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https://www.readbyqxmd.com/read/29156242/optimization-of-pmaxx-pretreatment-to-distinguish-between-human-norovirus-with-intact-and-altered-capsids-in-shellfish-and-sewage-samples
#1
Walter Randazzo, Mohammad Khezri, Joanna Ollivier, Françoise S Le Guyader, Jesús Rodríguez-Díaz, Rosa Aznar, Gloria Sánchez
Shellfish contamination by human noroviruses (HuNoVs) is a serious health and economic problem. Recently an ISO procedure based on RT-qPCR for the quantitative detection of HuNoVs in shellfish has been issued, but these procedures cannot discriminate between inactivated and potentially infectious viruses. The aim of the present study was to optimize a pretreatment using PMAxx to better discriminate between intact and heat-treated HuNoVs in shellfish and sewage. To this end, the optimal conditions (30min incubation with 100μM of PMAxx and 0...
November 15, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29155653/enhancing-laboratory-response-network-capacity-in-south-korea
#2
J Todd Parker, Ann-Christian Juren, Luis Lowe, Scott Santibañez, Gi-Eun Rhie, Toby L Merlin
Laboratory Response Network (LRN) laboratories help protect populations from biological and chemical public health threats. We examined the role of LRN biological laboratories in enhancing capacity to detect and respond to public health infectious disease emergencies in South Korea. The model for responding to infectious disease emergencies leverages standardized laboratory testing procedures, a repository of standardized testing reagents, laboratory testing cooperation among hospital sentinel laboratories and reference laboratories, and maintenance of a trained workforce through traditional and on-demand training...
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29134293/medicinal-foods-for-functional-gi-disorders
#3
REVIEW
Brent W Acker, Brooks D Cash
PURPOSE OF REVIEW: Over the past 10 years, there has been a dramatic increase in basic and clinical research involving functional gastrointestinal disorders (FGIDs). New diagnostic and biomarker procedures are helping to identify physiologic disruptions associated with FGIDs on cellular and molecular levels. Simultaneously, clinicians are using new approaches to help manage patients with FGIDs. Among these, an important component of care has been the use of medical foods. These include probiotics, prebiotics, synbiotics, peppermint oil, caraway oil, curcumin, bovine immunoglobulin and many others...
November 13, 2017: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29124121/patients-comorbidities-reduce-the-clinical-value-of-emergency-colonoscopy-results-of-a-retrospective-cohort-study
#4
Cristiano Cremone, Anouk Esch, Charlotte Gagniere, Alessandro Fugazza, Faria Mesli, Michael Levy, Aurelien Amiot, Alexis Laurent, Yann LeBaleur, Francois Hemery, Nicolas De'Angelis, Francesco Brunetti, Iradj Sobhani
Background and study aims:  Urgent endoscopy is often used to diagnose and sometimes treat acute upper gastrointestinal syndromes (hemorrhage, toxic ingestion, and occlusion). However, its suitability concerning the management of lower gastrointestinal conditions in emergency circumstances is controversial. Patients and methods:  We studied the role of emergency colonoscopy in diagnosis and treatment of all consecutive patients presenting with acute lower gastrointestinal symptoms referred to our hospital on an emergency basis...
November 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/29108983/a-novel-device-for-improving-visualization-in-an-inadequately-prepared-colon
#5
Seth Gross, Lauren Gerson, Blair Lewis, Robert Ganz
BACKGROUND AND AIMS: Adequate bowel preparation is essential for a quality colonoscopy. Poor bowel preparation can result in longer procedural times, missed adenomas, earlier repeat procedures, increase costs, and decreased patient satisfaction [1-5]. Pure-Vu (MOTUS GI, Tirat Carmel, Israel) is a system that facilitates intra-procedural cleaning of a poorly prepared colon during a colonoscopy by irrigating the colon and evacuating the fluid and feces. The study aims were to evaluate Pure-Vu's cleansing capabilities and its usability and safety, in a live animal colon METHODS: The Pure-Vu system was used by four experienced gastroenterologists in 35 Yorkshire cross swine (66% female) that received a reduced bowel preparation to ensure an inadequate bowel preparation at baseline...
