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https://www.readbyqxmd.com/read/28445826/exposure-to-fine-particulate-matter-causes-oxidative-and-methylated-dna-damage-in-young-adults-a-longitudinal-study
#1
Ching-Huang Lai, Han-Bin Huang, Yue-Cune Chang, Ting-Yao Su, Ying-Chuan Wang, Gia-Chi Wang, Jia-En Chen, Chin-Sheng Tang, Trong-Neng Wu, Saou-Hsing Liou
An increased understanding is needed of the physiological effects and plausible biological mechanisms that link PM2.5 (particulate matter with an aerodynamic diameter below 2.5μm) exposure to mortality and morbidities such as atherosclerosis and respiratory disease. PM2.5 causes carcinogenic health effects. Biomonitoring in humans has suggested that 8-oxo-7, 8-dihydro-2-deoxyguanosine (8-oxodG) and N7-methylguanine (N7-MeG) are correlated with oxidative and methylated DNA damage. Thus, it is meaningful to explore the mechanisms of mutagenesis and carcinogenesis associated with oxidative and methylated DNA damage by simultaneously measuring these two markers...
April 23, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28433929/pollution-characteristics-and-human-health-risks-of-potentially-eco-toxic-elements-ptes-in-road-dust-from-metropolitan-area-of-hefei-china
#2
Muhammad Ubaid Ali, Guijian Liu, Balal Yousaf, Qumber Abbas, Habib Ullah, Mehr Ahmed Mujtaba Munir, Biao Fu
This study aims to investigate the pollution characteristics of road dust and their associated health risks of potentially toxic elements (PTEs) to humans using array-based risk assessment models described by United States Environmental Protection Agency (USEPA) in a metropolitan area of Hefei, China. Geoaccumulation index (Igeo) was used to describe pollution characteristics of roadside dust in urban, periurban and industrial areas. Results indicate that industrial roadside dust was contaminated with Fe, Ni, Cu, Ti, V, Pb, Ba, Sb, Cr, Sn, Pb, As and Ga showing Igeo value (log2 (x)) between Igeo class 3 to 4...
April 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28433178/preparation-and-characterization-of-biodegradable-nanocomposites-derived-from-carboxymethyl-cellulose-and-hydroxyapatite
#3
K Azzaoui, E Mejdoubi, A Lamhamdi, S Jodeh, O Hamed, M Berrabah, S Jerdioui, R Salghi, N Akartasse, A Errich, Á Ríos, M Zougagh
Development of a cost-effective technology for extraction and quantification of carcinogenic and toxic organic materials which are widely used in the industry are critical to humans. Membrane technology received much attention and has already been widely used in this area. In this work, we offer a newly developed bio-based nanocomposite membrane for removal of bisphenol-A (BPA) from water. Three natural components hydroxyapatite (HAp), carboxymethyl cellulose and lysine as a diluent were used for making the bio-based membrane...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28432963/health-hazards-of-child-labor-in-the-leather-products-and-surgical-instrument-manufacturing-industries-of-sialkot-pakistan
#4
Muhammad Junaid, Riffat Naseem Malik, De-Sheng Pei
Child labor is a major challenge in the developing countries and comprehensive health hazard identification studies on this issue are still lacking. Therefore, the current study is an effort to highlight the health concerns of child labor exposed in the key small scale industries of Sialkot, Pakistan. Our findings revealed jolting levels of heavy metals in the urine, blood, serum, saliva, and hair samples collected from the exposed children. For example, in the urine samples, Cd, Cr, Ni, and Pb were measured at the respective concentrations of 39...
April 19, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28432879/seasonal-variation-and-health-risk-assessment-of-organochlorine-compounds-in-urban-soils-of-novi-sad-serbia
#5
Biljana D Škrbić, Vesna Marinković, Igor Antić, Anita Petrović Gegić
The aim of this paper was to determine spatial and seasonal variation of 6 indicator polychlorinated biphenyls (PCBs) and 18 organochlorine pesticides (OCPs) in urban soils of Novi Sad, Serbia. Sixty surface soil samples were collected during both winter and summer season, from different types of locations: schools, recreational areas, residential and industrial zones. Samples were treated using the method of accelerated solvent extraction, which allows simultaneous extraction and clean up of PCBs and OCPs...
April 15, 2017: Chemosphere
https://www.readbyqxmd.com/read/28420806/the-association-of-occupational-metals-exposure-and-oxidative-damage-telomere-shortening-in-fitness-equipments-manufacturing-workers
#6
Jiunn-Liang Ko, Yu-Jung Cheng, Guan-Cen Liu, I-Lun Hsin, Hsiu-Ling Chen
The welding is the major working process in fitness equipment manufacturing industry, and International Agency for Research on Cancer has classified welding fumes as possibly carcinogenic to humans (Group 2B). The present study aimed to evaluate associations between the occupational exposure of metals and oxidative damage and telomere length shortening in workers involved in the manufacture of fitness equipment. The blood metal concentrations were monitored and malondialdehyde (MDA), alkaline Comet assay was determined as oxidative damage in 117 workers from two representative fitness equipment manufacturing plants...
