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https://www.readbyqxmd.com/read/28429337/from-acute-to-chronic-pain-tapentadol-in-the-progressive-stages-of-this-disease-entity
#1
F Coluzzi, D Fornasari, J Pergolizzi, P Romualdi
OBJECTIVE: Chronic pain is now recognized as a neural disease, which results from a maladaptive functional and structural transformation process occurring over time. In its chronic phase, pain is not just a symptom but also a disease entity. Therefore, pain must be properly addressed, as many patients still report unsatisfactory pain control despite on-going treatment. The selection of the therapy - taking into account the pathophysiological mechanisms of pain - and the right timing can result in a successful analgesic outcome...
April 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28417234/central-lumbar-spinal-stenosis-natural-history-of-non-surgical-patients
#2
Per Wessberg, Karin Frennered
PURPOSE: The aim of the present study was to examine the natural history in patients with lumbar spinal stenosis. The incidence of surgery for this condition has increased considerably during the past decades in spite of a fairly favorable natural history in previous studies. METHODS: 146 consecutive patients with clinical signs and image findings of lumbar spinal stenosis, who were not recommended surgical treatment, were followed; the reason as to why surgery was not recommended was a moderate symptom level...
April 17, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28413736/targeted-intraspinal-radiofrequency-ablation-for-lumbar-spinal-stenosis
#3
Robert E Jacobson, Michelle Granville, Jesse Hatgis DO
INTRODUCTION: By using a combination of magnetic resonance imaging (MRI) and computed tomography (CT) of the lumbar spine, it is possible to distinguish between spinal stenosis caused by bone compression and specific soft tissue epidural intraspinal lesions that cause localized spinal canal stenosis and neural compression. Examples include facet cysts and yellow ligament hypertrophy. Many of these patients are elderly with medical comorbidities that make open surgery problematic. MATERIALS & METHODS: This is a study of patients with predominantly soft tissue stenosis being treated with targeted intraspinal radiofrequency (RF) heat ablation...
March 10, 2017: Curēus
https://www.readbyqxmd.com/read/28410481/leg-symptoms-associated-with-sacroiliac-joint-disorder-and-related-pain
#4
Eiichi Murakami, Toshimi Aizawa, Daisuke Kurosawa, Kyoko Noguchi
OBJECTIVE: The symptoms of sacroiliac joint (SIJ) disorders are usually detected in the buttock and groin, and occasionally referred to the thigh and leg. However, lumbar disorders also cause symptoms in these same body regions. The presence of a characteristic, symptomatic pattern in the legs would be useful for diagnosing SIJ disorders. This study aimed to identify specific leg symptoms in patients with SIJ pain originating from the posterior sacroiliac ligament and determine the rate of occurrence of these symptoms...
March 30, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28405472/course-of-patients-with-juvenile-spondyloarthritis-during-4%C3%A2-years-of-observation-juvenile-part-of-gespic
#5
Anja Weiß, Kirsten Minden, Joachim Listing, Ivan Foeldvari, Joachim Sieper, Martin Rudwaleit
OBJECTIVE: To describe the course and the 4-year outcome of juvenile spondyloarthritis (jSpA). METHODS: Patients with a diagnosis of jSpA and an age at onset ≤16 years were included in the German Spondyloarthritis Inception cohort (GESPIC) and followed up prospectively for 4 years. RESULTS: 118 patients (73% men, 66% HLA-B27 positive, mean age 13.5 years, mean symptom duration 2.2 years) were enrolled in 2 study centres: 52% of patients with jSpA were captured by the enthesitis-related arthritis subgroup of the International League of Associations for Rheumatology classification criteria...