November 3, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29108847/effective-methods-to-decrease-surgical-site-infections-in-pediatric-gastrointestinal-surgery
#6
Andrew B Nordin, Stephen P Sales, Gail E Besner, Marc A Levitt, Richard J Wood, Brian D Kenney
BACKGROUND: Gastrointestinal (GI) surgeries represent a significant proportion of the surgical site infection (SSI) burden in pediatric patients, resulting in significant morbidity. Previous studies have shown that perioperative bundles reduce SSIs, but few have focused on pediatric GI operations. We hypothesized that a GI bundle would decrease SSI rates, length of stay (LOS), and hospital charges. METHODS: After establishing baseline SSI rates, a GI bundle was created and implemented in November 2014...
October 10, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29075201/virtual-in-silico-modeling-guided-catheter-ablation-predicts-effective-linear-ablation-lesion-set-for-longstanding-persistent-atrial-fibrillation-multicenter-prospective-randomized-study
#7
Jaemin Shim, Minki Hwang, Jun-Seop Song, Byounghyun Lim, Tae-Hoon Kim, Boyoung Joung, Sung-Hwan Kim, Yong-Seog Oh, Gi-Byung Nam, Young Keun On, Seil Oh, Young-Hoon Kim, Hui-Nam Pak
Objective: Radiofrequency catheter ablation for persistent atrial fibrillation (PeAF) still has a substantial recurrence rate. This study aims to investigate whether an AF ablation lesion set chosen using in-silico ablation (V-ABL) is clinically feasible and more effective than an empirically chosen ablation lesion set (Em-ABL) in patients with PeAF. Methods: We prospectively included 108 patients with antiarrhythmic drug-resistant PeAF (77.8% men, age 60.8 ± 9.9 years), and randomly assigned them to the V-ABL (n = 53) and Em-ABL (n = 55) groups...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29074195/presence-of-enteric-viruses-bioaccumulation-and-stability-in-anomalocardia-brasiliana-clams-gmelin-1791
#8
Doris Sobral Marques Souza, Ana Ferreira Ávila Dominot, Vanessa Moresco, Célia Regina Monte Barardi
Bivalve mollusks are filter feeders and may accumulate human pathogens in their tissues. Many studies demonstrated human diseases associated with bivalve consumption, especially oysters. Anomalocardia brasiliana clams are distributed along the Brazilian coastal area and are an exotic ingredient for some typical dishes in Brazil. Even though there are several reports describing the contamination of oysters and mussels with human pathogens, there is a lack of studies reporting contamination of A. brasiliana with human pathogens...
August 12, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29071416/feasibility-and-safety-of-a-novel-magnetic-assisted-capsule-endoscope-system-in-a-preliminary-examination-for-upper-gastrointestinal-tract
#9
Gi-Shih Lien, Ming-Shun Wu, Chun-Nan Chen, Chih-Wen Liu, Fat-Moon Suk
BACKGROUND AND STUDY AIM: Current capsule endoscopy procedures are ineffective for upper gastrointestinal (GI) tract examination because they do not allow for operator-controlled navigation of the capsule. External controllability of a capsule endoscope with an applied magnetic field is a possible solution to this problem. We developed a novel magnetic-assisted capsule endoscope (MACE) system to visualize the entire upper GI tract. The present study evaluated the safety and feasibility of the MACE system for the examination of the upper GI tract, including the esophagus, stomach, and duodenum...
October 25, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29067157/guide-to-managing-persistent-upper-gastrointestinal-symptoms-during-and-after-treatment-for-cancer
#10
H Jervoise N Andreyev, Ann C Muls, Clare Shaw, Richard R Jackson, Caroline Gee, Susan Vyoral, Andrew R Davies
BACKGROUND: Guidance: the practical management of the gastrointestinal symptoms of pelvic radiation disease was published in 2014 for a multidisciplinary audience. Following this, a companion guide to managing upper gastrointestinal (GI) consequences was developed. AIMS: The development and peer review of an algorithm which could be accessible to all types of clinicians working with patients experiencing upper GI symptoms following cancer treatment. METHODS: Experts who manage patients with upper GI symptoms were asked to review the guide, rating each section for agreement with the recommended measures and suggesting amendments if necessary...
