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https://www.readbyqxmd.com/read/28945044/-effect-of-qishen-yiqi-droplet-on-adenylate-contents-in-myocardium-of-cor-pulmonale-rats
#1
Shi-Han Geng, Qiu-Yue Shan, Meng-Xi Xu, Yi-Dan Zhang, Li-Li Song, Ning Hou, Wen Zhang, Mi-Xia Zhang, Peng-Wei Zhuang, Yan-Jun Zhang
Cor pulmonale rat models were induced by a single intraperitoneal injection of monocrotaline(MCT), and the sham group received a single intraperitioneal injection of normal saline. After the model rats received intragastric administration of Qishen Yiqi droplet(QS) for 6 weeks, the contents of adenylate(ATP, ADP and AMP) in right myocardial tissues were measured by HPLC, and then the metabolism changes in myocardium of cor pulmonale rats with QS were investigated. The results showed that ATP, ADP, and AMP were well separated, with a good linearity within a certain range of concentration; and the recovery rates were within the range of 90%-108%...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28945024/-pathogenesis-and-treatment-of-insulin-resistance-in-chronic-kidney-disease-and-interventional-effects-of-chinese-herbal-medicine
#2
REVIEW
Wei Wu, Jing-Jing Yang, Yi-Gang Wan, Yue Tu, Ge Shi, Wen-Bei Han, Bu-Hui Liu, Jian Yao
The kidney is the target organ of insulin with abundant insulin receptors. Thereinto,the renal intrinsic cells including glomerular podocytes,endothelial cells,mesangial cells,renal tubular epitheliums and collecting duct epithelial cells are all highly sensitive to insulin as the effector cells. Furthermore,the structural and functional abnormalities of these cells are closely related to insulin and its receptors activity. It is reported that the chronic kidney disease(CKD)patients have systemic or renal insulin resistance(IR)...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28942189/anionically-reinforced-hydrogel-network-entrapped-fungal-cells-for-retention-of-cadmium-in-the-contaminated-aquatic-media
#3
Sema Çelik, Sibel Tunali Akar, Musa Şölener, Tamer Akar
A novel biomass/polymer composite was fabricated by embedding Thamnidium elegans cells in acrylic network of p(3-Methoxyprophyl)acrylamide p(MPA) enriched with 2-Akrylamido-2-methyl-1-propane sulfonic acid (AMPS). Cd(II) retention potential of hydrogel (p(MPA-co-AMPS)) increased by 20.66% times after this enrichment. The gel matrix could be effectively entrapped the biomass and resulting sorbent applied to remove Cd(II) from water in batch and continuous modes. The main physico-chemical parameters are discussed in addition to characterization, regeneration and application studies of the suggested sorbent...
September 20, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28941837/metabolic-phasing-of-anoxic-pdbr-for-high-rate-treatment-of-azo-dye-wastewater
#4
C Nagendranatha Reddy, A Naresh Kumar, S Venkata Mohan
The treatment of azo dye wastewater was studied in a periodic discontinuous batch reactor (PDBR) at high loading condition (1250mg/l) under anoxic microenvironments. PDBR performance was evaluated by varying the time period of aerobic microenvironment during the cycle operation [before multiphasing (BMP; Control), 0.014; after multiphasing (AMP): AMPI, 0.84; AMPII, 0.73; AMPIII, 0.65]. Induction of air in anoxic-PDBR facilitated the simultaneous oxidation and reduction conditions and thus resulted higher dye removal efficiency with AMPIII strategy (65%) followed by AMPII (59...
September 20, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28941793/complete-de-novo-sequencing-of-antimicrobial-peptides-in-the-venom-of-the-scorpion-isometrus-maculatus
#5
Masahiro Miyashita, Atsushi Kitanaka, Mao Yakio, Yuzo Yamazaki, Yoshiaki Nakagawa, Hisashi Miyagawa
Scorpion venom contains antimicrobial peptides (AMPs) in addition to neurotoxic peptides. Recent extensive transcriptomic analysis of venom glands of various scorpion species dramatically increased the number of identified AMPs. However, identification of peptides from genetic information requires reference sequences of similar peptides, and moreover, it is often difficult to predict post-translational modifications. In this study, we searched for unknown AMPs contained in the Isometrus maculatus scorpion venom based on the structural features, such as the hydrophobic nature and the lack of disulfide bonds, which are commonly observed in the majority of scorpion AMPs...
