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https://www.readbyqxmd.com/read/29723567/novel-observations-of-female-genital-anatomy-in-classic-bladder-exstrophy-using-three-dimensional-mri-reconstruction
#1
Karl S Benz, Emily Dunn, Meiyappan Solaiyappan, Mahir Maruf, Matthew Kasprenski, John Jayman, Jason E Michaud, James Facciola, John P Gearhart
PURPOSE: Understanding the distinct female anatomy in classic bladder exstrophy is crucial for optimal reconstructive and functional outcomes. This study presents novel quantitative anatomical data in females with classic bladder exstrophy prior to primary closure. MATERIALS AND METHODS: Patients underwent three-dimensional reconstruction of pelvic magnetic resonance imaging studies, and pelvic anatomy was characterized, including measurements of the vagina, cervix, and erectile bodies...
April 30, 2018: Journal of Urology
https://www.readbyqxmd.com/read/29704585/the-role-of-human-acellular-dermis-in-preventing-fistulas-after-bladder-neck-transection-in-the-exstrophy-epispadias-complex
#2
Karl S Benz, John Jayman, Mahir Maruf, Gregory Joice, Matthew Kasprenski, Nikolai Sopko, Heather Di Carlo, John Gearhart
OBJECTIVES: To evaluate Human Acellular Dermis (HAD) as an adjunct during Bladder Neck Transection (BNT) by comparing surgical outcomes with other types of tissue interposition. METHODS: A prospectively-maintained institutional database of Exstrophy-Epispadias Complex (EEC) patients was reviewed for those who underwent a BNT with at least 6 months follow-up. The primary outcome was the occurrence of BNT-related fistulas. RESULTS: In total, 147 EEC patients underwent a BNT with a mean follow-up time of 6...
April 25, 2018: Urology
https://www.readbyqxmd.com/read/29681696/technique-of-antireflux-procedure-without-creating-submucosal-tunnel-for-surgical-correction-of-vesicoureteric-reflux-during-bladder-closure-in-exstrophy
#3
Kanoujia Sunil, Archika Gupta, Digamber Chaubey, Anand Pandey, Shiv Narain Kureel, Ajay Kumar Verma
Aim: To report the clinical application of the new surgical technique of antireflux procedure without creating submucosal tunnel for surgical correction of vesicoureteric reflux during bladder closure in exstrophy. Materials and Methods: Based on the report of published experimental technique, the procedure was clinically executed in seven patients of classic exstrophy bladder with small bladder plate with polyps, where the creation of submucosal tunnel was not possible, in last 18 months...
April 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29681521/commentary-to-bladder-exstrophy-closure-in-the-newborn-period-is-it-safe-to-perform-external-pelvic-fixation-without-osteotomy
#4
R Maximilian Cervellione
No abstract text is available yet for this article.
April 13, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29681269/contemporary-issues-relating-to-transitional-care-in-bladder-exstrophy
#5
REVIEW
Fardod O'kelly, Daniel Keefe, Sender Herschorn, Armando J Lorenzo
No abstract text is available yet for this article.
April 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29649545/complete-primary-repair-of-bladder-exstrophy-cpre-critical-analysis-of-the-long-term-outcome
#6
Hesham O Arab, Tamer E Helmy, Ahmed Abdelhalim, Mohamed Soltan, Mohamed E Dawaba, Ashraf T Hafez
OBJECTIVES: To demonstrate the long term outcome of a contemporary series of 64 children who underwent CPRE in a single tertiary referral center. METHODS: Between 1998 and 2012, 64 children; 47 boys and 17 girls were identified. Only 60 out of the 64 cases were available for follow up. Follow up was done by renal bladder ultrasound (RBUS) and serum creatinine every 3 months and Voiding cystourethrogram (VCUG) between 6 to 12 months post operatively. Continence was defined as dryness ≥3 hours...
April 9, 2018: Urology
https://www.readbyqxmd.com/read/29627154/how-to-close-classic-bladder-exstrophy-are-subspecialty-training-and-technique-important
#7
Brian M Inouye, J Todd Purves, Jonathan C Routh, Mahir Maruf, Daniel Friedlander, John Jayman, John P Gearhart
INTRODUCTION: Successful primary closure is one of the main factors for achieving continence in a classic bladder exstrophy (CBE) patient. Even with contemporary management, patients still have failed primary closures. We sought to understand the role of training, surgical technique, and their impacts on outcomes of CBE closure. MATERIALS AND METHODS: A retrospective cohort study from the largest single-institution database of primary and re-closure CBE patients in the world was performed...