2017: RMD Open
https://www.readbyqxmd.com/read/28397576/association-between-sluggish-cognitive-tempo-symptoms-and-attentional-network-and-working-memory-in-primary-schoolchildren
#6
E Camprodon-Rosanas, N Ribas-Fitó, S Batlle, C Persavento, M Alvarez-Pedrerol, J Sunyer, J Forns
BACKGROUND: Few consistent data are available in relation to the cognitive and neuropsychological processes involved in sluggish cognitive tempo (SCT) symptoms. The objective of this study was to determine the association of working memory and attentional networks with SCT symptoms in primary schoolchildren. METHODS: The participants were schoolchildren aged 7 to 10 years ( n = 183) from primary schools in Catalonia (Spain). All the participants completed a working memory task (n-back) and an attentional network task (ANT)...
April 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28397030/electroencephalographic-evidence-of-altered-top-down-attentional-modulation-in-fibromyalgia-patients-during-a-working-memory-task
#7
Alberto J González-Villar, Marina Pidal-Miranda, Manuel Arias, Dolores Rodríguez-Salgado, María T Carrillo-de-la-Peña
Fibromyalgia (FM) is a chronic syndrome involving widespread pain of unclear pathophysiology. FM patients frequently complain about cognitive symptoms that interfere with their daily life activities. Several studies have reported attentional deficits and working memory impairment in FM patients. Nevertheless, the mechanisms involved in these alterations are still poorly understood. In this study we recorded electroencephalographic activity in 32 women with FM and 30 matched controls while they performed a 2-back working memory task...
April 10, 2017: Brain Topography
https://www.readbyqxmd.com/read/28391891/statin-associated-muscle-symptoms-managing-the-highly-intolerant
#8
REVIEW
James M Backes, Janelle F Ruisinger, Cheryl A Gibson, Patrick M Moriarty
Musculoskeletal symptoms are the most commonly reported adverse effects associated with statin therapy. Yet, certain data indicate that these symptoms often present in populations with underlying musculoskeletal complaints and are not likely statin related. Switching statins or using lower doses resolves muscle complaints in most patients. However, there is a growing population of individuals who experience intolerable musculoskeletal symptoms with multiple statins, regardless of the individual agent or prescribed dose...
January 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28390970/transcranial-direct-current-stimulation-can-enhance-working-memory-in-huntington-s-disease
#9
Clare M Eddy, Kimron Shapiro, Andrew Clouter, Peter C Hansen, Hugh E Rickards
Transcranial direct current stimulation (tDCS) combined with a cognitive task can enhance targeted aspects of cognitive functioning in clinical populations. The movement disorder Huntington's disease (HD) is associated with progressive cognitive impairment. Deficits in working memory (WM) can be apparent early in the disease and impact functional capacity. We investigated whether tDCS combined with cognitive training could improve WM in patients with HD, and if baseline clinical or cognitive measures may predict efficacy...
April 5, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28390165/default-mode-and-task-positive-networks-connectivity-during-the-n-back-task-in-remitted-depressed-patients-with-or-without-emotional-residual-symptoms
#10
Pauline Delaveau, Tiago Arruda Sanchez, Ricardo Steffen, Karine Deschet, Maritza Jabourian, Vincent Perlbarg, Emerson Leandro Gasparetto, Stéphanie Dubal, Jorge Costa E Silva, Philippe Fossati
Clinical remission of depression may be associated with emotional residual symptoms. We studied the association of emotional blunting, rumination with neural networks dynamics in remitted depressed patients and cognitive performance during an N-Back task. Twenty-six outpatients in remission of depression (Hamilton Depressive rating scale score <7) performed an N-Back task during fMRI assessment. All patients had been treated by paroxetine for a minimum of 4 months. Two subgroups of patients [Nonemotionally blunted (NEB) = 14 and emotionally blunted (EB) = 12] were determined...
April 8, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28385420/less-is-more-efficacy-of-rapid-3d-t2-space-in-ed-patients-with-acute-atypical-low-back-pain
#11
Nicholas A Koontz, Richard H Wiggins, Megan K Mills, Michael S McLaughlin, Elaine C Pigman, Yoshimi Anzai, Lubdha M Shah
RATIONALE AND OBJECTIVES: Emergency department (ED) patients with acute low back pain (LBP) may present with ambiguous clinical findings that pose diagnostic challenges to exclude cauda equina syndrome (CES). As a proof of concept, we aimed to determine the efficacy of a rapid lumbar spine (LS) magnetic resonance imaging (MRI) screening protocol consisting of a single 3D-T2 SPACE FS (3D-T2 Sampling Perfection with Application optimized Contrasts using different flip angle Evolution fat saturated) sequence relative to conventional LS MRI to exclude emergently treatable pathologies in this complex patient population...
