keyword
https://read.qxmd.com/read/38494618/xdemvy-tm-lotilaner-ophthalmic-solution-0-25-topical-solution-for-the-treatment-of-demodex-blepharitis
#21
JOURNAL ARTICLE
Aditya K Gupta, Avantika Mann, Kimberly Vincent, William Abramovits
XdemvyTM (lotilaner ophthalmic solution) 0.25% topical solution was recently approved for the treatment of Demodex blepharitis in adults aged ≥18 years. As an antiparasitic agent, lotilaner selectively inhibits gamma-aminobutyric acid chloride channels specific to the parasite and induces spastic paralysis, leading to death of Demodex blepharitis mites. In two randomized, double-masked, vehicle-controlled, multi-center, phase-3 clinical trials (Saturn-1 and Satuirn-2), lotilaner 0.25% topical solution was investigated for the treatment of Demodex blepharitis...
2024: Skinmed
https://read.qxmd.com/read/38493646/microplastics-in-packaged-water-community-stored-water-groundwater-and-surface-water-in-rivers-of-tamil-nadu-after-the-covid-19-pandemic-outbreak
#22
JOURNAL ARTICLE
K Pavithra, Tharmaraj Vairaperumal, Vignesh Ks, Moitraiyee Mukhopadhyay, P Malar, Paromita Chakraborty
The increased load of plastic in waste streams after the COVID-19 pandemic outbreak has increased the possibility of microplastics (MPs) contamination channelling through the rivers and infiltrating the aquatic ecosystems. MPs in packaged water, community-stored water, groundwater, and surface water of Kaveri River (KR), Thamirabarani River (TR), Adyar River (AR), and Cooum River (CR) in Tamil Nadu were therefore investigated about 2 years after the COVID-19 pandemic outbreak. Using μFTIR and μRaman spectroscopy, polyamide, polypropylene, polyethylene, ethylene vinyl alcohol copolymer resin, and polyvinyl chloride were identified as the primary polymer types...
March 16, 2024: Journal of Environmental Management
https://read.qxmd.com/read/38493004/cftr-function-is-impaired-in-a-subset-of-patients-with-pancreatitis-carrying-rare-cftr-variants
#23
JOURNAL ARTICLE
Dora Angyal, Karina Kleinfelder, Fabiana Ciciriello, Tessa A Groeneweg, Giulia De Marchi, Nicolò de Pretis, Laura Bernardoni, Luca Rodella, Francesco Tomba, Paola De Angelis, Cecilia Surace, Emily Pintani, Federico Alghisi, Hugo R de Jonge, Paola Melotti, Claudio Sorio, Vincenzina Lucidi, Marcel J C Bijvelds, Luca Frulloni
BACKGROUND: Many affected by pancreatitis harbor rare variants of the cystic fibrosis (CF) gene, CFTR, which encodes an epithelial chloride/bicarbonate channel. We investigated CFTR function and the effect of CFTR modulator drugs in pancreatitis patients carrying CFTR variants. METHODS: Next-generation sequencing was performed to identify CFTR variants. Sweat tests and nasal potential difference (NPD) assays were performed to assess CFTR function in vivo. Intestinal current measurement (ICM) was performed on rectal biopsies...
March 10, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38484520/polyelectrolyte-modified-black-phosphorus-titania-nanosheet-heterojunction-enhanced-photocatalysis-synergistic-enhancement-effect-of-interface-affinity-and-electron-transport-channel
#24
JOURNAL ARTICLE
Hui Zhao, Derui Liang, Qian Zhang, Zihan Zhang, Xu Ma, Ning Zhang, Menglan Zhao, Yu Wang, Zilin Meng, Hailin Cong
The instability and high electron-hole recombination have limited the application of black phosphorus (BP) as an excellent photocatalyst. To address these challenges, poly dimethyl diallyl ammonium chloride (PDDA), poly (allylamine hydrochloride) (PAH), and polyethyleneimine (PEI) are introduced to the functionalization of BP (F-BP), which can not only enhance its stability, but also boost the carrier transfer. Furthermore, a high-performance heterojunction photocatalyst is fabricated using F-BP and titania nanosheets (TNs) via a layer-by-layer self-assembly approach...
