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Acral melanoma

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https://www.readbyqxmd.com/read/29773286/acral-melanoma-mimicking-toe-gangrene-in-diabetic-foot
#1
Yunfang Han, Zhongzhi Jia
No abstract text is available yet for this article.
May 14, 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29746316/the-clinical-significance-of-kit-mutations-in-melanoma-a-meta-analysis
#2
Hui Z Gong, He Y Zheng, Jun Li
This study aimed to evaluate the association of KIT mutations with clinicopathologic features of melanomas using a meta-analysis and to identify differences between Asian and White populations using subgroup analyses. We selected 32 studies from the literature including 5224 patients. The pooled data were combined, and odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity and publication bias were also determined. KIT mutations were reported in 497 (9.5%) of 5224 patients with melanomas, and were associated significantly with age, clinical melanoma subtype, anatomic location, and chronic sun-damage (CSD), but not with sex, histological type, Breslow thickness, ulceration, mitotic rate, or tumor stage...
May 9, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29689095/correction-acral-melanoma-detection-using-a-convolutional-neural-network-for-dermoscopy-images
#3
Chanki Yu, Sejung Yang, Wonoh Kim, Jinwoong Jung, Kee-Yang Chung, Sang Wook Lee, Byungho Oh
[This corrects the article DOI: 10.1371/journal.pone.0193321.].
2018: PloS One
https://www.readbyqxmd.com/read/29675108/increased-aurka-gene-copy-number-correlates-with-poor-prognosis-and-predicts-the-efficacy-of-high-dose-interferon-therapy-in-acral-melanoma
#4
Junya Yan, Jiayi Yu, Xiaowen Wu, Tianxiao Xu, Huan Yu, Jie Dai, Meng Ma, Huan Tang, Longwen Xu, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Yan Kong, Jun Guo
Background: AURKA kinase is an essential serine/threonine kinase for mitosis and chromosome stability. The aberrant amplification and overexpression of AURKA are commonly observed in various types of cancer, including cutaneous melanoma. However, the status and the clinical significance of AURKA copy number (CN) in acral melanoma (AM) have not been fully elucidated. Methods: Four hundred and seventy-two AM samples were included in the study. AURKA CN was examined using the QuantiGenePlex DNA Assay. We analysed the relationship of AURKA CN to clinicopathological characteristics and survival of patients with AM...
2018: Journal of Cancer
https://www.readbyqxmd.com/read/29673774/clinical-features-and-prognosis-of-asian-patients-with-acral-lentiginous-melanoma-who-have-nodal-nevi-in-their-sentinel-lymph-node-biopsy-specimen
#5
Ho-Jin Kim, Jeong-Wan Seo, Mee-Sook Roh, Ji-Hyun Lee, Ki-Hoon Song
BACKGROUND: Nodal melanocytic nevi (NN) encountered during sentinel lymph node biopsy (SLB) for malignant melanoma are usually difficult to distinguish from metastatic melanoma. However, NN have not been studied well in acral lentiginous melanoma (ALM) in Asian populations. OBJECTIVE: To investigate the clinical characteristics and significance of NN in SLBs from ALM patients. METHODS: We retrospectively analyzed 84 patients with ALM who underwent SLB between June 2010 and July 2017...
April 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29673240/the-major-role-of-nf-kb-in-the-depth-of-invasion-on-acral-melanoma-by-decreasing-cd8-t-cells
#6
Hermin Aminah Usman, Bethy S Hernowo, Maringan Diapari Lumban Tobing, Reti Hindritiani
Background: The tumor microenvironment including immune surveillance affects malignant melanoma (MM) behavior. Nuclear factor кB (NF-κB) stimulates the transcription of various genes in the nucleus and plays a role in the inflammatory process and in tumorigenesis. CD8+ T cells have cytotoxic properties important in the elimination of tumors. However, inhibitory receptors on the cell surface will bind to programmed death-ligand 1 (PD-L1), causing CD8+ T cells to lose their ability to initiate an immune response...
