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https://www.readbyqxmd.com/read/28323724/ebus-stat-subscore-analysis-to-predict-the-efficacy-and-assess-the-validity-of-virtual-reality-simulation-for-ebus-tbna-training-among-experienced-bronchoscopists
#1
Simone Scarlata, Patrizio Palermo, Piero Candoli, Ariela Tofani, Tommasangelo Petitti, Lorenzo Corbetta
BACKGROUND: Linear endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) represents a pivotal innovation in interventional pulmonology; determining the best approach to guarantee systematic and efficient training is expected to become a main issue in the forthcoming years. Virtual reality simulators have been proposed as potential EBUS-TBNA training instruments, to avoid unskilled beginners practicing directly in real-life settings. A validated and perfected simulation program could be used before allowing beginners to practice on patients...
April 2017: Journal of Bronchology & Interventional Pulmonology
https://www.readbyqxmd.com/read/28318972/persistent-single-neuron-activity-during-working-memory-in-the-human-medial-temporal-lobe
#2
Simon Kornblith, Rodrigo Quian Quiroga, Christof Koch, Itzhak Fried, Florian Mormann
Working memory is an essential component of human cognition. Persistent activity related to working memory has been reported in many brain areas, including the inferior temporal and prefrontal cortex [1-8]. The medial temporal lobe (MTL) contains "concept cells" that respond invariantly to specific individuals or places whether presented as images, text, or speech [9, 10]. It is unknown, however, whether the MTL also participates in working memory processes. We thus sought to determine whether human MTL neurons respond to images held in working memory...
March 15, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28315756/interleukin-4-is-a-participant-in-the-regulation-of-depressive-like-behavior
#3
Simone Wachholz, Alexandra Knorr, Leonie Mengert, Jennifer Plümper, Rainer Sommer, Georg Juckel, Astrid Friebe
Inflammatory immune activation has been frequently associated with the development of major depression. Microglia might serve as an important interface in this immune system-to-brain communication. Interleukin-4, the major Th2 type cytokine, might be protective against depression due to its ability to counter-regulate inflammation and to inhibit serotonin transporter activity. By using an Interferon-α mouse model, we show that a decreased IL-4 responsiveness of microglia was specifically related to the development of depressive-like behavior...
March 15, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28300615/heritability-of-brain-activity-related-to-response-inhibition-a-longitudinal-genetic-study-in-adolescent-twins
#4
Andrey P Anokhin, Simon Golosheykin, Julia D Grant, Andrew C Heath
The ability to inhibit prepotent but context- or goal-inappropriate responses is essential for adaptive self-regulation of behavior. Deficits in response inhibition, a key component of impulsivity, have been implicated as a core dysfunction in a range of neuropsychiatric disorders such as ADHD and addictions. Identification of genetically transmitted variation in the neural underpinnings of response inhibition can help to elucidate etiological pathways to these disorders and establish the links between genes, brain, and behavior...
March 11, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/28293982/visual-versus-auditory-simon-effect-a-behavioural-and-physiological-investigation
#5
Stefania D'Ascenzo, Luisa Lugli, Giulia Baroni, Roberto Guidotti, Sandro Rubichi, Cristina Iani, Roberto Nicoletti
The present study investigated whether the visual and auditory Simon effects could be accounted for by the same mechanism. In a single experiment we performed a detailed comparison of the visual and the auditory Simon effects arising in behavioural responses and in pupil dilation, a psychophysiological measure considered as a marker of the cognitive effort induced by conflict processing. To address our question, we performed sequential and distributional analyses on both reaction times and pupil dilation. Results confirmed that the mechanisms underlying the visual and auditory Simon effects are functionally equivalent in terms of the interaction between unconditional and conditional response processes...
March 15, 2017: Quarterly Journal of Experimental Psychology: QJEP
https://www.readbyqxmd.com/read/28287057/verbal-learning-and-memory-enhancement-strategies-in-schizophrenia-a-randomized-controlled-investigation
#6
Matthew M Kurtz, Christi L Trask, Rachel Rosengard, Simone Hyman, Lisa Kremen, Shyle Mehta, Rachel Olfson, Sam Rispaud, Sofia Zaidman, Jimmy Choi
OBJECTIVES: Verbal episodic memory is a key domain of impairment in people with schizophrenia with close ties to a variety of aspects of functioning and therapeutic treatment response. A randomized, blinded trial of two mnemonic strategies for verbal episodic memory deficits for people with schizophrenia was conducted. METHODS: Sixty-one people with schizophrenia were assigned to one of three experimental conditions: training in a mnemonic strategy that included both visualization and narrative structure (Story Method), a condition in which participants were trained to visualize words interacting with one another (Imagery), or a non-trained control condition in which participants received equivalent exposure to training word lists and other verbal memory assessments administered in the other two conditions, but without provision of any compensatory mnemonic strategy...
