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https://www.readbyqxmd.com/read/28642818/nivolumab-as-salvage-treatment-in-a-patient-with-hiv-related-relapsed-refractory-hodgkin-lymphoma-and-liver-failure-with-encephalopathy
#1
Jose D Sandoval-Sus, Francis Mogollon-Duffo, Ankita Patel, Nathan Visweshwar, Damian A Laber, Richard Kim, Michael V Jagal
BACKGROUND: We report the first case to our knowledge of a patient with relapsed/refractory classical hodgkin lymphoma and liver failure with encephalopathy along with human immunodeficiency virus/acquired immunodeficiency syndrome infection, successfully treated with nivolumab without major side effects and encouraging prolonged disease control. CASE PRESENTATION: In December 2015, at the time of the patient's progression from his Hodgkin lymphoma after fourth line treatment, he developed persistent fevers, abdominal distension, jaundice and worsening of his liver function tests...
2017: Journal for Immunotherapy of Cancer
https://www.readbyqxmd.com/read/28639407/factorial-structure-and-construct-validity-of-an-italian-version-of-the-fears-of-compassion-scales-a%C3%A2-study-on-non-clinical-subjects
#2
Francesco Dentale, Nicola Petrocchi, Michele Vecchione, Claudia Biagioli, Accursio Gennaro, Cristiano Violani
OBJECTIVES: This study was aimed at investigating the factorial structure and the construct validity of the Italian translation of the Fears of Compassion (FC) Scales in a non-clinical sample (i.e., Fear of Compassion From Others [FCFO], Fear of Compassion Towards Others [FCTO] and Fear of Self-Compassion [FSC]). An exploratory factor analysis was conducted on all the items to investigate the dimensionality of the FC scales. To assess construct validity, correlations between the FC scales and a series of construct-related measures were analysed...
June 22, 2017: Psychology and Psychotherapy
https://www.readbyqxmd.com/read/28635533/the-burden-of-endometriosis-symptoms-on-health-related-quality-of-life-in-women-in-the-united-states-a-cross-sectional-study
#3
Ahmed M Soliman, Karin S Coyne, Erica Zaiser, Jane Castelli-Haley, Mahesh J Fuldeore
INTRODUCTION: To examine the symptomatic burden of endometriosis on health-related quality of life (HRQL) in women in the United States (US). METHODS: A cross sectional web-based survey study was conducted among women using survey panels. The survey included study-specific questions and standardized HRQL questionnaires. Participants reviewed a list of endometriosis symptoms and selected all symptoms they had ever or were currently experiencing. For current symptoms, participants rated the severity and bothersomeness of each symptom...
February 21, 2017: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28632548/are-modic-changes-able-to-help-us-in-our-clinical-practice-a-study-of-the-modic-changes-in-young-adults-during-working-age
#4
José V Martínez-Quiñones, José Aso-Escario, Laura González-García, Fabián Consolini, Ricardo Arregui-Calvo
STUDY DESIGN: Modic changes [vertebral endplate spinal changes (VESC)] have been related to degenerative disk disease, and in past decades it was thought that their presence justified the surgical treatment, in particular spinal fusion. OBJECTIVE: The aim of the present study is to investigate its prevalence and features in a population of young workers suffering from low back pain, and explore the eventual relationship with the treatment applied in each case. BACKGROUND DATA: We conducted a retrospectively review of 450 magnetic resonance images from our hospital, in patients with low back pain or sciatica and age below 40...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28631069/-s2-ala-iliac-screws-for-extended-pelvic-fixation-in-longer-lumbar-instrumentations-description-of-a-freehand-technique
#5
REVIEW
F Lattig, S Weckbach
OBJECTIVE: To reduce the rate of implant failures at the lumbosacral junction in polysegmental lumbar fusions. INDICATIONS: Spinal fusion with deformity correction including L5/S1, revision surgery for pseudoarthrosis L5/S1, screw pull-out and pedicle fractures in S1, and S1/S2 fractures after polysegmental fusions. CONTRAINDICATIONS: Osteosynthesis of complex pelvic ring fractures, tumors of the ilium. Relative contraindication: infection, to avoid contamination of the iliosacral joint...