March 29, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29619236/evaluation-of-the-isl1-gene-in-the-pathogenesis-of-bladder-exstrophy-in-a-swedish-cohort
#8
Samara Arkani, Jia Cao, Johanna Lundin, Daniel Nilsson, Thomas Källman, Gillian Barker, Gundela Holmdahl, Christina Clementsson Kockum, Hans Matsson, Agneta Nordenskjöld
Bladder exstrophy is a congenital closure defect of the urinary bladder with a profound effect on morbidity. Although the malformation is usually sporadic, a genetic background is supported by an increased recurrence risk in relatives, higher concordance rates in monozygotic twins and several associated chromosomal aberrations. Recently, the ISL1 gene was presented as a candidate gene for bladder exstrophy and epispadias complex (BEEC) development in two different studies. In our study, we screened for genetic variants in the ISL1 gene in DNA from 125 Swedish patients using Sanger sequencing and array-CGH analysis...
2018: Human Genome Variation
https://www.readbyqxmd.com/read/29618582/uropathogens-and-pyuria-in-children-with-neurogenic-bladders
#9
Catherine S Forster, Nader Shaikh, Alejandro Hoberman, Elizabeth Jackson
: media-1vid110.1542/5727212324001PEDS-VA_2017-3006 Video Abstract BACKGROUND: A recent study revealed that specific uropathogens are associated with lower odds of pyuria in a general pediatrics population. Children with neurogenic bladders who require clean intermittent catheterization (CIC) frequently have pyuria. Our objective with this study was to determine if an association exists between pyuria and type of uropathogen in CIC-dependent children. METHODS: We obtained urinalysis and urine culture results from electronic medical records from January 2008 through December 2014 for patients ≤18 years of age with neurogenic bladders managed at a single institution...
May 2018: Pediatrics
https://www.readbyqxmd.com/read/29606357/who-where-and-why-are-patients-lost-to-follow-up-a-20-year-study-of-bladder-exstrophy-patients-at-a-single-institution
#10
Emily Haddad, Ahmet Ali Sancaktutar, Blake W Palmer, Christopher Aston, Bradley P Kropp
INTRODUCTION: Individuals with bladder and cloacal exstrophy are at increased risk for kidney disease, renal failure, and bladder complications. Given the social implications and sensitive nature of the disease, these patients are also at risk for psychosocial problems. Lack of regular medical follow-up visits may pose serious risks to their long-term health status. The aim of this study is determine what factors place an affected individual at risk for limited long term follow up. MATERIALS AND METHODS: We identified all patients with bladder or cloacal exstrophy seen by the pediatric urology department at the Oklahoma University Health Sciences Center (OUHSC) between January 1996 and August 2016...
March 19, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29594008/pregnancy-in-a-woman-with-untreated-bladder-exstrophy-a-case-report
#11
Suhui Wu, Jingfen Sun, Huimin Lv, Yangang Zhang, Haixia Shang, Huajun Zhang, Jerome L Belinson
Objective: To report the management of urinary tract obstruction and infection in a pregnant woman with unrepaired bladder exstrophy. Case Report: A 27-year-old pregnant woman with unrepaired bladder exstrophy was referred to our hospital with a complaint of bilateral flank pain in the second trimester. After two-dimensional abdominal ultrasound, magnetic resonance imaging and a urine analysis, she was diagnosed with an upper urinary tract infection due to ureteral obstruction secondary to unrepaired congenital bladder exstrophy and an intrauterine pregnancy...
January 2018: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29555156/achieving-urinary-continence-in-cloacal-exstrophy-the-surgical-cost
#12
Mahir Maruf, Matthew Kasprenski, John Jayman, Seth D Goldstein, Karl Benz, Timothy Baumgartner, John P Gearhart
INTRODUCTION: Cloacal exstrophy (CE) is a severe midline congenital abnormality that requires numerous surgical corrections to achieve an acceptable quality of life. Candidates for urinary continence undergo multiple procedures, most often continent bladder diversions, to become socially dry. Here, the authors investigate the number of genitourinary interventions that patients with CE undergo to attain urinary continence. MATERIALS AND METHODS: A retrospective review of a prospectively maintained database of 1311 exstrophy epispadias complex patients was performed...
February 24, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29550866/fetal-anterior-abdominal-wall-defects-prenatal-imaging-by-magnetic-resonance-imaging
#13
REVIEW
Teresa Victoria, Savvas Andronikou, Diana Bowen, Pablo Laje, Dana A Weiss, Ann M Johnson, William H Peranteau, Douglas A Canning, N Scott Adzick
Abdominal wall defects range from the mild umbilical cord hernia to the highly complex limb-body wall syndrome. The most common defects are gastroschisis and omphalocele, and the rarer ones include the exstrophy complex, pentalogy of Cantrell and limb-body wall syndrome. Although all have a common feature of viscera herniation through a defect in the anterior body wall, their imaging features and, more important, postnatal management, differ widely. Correct diagnosis of each entity is imperative in order to achieve appropriate and accurate prenatal counseling and postnatal management...
April 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29539957/re-newborn-exstrophy-closure-without-osteotomy-is-there-a-role
#14
Douglas A Canning
No abstract text is available yet for this article.
