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https://www.readbyqxmd.com/read/28074859/identifying-a-gene-expression-signature-of-cluster-headache-in-blood
#1
Else Eising, Nadine Pelzer, Lisanne S Vijfhuizen, Boukje de Vries, Michel D Ferrari, Peter A C 't Hoen, Gisela M Terwindt, Arn M J M van den Maagdenberg
Cluster headache is a relatively rare headache disorder, typically characterized by multiple daily, short-lasting attacks of excruciating, unilateral (peri-)orbital or temporal pain associated with autonomic symptoms and restlessness. To better understand the pathophysiology of cluster headache, we used RNA sequencing to identify differentially expressed genes and pathways in whole blood of patients with episodic (n = 19) or chronic (n = 20) cluster headache in comparison with headache-free controls (n = 20)...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28067594/nicotine-withdrawal-relapse-of-mental-illness-or-medication-side-effect-implementing-a-monitoring-tool-for-people-with-mental-illness-into-quitline-counseling
#2
Catherine J Segan, Amanda L Baker, Alyna Turner, Jill M Williams
BACKGROUND: Smokers with mental illness and their health care providers are often concerned that smoking cessation will worsen mental health. Smokers with mental illness tend to be more nicotine dependent and experience more severe symptoms of nicotine withdrawal, some of which are difficult to distinguish from psychiatric symptoms. In addition, smoking cessation can increase the blood levels and hence side-effects of some psychotropic medications. Improved monitoring of nicotine withdrawal and medication side-effects may help distinguish temporary withdrawal symptoms from psychiatric symptoms and facilitate targeted treatment to help smokers with mental illness manage the acute phase of nicotine withdrawal...
January 9, 2017: Journal of Dual Diagnosis
https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#3
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28065402/genetics-of-restless-legs-syndrome
#4
Juliane Winkelmann, Barbara Schormair, Lan Xiong, Patrick A Dion, David B Rye, Guy A Rouleau
At the outset of genetic studies in restless legs syndrome (RLS), the disorder was assumed to be a classical monogenic disorder that runs in families. However, years of family studies did not reveal any causally-related genes or genetic variants. The advent of high-throughput genotyping technology led to a change; genome-wide association studies in large case-control samples became feasible, which led to the identification of first genetic risk variants for RLS. Variants detected by this approach are common ones, which that individually confer only a minor increase in risk of disease...
November 12, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28057495/iron-and-restless-legs-syndrome-treatment-genetics-and-pathophysiology
#5
James R Connor, Stephanie M Patton, Konrad Oexle, Richard Allen
In this article, we review the original findings from MRI and autopsy studies that demonstrated brain iron status is insufficient in individuals with restless legs syndrome (RLS). The concept of deficient brain iron status is supported by proteomic studies from cerebrospinal fluid (CSF) and from the clinical findings where intervention with iron, either dietary or intravenous, can improve RLS symptoms. Therefore, we include a section on peripheral iron status and how peripheral status may influence both the RLS symptoms and treatment strategy...
November 10, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28057493/effect-of-restless-legs-syndrome-on-blood-pressure-is-it-sleep-disturbance
#6
EDITORIAL
Arshad Jahangir, Vishnubhakta Murthy
No abstract text is available yet for this article.
November 23, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28057302/unraveling-the-neurobiology-of-sleep-and-sleep-disorders-using-drosophila
#7
L Chakravarti, E H Moscato, M S Kayser
Sleep disorders in humans are increasingly appreciated to be not only widespread but also detrimental to multiple facets of physical and mental health. Recent work has begun to shed light on the mechanistic basis of sleep disorders like insomnia, restless legs syndrome, narcolepsy, and a host of others, but a more detailed genetic and molecular understanding of how sleep goes awry is lacking. Over the past 15 years, studies in Drosophila have yielded new insights into basic questions regarding sleep function and regulation...
2017: Current Topics in Developmental Biology
https://www.readbyqxmd.com/read/28035549/prevalence-of-restless-legs-syndrome-in-patients-with-inflammatory-bowel-disease
#8
Ikuko Takahara, Fuminao Takeshima, Tatsuki Ichikawa, Toshihisa Matsuzaki, Hidetaka Shibata, Satoshi Miuma, Yuko Akazawa, Hisamitsu Miyaaki, Naota Taura, Kazuhiko Nakao
BACKGROUND AND AIM: There has been increased interest in sleep disorders in patients with inflammatory bowel disease (IBD). Studies in North America and Europe reported that the prevalence of restless legs syndrome (RLS) is much higher in patients with Crohn's disease (CD) than in the general population. The aim of this study was to reveal the prevalence and clinical features of RLS in Japanese patients with IBD and investigate the influence of RLS on sleep quality and quality of life (QOL)...
