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https://www.readbyqxmd.com/read/29033618/schizophrenia-and-sleep-disorders-links-risks-and-management-challenges
#1
REVIEW
Rachel E Kaskie, Bianca Graziano, Fabio Ferrarelli
Schizophrenia is a major psychiatric disorder that has a massive, long-lasting negative impact on the patients as well as society. While positive symptoms (i.e., delusions and hallucinations), negative symptoms (i.e., anhedonia, social withdrawal), and cognitive impairments are traditionally considered the most prominent features of this disorder, the role of sleep and sleep disturbances has gained increasing prominence in clinical practice. Indeed, the vast majority of patients with schizophrenia report sleep abnormalities, which tend to precede illness onset and can predict an acute exacerbation of psychotic symptoms...
2017: Nature and Science of Sleep
https://www.readbyqxmd.com/read/29033051/genetics-of-restless-legs-syndrome-an-update
#2
REVIEW
Félix J Jiménez-Jiménez, Hortensia Alonso-Navarro, Elena García-Martín, José A G Agúndez
A major role of genetic factors in the risk of developing restless legs syndrome (RLS) is supported by the high frequency of positive family history of RLS in patients affected with this disease, and the higher concordance rates in monozygotic twins compared with dizygotic ones in twin studies. In this review we have focused on those reports describing inheritance patterns of RLS, genetic anticipation, the results of studies performed on positivity of family history of RLS, twin studies, linkage studies in familial RLS, genome-wide association studies (GWAS), exome sequencing studies, and case-control association studies on candidate genes in RLS...
August 31, 2017: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29031764/combined-resting-state-functional-magnetic-resonance-imaging-and-diffusion-tensor-imaging-study-in-patients-with-idiopathic-restless-legs-syndrome
#3
Yaoyao Zhuo, Yuncheng Wu, Yanhong Xu, Lunbo Lu, Ting Li, Xifu Wang, Kangan Li
OBJECTIVE: Restless legs syndrome (RLS) is a common neurological disorder characterized by an urge to move the legs along with paraesthesia deep within them. In this study, we aimed to use diffusion tensor imaging (DTI) and regional homogeneity (ReHo) to investigate the changes in regional spontaneous brain activity change for RLS patients against age- and gender-matched normal control (NC) subjects. METHODS: A total of 35 RLS patients and 27 age- and gender-matched NC subjects were recruited for group comparison research that used DTI and ReHo techniques...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29031755/allocating-provider-resources-to-diagnose-and-treat-restless-legs-syndrome-a-cost-utility-analysis
#4
William V Padula, Charles E Phelps, Dane Moran, Christopher Earley
OBJECTIVES: Restless legs syndrome (RLS) is a neurological disorder that is frequently misdiagnosed, resulting in delays in proper treatment. The objective of this study was to analyze the cost-utility of training primary care providers (PCP) in early and accurate diagnosis of RLS. METHODS: We used a Markov model to compare two strategies: one where PCPs received training to diagnose RLS (informed care) and one where PCPs did not receive training (standard care)...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29031750/the-urge-to-move-and-breathe-the-impact-of-obstructive-sleep-apnea-syndrome-treatment-in-patients-with-previously-diagnosed-clinically-significant-restless-legs-syndrome
#5
Cristiana Silva, Ana Rita Peralta, Carla Bentes
OBJECTIVE: The association between restless legs syndrome (RLS) and obstructive sleep apnea syndrome (OSAS) has seldom been reported. There is one study reporting improvement of RLS symptoms severity in patients naive of treatment after initiation of continuous positive airway pressure (CPAP) for OSAS. The aim of this study was to evaluate the impact of the OSAS treatment in patients with previously diagnosed, clinically significant RLS in a usual clinical setting. METHODS: This was a retrospective study of RLS patients from a sleep clinic with a concomitant or subsequent diagnosis of OSAS...
October 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29029846/identification-of-novel-risk-loci-for-restless-legs-syndrome-in-genome-wide-association-studies-in-individuals-of-european-ancestry-a-meta-analysis
#6
Barbara Schormair, Chen Zhao, Steven Bell, Erik Tilch, Aaro V Salminen, Benno Pütz, Yves Dauvilliers, Ambra Stefani, Birgit Högl, Werner Poewe, David Kemlink, Karel Sonka, Cornelius G Bachmann, Walter Paulus, Claudia Trenkwalder, Wolfgang H Oertel, Magdolna Hornyak, Maris Teder-Laving, Andres Metspalu, Georgios M Hadjigeorgiou, Olli Polo, Ingo Fietze, Owen A Ross, Zbigniew Wszolek, Adam S Butterworth, Nicole Soranzo, Willem H Ouwehand, David J Roberts, John Danesh, Richard P Allen, Christopher J Earley, William G Ondo, Lan Xiong, Jacques Montplaisir, Ziv Gan-Or, Markus Perola, Pavel Vodicka, Christian Dina, Andre Franke, Lukas Tittmann, Alexandre F R Stewart, Svati H Shah, Christian Gieger, Annette Peters, Guy A Rouleau, Klaus Berger, Konrad Oexle, Emanuele Di Angelantonio, David A Hinds, Bertram Müller-Myhsok, Juliane Winkelmann
BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve treatment options. We did a meta-analysis of genome-wide association studies (GWASs) to identify potential molecular targets. METHODS: In the discovery stage, we combined three GWAS datasets (EU-RLS GENE, INTERVAL, and 23andMe) with diagnosis data collected from 2003 to 2017, in face-to-face interviews or via questionnaires, and involving 15 126 cases and 95 725 controls of European ancestry...
