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Demodex

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https://www.readbyqxmd.com/read/29194776/endosymbiosis-and-its-significance-in-dermatology
#1
REVIEW
Katarzyna Kubiak, Hanna Sielawa, Wenchieh Chen, Ewa Dzika
Proposed at the beginning of the 20th to explain the origin of eukaryotic organelles from prokaryotes, endosymbiosis is now medically defined by various interaction patterns between microorganisms and their residing hosts, best exemplified by the bacterial endosymbiont Wolbachia identified in arthropods and filarial nematodes, which can influence normal development, reproduction, survival, and transmission of the hosts. Based on the transmission modes, vertical or horizontal, and the function of the endosymbionts, the host-symbiont dependence can be divided into primary or secondary...
December 1, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29165413/-ophthalmoferon-efficacy-in-the-treatment-of-children-with-chronic-blepharoconjunctivitis
#2
L P Prozornaya, V V Brzheskiy
AIM: To study possibilities of using the medication Ophthalmoferon in the treatment of children with chronic allergic and Demodex blepharoconjunctivitis. MATERIAL AND METHODS: We examined 40 children (80 eyes) aged 3 to 17 years with chronic allergic (group I) and Demodex (group II) blepharoconjunctivitis. Each group was divided into two subgroups ('A' and 'B') respectively based on the treatment regimen used. Subgroup 'A' patients received Ophtalmoferon instillations (four times per day for four weeks) in addition to the standard therapy, whereas subgroup 'B' patients got only basic treatment of blepharoconjunctivitis...
2017: Vestnik Oftalmologii
https://www.readbyqxmd.com/read/29090055/severe-rosacea-a-case-report
#3
Ebrahim Shirzadeh, Abbas Bagheri, Mojtaba Fattahi Abdizadeh, Mozhgan Rezaei Kanavi
PURPOSE: To describe a case of severe rosacea with ocular involvement. CASE REPORT: A 28-year-old female patient presented with extensive facial and ocular eruptions. She had a history of treatment with oral prednisolone due to the clinical diagnosis of lupus erythematosus (LE), which had resulted in transient improvement of the lesions, but was followed by exacerbation of the lesions. With the clinical diagnosis of severe oculofacial rosacea, she was successfully treated with oral doxycycline, steroid eye drops, and ocular lubricants...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29089049/efficacy-of-lotilaner-credelio%C3%A2-a-novel-oral-isoxazoline-against-naturally-occurring-mange-mite-infestations-in-dogs-caused-by-demodex-spp
#4
Daniel E Snyder, Scott Wiseman, Julian E Liebenberg
BACKGROUND: The oral systemic efficacy of lotilaner (Credelio™, Elanco) was evaluated against Demodex spp. in naturally infested dogs with generalized demodicosis. METHODS: In this study, 10 dogs with clinical signs of generalized demodicosis and positive for Demodex spp. mites based on skin scrapings were assigned to a single group orally treated with lotilaner (minimum dose of 20 mg/kg) on Days 0, 28 and 56. RESULTS: For lotilaner-treated dogs, pre-treatment mite counts based on skin scrapings performed at five different sites were reduced by > 99...
November 1, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/29074306/the-efficacy-of-tea-tree-face-wash-1-2-octanediol-and-microblepharoexfoliation-in-treating-demodex-folliculorum-blepharitis
#5
Orla Murphy, Veronica O'Dwyer, Aoife Lloyd-McKernan
PURPOSE: To compare the efficacy of Dr Organic Tea Tree Face Wash, OcuSoft Lids Scrub Plus and the BlephEx™ device at treating of Demodex folliculorum blepharitis. METHODS: Eighty-six subjects (33 males/36 females) were enrolled in a randomised controlled interventional treatment study. Subjects completed a dry eye symptom questionnaire and were assessed for presence of Demodex folliculorum. Subjects were divided into three groups according to treatment: Dr Organic Tea Tree Face Wash (A) (n=28), OcuSoft Lid Scrub Plus (B) (n=30), or in-house lid scrub with the BlephEx™ device before nightly lid scrubs with OcuSoft Lid Scrub Plus (C) (n=28)...
October 23, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29066489/demodex-as-a-delivery-vector-for-topical-targeted-medications-in-the-skin-for-early-melanoma-and-non-melanoma-skin-cancer
#6
Stephen L Strobel
The potential utilization of Demodex mites as delivery vectors for cytotoxic medications directed to early skin cancer is proposed. Potential benefits, proof of concept, and limitations are discussed.
