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Conflict adaptation

Bart Aben, Tom Verguts, Eva Van den Bussche
The idea that adaptation to stimulus or response conflict can operate over different time scales takes a prominent position in various theories and models of cognitive control. The mechanisms underlying temporal variations in control are nevertheless poorly understood, which is partly due to a lack of appropriate empirical measures. Inspired by reinforcement learning models, we developed a method to quantify the time scale of control behaviorally, by computing trial-by-trial effects that go beyond the preceding trial...
January 12, 2017: Journal of Experimental Psychology. Human Perception and Performance
Tammarah Sklarz, Peng Guan, Mercy Gohil, Renee M Cotton, Moyar Q Ge, Angela Haczku, Rupali Das, Martha S Jordan
Invariant NKT (iNKT) cells bridge innate and adaptive immunity by rapidly secreting cytokines and lysing targets following TCR recognition of lipid antigens. Based on their ability to secrete IFN-γ, IL-4 and IL-17A, iNKT-cells are classified as NKT-1, NKT-2 and NKT-17 subsets, respectively. The molecular pathways regulating iNKT-cell fate are not fully defined. Recent studies implicate Rictor, a required component of mTORC2, in the development of select iNKT-cell subsets, however these reports are conflicting...
January 12, 2017: European Journal of Immunology
Lukas Scheef, Jurek A Nordmeyer-Massner, Adam Pr Smith-Collins, Nicole Müller, Gaby Stegmann-Woessner, Jacob Jankowski, Jürgen Gieseke, Mark Born, Hermann Seitz, Peter Bartmann, Hans H Schild, Klaas P Pruessmann, Axel Heep, Henning Boecker
BACKGROUND: Functional magnetic resonance imaging (fMRI) in neonates has been introduced as a non-invasive method for studying sensorimotor processing in the developing brain. However, previous neonatal studies have delivered conflicting results regarding localization, lateralization, and directionality of blood oxygenation level dependent (BOLD) responses in sensorimotor cortex (SMC). Amongst the confounding factors in interpreting neonatal fMRI studies include the use of standard adult MR-coils providing insufficient signal to noise, and liberal statistical thresholds, compromising clinical interpretation at the single subject level...
2017: PloS One
Takuro Noguchi, Jeffrey P Ward, Matthew M Gubin, Cora D Arthur, Sang Hun Lee, Jasreet Hundal, Mark Selby, Robert F Graziano, Elaine R Mardis, Alan J Korman, Robert D Schreiber
Antibody blockade of Programmed Death-1 (PD-1) or its ligand, PD-L1, has led to unprecedented therapeutic responses in certain tumor-bearing individuals, but PD-L1 expression's prognostic value in stratifying cancer patients for such treatment remains unclear. Reports conflict on the significance of correlations between PD-L1 on tumor cells and positive clinical outcomes to PD-1/PD-L1 blockade. We investigated this issue using genomically-related, clonal subsets from the same methylcholanthrene-induced sarcoma: a highly immunogenic subset that is spontaneously eliminated in vivo by adaptive immunity and a less immunogenic subset that forms tumors in immunocompetent mice, but is sensitive to PD-1/PD-L1 blockade therapy...
January 10, 2017: Cancer Immunology Research
Bauke Buwalda, Jaap M Koolhaas, Sietse F de Boer
Hierarchical social status greatly influences health and well-being in mammals, including humans. The social rank of an individual is established during competitive encounters with conspecifics. Intuitively, therefore, social dominance and aggressiveness may seem intimately linked. Yet, whether an aggressive personality trait may predispose individuals to a particular rank in a social colony setting remains largely unclear. Here we tested the hypothesis that high trait aggressiveness in Wildtype Groningen (WTG) rats, as assessed in a classic resident-intruder offensive aggression paradigm predicts social dominance in a mixed-sex colony housing using the Visible Burrow System (VBS)...