September 20, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28941686/barley-sprout-extracts-reduce-hepatic-lipid-accumulation-in-ethanol-fed-mice-by-activating-hepatic-amp-activated-protein-kinase
#6
Yeon-Ji Kim, Su Hyeon Hwang, Yaoyao Jia, Woo-Duck Seo, Sung-Joon Lee
Chronic alcohol consumption leads to hepatic lipid accumulation and alcoholic fatty liver disease. Previously, we demonstrated that barley sprout extract, which contains saponarin as an active compound, reduces hepatic steatosis. In this study, we investigated the effect of barley sprout extracts (BSE) on hepatic lipid accumulation in a mouse model of alcoholic fatty liver disease. Seven-week-old C57BL/6 mice were fed an alcohol-containing diet (5% ethanol) and a low or high dose of BSE (100 or 200mg/kg body weight, respectively) for 10days...
November 2017: Food Research International
https://www.readbyqxmd.com/read/28940468/the-catalytic-mechanism-of-cyclic-gmp-amp-synthase-cgas-and-implications-for-innate-immunity-and-inhibition
#7
Justin Hall, Erik C Ralph, Suman Shanker, Hong Wang, Laura J Byrnes, Reto Horst, Jimson Wong, Amy Brault, Darren Dumlao, James F Smith, Leslie A Dakin, Daniel C Schmitt, John Trujillo, Fabien Vincent, Matt Griffor, Ann E Aulabaugh
Cyclic GMP-AMP synthase (cGAS) is activated by ds-DNA binding to produce the secondary messenger 2',3'-cGAMP. cGAS is an important control point in the innate immune response; dysregulation of the cGAS pathway is linked to autoimmune diseases while targeted stimulation may be of benefit in immunoncology. We report here the structure of cGAS with dinucleotides and small molecule inhibitors, and kinetic studies of the cGAS mechanism. Our structural work supports the understanding of how ds-DNA activates cGAS, suggesting a site for small molecule binders that may cause cGAS activation at physiological ATP concentrations, and an apparent hotspot for inhibitor binding...
September 22, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/28939971/pharmacological-chaperones-as-potential-therapeutic-strategies-for-misfolded-mutant-vasopressin-receptors
#8
Bernard Mouillac, Christiane Mendre
Pharmacological chaperones recently opened new possibilities in G protein-coupled receptor drug discovery. Even more interestingly, some unique ligands combine pharmacological chaperoning and biased agonism properties, boosting their therapeutic interest in many human diseases resulting from G protein-coupled receptor mutation and misfolding. These compounds displaying dual characteristics would constitute a perfect treatment for congenital Nephrogenic Diabetes Insipidus, a typical conformational disease. This X-linked genetic pathology is mostly associated with inactivating mutations of the renal arginine-vasopressin V2 receptor leading to misfolding and intracellular retention of the receptor, causing the inability of patients to concentrate their urine in response to the antidiuretic hormone...
September 23, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28939760/nemo-ikk%C3%AE-are-essential-for-irf3-and-nf-%C3%AE%C2%BAb-activation-in-the-cgas-sting-pathway
#9
Run Fang, Chenguang Wang, Qifei Jiang, Mengze Lv, Pengfei Gao, Xiaoyu Yu, Ping Mu, Rui Zhang, Sheng Bi, Ji-Ming Feng, Zhengfan Jiang
Cytosolic dsDNA activates the cyclic GMP-AMP synthase (cGAS)-stimulator of IFN genes (STING) pathway to produce cytokines, including type I IFNs. The roles of many critical proteins, including NEMO, IKKβ, and TBK1, in this pathway are unclear because of the lack of an appropriate system to study. In this article, we report that lower FBS concentrations in culture medium conferred high sensitivities to dsDNA in otherwise unresponsive cells, whereas higher FBS levels abrogated this sensitivity. Based on this finding, we demonstrated genetically that NEMO was critically involved in the cGAS-STING pathway...
September 22, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28939559/microbiome-symbionts-and-diet-diversity-incur-costs-on-the-immune-system-of-insect-larvae
#10
Indrikis A Krams, Sanita Kecko, Priit Jõers, Giedrius Trakimas, Didzis Elferts, Ronalds Krams, Severi Luoto, Markus J Rantala, Inna Inashkina, Dita Gudrā, Dāvids Fridmanis, Jorge Contreras-Garduño, Lelde Grantiņa-Ieviņa, Tatjana Krama
Communities of symbiotic microorganisms that colonize the gastrointestinal tract play an important role in food digestion and protection against opportunistic microbes. Diet diversity increases the number of symbionts in the intestines, a benefit that is considered to impose no cost for the host organism. However, less is known about the possible immunological investments that hosts have to make in order to control the infections caused by symbiont populations that increase due to diet diversity. By using taxonomical composition analysis of the 16S rRNA V3 region, we show that Enterococci are the dominating group of bacteria in the midgut of the larvae of the greater wax moth (Galleria mellonella)...
