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https://www.readbyqxmd.com/read/28239148/amotl1-mediates-sequestration-of-the-hippo-effector-yap1-downstream-of-fat4-to-restrict-heart-growth
#1
Chiara V Ragni, Nicolas Diguet, Jean-François Le Garrec, Marta Novotova, Tatiana P Resende, Sorin Pop, Nicolas Charon, Laurent Guillemot, Lisa Kitasato, Caroline Badouel, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alain Trouvé, Helen McNeill, Sigolène M Meilhac
Although in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, the closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth. Here we show in the mouse heart that Fat4 modulates Hippo signalling to restrict growth. Fat4 mutant myocardium is thicker, with increased cardiomyocyte size and proliferation, and this is mediated by an upregulation of the transcriptional activity of Yap1, an effector of the Hippo pathway. Fat4 is not required for the canonical activation of Hippo kinases but it sequesters a partner of Yap1, Amotl1, out of the nucleus...
February 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28198976/role-of-candida-species-from-hiv-infected-children-in-enamel-caries-lesions-an-in-vitro-study
#2
Senda Charone, Maristela Barbosa Portela, Karol de Oliveira Martins, Rosangela Maria Soares, Gloria Fernanda Castro
Objectives: This study analyzed the capacity of Candida spp. from dental biofilm of HIV infected (HIV+) children to demineralize primary molar enamel in vitro by Transversal Microhardness (TMH), Polarized Light Microscopy (PLM) and the quantity of calcium ions (Ca2+) released from the enamel. Material and Methods: Candida spp. samples were isolated from the supragingival biofilm of HIV+ children. A hundred and forty (140) enamel blocks were randomly assigned to six groups: biofilm formed by C...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28197155/dissecting-the-biochemical-and-transcriptomic-effects-of-a-locally-applied-heat-treatment-on-developing-cabernet-sauvignon-grape-berries
#3
Fatma Lecourieux, Christian Kappel, Philippe Pieri, Justine Charon, Jérémy Pillet, Ghislaine Hilbert, Christel Renaud, Eric Gomès, Serge Delrot, David Lecourieux
Reproductive development of grapevine and berry composition are both strongly influenced by temperature. To date, the molecular mechanisms involved in grapevine berries response to high temperatures are poorly understood. Unlike recent data that addressed the effects on berry development of elevated temperatures applied at the whole plant level, the present work particularly focuses on the fruit responses triggered by direct exposure to heat treatment (HT). In the context of climate change, this work focusing on temperature effect at the microclimate level is of particular interest as it can help to better understand the consequences of leaf removal (a common viticultural practice) on berry development...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28131910/polymorphisms-in-genes-involved-in-enamel-development-are-associated-with-dental-fluorosis
#4
Erika Calvano Küchler, Patricia Nivoloni Tannure, Daniela Silva Barroso de Oliveira, Senda Charone, Paulo Nelson-Filho, Raquel Assed Bezerra da Silva, Marcelo de Castro Costa, Leonardo Santos Antunes, Mônica Diuana Calasans Maia, Lívia Azeredo Alves Antunes
OBJECTIVE: To evaluate the association between polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 genes with dental fluorosis (DF) phenotype. DESIGN: Four hundred and eighty one subjects (108 with DF and 373 DF free) from 6 to 18 years of age were recruited. This population lived in Rio de Janeiro, a city with fluoridation of public water supplies. DF was assessed using the Deańs index modified. Only erupted permanent teeth were assessed. Genetic polymorphisms in DLX1, DLX2, MMP13, TIMP1 and TIMP2 were analyzed by real-time PCR from genomic DNA...
January 18, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28054471/in-memorium
#5
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
January 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28042175/morphology-ecology-and-molecular-biology-of-a-new-species-of-giant-larvacean-in-the-eastern-north-pacific-bathochordaeus-mcnutti-sp-nov
#6
R E Sherlock, K R Walz, K L Schlining, B H Robison
Bathochordaeus mcnutti sp. nov. is described from the mesopelagic northeast Pacific Ocean (Monterey Bay, California, USA). Larvaceans in the genus Bathochordaeus are large, often abundant zooplankters found throughout much of the world ocean, but until recently it was unclear whether more than a single species of Bathochordaeus existed. Using remotely operated vehicles, we have made hundreds of in situ observations, compiled two decades of time-series data, and carefully collected enough specimens to determine that three species of Bathochordaeus occur in Monterey Bay: B...