December 29, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28033486/adhd-and-temporality-a-desynchronized-way-of-being-in-the-world
#9
Mikka Nielsen
ADHD is, I argue, an impairment in sense of time and a matter of difference in rhythm; it can be understood as a certain being in the world, or more specifically, as a disruption in the experience of time and a state of desynchronization and arrhythmia. Through excerpts of interviews with adults diagnosed with ADHD and observations, I illustrate how impairment in time is manifested in an embodied experience of being out of sync. I suggest that the experience of ADHD is characterized as 1) an inner restlessness and bodily arrhythmia; 2) an intersubjective desynchronization between the individual and its surroundings; and 3) a feeling of lagging behind socially due to difficulties in social skills...
December 29, 2016: Medical Anthropology
https://www.readbyqxmd.com/read/28019055/quality-of-life-in-patients-with-an-idiopathic-rapid-eye-movement-sleep-behaviour-disorder-in-korea
#10
Keun Tae Kim, Gholam K Motamedi, Yong Won Cho
There have been few quality of life studies in patients with idiopathic rapid eye movement sleep behaviour disorder. We compared the quality of life in idiopathic rapid eye movement sleep behaviour disorder patients to healthy controls, patients with hypertension, type 2 diabetes mellitus without complication and idiopathic restless legs syndrome. Sixty patients with idiopathic rapid eye movement sleep behaviour disorder (24 female; mean age: 61.43 ± 8.99) were enrolled retrospectively. The diagnosis was established based on sleep history, overnight polysomnography, neurological examination and Mini-Mental State Examination to exclude secondary rapid eye movement sleep behavior disorder...
December 26, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/28017182/prevalence-of-restless-legs-syndrome-during-detoxification-from-alcohol-and-opioids
#11
Susan E Mackie, R Kathryn McHugh, Katherine McDermott, Margaret L Griffin, John W Winkelman, Roger D Weiss
BACKGROUND AND AIMS: Restless legs syndrome (RLS) is a movement disorder associated with adverse health outcomes and decreased quality of life. Small case series suggest that symptoms of RLS occur during opioid withdrawal. However, the prevalence is unknown. METHODS: We conducted an observational study to determine the prevalence of RLS among inpatients patients receiving buprenorphine detoxification from opioids. To assess the specificity of RLS to opioid detoxification, we also evaluated patients receiving detoxification from alcohol as a comparison group...
February 2017: Journal of Substance Abuse Treatment
https://www.readbyqxmd.com/read/28011408/measurement-of-fidgeting-in-patients-with-anorexia-nervosa-using-a-novel-shoe-based-monitor
#12
Lauren Belak, Loren Gianini, Diane A Klein, Edward Sazonov, Kathryn Keegan, Esther Neustadt, B Timothy Walsh, Evelyn Attia
OBJECTIVE: To objectively assess seated non-exercise physical activity in patients with anorexia nervosa (AN) relative to healthy controls (HCs) and examine the associations between this physical activity, eating disorder pathology, and levels of anxiety and depression. METHOD: Eleven inpatients with AN and 10 HCs wore a shoe-based accelerometer (SmartShoe) at three time points: a) while eating lunch, b) filling out questionnaires, and c) watching television for 1h...
December 9, 2016: Eating Behaviors
https://www.readbyqxmd.com/read/28009385/a-study-on-mobbing-in-maritime-field-a-case-study-in-the-turkish-maritime-industry
#13
Serdar Kum, Yildiray Ertas
Nowadays, there are many reasons for people to be stressful and restless in their working environments. One of the reasons leading to this situation is known as "mobbing". The term "mobbing" means "bullying of an individual by a group". It usually happens among employees. The main effects of mobbing are the generation of stress and reduction of employee performance at work. In general, research shows that mobbing is particularly common in the public sector. The aim of this research is to understand the frequency of mobbing on employees in the Turkish maritime industry as a case study...
2016: International Maritime Health
https://www.readbyqxmd.com/read/28007405/ephedrine-treatment-for-autoimmune-myasthenia-gravis
#14
Alexander F Lipka, Charlotte Vrinten, Erik W van Zwet, Kirsten J M Schimmel, Martina C Cornel, Marja R Kuijpers, Yechiel A Hekster, Stephanie S Weinreich, Jan J G M Verschuuren
We studied the effect and safety of ephedrine as add-on treatment for patients with myasthenia gravis with acetylcholine receptor antibodies (AChR MG), who do not sufficiently respond to standard treatment. Four patients with AChR MG were included in a placebo-controlled, double-blind, and randomised, multiple crossover series of n-of-1 trials. Each n-of-1 trial consisted of 3 cycles, in which two 5-day intervention periods were followed by 2 days washout. In each cycle, ephedrine 50 mg daily in 2 doses was compared with placebo in the alternate treatment period...