April 20, 2018: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/29665123/pilot-study-on-the-correlation-between-dermoscopic-patterns-and-fluorescence-in-situ-hybridization-findings-using-whole-slide-digital-imaging-for-acral-volar-melanocytic-lesions
#7
Dai Ogata, Eiichi Arai, Yoshiya Goto, Tetsuya Tsuchida
Dermoscopic evaluation of acral volar skin is helpful in differentiating malignant melanomas (MM) from benign melanocytic nevi. However, histological diagnosis remains difficult because sufficient evidence of histopathological changes to establish a diagnosis of MM are not easily obtained. The aim of the present study was to evaluate the effective use of fluorescence in situ hybridization (FISH) in the diagnosis of acral volar melanocytic lesions, and to determine whether acral volar melanocytic lesions show characteristic molecular biological features of malignant melanoma via FISH...
April 17, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29660787/high-gtse1-expression-promotes-acral-melanoma-progression-and-correlates-with-poor-clinical-prognosis
#8
Tianxiao Xu, Meng Ma, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Jie Dai, Sifan Yu, Junya Yan, Huan Yu, Xiaowen Wu, Huan Tang, Jiayi Yu, Yan Kong, Jun Guo
G-2 and S-phase expressed 1 (GTSE1) regulates cell cycle progression in human cancers. However, its significance and mechanism of action in acral melanoma (AM) remain unknown. In this study, we found that GTSE1 expression was upregulated in advanced stage/metastatic AM tissues and metastatic cell lines, and correlated with higher stage (P = 0.028) and poor disease-free survival (DFS) in patients with AM (P = 0.003). Cox regression assays validated GTSE1 expression to be an independent prognostic factor of DFS for patients with AM (P = 0...
April 16, 2018: Cancer Science
https://www.readbyqxmd.com/read/29600692/the-window-of-opportunities-for-targeted-therapy-in-brafwt-nraswt-kitwt-melanoma-biology-and-clinical-implications-of-fusion-proteins-and-other-mutations
#9
Marina Berger, Georg Richtig, Karl Kashofer, Ariane Aigelsreiter, Erika Richtig
Treatment options in advanced melanoma have been subject to a major change over the last years. The discovery of the oncogenic point mutation BRAFV600E and subsequently developed BRAF inhibitors had a major impact on patient's survival. Further important mutations have been found in the NRAS gene, although not yet druggable, and others involve c-kit in acral and mucosal melanoma. Imatinib was shown to achieve high response rates in c-kit mutated melanoma. Despite good response rates in these targeted therapies and introduction of immunotherapy, there are still patients left, who develop resistance upon therapy or patients without the option of targeted therapy...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29567352/mechanical-forces-in-skin-disorders
#10
REVIEW
Chao-Kai Hsu, Hsi-Hui Lin, Hans I-Chen Harn, Michael W Hughes, Ming-Jer Tang, Chao-Chun Yang
Mechanical forces are known to regulate homeostasis of the skin and play a role in the pathogenesis of skin diseases. The epidermis consists of keratinocytes that are tightly adhered to each other by cell junctions. Defects in keratins or desmosomal/hemidesmosomal proteins lead to the attenuation of mechanical strength and formation of intraepidermal blisters in the case of epidermolysis bullosa simplex. The dermis is rich in extracellular matrix, especially collagen, and provides the majority of tensile force in the skin...