April 14, 2017: Industrial Health
https://www.readbyqxmd.com/read/28409430/spatio-temporal-distribution-of-metals-in-household-dust-from-rural-semi-urban-and-urban-environments-in-the-niger-delta-nigeria
#7
Chukwujindu M A Iwegbue, Ejiro C Oliseyenum, Bice S Martincigh
Concentrations of metals in household dust samples from rural, semi-urban and urban zones of the Niger Delta in Nigeria were measured during both 2009 and 2014 with the aim of providing information on changes in the concentrations, distribution patterns, sources and risks of metals in these zones. The concentrations of metals in the dust samples were quantified by using inductively coupled plasma atomic emission spectrophotometry (ICP-AES) after digestion with aqua regia. The measured concentrations (mg kg(-1)) of metals in the three zones within the study periods were as follows: <LOQ-21...
April 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28403898/health-risks-associated-with-the-pharmaceuticals-in-wastewater
#8
EDITORIAL
Nasser Nassiri Koopaei, Mohammad Abdollahi
The overwhelming population growth in recent decades and water crisis along with limited and uneven geographical distribution of fresh water resources is a growing challenge for the economic and human development. Wastewater reclamation and use could be an alternative for intact water sources and a promising solution to water scarcity and unequal distribution. However, wastewater is a double-edged resource both as an accessible water source for food production and human usage and concurrently may carry uncharacterized content with unknown toxicological profile causing acute or long-term health risks...
April 12, 2017: Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences
https://www.readbyqxmd.com/read/28400324/impact-of-anatase-titanium-dioxide-nanoparticles-on-mutagenic-and-genotoxic-response-in-chinese-hamster-lung-fibroblast-cells-v-79-the-role-of-cellular-uptake
#9
Abhishek Kumar Jain, Violet Aileen Senapati, Divya Singh, Kavita Dubey, Renuka Maurya, Alok Kumar Pandey
The unique physico-chemical properties of nano crystalline anatase titanium dioxide nanoparticles (TiO2 NPs) render them with different biological and chemical activities. Hence, it is widely used in industrial and consumer applications. Previous studies have shown the genotoxicity of TiO2 NPs. However, there is a paucity of data regarding mutagenicity of these NPs. In the present study, the cellular uptake, sub-cellular localization, cytotoxicity and short term DNA interaction of TiO2 NPs (1-100 μgmL(-1)) of diameter ranging from 12 to 25 nm on mammalian lung fibroblast cells (V-79) has been studied...
April 8, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28398075/disturbance-response-indicators-of-impatiens-walleriana-exposed-to-benzene-and-chromium
#10
V Campos, S S Lessa, R L Ramos, M C Shinzato, T A M Medeiros
The purpose of this study was to evaluate the remediation potential and disturbance response indicators of Impatiens walleriana exposed to benzene and chromium. Numerous studies over the years have found abundant evidence of the carcinogenicity of benzene and chromium (VI) in humans. Benzene and chromium are two toxic industrial chemicals commonly found together at contaminated sites, and one of the most common management strategies employed in the recovery of sites contaminated by petroleum products and trace metals is in situ remediation...
April 11, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/28397267/stability-assessment-of-lycopene-microemulsion-prepared-using-tomato-industrial-waste-against-various-processing-conditions
#11
Atefeh Amiri-Rigi, Soleiman Abbasi
BACKGROUND: Green separation techniques are growing at a greater rate than solvent extraction owing to the constant consumer drive to "go natural". Considering the increasing evidences of the health benefits of lycopene and massive tomato industrial waste, in the present study, using microemulsion technique the lycopene was extracted from tomato industrial waste and its mean droplet size and size distribution was determined. Moreover, the effects of pasteurization, sterilization, freeze-thaw cycles and UV irradiation on the thermodynamic stability, turbidity and lycopene concentration of the lycopene microemulsion were monitored...
April 11, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28395310/national-estimates-of-exposure-to-formaldehyde-in-italian-workplaces
#12
Alberto Scarselli, Marisa Corfiati, Davide Di Marzio, Sergio Iavicoli
Purpose: Formaldehyde is classified as human carcinogen and the association with nasopharyngeal cancer has been observed in many epidemiological studies. The aim of this study is to evaluate data about occupational exposure levels to formaldehyde in the Italian working force. Methods: Airborne concentrations of formaldehyde were extracted from the Italian database on occupational exposure to carcinogens and refer to the period 1996-2014. Descriptive statistics were calculated for exposure-related variables...