September 22, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28939483/mkk4-from-litopenaeus-vannamei-is-a-regulator-of-p38-mapk-kinase-and-involved-in-anti-bacterial-response
#11
Sheng Wang, Bin Yin, Haoyang Li, Bang Xiao, Kai Lǚ, Chiguang Feng, Jianguo He, Chaozheng Li
LvMKK4, a homologue of the mammalian mitogen-activated protein kinase kinase 4 (MKK4), was isolated and identified from Litopenaeus vannamei in the present study. The full-length cDNA of LvMKK4 is 1947 bp long, with an open reading frame (ORF) of 1185 bp encoding a putative protein of 388 amino acids. LvMKK4 contains several characteristic domains such as D domain, SIAKT motif and kinase domain, all of which are conserved in MAP kinase kinase family. Like mammalian MKK4 but not Drosophila MKK4, LvMKK4 could bind to, phosphorylate and activate p38 MAPK, which provided some insights into the signal transduction mechanism of MKK4-p38 cascade in invertebrates...
September 19, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28939294/the-novel-compound-mp407-inhibits-platelet-aggregation-through-cyclic-amp-dependent-processes
#12
Chung-Shuen Lin, Tso-Hsiao Chen, I-Hsin Lin, An-Rong Lee, Tz-Chong Chou
Platelet hyperactivity plays a critical role for initiating several vascular diseases such as atherothrombosis. Therefore, development of effective antiplatelet agents is necessary for ameliorating platelet-related diseases. In this study, we investigated the effects of the new synthesized compound, MP407 on platelet aggregation and further elucidated the underlying mechanisms. Our results demonstrated that MP407 dose-dependently inhibited collagen-induced platelet aggregation, thromboxane B2 (TXB2) production, intracellular Ca(2+) mobilization, platelet membrane GPIIb/IIIa expression, and the phosphorylation of Akt, GSK3β, p38MAPK, and phospho (Ser) PKC substrate (p47)...
September 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28939104/new-kids-on-the-block-the-popeye-domain-containing-popdc-protein-family-acting-as-a-novel-class-of-camp-effector-proteins-in-striated-muscle
#13
REVIEW
Thomas Brand, Roland Schindler
The cyclic 3',5'-adenosine monophosphate (cAMP) signalling pathway constitutes an ancient signal transduction pathway present in prokaryotes and eukaryotes. Previously, it was thought that in eukaryotes three effector proteins mediate cAMP signalling, namely protein kinase A (PKA), exchange factor directly activated by cAMP (EPAC) and the cyclic-nucleotide gated channels. However, recently a novel family of cAMP effector proteins emerged and was termed the Popeye domain containing (POPDC) family, which consists of three members POPDC1, POPDC2 and POPDC3...
September 19, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/28938894/in-vitro-progesterone-production-by-luteinized-human-mural-granulosa-cells-is-modulated-by-activation-of-ampk-and-cause-of-infertility
#14
E C Bowdridge, M W Vernon, J A Flores, M J Clemmer
BACKGROUND: Mural granulosa cells from IVF patients were provided by the West Virginia University Center for Reproductive Medicine in Morgantown, WV. The effect of adenosine monophosphate activated protein kinase (AMPK) activation, primary cause of infertility, age, BMI, and pregnancy outcome on production of progesterone were examined separately. METHODS: Isolated mural sheets from IVF patients (n = 26) were centrifuged, supernatant discarded, and the pellet re-suspended in 500 μl of DMEM/F12...
September 22, 2017: Reproductive Biology and Endocrinology: RB&E
https://www.readbyqxmd.com/read/28938518/antimicrobial-peptides-amps-the-quintessential-offense-and-defense-molecules-are-more-than-antimicrobials
#15
REVIEW
Seema Patel, Nadeem Akhtar
Antimicrobial peptides (AMPs) are cationic amphiphilic molecules with α-helix or β-sheet linear motifs and linear or cyclic configurations. For their role in 'defense and offense', they are present in all living organisms. AMPs are named so, as they inhibit a wide array of microbes by membrane pore formation and subsequent perturbation of mitochondrial membrane ionic balance. However, their functional repertoire is expanding with validated roles in cytotoxicity, wound healing, angiogenesis, apoptosis, and chemotaxis [1]...