June 19, 2017: Operative Orthopädie und Traumatologie
https://www.readbyqxmd.com/read/28624722/age-related-differences-in-the-response-of-the-l5-s1-intervertebral-disc-to-spinal-traction
#6
Ulrike H Mitchell, Paul F Beattie, Jennifer Bowden, Robert Larson, Haonan Wang
BACKGROUND: Lumbar traction is a common treatment for low back pain; however its mechanisms of action are poorly understood. It has been hypothesized that a key effect of lumbar traction is its capacity to influence fluid movement within the intervertebral disc (IVD). OBJECTIVES: To determine differences in the apparent diffusion coefficient (ADC) obtained with lumbar diffusion-weighted imaging (DWI) of the L5-S1 IVD before, and during, the application of lumbar traction...
June 9, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28619301/the-effects-of-gua-sha-on-symptoms-and-inflammatory-biomarkers-associated-with-chronic-low-back-pain-a-randomized-active-controlled-crossover-pilot-study-in-elderly
#7
John W M Yuen, William W N Tsang, Sonny H M Tse, Wings T Y Loo, Suk-Tak Chan, Diana L Y Wong, Hilary H Y Chung, Jacky K K Tam, Thomas K S Choi, Vico C L Chiang
OBJECTIVE: To address the challenges for trialing with elderly and the lacking of valid sham/placebo control, a randomized crossover pilot study is designed and its feasibility on elderly subjects is evaluated. DESIGN: A pilot randomized crossover study was conducted with hydrocollator-based hot pack therapy as active control. Pain intensity, physical disability, depression, general health status, and salivary biomarkers were assessed as outcome measures. RESULTS: Despite there was no significant difference observed between any outcome measures attained by the two interventions, several important differences were noted during the one-week follow-up period...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28614434/post-stroke-psychosis-how-long-should-we-treat
#8
Maria do Céu Ferreira, Célia Machado, Beatriz Santos, Álvaro Machado
Objective: To describe a rare case of a patient who developed psychotic symptoms after a right stroke that disappeared with antipsychotic treatment, but appears to need low-dose maintenance antipsychotic therapy. Case description: A 65-year-old man presented at the psychiatric emergency service with a history of persistent delusional jealousy, visual illusions and agitation with onset about 1 month after a right posterior cerebral artery ischemic stroke. These symptoms only disappeared with therapeutic dosages of an antipsychotic drug (3 mg/day of risperidone)...
June 12, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28611320/prevalence-of-low-back-pain-and-carpal-tunnel-syndrome-among-dental-practitioners-in-dakshina-kannada-and-coorg-district
#9
D Anupama Prasad, Drithi Appachu, Vinayak Kamath, D Krishna Prasad
CONTEXT: Dental practitioners who usually have to work for long durations in a particular fixed posture are more prone to musculoskeletal disorders (MSDs), particularly those involving the hand and wrist and also of the lower back. AIMS: To study the prevalence of carpal tunnel syndrome (CTS) and low back pain (LBP) among dental practitioners and to correlate the symptoms with the duration of practice. SUBJECTS AND METHODS: A closed-end questionnaire was distributed to 100 dental practitioners from Dakshina Kannada and Coorg districts of Karnataka, India...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28609182/infrared-thermography-reveals-effect-of-working-posture-on-skin-temperature-in-office-workers
#10
Roope Lasanen, Markus K H Malo, Olavi Airaksinen, Jari Karhu, Juha Töyräs, Petro Julkunen
INTRODUCTION: Musculoskeletal symptoms related to using traditional computer workstations are common. To improve ergonomics of workstations quantitative methods for measuring muscle stress and strain are needed. We hypothesize that infrared thermography (IRT) is suited for this purpose. METHODS: This hypothesis was evaluated by estimating muscle activity in upright and traditional working postures with IRT and surface electromyography (sEMG). IRT and sEMG measurements were conducted in 14 female participants with both working postures...
