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https://www.readbyqxmd.com/read/29444537/a-novel-patient-recruitment-strategy-patient-selection-directly-from-the-community-through-linkage-to-clinical-data
#1
Lindsay P Zimmerman, Satyender Goel, Shazia Sathar, Charon E Gladfelter, Alejandra Onate, Lindsey L Kane, Shelly Sital, Jasmin Phua, Paris Davis, Helen Margellos-Anast, David O Meltzer, Tamar S Polonsky, Raj C Shah, William E Trick, Faraz S Ahmad, Abel N Kho
OBJECTIVE:  This article presents and describes our methods in developing a novel strategy for recruitment of underrepresented, community-based participants, for pragmatic research studies leveraging routinely collected electronic health record (EHR) data. METHODS:  We designed a new approach for recruiting eligible patients from the community, while also leveraging affiliated health systems to extract clinical data for community participants. The strategy involves methods for data collection, linkage, and tracking...
January 2018: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29399395/tumor-lymphocyte-immune-response-to-preoperative-radiotherapy-in-locally-advanced-rectal-cancer-the-lymphorec-study
#2
C Mirjolet, C Charon-Barra, S Ladoire, F Arbez-Gindre, A Bertaut, F Ghiringhelli, A Leroux, D Peiffert, C Borg, J F Bosset, G Créhange
Introduction: Some studies have suggested that baseline tumor-infiltrating-lymphocytes (TILs), such as CD8+ and FoxP3+ T-cells, may be associated with a better prognosis in colorectal cancer. We sought to investigate modulation of the immune response by preoperative radiotherapy (preopRT) and its impact on survival in locally advanced rectal cancer (LARC). Materials & Methods: We analyzed data for 237 patients with LARC who received RT. Density of TILS (CD8+ and FoxP3+) in intraepithelial (iTILs) and stromal compartments (sTILs) were evaluated from surgery pathological specimens and biopsies performed at baseline...
2018: Oncoimmunology
https://www.readbyqxmd.com/read/29368117/beyond-v40-31-narrative-phenomenology-of-wandering-in-autism-and-dementia
#3
Olga Solomon, Mary C Lawlor
Research on autism spectrum disorder (ASD) and on Alzheimer's Disease (AD) and other types of dementia describes a behaviour called 'wandering', a term that denotes movement through space lacking intention or exact destination, as when a person is disoriented or not self-aware. In the U.S., 'wandering' in both ASD and AD has been examined mostly from a management and prevention perspective. It prioritizes safety while primarily overlooking personal experiences of those who 'wander' and their families, thus limiting the range of potentially effective strategies to address this issue...
January 24, 2018: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/29280360/it-takes-a-village%C3%A2
#4
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
December 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29261540/looking-back-to-move-forward-first-year-medical-students-meta-reflections-on-their-narrative-portfolio-writings
#5
Hetty Cunningham, Delphine Taylor, Urmi A Desai, Samuel C Quiah, Benjamin Kaplan, Lorraine Fei, Marina Catallozzi, Boyd Richards, Dorene F Balmer, Rita Charon
The day-to-day rigors of medical education often preclude learners from gaining a longitudinal perspective on who they are becoming. Furthermore, the current focus on competencies, coupled with concerning rates of trainee burnout and a decline in empathy, have fueled the search for pedagogic tools to foster students' reflective capacity. In response, many scholars have looked to the tradition of narrative medicine to foster "reflective spaces" wherein holistic professional identity construction can be supported...
December 19, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/29248934/proteomic-mapping-of-dental-enamel-matrix-from-inbred-mouse-strains-unraveling-potential-new-players-in-enamel
#6
Aline Lima Leite, Mileni Silva Fernandes, Senda Charone, Gary Milton Whitford, Eric T Everett, Marília Afonso Rabelo Buzalaf
Enamel formation is a complex 2-step process by which proteins are secreted to form an extracellular matrix, followed by massive protein degradation and subsequent mineralization. Excessive systemic exposure to fluoride can disrupt this process and lead to a condition known as dental fluorosis. The genetic background influences the responses of mineralized tissues to fluoride, such as dental fluorosis, observed in A/J and 129P3/J mice. The aim of the present study was to map the protein profile of enamel matrix from A/J and 129P3/J strains...
