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https://www.readbyqxmd.com/read/29031092/one-step-synthesis-of-silicon-carbide-foams-supported-hierarchical-porous-sludge-derived-activated-carbon-as-efficient-odor-gas-adsorbent
#1
Jingling Yang, Wenjun Xu, Chun He, Yajing Huang, Zaili Zhang, Yunchen Wang, Lingling Hu, Dehua Xia, Dong Shu
Hierarchical porous sludge-derived activated carbon coated on macroporous silicon carbide (SiC) foams substrate has been facilely fabricated via a simple one-step strategy by utilizing sludge as carbon source, and jointly using zinc chloride and hexadecanol as pore forming agents. The sludge-derived carbon has been confirmed to be hierarchical macro-meso-microporous structure based on detailed characterization by scanning electron microscopy (SEM), X-ray diffraction (XRD), Raman spectra and nitrogen adsorption-desorption measurement...
October 2, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29023772/negative-modulation-of-the-gabaa-%C3%AF-1-receptor-function-by-l-cysteine
#2
Andrea N Beltrán González, Florencia Vicentini, Daniel J Calvo
L-Cysteine is an endogenous Sulphur containing amino acid with multiple and varied roles in the central nervous system, including neuroprotection and the maintenance of the redox balance. However, it was also suggested as an excitotoxic agent implicated in the pathogenesis of neurological disorders such as Parkinson's and Alzheimer's disease. L-Cysteine can modulate the activity of ionic channels, including voltage-gated calcium channels and glutamatergic NMDA receptors, whereas its effects on GABAergic neurotransmission had not been studied before...
October 10, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29022974/the-mechanism-of-cesium-ions-immobilization-in-the-nanometer-channel-of-calcium-silicate-hydrate-a-molecular-dynamics-study
#3
Jinyang Jiang, Pan Wang, Dongshuai Hou
The cement-based matrices are preferred candidates in disposing nuclear waste due to the immobilization role of the calcium-silicate-hydrate (C-S-H) gel. To better understand the immobilization mechanism of cementitious materials, molecular dynamics was utilized to investigate the intensity distribution, local structure and dynamics properties of Cs(+) ions in the vicinity of the calcium silicate surface. The strong inner-sphere adsorbed cesium ions were restricted by coordinated oxygen atoms in bridging and pair silicate tetrahedron and water molecules were fixed in the silicate channel by H-bonds network...
October 12, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29021362/chloride-channels-take-center-stage-in-acute-regulation-of-excitability-in-skeletal-muscle-implications-for-fatigue
#4
REVIEW
Ole Bækgaard Nielsen, Frank Vincenzo de Paoli, Anders Riisager, Thomas Holm Pedersen
Initiation and propagation of action potentials in muscle fibers is a key element in the transmission of activating motor input from the central nervous system to their contractile apparatus, and maintenance of excitability is therefore paramount for their endurance during work. Here, we review current knowledge about the acute regulation of ClC-1 channels in active muscles and its importance for muscle excitability, function, and fatigue.
November 2017: Physiology
https://www.readbyqxmd.com/read/29016141/an-x-ray-and-neutron-reflectivity-study-shows-clic1-undergoes-cholesterol-dependant-structural-re-organisation-in-lipid-monolayers
#5
Khondker Rufaka Hossain, Stephen Andrew Holt, Anton P Le Brun, Heba Al Khamici, Stella M Valenzuela
CLIC1 belongs to the ubiquitous family of Chloride Intracellular Ion Channel proteins that are evolutionarily conserved across species. The CLICs are unusual in that they exist mainly as soluble proteins but possess the intriguing property of spontaneous conversion from the soluble to an integral membrane-bound form. This conversion is regulated by the membrane lipid composition especially cholesterol together with external factors such as oxidation and pH. However, the precise physiological mechanism regulating CLIC1 membrane insertion is currently unknown...
