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https://www.readbyqxmd.com/read/28811865/oxidative-biochemistry-disbalance-and-changes-on-proteomic-profile-in-salivary-glands-of-rats-induced-by-chronic-exposure-to-methylmercury
#1
Leonardo Oliveira Bittencourt, Bruna Puty, Senda Charone, Walessa Alana Bragança Aragão, Paulo Mecenas Farias-Junior, Marcia Cristina Freitas Silva, Maria Elena Crespo-Lopez, Aline de Lima Leite, Marilia Afonso Rabelo Buzalaf, Rafael Rodrigues Lima
Methylmercury (MeHg) is one of the most toxic mercury species, which can cause many systemic damages, but little is known about its effect in the salivary glands. This study aimed to analyze the mercury levels, oxidative stress, and proteomic profile in parotid, submandibular, and sublingual salivary glands of rats, after chronic MeHg intoxication. Two groups of twenty male Wistar rats (90 days of age) were used on the experiment. MeHg group was intoxicated by intragastric gavage with MeHg at a dose of 0.04 mg/kg/day for 60 days, while the control group received only oil...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28783707/turning-charon-around-on-the-styx
#2
Hugues Allard-Chamard, Shiv Pillai
Sestrins drive immune senescence, and their inhibition may restore immunity in the elderly and improve vaccine responses.
July 7, 2017: Science Immunology
https://www.readbyqxmd.com/read/28747871/age-and-glaucoma-related-characteristics-in-retinal-nerve-fiber-layer-and-choroid-localized-morphometrics-and-visualization-using-functional-shapes-registration
#3
Sieun Lee, Morgan L Heisler, Karteek Popuri, Nicolas Charon, Benjamin Charlier, Alain Trouvé, Paul J Mackenzie, Marinko V Sarunic, Mirza Faisal Beg
Optical coherence tomography provides high-resolution 3D imaging of the posterior segment of the eye. However, quantitative morphological analysis, particularly relevant in retinal degenerative diseases such as glaucoma, has been confined to simple sectorization and averaging with limited spatial sensitivity for detection of clinical markers. In this paper, we present point-wise analysis and visualization of the retinal nerve fiber layer and choroid from cross-sectional data using functional shapes (fshape) registration...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28726009/what-is-narrative-medicine-the-principles-and-practice-of-narrative-medicine-by-rita-charon-sayantani-dasgupta-nellie-hermann-craig-irvine-eric-r-marcus-edgar-rivera-col%C3%A3-n-danielle-spencer-and-maura-spiegel-oxford-university-press-2017
#4
https://www.readbyqxmd.com/read/28695712/transparency-and-full-disclosures-keys-to-ethical-publishing
#5
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
July 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28666530/development-of-a-supercritical-fluid-chromatography-method-with-ultraviolet-and-mass-spectrometry-detection-for-the-characterization-of-biomass-fast-pyrolysis-bio-oils
#6
Julien Crepier, Agnès Le Masle, Nadège Charon, Florian Albrieux, Sabine Heinisch
The characterization of complex mixtures is a challenging issue for the development of innovative processes dedicated to biofuels and bio-products production. The huge number of compounds present in biomass fast pyrolysis oils combined with the large diversity of chemical functions represent a bottleneck as regards analytical technique development. For the extensive characterization of complex samples, supercritical fluid chromatography (SFC) can be alternative to usual separation techniques such as gas (GC) or liquid chromatography (LC)...
August 11, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28664820/ten-thousand-kilometre-transfer-of-cardiogenic-shock-patients-on-venoarterial-extracorporeal-membrane-oxygenation-for-emergency-heart-transplantation-cooperation-between-reunion-island-and-metropolitan-france
#7
Clément Charon, Jérôme Allyn, Bruno Bouchet, Fréderic Nativel, Eric Braunberger, Caroline Brulliard, Olivier Martinet, Nicolas Allou
BACKGROUND: There is no heart transplantation centre on the French overseas territory of Reunion Island (distance of 10,000 km). The aim of this study was to describe the characteristics of cardiogenic shock adult patients on venoarterial extracorporeal membrane oxygenation (VA-ECMO) who were transferred from Reunion Island to mainland France for emergency heart transplantation. METHODS: This retrospective observational study was conducted between 2005 and 2015...