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29029839/restless-legs-syndrome-is-it-all-in-the-genes
#7
Sonja W Scholz
No abstract text is available yet for this article.
November 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29019963/organ-on-chip-technology-current-state-and-future-developments
#8
EDITORIAL
Rimantas Kodzius, Frank Schulze, Xinghua Gao, Marlon R Schneider
In the early days of pharmacy, the development of new drugs was frequently achieved by restless chemists who worked solitarily, day by day for years [...].
October 11, 2017: Genes
https://www.readbyqxmd.com/read/29018894/abstinence-induced-withdrawal-severity-among-adolescent-smokers-with-and-without-adhd-disentangling-effects-of-nicotine-and-smoking-reinstatement
#9
L Cinnamon Bidwell, Sara G Balestrieri, Suzanne M Colby, Valerie S Knopik, Jennifer W Tidey
RATIONALE: Individuals with attention deficit hyperactivity disorder (ADHD) start smoking earlier, are more likely to progress to nicotine dependence, and have a more difficult time quitting smoking compared to their non-ADHD peers. Little is known about the underlying behavioral mechanisms associated with this increased risk, particularly at the adolescent stage. OBJECTIVE: This study aimed to assess the effects of overnight nicotine abstinence and smoking reinstatement on subjective withdrawal states in adolescent smokers with and without ADHD...
October 10, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29018204/a-new-stress-sensor-and-risk-factor-for-suicide-the-t-allele-of-the-functional-genetic-variant-in-the-gabra6-gene
#10
Xenia Gonda, Jane Sarginson, Nora Eszlari, Peter Petschner, Zoltan G Toth, Daniel Baksa, Gabor Hullam, Ian M Anderson, J F William Deakin, Gabriella Juhasz, Gyorgy Bagdy
Low GABA transmission has been reported in suicide, and GABRA6 rs3219151 T allele has been associated with greater physiological and endocrine stress response in previous studies. Although environmental stress also plays a role in suicide, the possible role of this allele has not been investigated in this respect. In our present study effect of rs3219151 of GABRA6 gene in interaction with recent negative life events on lifetime and current depression, current anxiety, as well as lifetime suicide were investigated using regression models in a white European general sample of 2283 subjects...
October 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28993491/methods-in-field-chronobiology
#11
REVIEW
Davide M Dominoni, Susanne Åkesson, Raymond Klaassen, Kamiel Spoelstra, Martin Bulla
Chronobiological research has seen a continuous development of novel approaches and techniques to measure rhythmicity at different levels of biological organization from locomotor activity (e.g. migratory restlessness) to physiology (e.g. temperature and hormone rhythms, and relatively recently also in genes, proteins and metabolites). However, the methodological advancements in this field have been mostly and sometimes exclusively used only in indoor laboratory settings. In parallel, there has been an unprecedented and rapid improvement in our ability to track animals and their behaviour in the wild...
November 19, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28993347/interrupted-aortic-arch-complicated-with-takotsubo-cardiomyopathy-mimicking-aortic-dissection
#12
Farhala Mari Baloch, Javed Majid Tai, Aamir Hameed Khan, Abdul Baqi
A 50-year-old man presented to the emergency department with interscapular pain, diaphoresis and restlessness. Initial examination raised the possibility of aortic dissection; however, the CT scan did not concur with the diagnosis. An ECG showed ST segment elevation in leads V1-V6 and echocardiography showed severe left ventricular systolic dysfunction. Coronary angiography through the right femoral artery was attempted but the diagnostic catheter could not be advanced to the ascending aorta. Radiocontrast injection showed complete obstruction of the descending aorta...
October 9, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28993209/rotigotine-a-dopamine-receptor-agonist-increased-bdnf-protein-levels-in-the-rat-cortex-and-hippocampus
#13
Naoki Adachi, Aya Yoshimura, Shuichi Chiba, Shintaro Ogawa, Hiroshi Kunugi
Brain-derived neurotrophic factor (BDNF) critically controls the fate and function of the neuronal network and has received much attention as a target of many brain diseases. Dopaminergic system dysfunction has also been implicated in a variety of neuropsychiatric diseases. Rotigotine, a non-ergot dopamine receptor agonist, is used in the treatment of Parkinson's disease and restless legs syndrome. To investigate the effects of rotigotine on neuronal functions both in vivo and in vitro, rats and primary cortical neurons were administered rotigotine, and the mRNA and protein expression levels of BDNF, its receptor TrkB and downstream signaling molecules, and synaptic proteins were determined...
