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https://www.readbyqxmd.com/read/28212890/annexin-a1-influences-in-breast-cancer-controversies-on-contributions-to-tumour-host-and-immunoediting-processes
#1
REVIEW
Yan Tu, Cameron N Johnstone, Alastair G Stewart
Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels suggest a potential influence on tumorigenic and metastatic processes. However, reports of conflicting results reveal a relationship that is much more complex than first conceptualised. In this review, we explore the diverse actions of annexin A1 on breast tumour cells and various host cell types, including stromal immune and structural cells, particularly in the context of cancer immunoediting...
February 14, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28206693/plasmid-and-clonal-interference-during-post-horizontal-gene-transfer-evolution
#2
S Bedhomme, D Perez Pantoja, I G Bravo
Plasmids are nucleic acid molecules that can drive their own replication in a living cell. They can be transmitted horizontally and can thrive in the host cell to high copy numbers. Plasmid replication and gene expression consume cellular resources and cells carrying plasmids incur fitness costs. But many plasmids carry genes that can be beneficial under certain conditions, allowing the cell to endure in the presence of antibiotics, toxins, competitors or parasites. Horizontal transfer of plasmid-encoded genes can thus instantaneously confer differential adaptation to local or transient selection conditions...
February 16, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28203385/appraising-the-methodological-quality-of-the-clinical-practice-guideline-for-diabetes-mellitus-using-the-agree-ii-instrument-a-methodological-evaluation
#3
Mahmoud Radwan, Ali Akbari Sari, Arash Rashidian, Amirhossein Takian, Sanaa Abou-Dagga, Aymen Elsous
OBJECTIVES: To evaluate the methodological quality of the Palestinian Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II. DESIGN: Methodological evaluation. A cross-cultural adaptation framework was followed to translate and develop a standardised Translated Arabic Version of the AGREE II. SETTING: Palestinian Primary Healthcare Centres. PARTICIPANTS: Sixteen appraisers independently evaluated the Clinical Practice Guideline for Diabetes Mellitus using the Translated Arabic Version of the AGREE II...
February 2017: JRSM Open
https://www.readbyqxmd.com/read/28196564/teaching-millennials-and-generation-z-bridging-the-generational-divide
#4
Bobbi Shatto, Kelly Erwin
Most undergraduate students today are part of the millennial generation. However, the next wave of students-Generation Z-are just beginning to enter universities. Although these groups share many similarities, they each have unique characteristics that create challenges in the classroom. Incorporating technology, engaging students with adaptive learning activities, and understanding basic generational differences are ways to limit the effects of generational conflict while keeping both millennials and Generation Z students engaged in learning...
February 1, 2017: Creative Nursing
https://www.readbyqxmd.com/read/28195005/current-evidence-for-ampk-activation-involvement-on-resveratrol-induced-neuroprotection-in-cerebral-ischemia
#5
Narayana Pineda-Ramírez, Germán Fernando Gutiérrez Aguilar, Mónica Espinoza-Rojo, Penélope Aguilera
OBJECTIVES: Cerebral ischemia is a neurological condition in which energetics and oxidative stress are dysregulated. Resveratrol is a stilbene with potent pharmacological effects associated with its antioxidant properties. In the brain, resveratrol produces protective responses against ischemia, decreases infarct volume and improves neurological function. Adenosine monophosphate-activated protein kinase (AMPK) is a cellular sensor that acts as a switch to initiate adaptive changes in response to fluctuations in energy metabolism...
February 14, 2017: Nutritional Neuroscience
https://www.readbyqxmd.com/read/28194314/evolutionary-and-functional-implications-of-hypervariable-loci-within-the-skin-virome
#6
Geoffrey D Hannigan, Qi Zheng, Jacquelyn S Meisel, Samuel S Minot, Frederick D Bushman, Elizabeth A Grice
Localized genomic variability is crucial for the ongoing conflicts between infectious microbes and their hosts. An understanding of evolutionary and adaptive patterns associated with genomic variability will help guide development of vaccines and antimicrobial agents. While most analyses of the human microbiome have focused on taxonomic classification and gene annotation, we investigated genomic variation of skin-associated viral communities. We evaluated patterns of viral genomic variation across 16 healthy human volunteers...
2017: PeerJ
https://www.readbyqxmd.com/read/28193686/paraventricular-thalamus-balances-danger-and-reward
#7
Eun A Choi, Gavan P McNally
Foraging animals balance the need to seek food and energy against the accompanying dangers of injury and predation. To do so, they rely on learning systems encoding reward and danger. Whereas much is known about these separate learning systems, little is known about how they interact to shape and guide behavior. Here we show a key role for the rat paraventricular nucleus of the thalamus (PVT), a nucleus of the dorsal midline thalamus, in this interaction. First we show behavioral competition between reward and danger: the opportunity to seek food reward negatively modulates expression of species-typical defensive behavior...