March 11, 2024: Journal of Colloid and Interface Science
https://read.qxmd.com/read/38483547/the-pde4-inhibitors-roflumilast-and-rolipram-rescue-ado2-osteoclast-resorption-dysfunction
#25
JOURNAL ARTICLE
Jung Min Hong, Rita L Gerard-O'Riley, Dena Acton, Imranul Alam, Michael J Econs, Angela Bruzzaniti
Autosomal Dominant Osteopetrosis type II (ADO2) is a rare bone disease of impaired osteoclastic bone resorption caused by heterozygous missense mutations in the chloride channel 7 (CLCN7). Adenylate cyclase, which catalyzes the formation of cAMP, is critical for lysosomal acidification in osteoclasts. We found reduced cAMP levels in ADO2 osteoclasts compared to wild-type (WT) osteoclasts, leading us to examine whether regulating cAMP would improve ADO2 osteoclast activity. Although forskolin, a known activator of adenylate cyclase and cAMP levels, negatively affected osteoclast number, it led to an overall increase in ADO2 and WT osteoclast resorption activity in vitro...
March 14, 2024: Calcified Tissue International
https://read.qxmd.com/read/38478568/field-application-of-de-novo-transcriptomic-analysis-to-evaluate-the-effects-of-sublethal-freshwater-salinization-on-gasterosteus-aculeatus-in-urban-streams
#26
JOURNAL ARTICLE
Camilo Escobar-Sierra, Kathrin P Lampert
Freshwater salinization poses global challenges for aquatic organisms inhabiting urban streams, impacting their physiology and ecology. However, current salinization research predominantly focuses on mortality endpoints in limited model species, overlooking the sublethal effects on a broader spectrum of organisms and the exploration of adaptive mechanisms and pathways under natural field conditions. To address these gaps, we conducted high-throughput sequencing transcriptomic analysis on the gill tissue of the euryhaline fish Gasterosteus aculeatus, investigating its molecular response to salinity stress in the highly urbanized river Boye, Germany...
2024: PloS One
https://read.qxmd.com/read/38478312/influence-of-industrial-waste-and-mineral-admixtures-on-durability-and-sustainability-of-high-performance-concrete
#27
JOURNAL ARTICLE
Raghubir Singh, Moinul Haq, Rizwan Ahmad Khan
The present research explores the strength, durability, microstructure, embodied energy, and global warming potential investigations made toward cleaner production of high-performance concrete (HPC) using a new composition. For this, various mixes were considered by replacing cement with metakaolin (MK) and silica fumes (SF) while simultaneously altering fine aggregates with industrial waste, copper slag (CS) in 0%, 25%, 50%, 75%, and 100% at 0.23 w/b ratio. The observations on fresh properties show a decrease in the slump due to pozzolans MK and SF but get compensated by the inclusion of copper slag simultaneously...
March 13, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38474548/establishing-an-ano1-based-cell-model-for-high-throughput-screening-targeting-trpv4-regulators
#28
JOURNAL ARTICLE
Kai Zheng, Jiang Hu, Cheng Hu, Xueying Liu, Yanyan Wang, Haojian Han, Wenzhu Xing, Liu Yang, Junran Zhang, Qiyuan Hong, Feng Hao, Wenliang Li
Transient receptor potential vanilloid 4 (TRPV4) is a widely expressed cation channel that plays an important role in many physiological and pathological processes. However, most TRPV4 drugs carry a risk of side effects. Moreover, existing screening methods are not suitable for the high-throughput screening (HTS) of drugs. In this study, a cell model and HTS method for targeting TRPV4 channel drugs were established based on a calcium-activated chloride channel protein 1 Anoctamin 1 (ANO1) and a double mutant (YFP-H148Q/I152L) of the yellow fluorescent protein (YFP)...
February 28, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38474002/pathophysiological-roles-of-ion-channels-in-epidermal-cells-immune-cells-and-sensory-neurons-in-psoriasis
#29
REVIEW
Hyungsup Kim, Mi Ran Choi, Seong Ho Jeon, Yongwoo Jang, Young Duk Yang
Psoriasis is a chronic inflammatory skin disease characterized by the rapid abnormal growth of skin cells in the epidermis, driven by an overactive immune system. Consequently, a complex interplay among epidermal cells, immune cells, and sensory neurons contributes to the development and progression of psoriasis. In these cellular contexts, various ion channels, such as acetylcholine receptors, TRP channels, Ca2+ release-activated channels, chloride channels, and potassium channels, each serve specific functions to maintain the homeostasis of the skin...