October 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28990833/prevalence-of-restless-legs-symptoms-according-to-depressive-symptoms-and-depression-type-a-cross-sectional-study
#14
Piritta Auvinen, Pekka Mäntyselkä, Hannu Koponen, Hannu Kautiainen, Katariina Korniloff, Tiina Ahonen, Mauno Vanhala
BACKGROUND: Restless legs syndrome is a sensorimotor disorder and it is associated with several other diseases especially mental illnesses. AIMS: To analyze the relationship between the symptoms of restless legs syndrome and the severity of depressive symptoms and the prevalence of restless legs symptoms in depression subtypes. METHODS: A cross-sectional study of primary care patients in the Central Finland Hospital District. The prevalence of restless legs symptoms was studied in 706 patients with increased depressive symptoms and 426 controls without a psychiatric diagnosis by using a structured questionnaire...
October 9, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/28988104/sleep-widespread-pain-and-restless-legs-what-is-the-connection
#15
Stephen Butler
No abstract text is available yet for this article.
October 5, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28979226/adults-with-attention-deficit-hyperactivity-disorder-report-high-symptom-levels-of-troubled-sleep-restless-legs-and-cataplexy
#16
Bjørn Bjorvatn, Erlend J Brevik, Astri J Lundervold, Anne Halmøy, Maj-Britt Posserud, Johanne T Instanes, Jan Haavik
Objective: To compare the occurrence of a spectrum of different self-reported sleep problems in adults with ADHD and a control group, and to study the impact of current ADHD medication use and clinical ADHD subtype. Method: Cross-sectional study of 268 clinically ascertained adult ADHD patients (DSM-IV criteria) and 202 randomly selected controls. Sleep problems were self-reported using validated questions, partly from Global Sleep Assessment Questionnaire. Results: ADHD patients reported more sleep problems than controls: Lifetime occurrence of sleep problems (82...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28976394/-approach-to-venous-diseases-in-the-elderly
#17
Ahmet Kürşat Bozkurt, Ozan Onur Balkanay
Incidence and severity of both deep vein thrombosis and chronic venous insufficiency are increased with age. Today, however, the significance of these diseases in the elderly patient population are still poorly comprehended. Although most patients have a history of previous treatment, chronic venous insufficiency is usually encountered in the advanced clinical stage. As a result, there is an increase in mobility restrictions, the need for assistance in daily activities and the risk of falls in elderly patients...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28972633/undergraduate-placements-in-geriatric-care-facilities-students-gaining-experience-with-challenging-responsive-behaviors
#18
Beverly O'Connell, Lorna Guse, Loreley Greenslade, Angela Osterreicher, Fiona Jensen
BACKGROUND: Undergraduate nursing students may experience challenging behaviors in residents during their clinical placement in geriatric long-term care (GLTC) facilities. METHOD: Bachelor of Nursing students participated in an anonymous online questionnaire (n = 116). RESULTS: The students witnessed a wide range of challenging behaviors, also referred to as responsive behaviors, in GLTC residents. The most frequent behaviors included agitation/restlessness, repetitive talk, and wandering...
October 1, 2017: Journal of Nursing Education
https://www.readbyqxmd.com/read/28966745/heart-rate-variability-in-restless-legs-syndrome-and-periodic-limb-movements-of-sleep
#19
Daniel A Barone, Matthew R Ebben, Miles DeGrazia, David Mortara, Ana C Krieger
INTRODUCTION: The relationship between the autonomic nervous system and restless legs syndrome (RLS) and periodic limb movements of sleep (PLMS) consists of varied and somewhat conflicting reports. In order to further elucidate these complexities, a retrospective analysis of polysomnography (PSG) records and clinical data was performed. METHODS: Records from 233 adult subjects were randomly selected and organized into one of four groups ("non-RLS/PLMS" [n=61], "RLS" [n=60], "PLMS" [n=58], and "RLS/PLMS" [n=54])...
April 2017: Sleep Science
https://www.readbyqxmd.com/read/28966732/restless-legs-syndrome-in-adolescents-relationship-with-sleep-quality-cardiorespiratory-fitness-and-body-fat
#20
Christoforos D Giannaki, Georgios M Hadjigeorgiou, George Aphamis, Marios Pantzaris, Giorgos K Sakkas
OBJECTIVE: The aim of the current study was to investigate the relationship between restless legs syndrome (RLS) and cardiorespiratory fitness, body composition and sleep quality in a sample of adolescents. METHODS: One hundred fifty seven volunteer adolescents (16.6 ± 0.7 yrs) participated in the study. Sleep quality was assessed by the Pittsburg sleep quality index. Cardiorespiratory fitness was assessed by the 20 m shuttle run test and body composition by bioelectrical impedance analysis...
January 2017: Sleep Science
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