January 6, 2017: Physiology & Behavior
Rosa Esteve, Alicia E López-Martínez, Madelon L Peters, Elena R Serrano-Ibáñez, Gema T Ruíz-Párraga, Henar González-Gómez, Carmen Ramírez-Maestre
: The aim of this cross-sectional study was to identify subgroups of patients based on their activity patterns and to investigate their relationship with life goals, optimism, affect, and functioning. The sample comprised 276 patients with chronic musculoskeletal pain. Hierarchical cluster analysis was performed on the activity pattern variables and the resulting clusters were compared using 1-way ANOVA. The 4-cluster was the optimal solution. The four clusters comprised: a) Avoiders: patients with high levels of avoidance and low levels of persistence, who use pacing to reduce pain; b) Doers: patients with high levels of persistence and low levels of pacing and avoidance; c) Extreme Cyclers: patients with high levels of avoidance and persistence and low levels of pacing; and d) Medium Cyclers: patients with moderately high levels of avoidance and persistence and high levels of pacing...
January 4, 2017: Journal of Pain: Official Journal of the American Pain Society
Richard N McLaughlin, Harmit S Malik
Selfishness is pervasive and manifests at all scales of biology, from societies, to individuals, to genetic elements within a genome. The relentless struggle to seek evolutionary advantages drives perpetual cycles of adaptation and counter-adaptation, commonly referred to as Red Queen interactions. In this review, we explore insights gleaned from molecular and genetic studies of such genetic conflicts, both extrinsic (between genomes) and intrinsic (within genomes or cells). We argue that many different characteristics of selfish genetic elements can be distilled into two types of advantages: an over-replication advantage (e...
January 1, 2017: Journal of Experimental Biology
Arif Jetha, Laura Kernan, Alicia Kurowski
BACKGROUND: Workplace stress is a complex phenomenon that may often be dynamic and evolving over time. Traditional linear modeling does not allow representation of recursive feedback loops among the implicated factors. The objective of this study was to develop a multidimensional system dynamics model (SDM) of workplace stress among nursing aides and conduct simulations to illustrate how changes in psychosocial perceptions and workplace factors might influence workplace stress over time...
January 5, 2017: BMC Health Services Research
Willa A Marquis, Amanda N Noroña, Bruce L Baker
Cumulative risk research has increased understanding of how multiple risk factors impact various socioemotional and interpersonal outcomes across the life span. However, little is known about risk factors for parent-child conflict early in development, where identifying predictors of change could be highly salient for intervention. Given their established association with parent-child conflict, child developmental delay (DD) and emotion dysregulation were examined as predictors of change in conflict across early to middle childhood (ages 3 to 7 years)...
January 5, 2017: Journal of Family Psychology: JFP
M Chen, S Jiang, Y Shao, W Lu
PURPOSE: In-vivo range detection/verification is crucial in particle therapy for effective and safe delivery. The state-of-art techniques are not sufficient for in-vivo on-line range verification due to conflicts among patient dose, signal statistics and imaging time. We propose a novel intra-beam range detection and adaptation strategy for particle therapy. METHODS: This strategy uses the planned mid-range spots as probing beams without adding extra radiation to patients...
June 2016: Medical Physics
Tsui-Fen Chang, Chung-Kuang Chen, Ming-Jia Chen
BACKGROUND: Team collaboration is an important factor that affects the performance of the operating room (OR). Therefore, the ability of OR nurses to adapt to and manage interpersonal conflict incidents properly is very important. PURPOSE: The aims of this study were to investigate the interpersonal conflict management capabilities of OR nursing staffs and to find the relationships among the demographics of OR nurses and the following: work-related variables, interpersonal conflict management style, and target of interpersonal conflict...
December 29, 2016: Journal of Nursing Research: JNR
L Cerniglia, F Zoratto, S Cimino, G Laviola, M Ammaniti, W Adriani
Despite it has not been formally included in DSM-5 as a disorder, 'Internet addiction (IA)' has become a worldwide issue. It can be broadly defined as a non-chemical, behavioral addiction, which involves human-machine interaction. We pinpoint it as an "instrumental" form of social interaction (i.e. mediated by machines), a notion that appears useful for the sake of possible preclinical modeling. The features of Internet use reveals as addictive when this comes at the expense of genuine real-life sociability, with an overlap towards the hikikomori phenomenon (i...
December 24, 2016: Neuroscience and Biobehavioral Reviews
(no author information available yet)
Advances in medical care may occur when a change in practice incorporates a new treatment or methodology. In surgery, this may involve the translation of a completely novel concept into a new procedure or device or the adaptation of existing treatment approaches or technology to a new clinical application. Regardless of the specifics, innovation should have, as its primary goal, the enhancement of care leading to improved outcomes from the patient's perspective. This policy statement examines innovation as it pertains to surgical care, focusing on some of the definitions that help differentiate applied innovation or innovative therapy from research...