December 16, 2017: Caries Research
https://www.readbyqxmd.com/read/29211023/charomers-interleukin-6-receptor-specific-aptamers-for-cellular-internalization-and-targeted-drug-delivery
#7
REVIEW
Ulrich Hahn
Interleukin-6 (IL-6) is a key player in inflammation and the main factor for the induction of acute phase protein biosynthesis. Further to its central role in many aspects of the immune system, IL-6 regulates a variety of homeostatic processes. To interfere with IL-6 dependent diseases, such as various autoimmune diseases or certain cancers like multiple myeloma or hepatocellular carcinoma associated with chronic inflammation, it might be a sensible strategy to target human IL-6 receptor (hIL-6R) presenting cells with aptamers...
December 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29190145/the-principles-and-practice-of-narrative-medicine-edited-by-rita-charon-sayantani-dasgupta-nellie-hermann-craig-irvine-eric-marcus-edgar-rivera-col%C3%A3-n-danielle-spencer-and-maura-spiegel
#8
https://www.readbyqxmd.com/read/29131556/home-alone-it-s-not-a-movie-it-s-reality
#9
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
November 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029374/a-look-at-some-changes-in-publishing-infrastructure
#10
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
October 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29029259/first-experimental-assessment-of-protein-intrinsic-disorder-involvement-in-an-rna-virus-natural-adaptive-process
#11
Justine Charon, Amandine Barra, Jocelyne Walter, Pauline Millot, Eugénie Hébrard, Benoît Moury, Thierry Michon
Intrinsic disorder (ID) in proteins is defined as a lack of stable structure in physiological conditions. Intrinsically disordered regions (IDRs) are highly abundant in some RNA virus proteomes. Low topological constraints exerted on IDRs are expected to buffer the effect of numerous deleterious mutations and could be related to the remarkable adaptive potential of RNA viruses to overcome resistance of their host. To experimentally test this hypothesis in a natural pathosystem, a set of four variants of Potato virus Y (PVY; Potyvirus genus) containing various ID degrees in the Viral genome-linked (VPg) protein, a key determinant of potyvirus adaptation, was designed...
September 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/29019799/to-see-the-suffering
#12
Rita Charon
The author notes the impressive growth in medical humanities programs, scholarly journals, textbooks, and national and international conferences as well as the convening of two recent national forums or boards addressing the potential of the humanities and the arts to improve medical practice. She also notes that the field of medical humanities seems to have shifted from addressing topics on the margins of medical education to equipping students with the foundational skills required for effective doctoring...
October 10, 2017: Academic Medicine: Journal of the Association of American Medical Colleges
https://www.readbyqxmd.com/read/28922643/vacuum-ultraviolet-photoabsorption-of-prime-ice-analogues-of-pluto-and-charon
#13
S Pavithraa, J-I Lo, K Rahul, B N Raja Sekhar, B-M Cheng, N J Mason, B Sivaraman
Here we present the first Vacuum UltraViolet (VUV) photoabsorption spectra of ice analogues of Pluto and Charon ice mixtures. For Pluto the ice analogue is an icy mixture containing nitrogen (N2), carbon monoxide (CO), methane (CH4) and water (H2O) prepared with a 100:1:1:3 ratio, respectively. Photoabsorption of icy mixtures with and without H2O were recorded and no significant changes in the spectra due to presence of H2O were observed. For Charon a VUV photoabsorption spectra of an ice analogue containing ammonia (NH3) and H2O prepared with a 1:1 ratio was recorded, a spectrum of ammonium hydroxide (NH4OH) was also recorded...
August 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28919640/charon-tectonics
#14
Ross A Beyer, Francis Nimmo, William B McKinnon, Jeffrey M Moore, Richard P Binzel, Jack W Conrad, Andy Cheng, K Ennico, Tod R Lauer, C B Olkin, Stuart Robbins, Paul Schenk, Kelsi Singer, John R Spencer, S Alan Stern, H A Weaver, L A Young, Amanda M Zangari
New Horizons images of Pluto's companion Charon show a variety of terrains that display extensional tectonic features, with relief surprising for this relatively small world. These features suggest a global extensional areal strain of order 1% early in Charon's history. Such extension is consistent with the presence of an ancient global ocean, now frozen.