May 2017: Journal of Urology
https://www.readbyqxmd.com/read/29524978/t4-urothelial-carcinoma-in-undiagnosed-closed-bladder-exstrophy-in-a-post-menopausal-female
#15
Brian J McArdle, Patricia Vidal, Sarah P Psutka, Courtney M P Hollowell
It is rare to see an adult presenting with exstrophy of the bladder. Malignant conversion in exstrophy occurs in 4%, with adenocarcinoma as the most common histopathology. We report the first case of metastatic high grade urothelial carcinoma with squamous and sarcomatoid differentiation arising from undiagnosed, closed bladder exstrophy in a female at advanced age with associated bilateral deep vein thrombosis and clot retention. The patient developed clinical progression of disease despite neoadjuvant gemcitabine-cisplatin and salvage (or palliative) radiotherapy...
February 2018: Canadian Journal of Urology
https://www.readbyqxmd.com/read/29516095/a-model-for-sustained-collaboration-to-address-the-unmet-global-burden-of-bladder-exstrophy-epispadis-complex-and-penopubic-epispadis-the-international-bladder-exstrophy-consortium
#16
Rakesh S Joshi, Dhirendra Shrivastava, Richard Grady, Anjana Kundu, Jaishri Ramji, Pramod P Reddy, Joao Luiz Pippi-Salle, Jennifer R Frazier, Douglas A Canning, Aseem R Shukla
Importance: International collaboration to alleviate the massive burden of surgical disease is recognized by World Health Organization as an urgent need, yet the surgical mission model to treat reconstructive surgical challenges is often constrained in ensuring adequate patient follow-up, optimal outcomes, and sustainability. Objective: To determine whether a collaboration predicated on long-term commitment by surgeons returning to the same institution annually combined with an experienced host surgical team and infrastructure to ensure sustained patient follow-up could provide surgical care with acceptable outcomes to treat bladder exstrophy-epispadias complex (BE) and penopubic epispadias (PE)...
March 7, 2018: JAMA Surgery
https://www.readbyqxmd.com/read/29505857/genital-mobilization-of-intravesical-phallus-associated-with-covered-cloacal-exstrophy-a-case-report
#17
Akiko Haruna, Eiji Hisamatsu, Taketoshi Nara, Yoshifumi Sugita
Cloacal exstrophy is the most severe form of the exstrophy-epispadias complex, occurring in approximately 1 of every 200,000 to 400,000 live births. Variant such as covered cloacal exstrophy presentations are only one-tenth as common. Although exstrophy-epispadias complexes include genital anomalies, intravesical phallus is very rare. We report an extremely rare case of intravesical phallus with covered cloacal exstrophy that was successfully treated by phallic mobilization.
March 2, 2018: Urology
https://www.readbyqxmd.com/read/29504860/surgical-and-endoscopic-treatment-of-bladder-exstrophy-epispadias-complex-in-a-female-dog
#18
Brittani Jones, Allyson C Berent, Chick W Weisse, Robert Hart, Leilani Alvarez, Anthony Fischetti, B David Horn, Douglas Canning
CASE DESCRIPTION A 14-week-old 7.7-kg (16.9-lb) sexually intact female Golden Retriever was evaluated because of urine dripping from the caudoventral aspect of the abdomen. CLINICAL FINDINGS Ultrasonography, radiography, excretory CT urography, and vaginocystourethroscopy were performed. Results indicated eversion of the bladder through the ventral abdominal wall with exposure of the ureterovesicular junctions, pubic diastasis, and an open vulva and clitoral fossa. Clinical findings were suggestive of bladder exstrophy, a rare congenital anomaly...
March 15, 2018: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/29502980/male-sexuality-fertility-and-urinary-continence-in-bladder-exstrophy-epispadias-complex
#19
Nelly Reynaud, Frédérique Courtois, Pierre Mouriquand, Nicolas Morel-Journel, Kathleen Charvier, Marina Gérard, Alain Ruffion, Jean-Etienne Terrier
BACKGROUND: The bladder exstrophy-epispadias complex is a rare congenital malformation associated with severe dysfunction of the genital and urinary tracts and requiring a staged surgical reconstruction. AIM: The primary aims of this study were to report the sexuality, infertility, and urinary incontinence outcomes in a cohort of men born with bladder exstrophy-epispadias complex. The secondary aim was to highlight some predictive factors of infertility in this population...
March 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29479649/pelvic-organ-prolapse-and-pregnancy-in-the-female-bladder-exstrophy-patient
#20
REVIEW
Melissa R Kaufman
PURPOSE OF REVIEW: Classic bladder exstrophy (BE) remains one of the most demanding reconstructive challenges encountered in urology. In female BE patients, the long-term sequela of both primary and revision genitoplasty, as well as intrinsic pelvic floor deficits, predispose adult women to significant issues with sexual function, pelvic organ prolapse (POP), and complexities with reproductive health. RECENT FINDINGS: Contemporary data suggest 30-50% of women with BE develop prolapse at a mean age of 16 years...
February 26, 2018: Current Urology Reports
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