2017: Marine Biology
https://www.readbyqxmd.com/read/27910281/make-your-peer-reviews-more-organized-and-systematic-with-checklists
#7
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
December 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27905411/the-rapid-formation-of-sputnik-planitia-early-in-pluto-s-history
#8
Douglas P Hamilton, S A Stern, J M Moore, L A Young
Pluto's Sputnik Planitia is a bright, roughly circular feature that resembles a polar ice cap. It is approximately 1,000 kilometres across and is centred on a latitude of 25 degrees north and a longitude of 175 degrees, almost directly opposite the side of Pluto that always faces Charon as a result of tidal locking. One explanation for its location includes the formation of a basin in a giant impact, with subsequent upwelling of a dense interior ocean. Once the basin was established, ice would naturally have accumulated there...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27881140/early-signs-of-multi-walled-carbon-nanotbues-degradation-in-macrophages-via-an-intracellular-ph-dependent-biological-mechanism-importance-of-length-and-functionalization
#9
Marion Landry, Mathieu Pinault, Stéphane Tchankouo, Émeline Charon, Audrey Ridoux, Jorge Boczkowski, Martine Mayne-L'Hermite, Sophie Lanone
BACKGROUND: Carbon nanotubes (CNT) can interact with the biological environment, which could participate in their associated toxicity. We recently demonstrated that pH is an important player of CNT fate inside macrophages. We wanted to further characterize such process, and therefore designed a study dedicated to decipher CNT biodegradation by macrophages, as a function of two major physico-chemical properties in regard with nanotoxicology; length and degree of functionalization. To achieve our aim, we synthesized, following a single initial production process, four MWCNT differing in length and/or surface chemistry: S-CNT (short), SF-CNT (short functionalized), L-CNT (long) and LF-CNT (long functionalized)...
24, 2016: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/27851731/reorientation-and-faulting-of-pluto-due-to-volatile-loading-within-sputnik-planitia
#10
James T Keane, Isamu Matsuyama, Shunichi Kamata, Jordan K Steckloff
Pluto is an astoundingly diverse, geologically dynamic world. The dominant feature is Sputnik Planitia-a tear-drop-shaped topographic depression approximately 1,000 kilometres in diameter possibly representing an ancient impact basin. The interior of Sputnik Planitia is characterized by a smooth, craterless plain three to four kilometres beneath the surrounding rugged uplands, and represents the surface of a massive unit of actively convecting volatile ices (N2, CH4 and CO) several kilometres thick. This large feature is very near the Pluto-Charon tidal axis...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27807808/predictive-factors-of-pathologic-complete-response-of-her2-positive-breast-cancer-after-preoperative-chemotherapy-with-trastuzumab-development-of-a-specific-predictor-and-study-of-its-utilities-using-decision-curve-analysis
#11
Clémentine Jankowski, S Guiu, M Cortet, C Charon-Barra, I Desmoulins, V Lorgis, L Arnould, P Fumoleau, B Coudert, R Rouzier, C Coutant, F Reyal
PURPOSE: The aim of this study was to assess the Institut Gustave Roussy/M.D. Anderson Cancer Center (IGR/MDACC) nomogram in predicting pathologic complete response (pCR) to preoperative chemotherapy in a cohort of human epidermal growth factor receptor 2 (HER2)-positive tumors treated with preoperative chemotherapy with trastuzumab. We then combine clinical and pathological variables associated with pCR into a new nomogram specific to HER2-positive tumors treated by preoperative chemotherapy with trastuzumab...
January 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27701851/consent-to-publish-medical-case-reports
#12
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
October 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27689896/atlas-based-shape-analysis-and-classification-of-retinal-optical-coherence-tomography-images-using-the-functional-shape-fshape-framework
#13
Sieun Lee, Nicolas Charon, Benjamin Charlier, Karteek Popuri, Evgeniy Lebed, Marinko V Sarunic, Alain Trouvé, Mirza Faisal Beg
We propose a novel approach for quantitative shape variability analysis in retinal optical coherence tomography images using the functional shape (fshape) framework. The fshape framework uses surface geometry together with functional measures, such as retinal layer thickness defined on the layer surface, for registration across anatomical shapes. This is used to generate a population mean template of the geometry-function measures from each individual. Shape variability across multiple retinas can be measured by the geometrical deformation and functional residual between the template and each of the observations...
September 20, 2016: Medical Image Analysis
https://www.readbyqxmd.com/read/27670115/spirochaete-flagella-hook-proteins-self-catalyse-a-lysinoalanine-covalent-crosslink-for-motility
#14
Michael R Miller, Kelly A Miller, Jiang Bian, Milinda E James, Sheng Zhang, Michael J Lynch, Patrick S Callery, Justin M Hettick, Andrew Cockburn, Jun Liu, Chunhao Li, Brian R Crane, Nyles W Charon
Spirochaetes are bacteria responsible for several serious diseases, including Lyme disease (Borrelia burgdorferi), syphilis (Treponema pallidum) and leptospirosis (Leptospira interrogans), and contribute to periodontal diseases (Treponema denticola)(1). These spirochaetes employ an unusual form of flagella-based motility necessary for pathogenicity; indeed, spirochaete flagella (periplasmic flagella) reside and rotate within the periplasmic space(2-11). The universal joint or hook that links the rotary motor to the filament is composed of ∼120-130 FlgE proteins, which in spirochaetes form an unusually stable, high-molecular-weight complex(9,12-17)...