April 3, 2017: Academic Radiology
https://www.readbyqxmd.com/read/28380095/translation-and-validation-of-the-portuguese-version-of-a-dry-eye-disease-symptom-questionnaire
#12
Julia Silvestre de Castro, Iara Borin Selegatto, Rosane Silvestre de Castro, José Paulo Cabral de Vasconcelos, Carlos Eduardo Leite Arieta, Mônica Alves
Purposes: A symptom questionnaire is an important tool used to quantify and qualify the impact of a disease on a patient's related quality of life and to estimate the prevalence of a certain condition within a population. Ophthalmologists frequently encounter patients with dry eye disease (DED), and therefore, evaluating the symptoms reported by these patients influences diagnosis, therapeutic monitoring, and evaluations of disease progression. The latest consensus on dry eye (Dry Eye Workshop, DEWS), published in 2007, led to the standardization of several questionnaires and a better understanding of the prevalence, severity, and overall effect of DED on the patient's quality of life...
January 2017: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28377866/revision-of-minimally-invasive-sacroiliac-joint-fixation-technical-considerations-and-case-studies-using-decortication-and-threaded-implant-fixation
#13
Brett MenMuir, Louis C Fielding
BACKGROUND: Sacroiliac joint (SIJ) disease is increasingly recognized as a common source of low back pain. Arthrodesis of the SIJ has been shown to be clinically effective for this condition. In the last decade, minimally invasive (MI) SIJ fusion procedures have been developed to achieve the clinical effectiveness of open fusion procedures, with lower operative morbidity and faster recovery. However, SIJ fusion patients occasionally present with symptomatic nonunions necessitating revision...
2017: International Journal of Spine Surgery
https://www.readbyqxmd.com/read/28377250/acute-spinal-epidural-hematoma-after-acupuncture-personal-case-and-literature-review
#14
Maurizio Domenicucci, Daniele Marruzzo, Alessandro Pesce, Antonino Raco, Paolo Missori
BACKGROUND: Spinal acupuncture is a relatively safe and common analgesic treatment, but it may be complicated by serious adverse effects such as direct spinal cord and nerve root injury, subdural empyema and epidural abscesses. In this report we are comparing our case of an extremely uncommon spinal epidural hematoma which appeared following treatment by acupuncture with other similar documented cases. CASE DESCRIPTION: This is the case of a 64-year-old man who presented a left hemiparesis associated with paraesthesias...
April 1, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28366958/back-and-neck-pain-disability-and-upper-limb-symptoms-of-home-healthcare-workers-a-case-control-study-from-northern-italy
#15
Matteo Riccò, Federica Pezzetti, Carlo Signorelli
OBJECTIVES: Work-related musculoskeletal disorders (MSD) are quite frequent in healthcare workers (HCWs), but data about MSD in home-based healthcare workers (HHWs) are lacking. In this study we describe the prevalence of MSD among Italian HHWs. MATERIAL AND METHODS: A case-control study was carried out among 300 random-selected female HCWs, the sample comprising 100 HHWs, 100 HCWs with a low exposure to patient handling (MAPO - Movimentazione e Assistenza Pazienti Ospedalizzati - Movement and Assistance of Hospital Patients index 0-5) and 100 HCWs with high exposure to patient handling (MAPO index ≥ 5...
