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GI symptom infant

Letizia Zenzeri, Paolo Quitadamo, Renato Tambucci, Dario Ummarino, Antonio Poziello, Erasmo Miele, Annamaria Staiano
OBJECTIVES: Respiratory symptoms are a possible atypical clinical picture of gastro-esophageal reflux disease (GERD). However, a significant number of patients with GERD-related respiratory symptoms do not report improvement despite aggressive acid-suppressive therapy. Some of these refractory cases may be due to the recently appreciated entity of non-acid or weakly acidic reflux. The aim of our study is to assess the pH-impedance features of GER inducing airway symptoms, compared with GER inducing typical gastro-intestinal (GI) symptoms...
October 13, 2016: Pediatric Pulmonology
Jean-Christoph Caubet, Hania Szajewska, Raanan Shamir, Anna Nowak-Węgrzyn
Non-IgE-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) including food protein-induced enterocolitis syndrome (FPIES), food protein-induced enteropathy (FPE) and food protein-induced allergic proctocolitis (FPIAP) are relatively uncommon in infants and young children, but are likely under-diagnosed. Non-IgE-GI-FA have a favorable prognosis, with majority resolving by age 3-5 years. Diagnosis relies on the recognition of symptoms pattern in FPIAP and FPIES and biopsy in FPE. Further studies are needed for a better understanding of the pathomechanism, which will lead eventually to the development of diagnostic tests and treatments...
September 17, 2016: Pediatric Allergy and Immunology
Kelly A Shaw, Jennifer G Mulle, Michael P Epstein, Judith L Fridovich-Keil
Classic galactosemia (CG) is an autosomal recessive disorder of galactose metabolism that affects approximately 1/50,000 live births in the USA. Following exposure to milk, which contains large quantities of galactose, affected infants may become seriously ill. Early identification by newborn screening with immediate dietary galactose restriction minimizes or prevents the potentially lethal acute symptoms of CG. However, more than half of individuals with CG still experience long-term complications including cognitive disability, behavioral problems, and speech impairment...
July 1, 2016: JIMD Reports
Hendt P Versteegh, Stephen D Adams, Sally Boxall, David M Burge, Michael P Stanton
AIM: Antenatal detection of right-sided stomach (dextrogastria) is rare, and its significance in regards to intestinal rotation is unclear. We aimed to review all cases of antenatally-diagnosed dextrogastria in our regional fetal medicine unit over 10years. METHODS: A retrospective case-note review of patients identified from a prospectively-maintained database was performed. RESULTS: Twenty cases of antenatally-diagnosed dextrogastria were identified from 2004 to 2014...
February 2016: Journal of Pediatric Surgery
Audra S Rouster, Aryn C Karpinski, David Silver, Javier Monagas, Paul E Hyman
OBJECTIVES: Symptom-based diagnostic criteria have improved recognition and standardization of pediatric functional gastrointestinal disorders (FGIDs). We used Rome 3 diagnostic criteria to determine the prevalence of FGIDs in pediatric gastroenterology clinic. In the process, we developed a diagnostic questionnaire for infants and toddlers. METHODS: We enrolled new patients ≤18 years referred during 19 months to a pediatric gastroenterology clinic. Subjects or parents completed a demographic survey and a the Questionnaire on Pediatric Gastrointestinal symptoms, Rome 3 Version (if ≥4 years, or a new infant-toddler questionnaire) before their appointment...
June 2016: Journal of Pediatric Gastroenterology and Nutrition
Alfonso R Herrera, Thomas Ludwig, Hetty Bouritius, Rocio P Rubio, Antonio Muñoz, Massimo Agosti, Gianluca Lista, Luigi T Corvaglia, Juan L P Navero
OBJECTIVES AND STUDY: Hard stools can be commonly observed in formula-fed infants, but rarely in breast fed infants. The effects on stool frequency and stool consistency of a novel infant formula were evaluated in a randomized, controlled, double-blind, multicenter, parallel-group, intervention study on gastrointestinal (GI) tolerance. The novel infant formula (FF+) combined fermented formula (Lactofidus™) with short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS, ratio 9:1, 0...
October 2015: Journal of Pediatric Gastroenterology and Nutrition
Teemu J Taipale, Kaisu Pienihäkkinen, Erika Isolauri, Jorma T Jokela, Eva M Söderling
BACKGROUND: Specific probiotic bacteria have proven to be effective in the prevention and treatment of infectious diseases in early life in at-risk populations. The impact of administration of Bifidobacterium animalis subsp. lactis BB-12 (BB-12) on the risk of acute infectious diseases was studied in healthy children. METHODS: In this double-blind, placebo-controlled study, 109 1-mo-old infants were assigned randomly to a probiotic group receiving a BB-12-containing tablet (n = 55) or a placebo (n = 54)...