August 8, 2016: Nature Microbiology
https://www.readbyqxmd.com/read/27629517/observed-glacier-and-volatile-distribution-on-pluto-from-atmosphere-topography-processes
#15
Tanguy Bertrand, François Forget
Pluto has a variety of surface frosts and landforms as well as a complex atmosphere. There is ongoing geological activity related to the massive Sputnik Planitia glacier, mostly made of nitrogen (N2) ice mixed with solid carbon monoxide and methane, covering the 4-kilometre-deep, 1,000-kilometre-wide basin of Sputnik Planitia near the anti-Charon point. The glacier has been suggested to arise from a source region connected to the deep interior, or from a sink collecting the volatiles released planetwide. Thin deposits of N2 frost, however, were also detected at mid-northern latitudes and methane ice was observed to cover most of Pluto except for the darker, frost-free equatorial regions...
1, 2016: Nature
https://www.readbyqxmd.com/read/27626378/the-formation-of-charon-s-red-poles-from-seasonally-cold-trapped-volatiles
#16
W M Grundy, D P Cruikshank, G R Gladstone, C J A Howett, T R Lauer, J R Spencer, M E Summers, M W Buie, A M Earle, K Ennico, J Wm Parker, S B Porter, K N Singer, S A Stern, A J Verbiscer, R A Beyer, R P Binzel, B J Buratti, J C Cook, C M Dalle Ore, C B Olkin, A H Parker, S Protopapa, E Quirico, K D Retherford, S J Robbins, B Schmitt, J A Stansberry, O M Umurhan, H A Weaver, L A Young, A M Zangari, V J Bray, A F Cheng, W B McKinnon, R L McNutt, J M Moore, F Nimmo, D C Reuter, P M Schenk
A unique feature of Pluto's large satellite Charon is its dark red northern polar cap. Similar colours on Pluto's surface have been attributed to tholin-like organic macromolecules produced by energetic radiation processing of hydrocarbons. The polar location on Charon implicates the temperature extremes that result from Charon's high obliquity and long seasons in the production of this material. The escape of Pluto's atmosphere provides a potential feedstock for a complex chemistry. Gas from Pluto that is transiently cold-trapped and processed at Charon's winter pole was proposed as an explanation for the dark coloration on the basis of an image of Charon's northern hemisphere, but not modelled quantitatively...
November 3, 2016: Nature
https://www.readbyqxmd.com/read/27589071/recycling-is-good-for-trash-but-unacceptable-for-scientific-literature
#17
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
September 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27527593/charon-mediates-immune-deficiency-driven-parp-1-dependent-immune-responses-in-drosophila
#18
Yingbiao Ji, Colin Thomas, Nikita Tulin, Niraj Lodhi, Ernest Boamah, Vladimir Kolenko, Alexei V Tulin
Regulation of NF-κB nuclear translocation and stability is central to mounting an effective innate immune response. In this article, we describe a novel molecular mechanism controlling NF-κB-dependent innate immune response. We show that a previously unknown protein, termed as Charon, functions as a regulator of antibacterial and antifungal immune defense in Drosophila Charon is an ankyrin repeat-containing protein that mediates poly(ADP-ribose) polymerase-1 (PARP-1)-dependent transcriptional responses downstream of the innate immune pathway...
September 15, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27509540/the-four-r-s-of-revising-and-resubmitting-a-manuscript
#19
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
August 2016: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/27461236/a-family-based-genome-wide-association-study-reveals-an-association-of-spondyloarthritis-with-mapk14
#20
Félicie Costantino, Alice Talpin, Roula Said-Nahal, Ariane Leboime, Elena Zinovieva, Diana Zelenika, Ivo Gut, Céline Charon, Brigitte Izac, Michael Weissman, Gilles Chiocchia, John Reveille, Maxime Breban, Henri-Jean Garchon
OBJECTIVE: More than 40 loci have been associated with ankylosing spondylitis (AS), but less is known about genetic associations in spondyloarthritis (SpA) as a whole. We conducted a family-based genome-wide association study (GWAS) to identify new non-major histocompatibility complex (MHC) genetic factors associated with SpA. METHODS: 906 subjects from 156 French multiplex families, including 438 with SpA, were genotyped using Affymetrix 250K microarrays. Association was tested with Unphased...
January 2017: Annals of the Rheumatic Diseases
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