June 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29537991/acral-spitz-nevi-a-clinicopathologic-study-of-50-cases-with-immunohistochemical-analysis-of-p16-and-p21-expression
#11
Katharina Wiedemeyer, Antonio Guadagno, Jonathan Davey, Thomas Brenn
Spitz nevi on acral sites are rare and poorly documented. The combination of Spitzoid cytomorphology and atypical architectural features of the junctional component may lead to an erroneous diagnosis of melanoma. To study the clinicopthologic and immunohistochemical features, 50 Spitz nevi localized on the distal extremities were retrieved from departmental files. Clinical data and follow-up were obtained and the histologic features were analyzed. P16 and P21 immunohistochemical staining of the dermal component was compared with that of 10 acral lentiginous melanomas and 10 acral nevi...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29528339/cell-based-molecularly-targeted-therapy-targeting-oncoproteins-with-t-cell-receptor-gene-therapy
#12
Christian S Hinrichs
As oncogenes drive carcinogenesis and promote cancer cell survival, they are highly attractive therapeutic targets, and oncogene-targeting small molecules have achieved some clinical success. While many oncogenes are presently considered to be "druggable," tumors often acquire treatment resistance, and patients are rarely cured in response to oncogene-specific treatment. In this issue of the JCI, Veatch and colleagues describe a patient with metastatic acral melanoma who experienced a complete tumor response following infusion of tumor-infiltrating T cells that targeted multiple tumor antigens, including a BRAFV600E driver mutation...
March 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29513718/acral-melanoma-detection-using-a-convolutional-neural-network-for-dermoscopy-images
#13
Chanki Yu, Sejung Yang, Wonoh Kim, Jinwoong Jung, Kee-Yang Chung, Sang Wook Lee, Byungho Oh
BACKGROUND/PURPOSE: Acral melanoma is the most common type of melanoma in Asians, and usually results in a poor prognosis due to late diagnosis. We applied a convolutional neural network to dermoscopy images of acral melanoma and benign nevi on the hands and feet and evaluated its usefulness for the early diagnosis of these conditions. METHODS: A total of 724 dermoscopy images comprising acral melanoma (350 images from 81 patients) and benign nevi (374 images from 194 patients), and confirmed by histopathological examination, were analyzed in this study...
2018: PloS One
https://www.readbyqxmd.com/read/29512974/acral-melanoma-correlating-the-clinical-presentation-to-the-mutational-status
#14
Giulia M Ravaioli, Emi Dika, Martina Lambertini, Marco A Chessa, Pier A Fanti, Annalisa Patrizi
Acral lentiginous melanoma (ALM) is the most common type of malignant melanoma (MM) in Asians, Afro-Americans and Middle-Easterns. It represents 1.5-10% of all MM cases, being the most common histological type of MM arising on palms, soles and nail apparatus, which is more generically defined as acral MM. To date no risk factors have been officially established, however a history of trauma may be involved in the pathogenesis of acral MM. This shows heterogeneous clinical features and frequently presents with advanced stage and aggressive behaviour, often as a result of misdiagnosis or delayed identification...
March 6, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29505523/aberrations-and-clinical-significance-of-braf-in-malignant-melanoma-a-series-of-60-cases-in-chinese-uyghur
#15
Xiaojing Kang, Ying Zeng, Junqin Liang, Jing Li, Danyang Ren, Li Chai, Zhenzhu Sun, Shirong Yu, Xiujuan Wu, Wen Han, Weijia Wang
Malignant melanoma (MM) is a highly malignant melanocytic tumor, it occurs mostly in the skin, the mucous membrane close to the skin, but also in the tunicae rhagoides and the pia mater. The Uyghur is the largest ethnic group living in the Xinjiang Uyghur Autonomous Region of China, accounting for 46% of the total population of 20 million. Large-scale studies on MMs in Asian countries are limited. This study aimed to investigate BRAF mRNA expression and mutations in Chinese Uyghur patients with MMs and to identify the clinical features associated with these parameters...