October 2017: Frontline Gastroenterology
https://www.readbyqxmd.com/read/29063152/bone-grafts-used-for-arthroscopic-glenoid-reconstruction-restore-the-native-glenoid-anatomy
#11
Benjamin Bockmann, Arne Johannes Venjakob, Rolf Gebing, Frank Reichwein, Marthe Hagenacker, Wolfgang Nebelung
PURPOSE: Recurrent anterior instability of the glenohumeral joint is a demanding condition, especially in cases of glenoid bone loss. Various treatment options have been described, such as arthroscopic grafting techniques and the Latarjet procedure. In this study, the degree to which an arthroscopically applied iliac crest graft restores the glenoid anatomy was evalutated. METHODS: Nine patients (three women and six men) with an average age of 31 ± 9 years (21-46 years) who were treated with an arthroscopic iliac crest graft technique were included in this study...
October 23, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29060905/effects-of-nd-yag-laser-for-the-controlled-and-localized-treatment-of-early-gastrointestinal-tumors-preliminary-in-vivo-study
#12
P Saccomandi, G Quero, G Costamagna, M Diana, J Marescaux
Endoscopic submucosal dissection (ESD) is a minimally invasive technique allowing for the removal of early gastrointestinal (GI) tumors, widely considered as a valid alternative to conventional surgery. However, ESD is technically demanding, and potentially severe complications, such as bleeding and perforation, may occur. Energy-based techniques (e.g., radiofrequency ablation) might offer a potential alternative to ESD. However, their use mandates the ability to predict the damage induced and to identify a "signature" of the complete ablation, without the need for a physical specimen...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29053202/treatment-satisfaction-with-itca-650-a-novel-drug-device-delivering-continuous-exenatide-versus-twice-daily-injections-of-exenatide-in-type-2-diabetics-on-metformin
#13
Robert Henry, Julio Rosenstock, John F McCarthy, Ginger Carls, Tom Alessi, John Yee, Michelle Baron
AIMS: To evaluate treatment satisfaction in patients with type 2 diabetes (T2D), not adequately controlled by metformin, randomized to ITCA 650 (continuous exenatide in osmotic mini-pump) versus twice-daily exenatide injections (Ex-BID). MATERIALS AND METHODS: The Diabetes Medication Satisfaction Tool (DM-SAT) was administered and assessments made at baseline, week 8, and week 20 in a 24 week open-label phase 2 trial. In Stage I (weeks 1-12), 155 patients, comprising the ITT population, were randomized to three groups: ITCA 650 20 μg/day, ITCA 650 40 μg/day and Ex-BID 10 μg BID...
October 20, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29045348/choice-of-endoscopic-procedure-in-children-with-clinically-suspected-gastrointestinal-graft-versus-host-disease
#14
Thomas Mårtensson, Attila Szakos, Karin Mellgren, Jacek Toporski, Johan Arvidson, Thomas H Casswall, Britt Gustafsson
OBJECTIVES: Gastrointestinal graft-versus-host disease (GI-GVHD) is a potentially life-threatening complication after hematopoietic stem cell transplantation. Symptoms indicating GI-GVHD motivates endoscopy with biopsy sampling and histopathological confirmation. However, optimal extent of endoscopy in children is presently unknown. Therefore, we aimed to evaluate if biopsies from the rectosigmoid area versus the rest of the colon/ileocolon with or without biopsies from simultaneous upper endoscopy, were equally reliable for detection of GI-GVHD and relevant differential diagnoses...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29043576/submucosal-tunneling-endoscopic-resection-for-the-treatment-of-gastrointestinal-submucosal-tumors-originating-from-the-muscularis-propria-layer
#15
Chen Du, Enqiang Linghu
Surgical resection and endoscopic resection comprise two alternative options for the treatment of submucosal tumors (SMTs) originating from the muscularis propria (MP) layer. Endoscopic resection is minimally invasive compared with surgical resection. Conventional non-tunneling techniques, such as endoscopic submucosal dissection (ESD), endoscopic submucosal excavation (ESE), and endoscopic full-thickness resection (EFR) have been demonstrated to be safe and effective. However, these techniques fail to maintain the integrity of the mucosa and induce high risk of perforation, infection, and postoperative strictures...