November 18, 2016: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28000637/cohort-event-monitoring-of-patients-treated-for-uncomplicated-malaria-with-artemisinin-based-combination-therapies-in-selected-hospitals-and-community-pharmacies-in-nigeria
#15
P U Bassi, A I Osakwe, C Suku, M Kalat, C Elagbaje, A Isah, S Ayinbuomwan, R D Wammanda, I I Bob-Okon, J Ambe, Y Mava, A O Adesina, C G Ugochukwu, E E Nyong, O O Ogunleye, F Onuoha, I Jalo, V O Adegoke, S T Balogun, G Ntadom, F N Ejiekpe, R Tahir, K Dabit, A A Amodu, S Nwaosu, A T Habib
AIMS AND OBJECTIVES: The study was designed with the broad objective of determining the safety profile of artemisinin-based combination therapies amongst Nigerian population. PATIENTS AND METHODS: This was a cohort event monitoring (CEM) programme involving monitoring adverse events (AEs) in malaria patients treated with either artemether-lumefantrine (AL) or artesunate-amodiaquine (AA) in healthcare facilities in Nigeria. The study involved continuous enrolment of patients with malaria and treated with either AL or AA at the various sites until a total cohort of 600 patients were enrolled at each site...
October 2016: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28000424/sleep-disturbance-and-depressive-affect-in-patients-treated-with-haemodialysis
#16
Stephanie Maung, Ammar El Sara, Danielle Cohen, Cherylle Chapman, Subodh Saggi, Daniel Cukor
BACKGROUND: Sleep disorders and depression are prevalent conditions in patients with end-stage kidney disease. These co-morbidities have significant overlap and compounded morbidity and mortality burden. This overlap presents challenges to optimal clinical assessment and treatment. The goal of this study was to assess the prevalence of sleep disturbance in patients on maintenance haemodialysis, and to assess the impact of depressive affect. OBJECTIVES: This was a single-site, single group, cross-sectional study of 69 English-speaking patients undergoing maintenance haemodialysis...
December 21, 2016: Journal of Renal Care
https://www.readbyqxmd.com/read/27994356/a-double-blind-randomized-controlled-trial-to-compare-the-efficacy-and-tolerability-of-fixed-doses-of-ropinirole-bupropion-and-iron-in-treatment-of-restless-legs-syndrome-willis-ekbom-disease
#17
Kirti Vishwakarma, Juhi Kalra, Ravi Gupta, Mukesh Sharma, Taruna Sharma
BACKGROUND: We aimed to compare the efficacy of fixed doses of bupropion and ropinirole and iron alone for the treatment of restless legs syndrome (RLS) and to look for the tolerability of these medications. MATERIALS AND METHODS: Patients diagnosed with RLS were randomly divided into three groups with thirty patients in each group (Group A: Bupropion [300 mg/day], Group B: Ropinirole [0.25-0.5 mg/day], and Group C: Oral iron [150 mg elemental iron] along with folic acid [500 μg])...
October 2016: Annals of Indian Academy of Neurology
https://www.readbyqxmd.com/read/27988038/-acute-psychiatric-symptoms-during-methylphenidate-intravenous-injections-a-case-report
#18
Fabrice Vérité, Joëlle Micallef
We report the case of a 32-year-old man who developed acute psychiatric disorders after repeated intravenous injections of methylphenidate. The behavioural disorders with extreme psychomotor restlessness and delirious syndrome have resolved within 24hours. The available data highlight the fact that the prescriptions of methylphenidate, an amphetamine-like substance, are constantly increasing in Europe and Northern America. The potential of abuse and addiction to this drug, which is growingly misused, is now clearly established...
November 24, 2016: Thérapie
https://www.readbyqxmd.com/read/27970849/two-year-antecedent-versus-subsequent-diagnoses-of-patients-newly-diagnosed-with-primary-restless-legs-syndrome-a-large-scale-retrospective-claims-analysis
#19
C Hankin, D Lee, Z Wang
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27967164/phase-transition-of-social-learning-collectives-and-the-echo-chamber
#20
Shintaro Mori, Kazuaki Nakayama, Masato Hisakado
We study a simple model for social learning agents in a restless multiarmed bandit. There are N agents, and the bandit has M good arms that change to bad with the probability q_{c}/N. If the agents do not know a good arm, they look for it by a random search (with the success probability q_{I}) or copy the information of other agents' good arms (with the success probability q_{O}) with probabilities 1-p or p, respectively. The distribution of the agents in M good arms obeys the Yule distribution with the power-law exponent 1+γ in the limit N,M→∞, and γ=1+(1-p)q_{I}/pq_{O}...
November 2016: Physical Review. E
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