March 13, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28285156/the-role-of-cognition-for-different-stages-of-visuomotor-adaptation-in-younger-and-older-adults
#7
Anja Simon, Otmar Bock
A recent model identified three stages of learning, the first drawing on cognitive flexibility, the second on inhibition, and the third on automation. We explored the validity of this model for visuomotor learning and found that adaptation is associated with inhibition early during adaptation and with automaticity later on. An initial association with cognitive flexibility remained inconclusive. This work employs another marker of cognitive flexibility and extends our work to older adults. Twenty young and 20 older adults completed three cognitive tasks (switch task, Stroop task and four-choice-reaction-time-task)...
March 8, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28283411/where-do-uncertainties-reside-within-environmental-risk-assessments-testing-unisera-a-guide-for-uncertainty-assessment
#8
Daniel J C Skinner, Sophie A Rocks, Simon J T Pollard
A means for identifying and prioritising the treatment of uncertainty (UnISERA) in environmental risk assessments (ERAs) is tested, using three risk domains where ERA is an established requirement and one in which ERA practice is emerging. UnISERA's development draws on 19 expert elicitations across genetically modified higher plants, particulate matter, and agricultural pesticide release and is stress tested here for engineered nanomaterials (ENM). We are concerned with the severity of uncertainty; its nature; and its location across four accepted stages of ERAs...
March 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28283370/reduced-multimodal-integration-of-memory-features-following-continuous-theta-burst-stimulation-of-angular-gyrus
#9
Yasemin Yazar, Zara M Bergström, Jon S Simons
BACKGROUND: Lesions of the angular gyrus (AnG) region of human parietal cortex do not cause amnesia, but appear to be associated with reduction in the ability to consciously experience the reliving of previous events. OBJECTIVES/HYPOTHESIS: We used continuous theta burst stimulation to test the hypothesis that the cognitive mechanism implicated in this memory deficit might be the integration of retrieved sensory event features into a coherent multimodal memory representation...
March 1, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28280879/enhanced-verbal-abilities-in-the-congenitally-blind
#10
Valeria Occelli, Simon Lacey, Careese Stephens, Lotfi B Merabet, K Sathian
Numerous studies have found that congenitally blind individuals have better verbal memory than their normally sighted counterparts. However, it is not known whether this reflects superiority of verbal or memory abilities. In order to distinguish between these possibilities, we tested congenitally blind participants and normally sighted control participants, matched for age and education, on a range of verbal and spatial tasks. Congenitally blind participants were significantly better than sighted controls on all the verbal tasks but the groups did not differ significantly on the spatial tasks...
March 9, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/28276652/worker-brain-development-and-colony-organization-in-ants-does-division-of-labor-influence-neuroplasticity
#11
J Frances Kamhi, Aynsley Sandridge-Gresko, Christina Walker, Simon K A Robson, James F A Traniello
Brain compartment size allometries may adaptively reflect cognitive needs associated with behavioral development and ecology. Ants provide an informative system to study the relationship of neural architecture and development because worker tasks and sensory inputs may change with age. Additionally, tasks may be divided among morphologically and behaviorally differentiated worker groups (subcastes), reducing repertoire size through specialization and aligning brain structure with task-specific cognitive requirements...
March 9, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/28275707/the-importance-of-search-strategy-for-finding-targets-in-open-terrain
#12
Charlotte A Riggs, Katherine Cornes, Hayward J Godwin, Simon P Liversedge, Richard Guest, Nick Donnelly
A number of real-world search tasks (i.e. police search, detection of improvised explosive devices (IEDs)) require searchers to search exhaustively across open ground. In the present study, we simulated this problem by asking individuals (Experiments 1a and 1b) and dyads (Experiment 2) to search for coin targets pseudo-randomly located in a bounded area of open grassland terrain. In Experiment 1a, accuracy, search time, and the route used to search an area were measured. Participants tended to use an 'S'-shaped pattern with a common width of search lane...
