Veronica Loyo-Celis, Devendra Patel, Shridhar Sanghvi, Kamalpreet Kaur, Devasena Ponnalagu, Yang Zheng, Sahej Bindra, Harmeet Rireika Bhachu, Isabelle Deschenes, Shubha Gururaja Rao, Harpreet Singh
Chloride intracellular channels (CLICs) are a family of proteins that exist in soluble and transmembrane forms. The newest discovered member of the family CLIC6 is implicated in breast, ovarian, lung gastric, and pancreatic cancers, and is also known to interact with dopamine-(D(2)-like) receptors. The soluble structure of the channel has been resolved but the exact physiological role of CLIC6, biophysical characterization, and the membrane structure remains unknown. Here we aimed to characterize the biophysical properties of this channel using a patch-clamp approach...
October 12, 2023: Journal of Biological Chemistry