September 2017: Annals of Clinical and Laboratory Science
https://www.readbyqxmd.com/read/29055903/significant-correlation-between-meibomian-gland-dysfunction-and-keratitis-in-young-patients-with-demodex-brevis-infestation
#7
Lingyi Liang, Yan Liu, Xiaohu Ding, Hongmin Ke, Chuan Chen, Scheffer C G Tseng
AIMS: To report the clinical characteristics and correlation between meibomian gland dysfunction (MGD) and keratitis in young patients with ocular demodicosis. METHODS: Observational case series of 60 patients younger than 35 years with ocular demodicosis, of which the diagnosis was based on microscopic counting of Demodex folliculorum and D. brevis of epilated lashes. Severity of keratitis and MGD was graded by photography and meibography, respectively, in a masked fashion...
October 21, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29054722/the-eyelids-and-tear-film-in-contact-lens-discomfort
#8
Jaya Sowjanya Siddireddy, Ajay Kumar Vijay, Jacqueline Tan, Mark Willcox
PURPOSE: To investigate characteristics of the eyelid margins, meibomian glands and the tear film of contact lens wearers, and to determine whether these characteristics were related to symptoms of contact lens discomfort. METHODS: A cross sectional study was performed on thirty existing daily wear soft contact lens wearers (6 male; 24 female) with median age of 23 years (range 18-41). Eyelid signs and tear film characteristics were evaluated during a single visit and subjects completed the contact lens and dry eye questionnaire (CLDEQ-8) to evaluate ocular discomfort...
October 17, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/29035242/the-effect-of-skin-sebum-ph-and-moisture-on-demodex-infestation-in-acne-vulgaris-and-rosacea-patients
#9
Nergiz Turan, Yelda Kapıcıoğlu, Gülbahar Saraç
OBJECTIVE: Acne vulgaris is an inflammatory disease involving the pilosebaceous unit. Rosacea is a chronic inflammatory skin disease that affects the face in particular. This study aimed to determine if skin sebum, pH, and moisture affect the number of Demodex spp. in acne vulgaris and rosacea patients. METHODS: This study focused on 30 patients each with acne vulgaris and rosacea. As a control group, 60 healthy individuals were included. RESULTS: In acne vulgaris patients, when compared to those with Demodex mite more than 5 /cm2 in each area, less than 5/cm2 were found to be oily, acidic, dry or very dry...
September 2017: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/29032499/dna-barcoding-for-molecular-identification-of-demodex-based-on-mitochondrial-genes
#10
Li Hu, YuanJun Yang, YaE Zhao, DongLing Niu, Rui Yang, RuiLing Wang, Zhaohui Lu, XiaoQi Li
There has been no widely accepted DNA barcode for species identification of Demodex. In this study, we attempted to solve this issue. First, mitochondrial cox1-5' and 12S gene fragments of Demodex folloculorum, D. brevis, D. canis, and D. caprae were amplified, cloned, and sequenced for the first time; intra/interspecific divergences were computed and phylogenetic trees were reconstructed. Then, divergence frequency distribution plots of those two gene fragments were drawn together with mtDNA cox1-middle region and 16S obtained in previous studies...
December 2017: Parasitology Research
https://www.readbyqxmd.com/read/28945649/short-term-comfort-responses-associated-with-the-use-of-eyelid-cleansing-products-to-manage-demodex-folliculorum
#11
William Ngo, Lyndon Jones, Etty Bitton
PURPOSE: To quantify the discomfort over time of various eyelid cleansers against Demodex. METHODS: This was a prospective, randomized, controlled, crossover, open-label study that enrolled 26 participants. The cleansers used in this study were Biotissue Cliradex (CD), OCuSOFT Lid Scrubs Plus (OP), OCuSOFT OUST Demodex Swabstix (ODS), TheraTears Theralid (TT), NovaBay Avenova (NA). Bausch+Lomb Sensitive Eyes Plus saline was used as a control. Participants were asked to close their eyes as the product was gently rubbed (10 cycles of gentle lateral motion) into the eyelashes...
September 21, 2017: Eye & Contact Lens
https://www.readbyqxmd.com/read/28940244/demodicosis-in-two-patients-with-a-previous-history-of-langerhans-cell-histiocytosis
#12
Marcial Álvarez-Salafranca, Asunción Vicente, Carolina Prat Torres, Andrea Combalia, Manuel Monsonís, Veronica Paola Celis-Passini, María Antonia González-Enseñat
Demodex mites are commensal organisms rarely found in healthy children. Human demodicosis can be classified as a primary or a secondary form. The secondary form in children usually affects severely immunodepressed children. To our knowledge, this is the first report of human demodicosis associated with Langerhans cell histiocytosis. These cases show that this skin disorder can occur months after completing chemotherapy, without recurrence of the systemic disease.
September 21, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28938925/demodex-clusters
#13
Chantal Favier
No abstract text is available yet for this article.