2017: Cogn Res Princ Implic
https://www.readbyqxmd.com/read/28270937/the-cognitive-neuroplasticity-of-reading-recovery-following-chronic-stroke-a-representational-similarity-analysis-approach
#13
Simon Fischer-Baum, Ava Jang, David Kajander
Damage to certain left hemisphere regions leads to reading impairments, at least acutely, though some individuals eventually recover reading. Previous neuroimaging studies have shown a relationship between reading recovery and increases in contralesional and perilesional activation during word reading tasks, relative to controls. Questions remain about how to interpret these changes in activation. Do these changes reflect functional take-over, a reorganization of functions in the damaged brain? Or do they reveal compensatory masquerade or the use of alternative neural pathways to reading that are available in both patients and controls? We address these questions by studying a single individual, CH, who has made a partial recovery of reading familiar words following stroke...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28269643/identifying-montages-that-best-detect-the-electroencephalogram-power-spectrum-alteration-during-freezing-of-gait-in-parkinson-s-disease-patients
#14
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Our research team has previously used four Electroencephalography (EEG) leads to successfully detect and predict Freezing of Gait (FOG) in Parkinson's disease (PD). However, it remained to be determined whether these four sensor locations that were arbitrarily chosen based on their role in motor control are indeed the most optimal for FOG detection. The aim of this study was therefore to determine the most optimal location and combination of sensors to detect FOG amongst a 32-channel EEG montage using our EEG classification system...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268634/detection-of-gait-initiation-failure-in-parkinson-s-disease-patients-using-eeg-signals
#15
Quynh Tran Ly, A M Ardi Handojoseno, Moran Gilat, Nghia Nguyen, Rifai Chai, Yvonne Tran, Simon J G Lewis, Hung T Nguyen
Gait Initiation Failure (GIF) is one of the most disabling gait disturbances seen in advanced Parkinson's disease (PD). Gait Initiation is a complex motor task that requires motor and cognitive processing to enable the correct selection, timing and scaling of movement. Failure to initiate the first step often precipitates falls and leads to significant morbidity. However, the brain mechanisms underlying GIF remain unknown. This study utilized an ambulatory electroencephalography (EEG) technique to investigate the brain dynamic changes underlying GIF and aims to detect the occurrence of GIF in four PD patients...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267862/screening-for-gynecologic-conditions-with-pelvic-examination-us-preventive-services-task-force-recommendation-statement
#16
Kirsten Bibbins-Domingo, David C Grossman, Susan J Curry, Michael J Barry, Karina W Davidson, Chyke A Doubeni, John W Epling, Francisco A R García, Alex R Kemper, Alex H Krist, Ann E Kurth, C Seth Landefeld, Carol M Mangione, William R Phillips, Maureen G Phipps, Michael Silverstein, Melissa Simon, Albert L Siu, Chien-Wen Tseng
Importance: Many conditions that can affect women's health are often evaluated through pelvic examination. Although the pelvic examination is a common part of the physical examination, it is unclear whether performing screening pelvic examinations in asymptomatic women has a significant effect on disease morbidity and mortality. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on screening for gynecologic conditions with pelvic examination for conditions other than cervical cancer, gonorrhea, and chlamydia, for which the USPSTF has already made specific recommendations...
March 7, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28266334/processing-grammatical-gender-in-dutch-evidence-from-eye-movements
#17
Susanne Brouwer, Simone Sprenger, Sharon Unsworth
Previous research has demonstrated that grammatical gender in Dutch is typically acquired late. Most of this work used production data only, and consequently children's knowledge of Dutch gender may have been underestimated. In this study, therefore, we examined whether 49 4- to 7-year-old Dutch-speaking children (and 19 adult controls) were able to use gender marking in the article preceding the object label during online sentence processing to (a) anticipate the upcoming object label or to (b) facilitate the processing of that label as it is presented...
March 3, 2017: Journal of Experimental Child Psychology
https://www.readbyqxmd.com/read/28265499/exploring-biomedical-ontology-mappings-with-graph-theory-methods
#18
Simon Kocbek, Jin-Dong Kim
BACKGROUND: In the era of semantic web, life science ontologies play an important role in tasks such as annotating biological objects, linking relevant data pieces, and verifying data consistency. Understanding ontology structures and overlapping ontologies is essential for tasks such as ontology reuse and development. We present an exploratory study where we examine structure and look for patterns in BioPortal, a comprehensive publicly available repository of live science ontologies...
2017: PeerJ
https://www.readbyqxmd.com/read/28263926/dopamine-depletion-impairs-gait-automaticity-by-altering-cortico-striatal-and-cerebellar-processing-in-parkinson-s-disease
#19
Moran Gilat, Peter T Bell, Kaylena A Ehgoetz Martens, Matthew J Georgiades, Julie M Hall, Courtney C Walton, Simon J G Lewis, James M Shine
Impairments in motor automaticity cause patients with Parkinson's disease to rely on attentional resources during gait, resulting in greater motor variability and a higher risk of falls. Although dopaminergic circuitry is known to play an important role in motor automaticity, little evidence exists on the neural mechanisms underlying the breakdown of locomotor automaticity in Parkinson's disease. This impedes clinical management and is in great part due to mobility restrictions that accompany the neuroimaging of gait...
March 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/28263638/training-the-face-strategic-practice-as-a-means-to-regulate-affect-induced-facial-muscle-contractions
#20
Julia Kozlik, Roland Neumann
Recently, it has been shown that the activation of affect-induced emotional reactions (i.e., manual approach/avoidance movements) can be modulated by strategic practice. The present study explored whether this modulation would also apply to affect-induced facial muscle contractions, which have been discussed to be relatively inflexibly linked to the processing of affective stimuli. In 2 experiments, participants conducted 2 different categorization tasks on positive and negative pictures of facial expressions (Experiment 1) or emotional scenes (Experiment 2) which were randomly framed in different colors...
March 6, 2017: Journal of Experimental Psychology. Human Perception and Performance
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