September 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28937626/aspalathin-reverts-doxorubicin-induced-cardiotoxicity-through-increased-autophagy-and-decreased-expression-of-p53-mtor-p62-signaling
#16
Rabia Johnson, Samukelisiwe Shabalala, Johan Louw, Abidemi Paul Kappo, Christo John Frederick Muller
Doxorubicin (Dox) is an effective chemotherapeutic agent used in the treatment of various cancers. Its clinical use is often limited due to its potentially fatal cardiotoxic side effect. Increasing evidence indicates that tumour protein p53 (p53), adenosine monophosphate-activated protein kinase (AMPK), nucleoporin p62 (p62), and the mammalian target of rapamycin (mTOR) are critical mediators of Dox-induced apoptosis, and subsequent dysregulation of autophagy. Aspalathin, a polyphenolic dihydrochalcone C-glucoside has been shown to activate AMPK while decreasing the expression of p53...
September 22, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28937612/houttuynia-cordata-facilitates-metformin-on-ameliorating-insulin-resistance-associated-with-gut-microbiota-alteration-in-oletf-rats
#17
Jing-Hua Wang, Shambhunath Bose, Soo-Kyoung Lim, AbuZar Ansari, Young-Won Chin, Han Seok Choi, Hojun Kim
Metformin and Houttuynia cordata are representative anti-diabetic therapeutics in western and oriental medicine, respectively. The current study examined the synergistic anti-diabetic effect of Houttuynia cordata extraction (HCE) and metformin combination in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. Fecal microbiota were analyzed by denaturing gradient gel electrophoresis (DGGE) and real-time PCR. Combining HCE + metformin resulted in significantly ameliorated glucose tolerance (oral glucose tolerance test (OGTT))-the same as metformin alone...
September 22, 2017: Genes
https://www.readbyqxmd.com/read/28935403/suppression-of-progesterone-synthesis-in-human-trophoblast-cells-by-fine-particulate-matter-primarily-derived-from-industry
#18
Cui Wang, Jinhuan Yang, Zhengliang Hao, Chenxue Gong, Lihua Tang, Yingling Xu, Dezhao Lu, Zhuoyu Li, Meirong Zhao
Epidemiological studies have exhibited a positive association between fine particulate matter (PM2.5) exposure and adverse pregnancy outcome (APO). However, source-related effect and the potential mechanism have not been thoroughly elucidated in toxicology. In this study, PM2.5 was collected during a severe winter haze episode in an energy-base city of China. We coupled this approach with the source appointment by applying the Lagrangian Integrated Trajectory and Concentration Weighted Trajectory model. We observed that the primary trajectory with high polluted air mass came from the northwest of the sampling site...
September 18, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28935242/supplementation-of-cilostazol-during-in-vitro-maturation-enhances-the-meiosis-and-developmental-competence-of-yak-oocytes-by-influencing-camp-content-and-mrna-expression
#19
Xian-Rong Xiong, Dao-Liang Lan, Jian Li, Ya-Qiu Lin, Ming-Yang Li
The efficiency of in vitro embryo production remains low compared with that observed in vivo. Recent studies have independently shown that cyclic adenosine monophosphate (cAMP) modulation prior to in vitro maturation (IVM) supplementation improves oocyte developmental competence. In this context, special cAMP modulators have been applied during IVM as promising alternatives to improve this biotechnology. Accordingly, this study was conducted to evaluate the effects of treatment with cilostazol, a PDE3 inhibitor, during pre-IVM culture on oocyte meiotic maturation in yak...
August 24, 2017: Animal Reproduction Science
https://www.readbyqxmd.com/read/28934550/structural-and-mechanical-roles-for-the-c-terminal-non-repetitive-domain-become-apparent-in-recombinant-spider-aciniform-silk
#20
Lingling Xu, Thierry Lefèvre, Kathleen E Orrell, Qing Meng, Michèle Auger, Xiang-Qin Liu, Jan K Rainey
Spider aciniform (or wrapping) silk is the toughest of the seven types of spider silks/glue due to a combination of high elasticity and strength. Like most spider silk proteins (spidroins), aciniform spidroin (AcSp1) has a large core repetitive domain flanked by relatively short N- and C-terminal non-repetitive domains (the NTD and CTD, respectively). The major ampullate silk protein (MaSp) CTD has been shown to control protein solubility and fiber formation, but the aciniform CTD function remains unknown. Here, we compare fiber mechanical properties, solution-state structuring, and fibrous state secondary structural composition and orientation relative to native aciniform silk for two AcSp1 repeat units with or without fused AcSp1- and MaSp-derived CTDs alongside three AcSp1 repeat units without a CTD...
September 21, 2017: Biomacromolecules
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