February 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28183912/merging-paleobiology-with-conservation-biology-to-guide-the-future-of-terrestrial-ecosystems
#8
REVIEW
Anthony D Barnosky, Elizabeth A Hadly, Patrick Gonzalez, Jason Head, P David Polly, A Michelle Lawing, Jussi T Eronen, David D Ackerly, Ken Alex, Eric Biber, Jessica Blois, Justin Brashares, Gerardo Ceballos, Edward Davis, Gregory P Dietl, Rodolfo Dirzo, Holly Doremus, Mikael Fortelius, Harry W Greene, Jessica Hellmann, Thomas Hickler, Stephen T Jackson, Melissa Kemp, Paul L Koch, Claire Kremen, Emily L Lindsey, Cindy Looy, Charles R Marshall, Chase Mendenhall, Andreas Mulch, Alexis M Mychajliw, Carsten Nowak, Uma Ramakrishnan, Jan Schnitzler, Kashish Das Shrestha, Katherine Solari, Lynn Stegner, M Allison Stegner, Nils Chr Stenseth, Marvalee H Wake, Zhibin Zhang
Conservation of species and ecosystems is increasingly difficult because anthropogenic impacts are pervasive and accelerating. Under this rapid global change, maximizing conservation success requires a paradigm shift from maintaining ecosystems in idealized past states toward facilitating their adaptive and functional capacities, even as species ebb and flow individually. Developing effective strategies under this new paradigm will require deeper understanding of the long-term dynamics that govern ecosystem persistence and reconciliation of conflicts among approaches to conserving historical versus novel ecosystems...
February 10, 2017: Science
https://www.readbyqxmd.com/read/28178276/selfish-pups-weaning-conflict-and-milk-theft-in-free-ranging-dogs
#9
Manabi Paul, Anindita Bhadra
Parent-offspring conflict theory predicts the emergence of weaning conflict between a mother and her offspring arising from skewed relatedness benefits. Empirical observations of weaning conflict have not been carried out in canids. In a field-based study on free-ranging dogs we observed that nursing/suckling bout durations decrease, proportion of mother-initiated nursing bouts decrease and mother-initiated nursing/suckling terminations increase with pup age. We identified the 7th - 13th week period of pup age as the zone of conflict between the mother and her pups, beyond which suckling solicitations cease, and before which suckling refusals are few...
2017: PloS One
https://www.readbyqxmd.com/read/28178272/psychobiological-factors-affecting-cortisol-variability-in-human-dog-dyads
#10
Iris Schöberl, Manuela Wedl, Andrea Beetz, Kurt Kotrschal
Stress responses within dyads are modulated by interactions such as mutual emotional support and conflict. We investigated dyadic psychobiological factors influencing intra-individual cortisol variability in response to different challenging situations by testing 132 owners and their dogs in a laboratory setting. Salivary cortisol was measured and questionnaires were used to assess owner and dog personality as well as owners' social attitudes towards the dog and towards other humans. We calculated the individual coefficient of variance of cortisol (iCV = sd/mean*100) over the different test situations as a parameter representing individual variability of cortisol concentration...
2017: PloS One
https://www.readbyqxmd.com/read/28174018/evolving-plastic-responses-to-external-and-genetic-environments
#11
Max Reuter, M Florencia Camus, Mark S Hill, Filip Ruzicka, Kevin Fowler
Phenotypic plasticity can mitigate adaptive trade-offs in fluctuating environments but how plasticity arises is little known. New research documents this process in a bacterial system. We highlight remarkable parallels to the evolution of sexual dimorphism and argue that their approach can aid our understanding of adaptive conflicts between the sexes.
February 4, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28165061/the-interaction-of-perceptual-biases-in-bistable-perception
#12
Xue Zhang, Qian Xu, Yi Jiang, Ying Wang
When viewing ambiguous stimuli, people tend to perceive some interpretations more frequently than others. Such perceptual biases impose various types of constraints on visual perception, and accordingly, have been assumed to serve distinct adaptive functions. Here we demonstrated the interaction of two functionally distinct biases in bistable biological motion perception, one regulating perception based on the statistics of the environment - the viewing-from-above (VFA) bias, and the other with the potential to reduce costly errors resulting from perceptual inference - the facing-the-viewer (FTV) bias...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28161445/is-diapause-an-ancient-adaptation-in-drosophila
#13
Valeria Zonato, Lewis Collins, Mirko Pegoraro, Eran Tauber, Charalambos P Kyriacou
D. melanogaster enters a state of reproductive arrest when exposed to low temperatures (12°C) and shorter photoperiods. A number of studies have suggested that diapause has recently evolved in European D. melanogaster populations, that it is not present in the sibling species D. simulans, that it is non-photoperiodic in American D. melanogaster populations, and that it spontaneously terminates after 6-8weeks. We have studied the overwintering phenotype under different conditions and observe that American, European and, surprisingly, African D...