October 2017: Ophthalmology
https://www.readbyqxmd.com/read/28926882/-diagnostic-criteria-of-demodex-blepharitis
#14
L Y Liang, J Li, Y Liu
Demodex infestation is a common cause of blepharitis and now is drawing more and more attention from clinicians. Demodex mite is the most common age-related ectoparasite of human being and may be detected from asymptomatic normal population. Furthermore, the pathogenesis of demodicosis remains unclear. Therefore, the commonly accepted diagnostic criteria of demodex infestation related blepharitis have not been established. Herein, we summarize the related studies about ocular demodicosis and comment the debates about the diagnosis of the disease...
September 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28920478/pityriasis-folliculorum-of-the-back-thoracic-area-pityrosporum-keratin-plugs-or-demodex-involved
#15
Alin Laurentiu Tatu, Violeta Corina Cristea
No abstract text is available yet for this article.
September 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28902017/ocular-demodicosis-as-a-potential-cause-of-ocular-surface-inflammation
#16
Xiaohui Luo, Jing Li, Chuan Chen, Scheffer Tseng, Lingyi Liang
Among different species of mites, Demodex folliculorum and Demodex brevis are the only 2 that affect the human eye. Because demodicosis is highly age-dependent and can be found in asymptomatic adults, the pathogenicity of these mites has long been debated. In this study, we summarize our research experience including our most recent study regarding Demodex infestation as a potential cause of ocular inflammatory diseases. Specifically, we describe the pathogenesis of demodicosis and then discuss the results of work investigating the associations and relationships between ocular demodicosis and blepharitis, meibomian gland diseases, and keratitis, in turn...
November 2017: Cornea
https://www.readbyqxmd.com/read/28868794/canine-demodicosis-a-retrospective-study-of-a-veterinary-hospital-population-in-california-usa-2000-2016
#17
Daniel G Bowden, Catherine A Outerbridge, Marguerite B Kissel, Jerome N Baron, Stephen D White
BACKGROUND: Demodex spp. are cutaneous mites that cause clinical disease when present in increased numbers. There is an association in some dogs with underlying systemic disease or immunosuppressive medications. HYPOTHESIS/OBJECTIVES: Retrospective study to document breed predisposition, identify any concurrent diseases or underlying immunosuppressive conditions, and to determine the frequency of demodicosis recurrence after treatment completion. ANIMALS: There were 431 dogs with demodicosis presented to a veterinary teaching hospital in California, USA, from 2000 to 2016...
September 3, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28846817/the-usefulness-of-investigating-the-possible-underlying-conditions-in-rosacea
#18
G Ciccarese, A Parodi, A Rebora, F Drago
The paper entitled "Rosacea and demodicidosis with gain of function mutation in STAT1″ by Second et al.(1) is of indubitable interest and prompted us to make some observations. The Authors described a patient with cutaneous and ocular rosacea that they related to demodicidosis since oral ivermectin improved the cutaneous lesions(1) . However, the Authors did not demonstrate by skin scraping nor by standardized skin surface biopsy (SSSB) an excessive number of Demodex folliculorum (DF) mites in the pilosebaceous units to justify an oral antiparasitic treatment as a drug of first choice(1) ...
August 28, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28830578/characterization-of-demodex-musculi-infestation-associated-comorbidities-and-topographic-distribution-in-a-mouse-strain-with-defective-adaptive-immunity
#19
Melissa A Nashat, Kerith R Luchins, Michelle L Lepherd, Elyn R Riedel, Joanna N Izdebska, Neil S Lipman
A colony of B6.Cg-Rag1tm1Mom Tyrp1B-w Tg(Tcra,Tcrb)9Rest (TRP1/TCR) mice presented with ocular lesions and ulcerative dermatitis. Histopathology, skin scrapes, and fur plucks confirmed the presence of Demodex spp. in all clinically affected and subclinical TRP1/TCR mice examined (n = 48). Pasteurella pneumotropica and Corynebacterium bovis, both opportunistic pathogens, were cultured from the ocular lesions and skin, respectively, and bacteria were observed microscopically in abscesses at various anatomic locations (including retroorbital sites, tympanic bullae, lymph nodes, and reproductive organs) as well as the affected epidermis...
August 1, 2017: Comparative Medicine
https://www.readbyqxmd.com/read/28822351/granulomatous-rosacea-a-case-report
#20
A Kelati, F Z Mernissi
BACKGROUND: Granulomatous rosacea is a rare chronic inflammatory skin disease with an unknown origin. The role of Demodex follicularum in its pathogenesis is currently proved. CASE PRESENTATION: We report a case of a 54-year-old Moroccan man with a 3-month history of erythematous, nonpruritic papules on the lateral side around the eyes. Dermoscopy and histology confirmed the diagnosis of granulomatous rosacea. CONCLUSIONS: We describe another clinical presentation of granulomatous rosacea with a clinical-dermoscopic-pathological correlation...
August 20, 2017: Journal of Medical Case Reports
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