October 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/29031502/low-rates-of-gastrointestinal-and-non-gastrointestinal-complications-for-screening-or-surveillance-colonoscopies-in-a-population-based-study
#16
Wang Louise, Mannalithara Ajitha, Singh Gurkirpal, Ladabaum Uri
BACKGROUND: The full spectrum of serious non-gastrointestinal (non-GI) post-colonoscopy complications has not been well characterized. We analyzed rates of and factors associated with adverse post-colonoscopy GI and non-GI events (cardiovascular, pulmonary, or infectious) attributable to screening or surveillance colonoscopy (S-colo) and non-screening or non-surveillance colonoscopy (NS-colo). METHODS: We performed a population-based study of colonoscopy complications using databases from California hospital-owned and nonhospital-owned ambulatory facilities, emergency departments, and hospitals from January 1, 2005 through December 31, 2011...
October 11, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29023950/synthesis-and-evaluation-of-tc-99m-and-fluorescence-labeled-elastin-derived-peptide-vapg-for-multimodal-tumor-imaging-in-murine-tumor-model
#17
Myoung Hyoun Kim, Chang Guhn Kim, Seul-Gi Kim, Dae-Weung Kim
We developed a Tc-99m and fluorescence labeled peptide, Tc-99m TAMRA-GHEG-ECG-VAPG to target tumor cells, and evaluated the diagnostic performance as a dual-modality imaging agent for tumor in a murine model. TAMRA-GHEG-ECG-VAPG was synthesized using Fmoc solid-phase peptide synthesis. Radiolabeling of TAMRA-GHEG-ECG-VAPG with Tc-99m was done using ligand exchange via tartrate. Binding affinity and in vitro cellular uptake studies were performed. Gamma camera imaging, biodistribution and ex vivo imaging studies were performed in murine models with SW620 tumors...
October 11, 2017: Journal of Labelled Compounds & Radiopharmaceuticals
https://www.readbyqxmd.com/read/28991077/surveillance-of-duodenal-polyposis-in-familial-adenomatous-polyposis-should-the-spigelman-score-be-modified
#18
EDITORIAL
Isabelle Sourrouille, Jérémie H Lefèvre, Conor Shields, Chrystelle Colas, Jerôme Bellanger, Benoît Desaint, Francois Paye, Emmanuel Tiret, Yann Parc
BACKGROUND: Duodenal polyposis is a manifestation of adenomatous polyposis that predisposes to duodenal or ampullary adenocarcinoma. Duodenal polyposis is monitored by upper GI endoscopies and may require iterative resections and prophylactic radical surgical treatment when malignancy is threatening. OBJECTIVE: The purpose of this study was to evaluate severity scoring for surveillance and treatment in a large series of duodenal polyposis. DESIGN: From 1982 to 2014, every patient surveyed by upper GI endoscopies for duodenal polyposis was included...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28988448/clinical-outcomes-and-prognostic-factors-of-sialendoscopy-in-salivary-duct-stenosis
#19
Jeong-Seok Choi, Yoon-Gi Choi, Young-Mo Kim, Jae-Yol Lim
OBJECTIVES/HYPOTHESIS: This study aimed to analyze the clinical outcomes of sialendoscopy in patients with salivary duct stenosis and to investigate factors associated therewith. STUDY DESIGN: Retrospective case series. METHODS: This study included 47 patients with salivary stenosis who underwent sialendoscopy between January 2014 and December 2015. Subjective symptom, salivary flow rate, salivary scintigraphy, and radiologic evaluation using magnetic resonance (MR) sialography were performed preoperatively; direct ductal findings were evaluated during sialendoscopy...
October 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28974414/national-population-based-study-comparing-treatment-related-toxicity-in-men-who-received-intensity-modulated-versus-3-dimensional-conformal-radical-radiation-therapy-for-prostate-cancer
#20
A Sujenthiran, J Nossiter, S C Charman, M Parry, P Dasgupta, J van der Meulen, P J Cathcart, N W Clarke, H Payne, A Aggarwal
PURPOSE: To compare, in a national population-based study, severe genitourinary (GU) and gastrointestinal (GI) toxicity in patients with prostate cancer who were treated with radical intensity modulated radiation therapy (IMRT) or 3-dimensional conformal radiation therapy (3D-CRT). METHODS AND MATERIALS: Patients treated with IMRT (n=6933) or 3D-CRT (n=16,289) between January 1, 2010 and December 31, 2013 in the English National Health Service were identified using cancer registry data, the National Radiotherapy Dataset, and Hospital Episodes Statistics, the administrative database of care episodes in National Health Service hospitals...
September 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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