February 27, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38473107/variants-in-clcn1-and-pde4c-associated-with-muscle-hypertrophy-dysphagia-and-gait-abnormalities-in-young-french-bulldogs
#30
JOURNAL ARTICLE
G Diane Shelton, James R Mickelson, Steven G Friedenberg, Jonah N Cullen, Karina Graham, Missy C Carpentier, Ling T Guo, Katie M Minor
(1) Background: Muscle hypertrophy, swallowing disorders, and gait abnormalities are clinical signs common to many muscle diseases, including muscular dystrophies, non-dystrophic myotonias, genetic myopathies associated with deficiency of myostatin, and acquired inflammatory myopathies. Here, we investigated underlying causes of this triad of clinical signs in four young French bulldogs via muscle histopathology coupled with whole genome and Sanger sequencing. (2) Methods: Dogs were evaluated by veterinary clinical internists and neurologists, and biopsies were obtained for histopathological diagnosis...
February 25, 2024: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/38459671/naphthalene-diimide-based-metallacage-as-an-artificial-ion-channel-for-chloride-ion-transport
#31
JOURNAL ARTICLE
Qing-Hui Ling, Yuanyuan Fu, Zhen-Chen Lou, Bangkun Yue, Chenxing Guo, Xinyu Hu, Weiqiang Lu, Lianrui Hu, Wei Wang, Min Zhang, Hai-Bo Yang, Lin Xu
Developing synthetic molecular devices for controlling ion transmembrane transport is a promising research field in supramolecular chemistry. These artificial ion channels provide models to study ion channel diseases and have huge potential for therapeutic applications. Compared with self-assembled ion channels constructed by intermolecular weak interactions between smaller molecules or cyclic compounds, metallacage-based ion channels have well-defined structures and can exist as single components in the phospholipid bilayer...
March 8, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://read.qxmd.com/read/38456531/production-of-positronium-chloride-a-study-of-the-charge-exchange-reaction-between-ps-and-cl
#32
JOURNAL ARTICLE
K Lévêque-Simon, A Camper, R Taïeb, J Caillat, C Lévêque, E Giner
We present cross sections for the formation of positronium chloride (PsCl) in its ground state from the charge exchange between positronium (Ps) and chloride (Cl-) in the range of 10 meV-100 eV Ps energy. We have used theoretical models based on the first Born approximation in its three-body formulation. We simulated the collisions between Ps and Cl- using ab initio binding energies and positronic wave functions at both the mean-field and correlated levels extrapolated to the complete basis set limit...
March 14, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38453905/chloride-intracellular-channel-clic-proteins-function-as-fusogens
#33
JOURNAL ARTICLE
Bar Manori, Alisa Vaknin, Pavla Vaňková, Anat Nitzan, Ronen Zaidel-Bar, Petr Man, Moshe Giladi, Yoni Haitin
Chloride Intracellular Channel (CLIC) family members uniquely transition between soluble and membrane-associated conformations. Despite decades of extensive functional and structural studies, CLICs' function as ion channels remains debated, rendering our understanding of their physiological role incomplete. Here, we expose the function of CLIC5 as a fusogen. We demonstrate that purified CLIC5 directly interacts with the membrane and induces fusion, as reflected by increased liposomal diameter and lipid and content mixing between liposomes...
March 7, 2024: Nature Communications
https://read.qxmd.com/read/38444426/gene-expression-analysis-of-a-topical-serum-comprised-of-plant-based-adaptogens-developed-to-support-homeostasis-and-skin-quality
#34
JOURNAL ARTICLE
Zoe Diana Draelos, Pearl E Grimes, Jacqueline Watchmaker, Diane B Nelson
OBJECTIVE: A topical serum comprised of plant-based adaptogens was purposefully developed to support the ability of the skin to adapt and achieve balance. The study described herein evaluated changes in the expression of target genes related to skin homeostasis following topical exposure. METHODS: Utilizing an in vitro epidermal skin model, quantitative polymerase chain reaction (qPCR) analysis of gene expression was conducted following 48-hour exposure to 15μL of the study product (MYS serum) to the surface of each tissue (N=4)...
February 2024: Journal of Clinical and Aesthetic Dermatology
https://read.qxmd.com/read/38442240/impact-of-cftr-modulation-on-pseudomonas-aeruginosa-infection-in-people-with-cystic-fibrosis
#35
JOURNAL ARTICLE
Emma L Ledger, Daniel J Smith, Jing Jie Teh, Michelle E Wood, Page E Whibley, Mark Morrison, Joanna B Goldberg, David W Reid, Timothy J Wells
BACKGROUND: Pseudomonas aeruginosa is a multidrug-resistant pathogen causing recalcitrant pulmonary infections in people with cystic fibrosis (pwCF). Cystic fibrosis transmembrane conductance regulator (CFTR) modulators have been developed that partially correct the defective chloride channel driving disease. Despite the many clinical benefits, studies in adults have demonstrated that while P. aeruginosa sputum load decreases, chronic infection persists. Here, we investigate how P. aeruginosa in pwCF may change in the altered lung environment after CFTR modulation...