May 1, 2017: Icarus
https://www.readbyqxmd.com/read/28911223/direct-sampling-and-analysis-of-atmospheric-particulate-organic-matter-by-proton-transfer-reaction-mass-spectrometry
#15
Markus Müller, Philipp Eichler, Barbara D'Anna, Wen Tan, Armin Wisthaler
We report on a new method for analyzing atmospheric submicrometer particulate organic matter which combines direct particle sampling and volatilization with online chemical ionization mass spectrometric analysis. Technically, the method relies on the combined use of a CHARON ("Chemical Analysis of Aerosol Online") particle inlet and a proton-transfer-reaction time-of-flight mass spectrometer (PTR-ToF-MS). Laboratory studies on target analytes showed that the ionization conditions in the PTR-ToF-MS lead to extensive fragmentation of levoglucosan and cis-pinonic acid, while protonated oleic acid and 5α-cholestane molecules remain intact...
October 17, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28898274/periplasmic-flagella-in-borrelia-burgdoferi-function-to-maintain-cellular-integrity-upon-external-stress
#16
Bharath Kumar, Kelly Miller, Nyles W Charon, Justin Legleiter
Tapping mode atomic force microscopy (AFM) in solution was used to analyze the role of the internally located periplasmic flagella (PFs) of the Lyme disease spirochete Borrelia burgdorferi in withstanding externally applied cellular stresses. By systematically imaging immobilized spirochetes with increasing tapping forces, we found that mutants that lack PFs are more readily compressed and damaged by the imaging process compared to wild-type cells. This finding suggest that the PFs, aside from being essential for motility and involved in cell shape, play a cytoskeletal role in dissipating energy and maintaining cellular integrity in the presence of external stress...
2017: PloS One
https://www.readbyqxmd.com/read/28877425/peer-review-week-2017
#17
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
September 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28843615/faecal-glucocorticoid-metabolite-monitoring-as-a-measure-of-physiological-stress-in-captive-and-wild-vervet-monkeys
#18
Christopher Young, Andre Ganswindt, Richard McFarland, Charon de Villiers, Joritha van Heerden, Stefanie Ganswindt, Louise Barrett, S Peter Henzi
The development of non-invasive techniques to analyse physiological stress in mammalian species has revolutionised field-based endocrinology. However, careful validation of the methods used to determine faecal glucocorticoid metabolite (fGCM) and other hormone concentrations are required on a species- and sex-specific basis. In this study, we performed an adrenocorticotropic hormone (ACTH) stimulation test on four (two male and two female) captive vervet monkeys (Chlorocebus pygerythrus) to determine the most appropriate enzyme immunoassay (EIA) from a suite of available EIAs...
August 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28811865/oxidative-biochemistry-disbalance-and-changes-on-proteomic-profile-in-salivary-glands-of-rats-induced-by-chronic-exposure-to-methylmercury
#19
Leonardo Oliveira Bittencourt, Bruna Puty, Senda Charone, Walessa Alana Bragança Aragão, Paulo Mecenas Farias-Junior, Marcia Cristina Freitas Silva, Maria Elena Crespo-Lopez, Aline de Lima Leite, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima
Methylmercury (MeHg) is one of the most toxic mercury species, which can cause many systemic damages, but little is known about its effect in the salivary glands. This study aimed to analyze the mercury levels, oxidative stress, and proteomic profile in parotid, submandibular, and sublingual salivary glands of rats, after chronic MeHg intoxication. Two groups of twenty male Wistar rats (90 days of age) were used on the experiment. MeHg group was intoxicated by intragastric gavage with MeHg at a dose of 0.04 mg/kg/day for 60 days, while the control group received only oil...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28783707/turning-charon-around-on-the-styx
#20
Hugues Allard-Chamard, Shiv Pillai
Sestrins drive immune senescence, and their inhibition may restore immunity in the elderly and improve vaccine responses.
July 7, 2017: Science Immunology
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