June 1, 2017: European Heart Journal. Acute Cardiovascular Care
https://www.readbyqxmd.com/read/28614635/the-art-of-clear-thinking
#8
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
June 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28592434/effect-of-rosuvastatin-on-carotid-intima-media-thickness-in-children-with-heterozygous-familial-hypercholesterolemia-the-charon-study
#9
Marjet J A M Braamskamp, Gisle Langslet, Brian W McCrindle, David M Cassiman, Gordon A Francis, Claude Gagne, Daniel Gaudet, Katherine M Morrison, Albert Wiegman, Traci Turner, Elinor Miller, D Meeike Kusters, Joel S Raichlen, Paul D Martin, Evan A Stein, John J P Kastelein, Barbara A Hutten
Background -Heterozygous familial hypercholesterolemia (HeFH) is an autosomal dominant disorder leading to premature atherosclerosis. Children with HeFH exhibit early signs of atherosclerosis, manifested by increased carotid intima-media thickness (IMT). In this study, we assessed the effect of 2-year treatment with rosuvastatin on carotid IMT in HeFH children. Methods -Children with HeFH (aged 6 to <18 years) and low-density lipoprotein cholesterol (LDL-C) >4.9 mmol/L or >4.1 mmol/L in combination with other risk factors, received rosuvastatin for 2 years, starting at 5 mg once daily, with up-titration to 10 mg (aged 6 to <10 years) or 20 mg (aged 10 to <18 years)...
June 7, 2017: Circulation
https://www.readbyqxmd.com/read/28474857/the-village-of-care-helping-older-americans-age-out-loud
#10
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
May 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28472264/impact-of-a-supportive-housing-program-on-housing-stability-and-sexually-transmitted-infections-among-new-york-city-young-adults-aging-out-of-foster-care
#11
Sungwoo Lim, Tejinder P Singh, R Charon Gwynn
Former foster youth are at increased risk of housing instability and sexually transmitted infections (STI) during the transitional period following foster care. The authors measured housing stability using sequence analysis and assessed whether a New York City supportive housing program was effective in improving housing stability and reducing STI among former foster youth. Matched administrative records identified 895 former foster youth who were eligible for the housing program in 2007-10. The main outcomes included housing stability (as determined from episodes of homelessness, incarceration, hospitalization, and residence in supportive housing) and diagnosed STI case rates per 1,000 person-years during 2 years after baseline...
May 4, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28431496/the-phylogeny-of-fossil-whip-spiders
#12
Russell J Garwood, Jason A Dunlop, Brian J Knecht, Thomas A Hegna
BACKGROUND: Arachnids are a highly successful group of land-dwelling arthropods. They are major contributors to modern terrestrial ecosystems, and have a deep evolutionary history. Whip spiders (Arachnida, Amblypygi), are one of the smaller arachnid orders with ca. 190 living species. Here we restudy one of the oldest fossil representatives of the group, Graeophonus anglicus Pocock, 1911 from the Late Carboniferous (Duckmantian, ca. 315 Ma) British Middle Coal Measures of the West Midlands, UK...
April 21, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/28426302/innovations-in-population-health-surveillance-using-electronic-health-records-for-chronic-disease-surveillance
#13
Sharon E Perlman, Katharine H McVeigh, Lorna E Thorpe, Laura Jacobson, Carolyn M Greene, R Charon Gwynn
With 87% of providers using electronic health records (EHRs) in the United States, EHRs have the potential to contribute to population health surveillance efforts. However, little is known about using EHR data outside syndromic surveillance and quality improvement. We created an EHR-based population health surveillance system called the New York City (NYC) Macroscope and assessed the validity of diabetes, hyperlipidemia, hypertension, smoking, obesity, depression, and influenza vaccination indicators. The NYC Macroscope uses aggregate data from a network of outpatient practices...
June 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28394470/all-trials-registered-all-results-reported
#14
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
April 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28334505/effectiveness-of-an-evidence-based-practice-nurse-mentor-training-program
#15
LeeAnna Spiva, Patricia L Hart, Sara Patrick, Jessica Waggoner, Charon Jackson, Jamie L Threatt
BACKGROUND: Multiple reasons are cited for why nurses do not incorporate evidence into clinical practice, including lack of knowledge and skills, training, time, and organizational support. AIMS: To investigate the effectiveness of a mentor training program on mentors' perceptions of knowledge, attitude, skill, and confidence levels, and organizational readiness related to evidence-based practice (EBP) and research utilization; and to investigate the effectiveness of creating a formalized structure to enculturate EBP in order to prepare nurses to incorporate EBP into clinical practice on nurses' perceptions of knowledge, attitude, skill levels, barriers, nursing leadership, and organizational support related to EBP and research utilization...