March 5, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38428069/a-skin-interfaced-miniaturized-platform-for-triggered-induction-capture-and-colorimetric-multicomponent-analysis-of-microliter-volumes-of-sweat
#36
JOURNAL ARTICLE
Joohee Kim, Seyong Oh, Da Som Yang, Larissa Rugg, Radhika Mathur, Sung Soo Kwak, Seonggwang Yoo, Shupeng Li, Evangelos E Kanatzidis, Geumbee Lee, Hong-Joon Yoon, Yonggang Huang, Roozbeh Ghaffari, Susanna A McColley, John A Rogers
Eccrine sweat can serve as a source of biomarkers for assessing physiological health and nutritional balance, for tracking loss of essential species from the body and for evaluating exposure to hazardous substances. The growing interest in this relatively underexplored class of biofluid arises in part from its non-invasive ability for capture and analysis. The simplest devices, and the only ones that are commercially available, exploit soft microfluidic constructs and colorimetric assays with purely passive modes of operation...
February 23, 2024: Biosensors & Bioelectronics
https://read.qxmd.com/read/38422021/structural-basis-for-cftr-inhibition-by-cftr-inh-172
#37
JOURNAL ARTICLE
Paul G Young, Jesper Levring, Karol Fiedorczuk, Scott C Blanchard, Jue Chen
The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel that regulates electrolyte and fluid balance in epithelial tissues. While activation of CFTR is vital to treating cystic fibrosis, selective inhibition of CFTR is a potential therapeutic strategy for secretory diarrhea and autosomal dominant polycystic kidney disease. Although several CFTR inhibitors have been developed by high-throughput screening, their modes of action remain elusive. In this study, we determined the structure of CFTR in complex with the inhibitor CFTRinh -172 to an overall resolution of 2...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38421468/ivermectin-exerts-anticonvulsant-effects-against-status-epilepticus-induced-by-lithium-pilocarpine-in-rats-via-gaba-a-receptor-and-neuroinflammation-modulation-possible-interaction-of-opioidergic-pathways-and-k-atp-channel-with-nitrergic-system
#38
JOURNAL ARTICLE
Mohammad Amin Manavi, Samaneh Toutounchian, Sahar Afsahi, Zahra Ebrahim Soltani, Razieh Mohammad Jafari, Ahmad Reza Dehpour
Status epilepticus (SE) is a critical medical emergency marked by persistent or rapidly repeating seizures, posing a threat to life. Using the lithium-pilocarpine-induced SE model, we decide to evaluate the anti-seizure effects of ivermectin as a positive allosteric modulator of GABAA receptor and the underlying mechanisms involved. Lithium chloride was injected intraperitoneally at a dose of 127 mg/kg, followed by the administration of pilocarpine at a dose of 60 mg/kg after a 20-h interval in order to induce SE...
February 29, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38419371/concentration-driven-evolution-of-adaptive-artificial-ion-channels-or-nanopores-with-specific-anticancer-activities
#39
JOURNAL ARTICLE
Zhiqing Chen, Xiaopan Xie, Chunyan Jia, Qishuo Zhong, Qiuping Zhang, Daoxin Luo, Yin Cao, Yuguang Mu, Changliang Ren
In nature, ceramides are a class of sphingolipids possessing a unique ability to self-assemble into protein-permeable channels with intriguing concentration-dependent adaptive channel cavities. However, within the realm of artificial ion channels, this interesting phenomenon is scarcely recaptured. Herein, we report on a novel class of adaptive artificial channels, Pn-TPPs, based on PEGylated cholic acids bearing triphenylphosphonium (TPP) groups as anion binding motifs. Interestingly, the molecules self-assemble into chloride ion channels at low concentrations, while transforming into small molecule-permeable nanopores at high concentrations...
February 28, 2024: Angewandte Chemie
https://read.qxmd.com/read/38411570/circadian-rhythm-regulation-by-pacemaker-neuron-chloride-oscillation-in-flies
#40
REVIEW
Aylin R Rodan
Circadian rhythms in physiology and behavior sync organisms to external environmental cycles. Here, circadian oscillation in intracellular chloride in central pacemaker neurons of the fly, Drosophila melanogaster , is reviewed. Intracellular chloride links SLC12 cation-coupled chloride transporter function with kinase signaling and the regulation of inwardly rectifying potassium channels.
February 27, 2024: Physiology
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