October 10, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28990565/-calpain-as-a-new-therapeutic-target-for-treating-spasticity-after-a-spinal-cord-injury
#6
Vanessa Plantier, Frédéric Brocard
After a spinal cord injury (SCI), patients develop spasticity, a motor disorder characterized by hyperreflexia and stiffness of muscles. Spasticity results from alterations in motoneurons with an upregulation of their persistent sodium current (I NaP), simultaneously with a disinhibition caused by a reduction of expression of chloride (Cl(-)) co-transporters KCC2. Until recently the origin of alterations was unknown. After reviewing pathophysiology of spasticity, the manuscript relates our recent work showing a tight relationship between the calpain-dependent proteolysis of voltage-gated sodium channels, the upregulation of I NaP and spasticity following SCI...
June 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/28983075/cystic-fibrosis-swine-fail-to-secrete-airway-surface-liquid-in-response-to-inhalation-of-pathogens
#7
Xiaojie Luan, George Belev, Julian S Tam, Santosh Jagadeeshan, Noman Hassan, Paula Gioino, Nikolay Grishchenko, Yanyun Huang, James L Carmalt, Tanya Duke, Teela Jones, Bev Monson, Monique Burmester, Tomer Simovich, Orhan Yilmaz, Veronica A Campanucci, Terry E Machen, L Dean Chapman, Juan P Ianowski
Cystic fibrosis is caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR) channel, which can result in chronic lung disease. The sequence of events leading to lung disease is not fully understood but recent data show that the critical pathogenic event is the loss of the ability to clear bacteria due to abnormal airway surface liquid secretion (ASL). However, whether the inhalation of bacteria triggers ASL secretion and whether this is abnormal in cystic fibrosis has never been tested...
October 5, 2017: Nature Communications
https://www.readbyqxmd.com/read/28982976/activation-of-the-phospholipid-scramblase-tmem16f-by-nanosecond-pulsed-electric-field-nspef-facilitates-its-diverse-cytophysiological-effects
#8
Claudia Muratori, Andrei G Pakhomov, Elena Gianulis, Jade Meads, Maura Casciola, Peter A Mollica, Olga N Pakhomova
Nanosecond pulsed electric fields (nsPEFs) are emerging as a novel modality for cell stimulation and tissue ablation. However, the downstream protein effectors responsible for nsPEF bioeffects remain to be established. Here we demonstrate that nsPEFs activate TMEM16F, (or anoctamin 6), a protein functioning as a Ca(2+)-dependent phospholipid scramblase and Ca(2+)-activated chloride channel. Using confocal microscopy and patch-clamp recording, we investigated the relevance of TMEM16F activation for several bioeffects triggered by nsPEF, including phosphatidylserine (PS) externalization, nanopore-conducted currents, membrane blebbing, and cell death...
October 5, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28981824/thirst-increases-chorda-tympani-responses-to-sodium-chloride
#9
Thomas G Mast, Joseph M Breza, Robert J Contreras
In nature, water is present as a low-salt solution, thus we hypothesized that thirst would increase taste responses to low-salt solutions. We investigated the effect of thirst on the 2 different salt detection mechanisms present in the rat chorda tympani (CT) nerve. The first mechanism is dependent upon the epithelial sodium channel (ENaC), is blocked by benzamil, and is specific to the cation sodium. The second mechanism, while undefined, is independent of ENaC, and detects multiple cations. We expected thirst to increase benzamil-sensitive sodium responses due to mechanistically increasing the benzamil-sensitive ENaC...
October 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28981821/sodium-carbonate-is-saltier-than-sodium-chloride-to-sodium-depleted-rats
#10
Steven J St John, Anya M McBrayer, Erin E Krauskopf
In a series of behavioral experiments in the 1960s, G.R. Morrison identified several unique features of the taste of Na2CO3 to rats; namely, it is 1) considerably more intense than NaCl at isomolar concentrations, 2) avoided at 10 times lower concentrations than NaCl to thirsty rats, 3) preferred at 10 times lower concentrations than NaCl in sodium-depleted rats. He also demonstrated its qualitatively similarity to NaCl. In Experiment 1, we confirmed and extended many of Morrison's observations. Rats were injected with furosemide on 3 occasions to stimulate a sodium appetite...