January 2016: Pediatric Research
Laura Bayliss, Robert Carr, Obaghe Edeghere, Elizabeth Knapper, Kathy Nye, Gareth Harvey, Goutam Adak, Harsh Duggal
BACKGROUND: Verocytotoxin-producing Escherichia coli (VTEC) are bacteria that cause infectious gastroenteritis and in certain settings can cause widespread infection due to secondary transmission. We describe the findings of an investigation of a school-based outbreak of VTEC in Staffordshire, England. METHODS: Outbreak investigation at a school in February 2012 after two children were diagnosed with VTEC infection. Cases were defined as pupils and staff (or their household contacts) with gastrointestinal symptoms or asymptomatic screened persons, with laboratory confirmed VTEC O157 infection (phage type 32, verocytotoxin 2) occurring on or after 1 February 2012...
September 12, 2015: Journal of Public Health
Seiji P Yamamoto, Atsushi Kaida, Takuto Naito, Taisuke Hosaka, Yusuke Miyazato, Shin-ichi Sumimoto, Urara Kohdera, Atsushi Ono, Hideyuki Kubo, Nobuhiro Iritani
Human parechovirus (HPeV) infects humans early in life and typically causes asymptomatic or mild diseases such as gastrointestinal and respiratory illness but sometimes leads to more serious consequences in neonates and young infants. In 2014, we detected HPeV from 38 patients by real-time reverse transcription-PCR in Osaka City, Japan, and 33 HPeV strains were genotyped based on their VP1 sequences. HPeV genotype 3 (HPeV-3) was the most prevalent and accounted for 22 cases (66.7%) followed by nine HPeV-1 (27...
November 2015: Journal of Medical Microbiology
Hania Szajewska, Agata Skórka, Malgorzata Pieścik-Lech
UNLABELLED: Fermented formulas, i.e., those fermented with lactic acid-producing bacteria during the production process and not containing significant amounts of viable bacteria in the final product, are widely available in many countries. Our aim was to systematically review published evidence related to the safety and health effects of the administration of fermented infant formulas compared with standard infant formulas. The Cochrane Library, MEDLINE, and EMBASE databases and major pediatric conference proceedings were searched...
November 2015: European Journal of Pediatrics
Betina Hebbelstrup Jensen, Dennis Röser, Bente Utoft Andreassen, Katharina E P Olsen, Henrik Vedel Nielsen, Bent Bjørn Roldgaard, Susanne Schjørring, Hengameh Chloé Mirsepasi-Lauridsen, Steffen L Jørgensen, Esben Munk Mortensen, Andreas Munk Petersen, Karen Angeliki Krogfelt
AIM: Diarrhoea is very common in children attending day care centres. The aim of this study was to examine certain predisposing risk factors for an association with diarrhoea, including foreign travel, treatment with antibiotics, having household pets, infant colic, bottle feeding, using a pacifier and low birthweight. METHODS: A dynamic one-year follow-up cohort study comprising 179 children from 36 day care centres was conducted from September 2009 to July 2013 in Copenhagen, Denmark...
January 2016: Acta Paediatrica
Gerd Flodgren, Antoine Rachas, Andrew J Farmer, Marco Inzitari, Sasha Shepperd
BACKGROUND: Telemedicine (TM) is the use of telecommunication systems to deliver health care at a distance. It has the potential to improve patient health outcomes, access to health care and reduce healthcare costs. As TM applications continue to evolve it is important to understand the impact TM might have on patients, healthcare professionals and the organisation of care. OBJECTIVES: To assess the effectiveness, acceptability and costs of interactive TM as an alternative to, or in addition to, usual care (i...
2015: Cochrane Database of Systematic Reviews
Julie E Bines, Margaret Danchin, Pamela Jackson, Amanda Handley, Emma Watts, Katherine J Lee, Amanda West, Daniel Cowley, Mee-Yew Chen, Graeme L Barnes, Frances Justice, Jim P Buttery, John B Carlin, Ruth F Bishop, Barry Taylor, Carl D Kirkwood
BACKGROUND: Despite the success of rotavirus vaccines, suboptimal vaccine efficacy in regions with a high burden of disease continues to present a challenge to worldwide implementation. A birth dose strategy with a vaccine developed from an asymptomatic neonatal rotavirus strain has the potential to address this challenge and provide protection from severe rotavirus disease from birth. METHODS: This phase 2a randomised, double-blind, three-arm, placebo-controlled safety and immunogenicity trial was undertaken at a single centre in New Zealand between Jan 13, 2012, and April 17, 2014...
December 2015: Lancet Infectious Diseases
Miranda A L van Tilburg, Audra Rouster, David Silver, Gerard Pellegrini, John Gao, Paul E Hyman
OBJECTIVE: Functional gastrointestinal disorders (FGIDs) in infants and toddlers are common, but no questionnaire is available for use in clinic and research. The purpose of the present study was to develop and validate a questionnaire assessing symptoms associated with FGIDs in infants and toddlers. METHODS: Questions were developed based on the Rome III diagnostic criteria for FGIDs. A group of parents of children with FGIDs and experts in FGID reviewed the questionnaire for content, understandability, and completeness (face validity)...
