Jace Jones-Tabah, Kathy He, Konstantin Senkevich, Nathan Karpilovsky, Ghislaine Deyab, Yuting Cousineau, Daria Nikanorova, Taylor Goldsmith, Esther Del-Cid Pellitero, Carol Xq Chen, Wen Luo, Zhipeng You, Narges Abdian, Isabella Pietrantonio, Thomas Goiran, Jamil Ahmad, Jennifer A Ruskey, Farnaz Asayesh, Dan Spiegelman, Cheryl Waters, Oury Monchi, Yves Dauvilliers, Nicolas Dupre, Irina Miliukhina, Alla Timofeeva, Anton Emelyanov, Sofya Pchelina, Lior Greenbaum, Sharon HassinBaer, Roy N Alcalay, Austen Milnerwood, Thomas M Durcan, Ziv Gan-Or, Edward A Fon
Background Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B (catB) are associated with increased risk of Parkinson's disease (PD). However, neither the specific CTSB variants driving these associations nor the functional pathways that link catB to PD pathogenesis have been characterized. CatB activity contributes to lysosomal protein degradation and regulates signaling processes involved in autophagy and lysosome biogenesis. Previous in vitro studies have found that catB can cleave monomeric and fibrillar alpha-synuclein, a key protein involved in the pathogenesis of PD that accumulates in the brains of PD patients...
March 19, 2024: Research Square