keyword
MENU ▼
Read by QxMD icon Read
search

Acral melanoma

keyword
https://www.readbyqxmd.com/read/28317165/dermoscopic-findings-of-an-unusual-acral-nevus-on-the-hand-of-a-child
#1
Tracey N Liebman, Marla N Diakow, Sharon A Glick
Distinguishing benign acral nevi from small early acral melanomas may be challenging in certain cases. Dermoscopy is a noninvasive imaging technique that can help clinicians better visualize deeper lesion structures and thus more easily differentiate benign nevi from melanoma. We report the case of a 13-year-old girl with a changing dark brown to black macule with a central papular component on the volar surface of the right third finger. Dermoscopy revealed asymmetrically distributed irregular black blotches on a bluish-black background...
March 20, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28301623/subungual-melanoma-in-situ-treated-with-imiquimod-5-cream-after-conservative-surgery-recurrence
#2
Jorge Ocampo-Garza, Nilton Gioia Di Chiacchio, Eckart Haneke, Francisco le Voci, Francisco Macedo Paschoal
<p>Subungual melanoma is a rare variant of acral lentiginous melanoma that often has a poor prognosis compared with other types of melanoma. The aim of the present study is to report a case of a patient with recurrence of subungual melanoma treated with imiquimod 5%, which presented a total regression of the lesion and no recurrence for 4 years.</p> <p><em>J Drugs Dermatol. 2017;16(3):268-270.</em></p>.
March 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28296711/prognostic-role-of-the-histological-subtype-of-melanoma-on-the-hands-and-feet-in-caucasians
#3
Cristina Carrera, Adrià Gual, Alba Díaz, Joan A Puig-Butillé, Susanna Noguès, Antonio Vilalta, Carlos Conill, Ramón Rull, Ramon Vilana, Pedro Arguis, Sergi Vidal-Sicart, Llucia Alós, Josep Palou, Teresa Castel, Josep Malvehy, Susana Puig
Acral melanoma (AM) is associated with a poor prognosis in part because of delayed diagnosis, but probably also because of other intrinsic characteristics of location. The aim of this study was to review the specific characteristics and outcome of AM in Caucasians. This was a cross-sectional retrospective clinical-pathological study of 274 patients identified with AM in the database of a referral unit in Europe from 1986 to 2010. The mean age of the patients was 56.6 (SD 17.7) years. 269 cases could be histologically classified and included in the study...
March 14, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28295169/characteristic-features-of-cutaneous-melanoma-in-a-dermatology-referral-centre-in-tehran-iran
#4
Kambiz Kamyab, Sheyda Kazemi, Pourya Azimi, Arghavan Azizpour, Narges Ghandi, Elham Pirooz, Pedram Noormohammadpour, Mostafa Mirshams-Shahshahani, Maryam Daneshpazhooh
BACKGROUND/OBJECTIVES: The characteristics of cutaneous melanoma in the Middle-Eastern countries is poorly described. Therefore we conducted this study to determine the characteristics of melanoma in Iran. METHODS: A retrospective, cross sectional study of melanoma patients seen at a tertiary referral centre, Iran, from May 2004 to October 2014. Clinical data included age and gender of the patients at the time of diagnosis, tumour location and tumour size. Histological characteristics included Breslow thickness, Clark level and subtype of tumour...
March 15, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28267273/nf1-mutated-melanoma-tumors-harbor-distinct-clinical-and-biological-characteristics
#5
Helena Cirenajwis, Martin Lauss, Henrik Ekedahl, Therese Törngren, Anders Kvist, Lao H Saal, Håkan Olsson, Johan Staaf, Ana Carneiro, Christian Ingvar, Katja Harbst, Nicholas K Hayward, Göran Jönsson
In general, melanoma can be considered as a UV-driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral, mucosal and uveal melanomas) not induced by sunlight and possessing a lower mutational load. The most commonly activated pathway in melanoma is the mitogen-activated protein kinase (MAPK) pathway. However, the prognostic significance of mutational stratification is unclear and needs further investigation. Here, in silico we combined mutation data from 162 melanomas subjected to targeted deep sequencing with mutation data from three published studies...
March 7, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28256203/rf-acral-melanoma-and-repetitive-injury-to-the-sole-of-the-foot
#6
P Martín-Carrasco, M T Monserrat-García, A Ortiz-Prieto, J Conejo-Mir
No abstract text is available yet for this article.