February 2, 2017: Journal of Insect Physiology
https://www.readbyqxmd.com/read/28155700/multi-objective-optimization-of-coronary-stent-using-kriging-surrogate-model
#14
Hongxia Li, Junfeng Gu, Minjie Wang, Danyang Zhao, Zheng Li, Aike Qiao, Bao Zhu
BACKGROUND: In stent design optimization, the functional relationship between design parameters and design goals is nonlinear, complex, and implicit and the multi-objective design of stents involves a number of potentially conflicting performance criteria. Therefore it is hard and time-consuming to find the optimal design of stent either by experiment or clinic test. Fortunately, computational methods have been developed to the point whereby optimization and simulation tools can be used to systematically design devices in a realistic time-scale...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28150163/fatigue-and-recovery-in-rugby-a-review
#15
REVIEW
Francisco Tavares, Tiaki Brett Smith, Matthew Driller
The physical demands and combative nature of rugby lead to notable levels of muscle damage. In professional rugby, athletes only have a limited timeframe to recover following training sessions and competition. Through the implementation of recovery strategies, sport scientists, practitioners and coaches have sought to reduce the effect of fatigue and allow athletes to recover faster. Although some studies demonstrate that recovery strategies are extensively used by rugby athletes, the research remains equivocal concerning the efficacy of recovery strategies in rugby...
February 2, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28140662/pediatric-issues-in-return-of-results-and-incidental-findings-weighing-autonomy-and-best-interests
#16
Ingrid A Holm
Nowhere are the ethical issues in genomic research more complex than in pediatrics. Balancing the sometime conflicting autonomy of the parent and the child, and the best interest of the family and the child, brings up many challenging issues. Addressing this balance, especially in the context of the child's developing maturity and comprehension, requires deep analysis and discussion. Issues discussed include the impact of genetic information on the family, parental versus the child's autonomy, the best interests of the child versus the family, potential limitations on the parents' right to know or not know information about their child, and changing role of the developing child in return of research results...
January 31, 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28137968/two-independent-frontal-midline-theta-oscillations-during-conflict-detection-and-adaptation-in-a-simon-type-manual-reaching-task
#17
Thomas Töllner, Yijun Wang, Scott Makeig, Hermann J Müller, Tzyy-Ping Jung, Klaus Gramann
: One of the most firmly established factors determining the speed of human behavioral responses towards action-critical stimuli is the spatial correspondence between the stimulus and response locations. If both locations match, the time taken for response production is markedly reduced relative to when they mismatch-a phenomenon called Simon effect. While there is a consensus that this stimulus-response (S-R) conflict is associated with brief (4-7 Hz) frontal midline theta (fmθ) complexes generated in medial frontal cortex (MFC), it remains controversial (i) whether there are multiple, simultaneously active theta generator areas in the MFC that commonly give rise to conflict-related fmθ complexes; and if so, (ii) whether they are all related to the resolution of conflicting task information...
January 30, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28135636/phasic-valence-and-arousal-do-not-influence-post-conflict-adjustments-in-the-simon-task
#18
David Dignath, Markus Janczyk, Andreas B Eder
According to theoretical accounts of cognitive control, conflict between competing responses is monitored and triggers post conflict behavioural adjustments. Some models proposed that conflict is detected as an affective signal. While the conflict monitoring theory assumed that conflict is registered as a negative valence signal, the adaptation by binding model hypothesized that conflict provides a high arousal signal. The present research induced phasic affect in a Simon task with presentations of pleasant and unpleasant pictures that were high or low in arousal...
January 27, 2017: Acta Psychologica
https://www.readbyqxmd.com/read/28135270/optimal-sequential-immunization-can-focus-antibody-responses-against-diversity-loss-and-distraction
#19
Shenshen Wang
Affinity maturation is a Darwinian process in which B lymphocytes evolve potent antibodies to encountered antigens and generate immune memory. Highly mutable complex pathogens present an immense antigenic diversity that continues to challenge natural immunity and vaccine design. Induction of broadly neutralizing antibodies (bnAbs) against this diversity by vaccination likely requires multiple exposures to distinct but related antigen variants, and yet how affinity maturation advances under such complex stimulation remains poorly understood...
January 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28124092/a-word-to-the-wise-advice-for-scientists-engaged-in-collaborative-adaptive-management
#20
Peter Hopkinson, Ann Huber, David S Saah, John J Battles
Collaborative adaptive management is a process for making decisions about the environment in the face of uncertainty and conflict. Scientists have a central role to play in these decisions. However, while scientists are well trained to reduce uncertainty by discovering new knowledge, most lack experience with the means to mitigate conflict in contested situations. To address this gap, we drew from our efforts coordinating a large collaborative adaptive management effort, the Sierra Nevada Adaptive Management Project, to offer advice to our fellow environmental scientists...
January 25, 2017: Environmental Management
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