March 30, 2017: International Journal of Occupational Medicine and Environmental Health
https://www.readbyqxmd.com/read/28366302/results-of-the-valor-ii-trial-of-the-medtronic-valiant-thoracic-stent-graft
#16
Mark F Conrad, James Tuchek, Robert Freezor, Joseph Bavaria, Rodney White, Ronald Fairman
BACKGROUND: The 1-year results of endovascular exclusion of degenerative descending thoracic aortic aneurysms (DTA) with the Valiant Thoracic Stent Graft (Medtronic Vascular, Santa Rosa, Calif) have been previously reported. With long-term follow-up now complete, the 5-year results are reported. METHODS: The VALOR II trial (Evaluation of the Clinical Performance of the Valiant Thoracic Stent Graft System in the Treatment of Descending Thoracic Aneurysms of Degenerative Etiology in Subjects Who Are Candidates for Endovascular Repair) was a prospective, nonrandomized trial of the Valiant Thoracic Stent Graft system in patients with degenerative DTA...
March 30, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28365848/attenuation-of-cortical-activity-triggering-descending-pain-inhibition-in-chronic-low-back-pain-patients-a-functional-magnetic-resonance-imaging-study
#17
Yohei Matsuo, Jiro Kurata, Miho Sekiguchi, Katsuhiro Yoshida, Takuya Nikaido, Shin-Ichi Konno
PURPOSE: A considerable portion of chronic low back pain (cLBP) patients lack anatomical abnormality, resist conventional therapeutic interventions, and their symptoms are often complicated with psychological and social factors. Such patients have been reported to show cerebral abnormalities both in anatomy and function by neuroimaging studies. Here we examined differences in cerebral reactivity to a simulated low back pain stimulus between cLBP patients and healthy controls by functional magnetic resonance imaging (fMRI), and their behavioral correlates from a psychophysical questionnaire...
April 1, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28365168/verification-of-the-sensitivity-of-functional-scores-for-treatment-results-substantial-clinical-benefit-thresholds-for-the-japanese-orthopaedic-association-back-pain-evaluation-questionnaire-joabpeq
#18
Yuichi Kasai, Mitsuru Fukui, Kazuhisa Takahashi, Seiji Ohtori, Daisaku Takeuchi, Hiroshi Hashizume, Masahiko Kanamori, Noboru Hosono, Tsukasa Kanchiku, Eiji Wada, Miho Sekiguchi, Shinichi Konno, Mamoru Kawakami
BACKGROUND: Validity and reliability of the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) had already been verified as the patients' self-rating assessment of low back pain and lumbar spinal disease and, the present study demonstrated the responsiveness of this measure. METHODS: 192 subjects who were determined by medical instructors of the Japanese Society for Spine Surgery and Related Research were analyzed. They had completed a series of treatment and both surveys before and after the treatment...
March 29, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28361297/neuropathic-pain-in-patients-with-sickle-cell-disease-a-cross-sectional-study-assessing-teens-and-young-adults
#19
Fabricio Dias Antunes, Vynicius Goltran Sobral Propheta, Hulemar Andrade Vasconcelos, Rosana Cipolotti
Chronic pain conditions are little studied and may be underestimated in sickle cell disease (SCD). The aim of this study was to identify the occurrence and characteristics of neuropathic pain (NP) in SCD patients. A sample of 56 patients was chosen from a total of 554 patients submitted to the inclusion criteria between 2015 and 2016. The Leeds assessment of neuropathic symptoms and signs scale was used for detecting NP. The groups with and without NP were compared by sex, age, use of hydroxyurea, and sensory changes through Chi-square, Fisher's exact, ANOVA, and Kruskal-Wallis tests...
March 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28359131/-sports-injuries-and-illnesses-of-the-german-national-team-during-the-2016-olympic-summer-games-in-rio-de-janeiro
#20
Casper Grim, Thilo Hotfiel, Martin Engelhardt, Syndey Plewinski, Olav Spahl, Bernd Wolfarth
Background This article aims to survey and describe the injuries and illnesses of the German Team during the 2016 Olympic Games in Rio de Janeiro. Methods Through an electronic documentation system, injuries and illnesses requiring treatment were recorded and evaluated. An injury or illness was defined as any physical symptom that required medical attention and impaired participation in training and/or competition. The classification distinguished between type of injury (acute or overload), region and type of illness (infections, skin, allergy, etc...
January 2017: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
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