January 2017: Pediatrics
Steven M Thurman, Pinakin Gunvant Davey, Kaydee Lynn McCray, Violeta Paronian, Aaron R Seitz
Contrast sensitivity (CS) is widely used as a measure of visual function in both basic research and clinical evaluation. There is conflicting evidence on the extent to which measuring the full contrast sensitivity function (CSF) offers more functionally relevant information than a single measurement from an optotype CS test, such as the Pelli-Robson chart. Here we examine the relationship between functional CSF parameters and other measures of visual function, and establish a framework for predicting individual CSFs with effectively a zero-parameter model that shifts a standard-shaped template CSF horizontally and vertically according to independent measurements of high contrast acuity and letter CS, respectively...
December 1, 2016: Journal of Vision
Alice C Schermerhorn, John E Bates, Aina Puce, Dennis L Molfese
Theory and research indicate considerable influence of socio-emotionally significant experiences on children's functioning and adaptation. In the current study, we examined neurophysiological correlates of children's allocation of information processing resources to socio-emotionally significant events, specifically, simulated marital interactions. We presented 9- to 11-year-old children (n=24; 11 females) with 15 videos of interactions between two actors posing as a married couple. Task-irrelevant brief auditory probes were presented during the videos, and event-related potentials (ERPs) elicited to the auditory probes were measured...
December 16, 2016: International Journal of Psychophysiology
Jan Friesen, Leonor Rodriguez Sinobas, Laura Foglia, Ralf Ludwig
Semi-arid regions are facing the challenge of managing water resources under conditions of increasing scarcity and drought. These are recently pressured by the impact of climate change favoring the shifting from using surface water to groundwater without taking sustainability issues into account. Likewise, water scarcity raises the competition for water among users, increasing the risk of social conflicts, as the availability of fresh water in sufficient quality and quantity is already one of the major factors limiting socio-economic development...
December 15, 2016: Science of the Total Environment
Ralf Schiel, Alexander Kaps, Günter Stein, Antje Steveling
INTRODUCTION: Worldwide, overweight and obesity are known as posing serious health risks. Successful methods for weight reduction have remained elusive. This multicenter non-randomised trial aimed to identify parameters and determinants of long-term weight reduction. PATIENTS AND METHODS: A total of 143/159 overweight and obese children and adolescents (90 %) completed the prospective multicenter trial (age 13.9±2.4 years, BMI 31.2±5.4kg/m(2), BMI-SDS 2.51±0...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
Farshad A Mansouri, Tobias Egner, Mark J Buckley
Fifteen years ago, an influential model proposed that the human dorsal anterior cingulate cortex (dACC) detects conflict and induces adaptive control of behavior. Over the years support for this model has been mixed, in particular due to divergent findings in human versus nonhuman primates. We here review recent findings that suggest greater commonalities across species. These include equivalent behavioral consequences of conflict and similar neuronal signals in the dACC, but also a common failure of dACC lesions to reliably abolish conflict-driven behavior...
January 2017: Trends in Neurosciences
Marion E Snowdon, Stuart Cathcart
Previous studies suggest the dorsolateral prefrontal cortex (DLPFC) is involved in processing of empathic concern. This has not been experimentally tested to date. We tested the hypotheses that electrical potentiation in the right DLPFC would be associated with increased empathic concern and prosocial behavior. Participants were randomly allocated to one of three transcranial Direct Current Stimulation (tDCS) conditions: (a) relative right potentiation, (b) relative left potentiation, and (c) sham. Participants viewed images of African children in distressing circumstances, and completed measures of empathic concern pre- and post-tDCS manipulation...
January 2, 2017: Social Neuroscience
James R Schmidt
The proportion congruent (PC) effect is the observation that congruency effects are smaller when most trials are incongruent rather than congruent. The list-level PC (LLPC) effect is the finding that a PC effect can transfer from biased inducer items to unbiased diagnostic items. Such effects are generally interpreted as resulting from conflict monitoring and attentional adaptation. An alternative view proposes that PC effects result from simple learning biases unrelated to conflict. The temporal learning account proposes that LLPC effects stem from a different task rhythm in the mostly congruent and mostly incongruent conditions...
December 15, 2016: Canadian Journal of Experimental Psychology, Revue Canadienne de Psychologie Expérimentale
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