June 13, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/28607896/a-survey-of-work-related-musculoskeletal-disorders-among-otolaryngologists
#11
Twinkle Dabholkar, Sujata Yardi, Yogesh G Dabholkar, Haritosh K Velankar, Gaurav Ghuge
There are increased reports of prevalence of work-related musculoskeletal disorders (WRMSDs) in surgeons performing minimal access surgeries. Due to the nature of the speciality, otolaryngologists spend their work days in performing markedly precise procedures in small workspaces i.e. the patients' ear, nose and throat. Due to this, they frequently adopt awkward neck, back and shoulder postures while using devices like otoscope, endoscope and microscope. The field of otolaryngology has barely received any attention with respect to ergonomic assessment...
June 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/28600230/cytokine-and-chemokine-profile-changes-in-patients-with-lower-segment-lumbar-degenerative-spondylolisthesis
#12
Juraj Sutovsky, Martin Benco, Martina Sutovska, Michaela Kocmalova, Lenka Pappova, Juraj Miklusica, Andrej Frano, Egon Kurca
BACKGROUND: Lumbar degenerative spondylolisthesis (DS) develops as a result of inflammatory and remodeling processes in facet joints (FJs). Several inflammatory cytokines are involved in the osteoarthritic and remodeling changes that occur and in low-back and/or radicular pain, the most prevalent clinical symptom of disease. This study improves knowledge related to the roles that 27 cytokines, chemokines and growth factors play in the pathophysiology of lumbar DS. MATERIAL AND METHODS: Cytokine levels were examined using capture sandwich immunoassay using the Bio-Plex(®) 200 System and the Bio-PlexTM Human Cytokine Standard 27-Plex, Group I (Bio-Rad, Hercules, California, USA) separately in intervertebral discs (IVDs) and FJ bone tissue...
June 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28594195/pain-related-anxiety-as-a-predictor-of-early-lapse-and-relapse-to-cigarette-smoking
#13
Lisa R LaRowe, Kirsten J Langdon, Michael J Zvolensky, Emily L Zale, Joseph W Ditre
Although emerging research suggests that pain-related anxiety may play a role in the maintenance of tobacco dependence, no previous work has examined pain-related anxiety as a predictor of smoking cessation outcomes. The current study aimed to test the hypothesis that pain-related anxiety would predict early lapse and relapse to cigarette smoking. These data were collected in the context of a primary study examining the role of emotional vulnerabilities in smoking cessation. The current analyses were conducted among 55 daily cigarette smokers who attempted to quit without psychosocial or pharmacological cessation aids...
June 8, 2017: Experimental and Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28592580/the-influence-of-multisite-pain-and-psychological-comorbidity-on-prognosis-of-chronic-low-back-pain-longitudinal-data-from-the-norwegian-hunt-study
#14
Anne Lovise Nordstoga, Tom Ivar Lund Nilsen, Ottar Vasseljen, Monica Unsgaard-Tøndel, Paul Jarle Mork
OBJECTIVES: This study aimed to investigate the prospective influence of multisite pain, depression, anxiety, self-rated health and pain-related disability on recovery from chronic low back pain (LBP). SETTING: The data is derived from the second (1995-1997) and third (2006-2008) wave of the Nord-Trøndelag Health Study (HUNT) in Norway. PARTICIPANTS: The study population comprises 4484 women and 3039 men in the Norwegian HUNT Study who reported chronic LBP at baseline in 1995-1997...
June 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28591044/factors-associated-with-chronic-musculoskeletal-pain-in-japanese-community-dwelling-older-adults-a-cross-sectional-study
#15
Tatsuya Hirase, Hideki Kataoka, Shigeru Inokuchi, Jiro Nakano, Junya Sakamoto, Minoru Okita
Identifying older adults with chronic musculoskeletal pain (CMP) earlier is urgent because CMP is reportedly associated with deterioration in physical function, poor psychological status, and low physical activity level. The objective of this study was to identify factors that were most strongly associated with CMP in Japanese community-dwelling older adults.Using a cross-sectional design, we assessed 263 older adults (mean age = 79.1 ± 5.9 years, 85.9% women) who participated in community exercise classes...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28587123/work-related-musculoskeletal-disorders-and-risk-factors-among-chinese-medical-staff-of-obstetrics-and-gynecology
#16
Jingjing Wang, Ya Cui, Lihua He, Xiangrong Xu, Zhiwei Yuan, Xianning Jin, Zhimin Li
Medical staff in the department of obstetrics and gynecology are a group of professionals reportedly at high risk of work-related musculoskeletal disorders (WMSD), however, little is known about the current status of this problem in China. The aim of this study was to investigate prevalence and risk factors of work-related musculoskeletal disorders among this population in China. A self-developed questionnaire was distributed to 1017 obstetrics and gynecology practitioners to collect information on musculoskeletal symptoms and relevant factors...