February 27, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28243497/dermoscopic-and-confocal-features-of-an-axillary-special-site-nevus
#7
Riana Dutt, Harold S Rabinovitz, Rajendra Singh, Alon Scope
"Nevi of special sites" is a term that denotes melanocytic nevi presenting in specific anatomic locations including the scalp, genital area, flexural sites, and acral sites [1]. Nevi from these anatomic sites display at times histopathologic features that may lead the reading pathologist to recommend re-excision of these benign nevi. Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that allows for visualization of epidermal, dermal-epidermal junctional (DEJ), and superficial dermal tissue structures at cellular level resolution...
January 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/28224164/multiple-primary-acral-lentiginous-melanoma-on-the-feet-developing-in-lesions-of-nagashima-type-palmoplantar-keratoderma
#8
Akimasa Adachi, Mayumi Komine, Takeo Maekawa, Satoru Murata, Aiko Shiohama, Akiharu Kubo, Mamitaro Ohtsuki
is missing (Short communication).
February 22, 2017: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/28223769/double-primary-acral-lentiginous-melanoma-of-both-soles
#9
Jae Ho Lee, Youngkyung Lim, You Jin Lee, Ji-Hye Park, Dong-Youn Lee
No abstract text is available yet for this article.
February 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28191690/mutational-profiling-of-acral-melanomas-in-korean-populations
#10
Joon Ho Shim, Hyun-Tae Shin, Jiho Park, Ji-Hye Park, Jong-Hee Lee, Jun-Mo Yang, Duk-Hwan Kim, Kee-Taek Jang, Dong-Youn Lee
The proportion of acral melanoma (AM) is much higher in Asian populations than in Caucasians populations. Although mutational profiles associated with AM have been discovered in Caucasian populations, knowledge of its genetic alterations in the Asian populations is limited. To describe the molecular nature of AM in Korean patients, we performed mutational profilinge of AM and matched normal tissues of in patients. Fifty-one formalin-fixed paraffin-embedded AM samples and 32 matched pairs of from patients' saliva DNA were analyzed by next-generation sequencing...
February 13, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28187531/cutaneous-melanoma-attributable-to-solar-radiation-in-cali-colombia
#11
Esther de Vries, Julio R Amador, Carlos Javier Rincon, Claudia Uribe, Donald Maxwell Parkin
Estimating the population attributable fraction (PAF) of melanomas due to sun exposure is challenging as there are no unexposed population nor reliable exposure data. In high incidence countries, a historic cohort of the South Thames cancer registry was used as a minimally exposed population using the formula PAF = (observed incidence-incidence in minimally exposure)/observed incidence. In this study, we apply this method, constructing a minimally exposed cohort for Colombia and also using the historical South Thames data, using melanoma incidence data from the population-based cancer registry of Cali, Colombia for the period 1967-2012...
May 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28154916/-diagnostics-of-malignant-melanoma-of-the-skin-recommendations-of-the-current-s3-guidelines-on-histology-and-molecular-pathology
#12
C Rose
The updated S3 guidelines on malignant melanoma were established in August 2016. The principles of diagnostics and classification are based on the histopathological results from the primary tumor and if necessary the sentinel lymph nodes. The most important factor for prognosis is the tumor thickness according to Breslow and the detection of sentinel node micrometastases. The surgical safety margin after excision is dependent on the tumor thickness. Furthermore, ulceration of the primary tumor and presence of mitosis in melanomas less than 1 mm in thickness are also considered in the T‑classification...
February 2, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28154879/-18-f-fdg-pet-ct-in-the-detection-of-asymptomatic-malignant-melanoma-recurrence
#13
Ismaheel Lawal, Thabo Lengana, Kehinde Ololade, Tebatso Boshomane, Florette Reyneke, Moshe Modiselle, Mariza Vorster, Mike Sathekge
AIM: To evaluate the diagnostic accuracy of FDG PET/CT in the detection of asymptomatic recurrence in patients with malignant melanoma who have had resection of their primary lesion. We also aimed to determine the pattern and factors predisposing to disease recurrence. METHODS: Patients with malignant melanoma who have had surgical resection of their disease and without any clinical evidence of disease recurrence were followed-up with FDG PET/CT. The diagnostic accuracy of FDG PET/CT, pattern of recurrence and factors predictive of disease recurrence were determined...
February 3, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28150890/further-assessment-of-exome-wide-uvr-footprints-in-melanoma-and-their-possible-relevance
#14
Pamela Mukhopadhyay, James Roberts, Graeme J Walker
C > T substitutions at dipyrimidine sites dominate the melanoma genome. We recently analyzed the exomes of spontaneous and neonatal UVR-induced murine melanomas, noting a dramatic change in the genomic footprint at C > T substitutions in the latter. Here we re-analyzed published exome-wide footprints in human melanomas stratified in terms of likely previous sun exposure. Acral and mucosal melanomas were heterogeneous in terms of base substitution types, but most C > Ts occurred in the context of 3'G, probably resulting from spontaneous deamination of the cytosine...
