Aidan M Rose, Lindsay C Spender, Christopher Stephen, Alastair Mitchell, William Rickaby, Susan Bray, Alan T Evans, Jasbani Dayal, Karin J Purdie, Catherine A Harwood, Charlotte M Proby, Irene M Leigh, Philip J Coates, Gareth J Inman
The incidence of cutaneous squamous cell carcinoma (cSCC) is rising. Whilst the majority are cured surgically, aggressive metastatic cSCC carry a poor prognosis. Inactivating mutations in transforming growth factor beta (TGF-β) receptors have been identified amongst genetic drivers of sporadic tumours and murine models of cSCC, suggesting a tumour suppressor function for TGF-β in normal skin. However, paradoxically, TGF-β acts as a tumour promoter in some murine model systems. Few studies have analysed the role of TGF-β/activin signalling in human normal skin, hyper-proliferative skin disorders and cSCC...
March 6, 2018: Oncotarget