June 2017: Worldviews on Evidence-based Nursing
https://www.readbyqxmd.com/read/28327264/association-of-candida-species-isolated-from-the-dental-plaque-of-hiv-infected-children-and-prevalence-of-early-carious-lesions
#16
Cristiana Aroeira Rosa Oliveira, Senda Charone, Rosangela Maria de Araújo Soares, Maristela Barbosa Portela, Gloria Fernanda Barbosa de Aráujo Castro
PURPOSE: The purposes of this study were to: (1) quantify and identify Candida species (spp.) in the dental plaque of children infected with the human immunodeficiency virus (HIV) and compare with noninfected children; and (2) determine the association of Candida spp. with the presence of caries. METHODS: Seventy HIV-infected and 55 non-HIV-infected three- to 12-year-old children were examined to determine caries prevalence. After a visual inspection, supragingival plaque was collected from the cervical region using standard dental curettes...
September 15, 2016: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28267295/professionalism-and-authorship-taking-responsibility-for-sharing-nursing-science
#17
EDITORIAL
Charon A Pierson
No abstract text is available yet for this article.
March 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/28239148/amotl1-mediates-sequestration-of-the-hippo-effector-yap1-downstream-of-fat4-to-restrict-heart-growth
#18
Chiara V Ragni, Nicolas Diguet, Jean-François Le Garrec, Marta Novotova, Tatiana P Resende, Sorin Pop, Nicolas Charon, Laurent Guillemot, Lisa Kitasato, Caroline Badouel, Alexandre Dufour, Jean-Christophe Olivo-Marin, Alain Trouvé, Helen McNeill, Sigolène M Meilhac
Although in flies the atypical cadherin Fat is an upstream regulator of Hippo signalling, the closest mammalian homologue, Fat4, has been shown to regulate tissue polarity rather than growth. Here we show in the mouse heart that Fat4 modulates Hippo signalling to restrict growth. Fat4 mutant myocardium is thicker, with increased cardiomyocyte size and proliferation, and this is mediated by an upregulation of the transcriptional activity of Yap1, an effector of the Hippo pathway. Fat4 is not required for the canonical activation of Hippo kinases but it sequesters a partner of Yap1, Amotl1, out of the nucleus...
February 27, 2017: Nature Communications
https://www.readbyqxmd.com/read/28198976/role-of-candida-species-from-hiv-infected-children-in-enamel-caries-lesions-an-in-vitro-study
#19
Senda Charone, Maristela Barbosa Portela, Karol de Oliveira Martins, Rosangela Maria Soares, Gloria Fernanda Castro
Objectives: This study analyzed the capacity of Candida spp. from dental biofilm of HIV infected (HIV+) children to demineralize primary molar enamel in vitro by Transversal Microhardness (TMH), Polarized Light Microscopy (PLM) and the quantity of calcium ions (Ca2+) released from the enamel. Material and Methods: Candida spp. samples were isolated from the supragingival biofilm of HIV+ children. A hundred and forty (140) enamel blocks were randomly assigned to six groups: biofilm formed by C...
January 2017: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/28197155/dissecting-the-biochemical-and-transcriptomic-effects-of-a-locally-applied-heat-treatment-on-developing-cabernet-sauvignon-grape-berries
#20
Fatma Lecourieux, Christian Kappel, Philippe Pieri, Justine Charon, Jérémy Pillet, Ghislaine Hilbert, Christel Renaud, Eric Gomès, Serge Delrot, David Lecourieux
Reproductive development of grapevine and berry composition are both strongly influenced by temperature. To date, the molecular mechanisms involved in grapevine berries response to high temperatures are poorly understood. Unlike recent data that addressed the effects on berry development of elevated temperatures applied at the whole plant level, the present work particularly focuses on the fruit responses triggered by direct exposure to heat treatment (HT). In the context of climate change, this work focusing on temperature effect at the microclimate level is of particular interest as it can help to better understand the consequences of leaf removal (a common viticultural practice) on berry development...
2017: Frontiers in Plant Science
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