May 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28583869/total-disc-replacement-versus-multidisciplinary-rehabilitation-in-patients-with-chronic-low-back-pain-and-degenerative-discs-eight-year-follow-up-of-a-randomized-controlled-multicenter-trial
#17
Håvard Furunes, Kjersti Storheim, Jens Ivar Brox, Lars Gunnar Johnsen, Jan Sture Skouen, Eric Franssen, Tore K Solberg, Leiv Sandvik, Christian Hellum
BACKGROUND CONTEXT: Lumbar total disc replacement is a treatment option for selected patients with chronic low back pain that is non-responsive to conservative treatment. The long-term results of disc replacement compared to multidisciplinary rehabilitation have not been reported previously. PURPOSE: We aimed to assess the long-term relative efficacy of lumbar total disc replacement compared to multidisciplinary rehabilitation. DESIGN: We undertook a multicenter randomized controlled trial at five university hospitals in Norway...
June 2, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28582951/the-effects-of-physical-and-psychosocial-factors-and-ergonomic-conditions-on-the-prevalence-of-musculoskeletal-disorders-among-dentists-in-malaysia
#18
Mohd Firdaus Mohd Taib, Sangwoo Bahn, Myung Hwan Yun, Mohd Syukri Mohd Taib
BACKGROUND: Musculoskeletal disorders (MSDs) have been recognized as one of the main occupational health problems for dentists. Many studies have suggested that dentists experience work-related pain or discomfort in the neck, shoulder, and back, as well as in other parts of the body. OBJECTIVE: This study aimed to examine the relationship between specific physical and psychosocial factors and/or ergonomic conditions on MSD symptoms among dentists in Malaysia. METHODS: A group of 85 dentists was asked to complete a questionnaire to determine whether their complaints were related to physical and psychosocial factors and/or ergonomic conditions in their practices...
June 1, 2017: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/28551282/bowel-bladder-dysfunction-and-numbness-in-the-sole-of-the-both-feet-in-lumbar-spinal-stenosis-a-multicenter-cross-sectional-study
#19
Kazuyuki Watanabe, Miho Sekiguchi, Koji Yonemoto, Takuya Nikaido, Kinshi Kato, Koji Otani, Shoji Yabuki, Tatsuyuki Kakuma, Shin-Ichi Kikuchi, Shin-Ichi Konno
BACKGROUND: Numbness in the soles of both feet at rest or bowel/bladder dysfunction can occur in patients with lumbar spinal stenosis (LSS), especially in patients with cauda equina lesions. The purpose of this study was to clarify the relationship between cauda equina symptoms at rest and quality of life (QOL) in LSS patients using standardized questionnaires developed for the Japanese population. METHODS: A survey was conducted in 564 hospitals and general practice clinics nationwide from December 1, 2011 to December 31, 2012...
May 24, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28549339/typical-and-atypical-presenting-symptoms-of-breast-cancer-and-their-associations-with-diagnostic-intervals-evidence-from-a-national-audit-of-cancer-diagnosis
#20
Minjoung Monica Koo, Christian von Wagner, Gary A Abel, Sean McPhail, Greg P Rubin, Georgios Lyratzopoulos
INTRODUCTION: Most symptomatic women with breast cancer have relatively short diagnostic intervals but a substantial minority experience prolonged journeys to diagnosis. Atypical presentations (with symptoms other than breast lump) may be responsible. METHODS: We examined the presenting symptoms of breast cancer in women using data from a national audit initiative (n=2316). Symptoms were categorised topographically. We investigated variation in the length of the patient interval (time from symptom onset to presentation) and the primary care interval (time from presentation to specialist referral) across symptom groups using descriptive analyses and quantile regression...
May 23, 2017: Cancer Epidemiology
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