October 1, 2017: Chemical Senses
https://www.readbyqxmd.com/read/28981681/resistance-status-and-resistance-mechanisms-in-a-strain-of-aedes-aegypti-diptera-culicidae-from-puerto-rico
#11
Alden S Estep, Neil D Sanscrainte, Christy M Waits, Jessica E Louton, James J Becnel
Puerto Rico (PR) has a long history of vector-borne disease and insecticide-resistant Aedes aegypti (L.). Defining contributing mechanisms behind phenotypic resistance is critical for effective vector control intervention. However, previous studies from PR have each focused on only one mechanism of pyrethroid resistance. This study examines the contribution of P450-mediated enzymatic detoxification and sodium channel target site changes to the overall resistance phenotype of Ae. aegypti collected from San Juan, PR, in 2012...
July 21, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28981267/salivary-proteome-patterns-affecting-human-salt-taste-sensitivity
#12
Theresa Stolle, Freya Grondinger, Andreas Dunkel, Chen Meng, Guillaume Médard, Bernhard Kuster, Thomas Hofmann
To investigate the role of perireceptor events in inter-individual variability in salt taste sensitivity, 31 volunteers were monitored in their detection functions for sodium chloride (NaCl) and classified into sensitive (0.6-1.7 mmol/L), medium-sensitive (1.8-6.9 mmol/L), and nonsensitive (7.0-11.2 mmol/L) subjects. Chemosensory intervention of NaCl-sensitive (S(+)) and nonsensitive (S(-)) panellists with potassium chloride, ammonium chloride, and sodium gluconate showed the salt taste sensitivity to be specific for NaCl...
October 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28975865/novel-mutations-of-clcn7-cause-autosomal-dominant-osteopetrosis-type-ii-adoii-and-intermediate-autosomal-recessive-osteopetrosis-aro-in-seven-chinese-families
#13
Xiaoya Zhang, Zhanying Wei, Jinwei He, Chun Wang, Zhenlin Zhang
OBJECTIVES: Defects in the chloride channel 7 (CLCN7) gene lead to autosomal dominant osteopetrosis type II (ADOII, OPTA2 MIM 166600) and autosomal recessive osteopetrosis, autosomal recessive 4 (ARO, OPTB4 MIM 611490). The objective of the present study was to expand the mutational spectrum and analyze the correlation between mutational sites and clinical phenotypes. METHODS: Seven affected individuals from unrelated Chinese families were clinically examined. X-ray examination and biochemical markers were evaluated...
October 11, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28974231/clca1-suppresses-colorectal-cancer-aggressiveness-via-inhibition-of-the-wnt-beta-catenin-signaling-pathway
#14
Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu, Shu Zheng
BACKGROUND: Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix. This study was conducted to investigate the functions and mechanisms of CLCA1 in colorectal cancer (CRC). METHODS: The CLCA1 protein expression level in CRC patients was evaluated by enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), and western blotting analysis...
October 3, 2017: Cell Communication and Signaling: CCS
https://www.readbyqxmd.com/read/28970012/tanshinone-iia-sodium-sulfonate-regulates-antioxidant-system-inflammation-and-endothelial-dysfunction-in-atherosclerosis-by-downregulation-of-clic1
#15
Ji Zhu, Yingling Xu, Guangyan Ren, Xiao Hu, Cui Wang, Zhen Yang, Zhuoyu Li, Wei Mao, Dezhao Lu
BACKGROUND: Tanshinone IIA Sodium sulfonate (STS) is clinically used for treating cardiovascular diseases in Traditional Chinese Medicine due to its antioxidation and anti-inflammation activities. Intracellular chloride channel 1 (CLIC1) participates in the regulation of oxidative stress and inflammation. This study investigates whether CLIC1 mediates the cardioprotective effects of STS. METHODS: STS were used to treat atherosclerosis (AS) induced by feeding Apolipoprotein E-deficient (ApoE(-/-)) mice with a high-fat, cholesterol-rich diet...