February 2, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28134728/marker-protein-expression-combined-with-expression-heterogeneity-is-a-powerful-indicator-of-malignancy-in-acral-lentiginous-melanomas
#15
Fernando Cintra Lopes Carapeto, Andréia Neves Comodo, Andressa Germano, Daiane Pereira Guimarães, Denise Barcelos, Mariana Fernandes, Gilles Landman
PATIENTS AND METHODS: Samples of acral lentiginous melanomas (ALMs) were obtained from the Department of Pathology at Escola Paulista de Medicina-Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. Demographic, clinical, and follow-up data were obtained from the charts of Hospital São Paulo. From 2 tissue microarrays containing 60 nevi and quadruplicate samples of ≥1.0-mm of 49 ALM, sections were stained to evaluate SCF, KIT, BRAF, CYCLIND1, MYC, and PTEN immunohistochemical protein expression...
February 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28128089/thin-melanoma-a-generic-term-including-four-histological-subtypes-of-cutaneous-melanoma
#16
Luca Roncati, Teresa Pusiol, Francesco Piscioli
Today, the scientific community is focusing on the prognostic significance of different histological subtypes of thin melanoma (1). The current staging system for melanoma of the American Joint Committee on Cancer (AJCC) uses Breslow thickness as the primary attribute: melanomas with up to 1 mm thickness is defined as thin, because they present a good prognosis after surgical excision, with a 10-year survival rate of 85-90% in case of a tumor-free margin ≥1 cm (2). There is a significant interaction between mitotic rate and Breslow depth, so the predictive value of the mitotic rate on sentinel lymph node (SLN) positivity can be dependent on Breslow thickness (3)...
December 2016: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/28123854/telomerase-reverse-transcriptase-tert-promoter-mutations-in-korean-melanoma-patients
#17
Mi Ryung Roh, Kyu-Hyun Park, Kee Yang Chung, Sang Joon Shin, Sun Young Rha, Hensin Tsao
Telomerase reverse transcriptase (TERT) is the reverse transcriptase component of the telomeric complex, which synthesizes terminal DNA to protect chromosomal ends and to maintain genomic integrity. In melanoma, mutation in TERT promoter region is a common event and theses promoter variants have been shown to be associated with increased gene expression, decreased telomere length and poorer outcome. In this study, we determined the frequency of TERT promoter mutation in 88 Korean primary melanoma patients and aimed to see the association of TERT promoter mutation status to other major molecular features, such as BRAF, NRAS, KIT mutations and correlate with clinicopathological features...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28107203/clinicopathological-significance-of-intratumoral-and-peritumoral-lymphocytes-and-lymphocyte-score-based-on-the-histologic-subtypes-of-cutaneous-melanoma
#18
Cheol Keun Park, Sang Kyum Kim
The presence of tumor infiltrating lymphocytes is a favorable prognostic factor in cutaneous melanoma, but their clinicopathological significance in the intratumoral compartment compared to the peritumoral compartment is unclear. We investigated the clinicopathologic significance of tumor-infiltrating lymphocytes and lymphocyte score in intra- and peritumoral compartments in 177 Korean patients who had undergone surgical excision of cutaneous melanoma. No significant correlation was observed between various clinicopathologic factors and the presence of intratumoral lymphocytes...
January 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28092366/malignant-melanoma-of-sun-protected-sites-a-review-of-clinical-histological-and-molecular-features
#19
Emily A Merkel, Pedram Gerami
In most cases of cutaneous melanoma, ultraviolet (UV) radiation is recognized as a prominent risk factor. Less is known regarding the mechanisms of mutagenesis for melanoma arising in sun-protected sites, such as acral and mucosal melanoma. Acral and mucosal melanoma share many common features, including a late age of onset, a broad radial growth phase with prominent lentiginous growth, the presence of field cancerization cells, and, in most cases, lack of a precursor nevus. In addition to early chromosomal instability, many of the same genes are also involved in these two distinct melanoma subtypes...
January 16, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28087024/acral-melanoma
#20
Flavia Persechino, Caterina Longo, Elisa Benati, Stefania Borsari, Mara Lombardi, Simonetta Piana, Giuseppe Argenziano, Elvira Moscarella
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
keyword
keyword
72283
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"