January 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29484669/in-transit-sentinel-node-drainage-as-a-prognostic-factor-for-patients-with-cutaneous-melanoma
#16
Paulo H D M Brandão, Eduardo Bertolli, Eduardo Doria-Filho, Ivan D A O Santos Filho, Mariana P de Macedo, Clovis A L Pinto, João P Duprat Neto
BACKGROUND: Minor basin or in transit node drainage can be found in patients with cutaneous melanoma who undergo sentinel node biopsy. Its clinical impact is still unclear. Our objective is to evaluate clinical outcomes in patients who presented with in transit sentinel node (ITN) drainage. MATERIAL AND METHODS: Retrospective analysis of patients who underwent sentinel node biopsy (SNB) in a single Brazilian institution between 2000 and 2015. RESULTS: Our cohort comprised 1223 SNB...
February 26, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29484003/another-case-of-interdigital-located-metastasing-hematoma
#17
Georgi Tchernev, Ivan Pidakev, Anastasiya Atanasova Chokoeva, Uwe Wollina, Torello Lotti, Irina Yungareva, Ilia Lozev, Georgi Konstantinov Maximov
Interdigital spaces could be an area of affection of a various cutaneous conditions, most of them with benign origin. The spectrum of differential diagnosis of pigmented interdigital lesions with a recent occurrence is not so wide, in contrast. When considering pigmented lesions in the interdigital area, the most harmless differential diagnosis is a traumatic hematoma. But what would happen if we based our therapeutic behaviour or suspicious and unconfirmed harmless diagnosis, instead of considering the real life-threatening once with priority, if we kept in mind that acral lentiginous melanoma has rather an aggressive course and is the main cause of death in skin cancer patients? We present a case of misdiagnosed interdigital melanoma, treated as a hemangioma with curettage, with almost fatal consequences, in regard to uncontrolled tumor progression as a result of the wrong traumatic procedure in one hand, and the lack of adequate screening and follow up, leading to progress of the disease with lymph node metastasis and poor prognosis in general...
January 25, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29452217/gene-expression-screening-identifies-cdca5-as-a-potential-therapeutic-target-in-acral-melanoma
#18
Tianxiao Xu, Meng Ma, Jie Dai, Sifan Yu, Xiaowen Wu, Huan Tang, Jiayi Yu, Junya Yan, Huan Yu, Zhihong Chi, Lu Si, Xinan Sheng, Chuanliang Cui, Yan Kong, Jun Guo
Acral melanoma (AM) is a rapidly progressing subtype of melanoma with poor prognosis. The complete array of molecular changes that occur during AM metastasis remains unclear. In this study, we compared the gene expression profiles of six primary and 12 lymph node metastatic AM samples by tissue microarray analysis. We found that the expression levels of 396 genes were increased, and that of 766 genes were decreased in the metastatic tissues compared with that in the primary tumors. The top 19 genes upregulated in the metastatic tissue specimens were selected for high-content short interfering (si)RNA screening...
February 13, 2018: Human Pathology
https://www.readbyqxmd.com/read/29441559/prognostic-features-for-acral-lentiginous-melanoma
#19
EDITORIAL
A E Cust
No abstract text is available yet for this article.
February 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29441299/livedo-racemosa-reticulated-ulcerations-panniculitis-and-violaceous-plaques-in-a-46-year-old-woman
#20
Alfredo Agulló, Brian Hinds, Mónica Larrea, Ignacio Yanguas
Clinically amyopathic dermatomyositis (CADM) is a subset of dermatomyositis (DM) that has conventional cutaneous manifestations of DM, but paradoxically, little or no muscle involvement. In 2005, a novel antibody was described in association with CADM - anti-melanoma differentiation-associated gene 5 (anti-MDA5). Patients with this serologic marker have a characteristic mucocutaneous phenotype consisting of skin ulceration among other signs. We describe the case of a 46-year-old woman with CADM, elevated anti-MDA5 autoantibodies, and unusual clinical features (livedo racemosa, florid acral edema) among the classical phenotype of MDA5 DM (arthralgias, ulcerations, panniculitis) and classical DM lesions (Gottron papules, heliotrope rash)...
January 2018: Indian Dermatology Online Journal
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