September 29, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28969375/using-an-engineered-glutamate-gated-chloride-channel-to-silence-sensory-neurons-and-treat-neuropathic-pain-at-the-source
#16
Greg A Weir, Steven J Middleton, Alex J Clark, Tarun Daniel, Nikita Khovanov, Stephen B McMahon, David L Bennett
No abstract text is available yet for this article.
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28969029/suppression-of-clc-3-chloride-channel-reduces-the-aggressiveness-of-glioma-through-inhibiting-nuclear-factor-%C3%AE%C2%BAb-pathway
#17
Bing Wang, Jing Xie, Hai-Yong He, En-Wen Huang, Qing-Hua Cao, Lun Luo, Yong-Shi Liao, Ying Guo
CLC-3 chloride channel plays important roles on cell volume regulation, proliferation and migration in normal and cancer cells. Recent growing evidence supports a critical role of CLC-3 in glioma metastasis, however, the mechanism underlying is unclear. This study finds that CLC-3 is upregulated in glioma tissues and positively correlated with WHO histological grade. Patients with high CLC-3 expression had an overall shorter survival time, whereas patients with low expression of CLC-3 had a better survival time...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28968469/effects-of-glutamate-and-ivermectin-on-single-glutamate-gated-chloride-channels-of-the-parasitic-nematode-h-contortus
#18
Mohammed Atif, Argel Estrada-Mondragon, Bindi Nguyen, Joseph W Lynch, Angelo Keramidas
Ivermectin (IVM) is a widely-used anthelmintic that works by binding to and activating glutamate-gated chloride channel receptors (GluClRs) in nematodes. The resulting chloride flux inhibits the pharyngeal muscle cells and motor neurons of nematodes, causing death by paralysis or starvation. IVM resistance is an emerging problem in many pest species, necessitating the development of novel drugs. However, drug optimisation requires a quantitative understanding of GluClR activation and modulation mechanisms. Here we investigated the biophysical properties of homomeric α (avr-14b) GluClRs from the parasitic nematode, H...
October 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28966677/effects-of-sevoflurane-on-rats-with-ischemic-brain-injury-and-the-role-of-the-trek-1-channel
#19
Lixiao Pan, Fengyun Yang, Caixia Lu, Changxin Jia, Qing Wang, Kexue Zeng
The purpose of this investigation was to determine the effects of sevoflurane on rats with ischemic brain injury and to determine the potential role of the TREK-1 channel in this process. Normal rats were randomly divided into three groups: Sham operation, sevoflurane anesthesia or chloral hydrate anesthesia group, an additional group of TREK-1 knockout rats were also studied. Semi-quantitative PCR and western blot analysis confirmed the lack of TREK-1 expression in the brain of TREK-1 knockout rats. The thread-tie method was used to establish middle cerebral artery occlusion (MCAO) model to induce cerebral ischemic brain injury...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28965754/patchouli-alcohol-isolated-from-pogostemon-cablin-mediates-endothelium-independent-vasorelaxation-by-blockade-of-ca-2-channels-in-rat-isolated-thoracic-aorta
#20
Guan-Ying Hu, Cheng Peng, Xiao-Fang Xie, Liang Xiong, San-Yin Zhang, Xiao-Yu Cao
ETHNOPHARMACOLOGICAL RELEVANCE: The aerial parts of Pogostemon cablin (Blanco) Benth. for the treatment of cardiodynia have been documented in Mingyi Bielu of late Han Dynasty, in addition to that the Ca(2+) antagonized activities of P. cablin and its critically pharmacological ingredient patchouli alcohol (PA) were reported previously. AIM OF THE STUDY: To investigate the relaxant effects of PA on rat isolated thoracic aortas and further explore its potential mechanisms of actions...
September 28, 2017: Journal of Ethnopharmacology
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