March 2016: Journal of Pediatric Gastroenterology and Nutrition
Yvan Vandenplas, Abdelhak Abkari, Marc Bellaiche, Marc Benninga, Jean Pierre Chouraqui, FügenÇullu Çokura, Tracy Harb, Badriul Hegar, Carlos Lifschitz, Thomas Ludwig, Mohamed Miqdady, Mauro Batista de Morais, Seksit Osatakul, Silvia Salvatore, Raanan Shamir, Annamaria Staiano, Hania Szajewska, Nikhil Thapar
OBJECTIVES: The aim of the study was to review published evidence and the opinion of practising clinicians on the prevalence and long-term health consequences of functional gastrointestinal symptoms in infants younger than 12 months. METHODS: PubMed was searched from inception to November 2014 to find articles reporting the prevalence and long-term health outcomes of infantile colic, regurgitation, functional constipation, functional diarrhoea, and dyschezia in infants younger than <12 months...
November 2015: Journal of Pediatric Gastroenterology and Nutrition
Kedong Hou, Huadong Yang, Lin Zhang, Xifeng Zhang, Songhua Xiao, Ning Lu
AIMS: Tuberculosis of the upper cervical spine is a rare occurrence with serious consequence, and its optimal treatment protocol remains inconclusive. This study aims at investigating the clinical characteristics and management outcomes of the stepwise therapy for different stages of tuberculosis of the upper cervical spine. METHODS: We conducted a retrospective analysis of 11 patients with tuberculosis of the upper cervical spine who received anti-tuberculosis chemotherapy for 15 months...
2015: European Neurology
Mehmet Serif Arslan, Erol Basuguy, Hikmet Zeytun, Serkan Arslan, Bahattin Aydogdu, Mehmet Hanifi Okur, Mariah Ozkir, Ibrahim Ibiloglu, Ibrahim Uygun
Cases of neonatal gastrointestinal system (GIS) obstruction are quite complex for pediatric surgery clinics. A rare cause of intestinal obstruction is the duplication cyst (DC). A three-day-old male patient presented at our clinic with a history of abdominal distension and bilious vomiting on the second day following birth. Although pathology had not yet been determined from observation and examination, surgery was performed when the patient could not tolerate oral feeding. An ileal DC forming an incomplete obstruction was observed...
2015: Case Reports in Gastrointestinal Medicine
María Carmen Cenit, Marta Olivares, Pilar Codoñer-Franch, Yolanda Sanz
It is widely recognized that the intestinal microbiota plays a role in the initiation and perpetuation of intestinal inflammation in numerous chronic conditions. Most studies report intestinal dysbiosis in celiac disease (CD) patients, untreated and treated with a gluten-free diet (GFD), compared to healthy controls. CD patients with gastrointestinal symptoms are also known to have a different microbiota compared to patients with dermatitis herpetiformis and controls, suggesting that the microbiota is involved in disease manifestation...
August 2015: Nutrients
Molly E Raske, Molly E Dempsey, Jonathan R Dillman, Christopher E Dory, Matthew Garber, Laura L Hayes, Ramesh S Iyer, Abhaya V Kulkarni, John S Myseros, Henry E Rice, Cynthia K Rigsby, Maura E Ryan, Peter J Strouse, Sjirk J Westra, Sandra L Wootton-Gorges, Brian D Coley, Boaz Karmazyn
Vomiting is a commonly reported symptom in infants less than three months of age. There are a multitude of pathologies to consider, both within and outside the gastrointestinal tract. In addition to conducting a thorough history and physical examination, a clinician formulates a reasonable differential diagnosis by consideration of two main factors: the infant's age and the characterization of the vomit as bilious or nonbilious. In this endeavor, the clinician is able to determine if an imaging study is needed and, if so, the urgency of the request...
September 2015: Journal of the American College of Radiology: JACR
Bong Seok Choi, Suk Jin Hong, Suk Hyun Park, Heng Mi Kim, Byung-Ho Choe
Eosinophilic gastroenteritis (EGE) is a disorder characterized by eosinophilic infiltration of the bowel wall and various gastrointestinal (GI) manifestations. This study aimed to evaluate the characteristics of EGE in infants and children. A total of 22 patients were diagnosed with histologic EGE (hEGE) or possible EGE (pEGE). Serum specific IgE levels, peripheral eosinophil counts, and endoscopic biopsies were carried out. In the hEGE group (n = 13), initial symptoms included hematemesis, abdominal pain, and vomiting...
August 2015: Journal of Korean Medical Science
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