinicopathological-study-of-malignant-melanoma-at-tertiary-care-centre
#12
S Thapa, A Ghosh, D Ghartimagar, T Prasad, R Narasimhan, O Talwar
INTRODUCTION: Malignant melanoma, which causes three fourth of all deaths related to skin cancer, is more common in Caucasian population compared to Asian population. There is no reliable information about malignant melanoma in Nepal hence an effort has been made to assess the clinical and pathological features of melanoma patients. METHODS: This was a retrospective hospital based study done in the department of Pathology. All cases of malignant melanoma diagnosed on biopsy during a period of 13 years were retrieved, reviewed and collated...
January 2017: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28577153/tumor-infiltrating-lymphocytes-in-acral-lentiginous-melanoma-a-study-of-a-large-cohort-of-cases-from-latin-america
#13
C A Castaneda, C Torres-Cabala, M Castillo, V Villegas, S Casavilca, L Cano, J Sanchez, J Dunstan, G Calderon, M De La Cruz, J M Cotrina, H L Gomez, R Galvez, J Abugattas
PURPOSE: Acral lentiginous melanoma (ALM) is a poor prognosis subtype and is the most prevalent in non-Caucasian populations. The presence of tumor infiltrating lymphocytes (TILs) has been associated with poor prognosis in melanoma. A large cohort of ALM cases was studied to determine status of TIL and its association with outcome. METHODS: All patients with cutaneous melanoma presenting from 2005 to 2012 at Instituto Nacional de Enfermedades Neoplasicas in Peru were retrospectively identified...
June 2, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28574975/a-prognostic-model-for-resectable-acral-melanoma-patients-on-the-basis-of-preoperative-inflammatory-markers
#14
Yao Wang, Xi-Zhi Wen, Hong-Jun Ba, Dan-Dan Li, Ya Ding, Ke-Feng Wang, Jing-Jing Li, Xiao-Shi Zhang
Acral melanoma is a rare disease, but is common in Asia. Knowledge of its prognostic indicators is limited. Growing evidence indicates that inflammation plays a critical role in the development and progression of acral melanoma. We developed a novel prognostic model on the basis of preoperative inflammatory markers and examined its prognostic value in a cohort of patients. This retrospective study included 232 acral melanoma patients who underwent radical surgical resection between 2000 and 2010 at the Sun Yat-sen University Cancer Center...
June 1, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28567312/intracorneal-hematoma-showing-clinical-and-dermoscopic-features-of-acral-lentiginous-melanoma
#15
Ugur Uslu, Franz Heppt, Michael Erdmann
Intra- and subcorneal hematoma, a skin alteration seen palmar and plantar after trauma or physical exercise, can be challenging to distinguish from in situ or invasive acral lentiginous melanoma. Thus, careful examination including dermoscopic and histologic assessment may be necessary to make the correct diagnosis. We here present a case of a 67-year-old healthy female patient who presented with a pigmented plantar skin alteration. Differential diagnoses included benign skin lesions, for example, hematoma or melanocytic nevus, and also acral lentiginous melanoma or melanoma in situ...
2017: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/28566910/acral-lentiginous-melanoma-indolent-subtype-diagnosed-by-en-bloc-excision-a-case-report
#16
Jungyoon Ohn, Jeong Mo Bae, Ji Soo Lim, Jong Seo Park, Hyun-Sun Yoon, Soyun Cho, Hyun-Sun Park
Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious for malignancy. Acral lentiginous melanoma was not detected in punch and longitudinal biopsy specimens, but en bloc excision tissue revealed melanoma. Acral lentiginous melanoma is known to have a heterogeneous pathologic manifestation depending on the pigmented region and the time it takes to progress...
June 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28565919/age-and-anatomical-location-related-dermoscopic-patterns-of-210-acral-melanocytic-nevi-in-a-turkish-population
#17
Nazan Emiroglu, Fatma Pelin Cengiz, Nahide Onsun
BACKGROUND: Dermoscopy is a useful tool for earlier diagnosis and differentiating benign lesions from melanoma. OBJECTIVES: We aim to investigate dermoscopic features of acral nevi, age, and localisation-related findings of these lesions. METHODS: This was an observational, descriptive study. Patients were retrospectively collected from the Department of Dermatology. The patients with acral nevi were included in the study. Inclusion criteria were Turkish nationality and the presence of at least 1 acral nevus diagnosed both clinically and dermoscopically...
May 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28502087/palmar-melanoma-a-tertiary-centre-experience
#18
LETTER
J Seo, M R Roh, Y Oh, K A Nam, K Y Chung
No abstract text is available yet for this article.
May 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28499411/paraneoplastic-acral-vascular-syndrome-in-a-patient-with-metastatic-melanoma-under-immune-checkpoint-blockade
#19
Thilo Gambichler, Stefanie Strutzmann, Andrea Tannapfel, Laura Susok
BACKGROUND: Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested. CASE PRESENTATION: We report a 60-year-old Caucasian male attended our hospital with a bulky lymph node mass in the right axilla...
May 12, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28485171/braf-inhibitors-efficacious-and-tolerable-in-braf-mutant-acral-and-mucosal-melanoma
#20
X Bai, L L Mao, Z H Chi, X N Sheng, C L Cui, Y Kong, J Dai, X Wang, S M Li, B X Tang, B Lian, L Zhou, X Q Yan, J Guo, L Si
BRAF inhibitors substantially have impressive clinical efficacy in cutaneous melanoma. However, their role in acral and mucosal melanoma remains unclear. Records were reviewed of patients with metastatic or unresectable BRAF-mutant acral and mucosal melanoma hospitalized and administered BRAF inhibitors during January 2011 and March 2016. Clinical data were collected to determine PFS, ORR, DCR, OS, and safety. Among 28 acral and 12 mucosal melanoma treated with BRAF inhibitors, median PFS were 3.6 (95%CI 3...
May 9, 2017: Neoplasma
keyword
keyword
72283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"