January 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28385577/carbamates-and-ich-m7-classification-making-use-of-expert-knowledge
#13
Rachel Hemingway, Adrian Fowkes, Richard V Williams
Carbamates are widely used in the chemical industry so understanding their toxicity is important to safety assessment. Carbamates have been associated with certain toxicities resulting in publication of structural alerts, including alerts for mutagenicity. Structural alerts for bacterial mutagenicity can be used in combination with statistical systems to enable ICH M7 classification, which allows assessment of the genotoxic risk posed by pharmaceutical impurities. This study tested a hypothetical bacterial mutagenicity alert for carbamates and examined the impact it would have on ICH M7 classifications using QSAR predictions from the expert rule-based system Derek Nexus and the statistical-based system Sarah Nexus...
April 3, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28384248/acute-oral-dose-of-sodium-nitrite-induces-redox-imbalance-dna-damage-metabolic-and-histological-changes-in-rat-intestine
#14
Fariheen Aisha Ansari, Shaikh Nisar Ali, Hussain Arif, Aijaz Ahmed Khan, Riaz Mahmood
Industrialization and unchecked use of nitrate/nitrite salts for various purposes has increased human exposure to high levels of sodium nitrite (NaNO2) which can act as a pro-oxidant and pro-carcinogen. Oral exposure makes the gastrointestinal tract particularly susceptible to nitrite toxicity. In this work, the effect of administration of a single acute oral dose of NaNO2 on rat intestine was studied. Animals were randomly divided into four groups and given single doses of 20, 40, 60 and 75 mg NaNO2/kg body weight...
2017: PloS One
https://www.readbyqxmd.com/read/28372763/biodecoloration-of-reactive-black-5-by-the-methylotrophic-yeast-candida-boidinii-mm-4035
#15
María M Martorell, Hipólito F Pajot, Pablo M Ahmed, Lucía I C de Figueroa
Azo dyes are extensively used in textile dyeing and other industries. Effluents of dying industries are specially colored and could cause severe damage to the environment. The anaerobic treatment of textile dying effluents is nowadays the preferred option, but it could generate carcinogenic aromatic amines. Recently, yeasts have become a promising alternative, combining unicellular growth with oxidative mechanisms. This work reports the characterization of the first methylotrophic yeast with dye decolorizing ability, Candida boidinii MM 4035 and some insights into its decoloration mechanism...
March 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28364205/spatial-distribution-of-atmospheric-pahs-and-their-genotoxicity-in-petrochemical-industrialized-lanzhou-valley-northwest-china
#16
Li Wang, Yuan Zhao, Xin Yi, Zhanxiang Wang, Yayi Yi, Tao Huang, Hong Gao, Jianmin Ma
The present study investigated the spatial and seasonal variations and sources of 16 priority polycyclic aromatic hydrocarbons (PAHs) in Lanzhou, a petrochemical industrialized and the capital city of Gansu province, northwest China. The human health risks to these PAHs were assessed using an in vitro genotoxic bioassay technique. Associations among direct genotoxic potency, atmospheric PAH concentrations, and potential carcinogen risks were examined. Due to high PAH emissions from fossil fuel combustion and petrochemical industries, considerable higher PAH levels in the atmosphere were observed in Xigu district, a suburb featured by heavy petrochemical industry, compared with those collected at downtown and rural sampling sites...
March 31, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28361472/a-global-perspective-of-fine-particulate-matter-pollution-and-its-health-effects
#17
Arideep Mukherjee, Madhoolika Agrawal
Fine particulate matter (PM) in the ambient air is implicated in a variety of human health issues throughout the globe. Regulation of fine PM in the atmosphere requires information on the dimension of the problem with respect to variations in concentrations and sources. To understand the current status of fine particles in the atmosphere and their potential harmful health effects in different regions of the world this review article was prepared based on peer-reviewed scientific papers, scientific reports, and database from government organizations published after the year 2000 to evaluate the global scenario of the PM2...
March 31, 2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28355417/organosilane-based-coating-of-quartz-species-from-the-traditional-ceramics-industry-evidence-of-hazard-reduction-using-in-vitro-and-in-vivo-tests
#18
Christina Ziemann, Alberto Escrig, Giuliana Bonvicini, Maria Jesús Ibáñez, Eliseo Monfort, Arturo Salomoni, Otto Creutzenberg
The exposure to respirable crystalline silica (RCS), e.g. quartz, in industrial settings can induce silicosis and may cause tumours in chronic periods. Consequently, RCS in the form of quartz and cristobalite has been classified as human lung carcinogen category 1 by the International Agency for Research on Cancer in 1997, acknowledging differences in hazardous potential depending on source as well as chemical, thermal, and mechanical history. The physico-chemical determinants of quartz toxicity are well understood and are linked to density and abundance of surface silanol groups/radicals...
May 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28355413/maintenance-of-low-pressure-carburising-furnaces-a-source-of-pah-exposure
#19
Catherine Champmartin, Fanny Jeandel, Hubert Monnier
Objectives: Low-pressure carburising is a new technology used to harden steel; the process has been shown to be a source of considerable polycyclic aromatic hydrocarbons (PAH) pollution. Some PAH are carcinogenic, and activities such as furnace maintenance may thus represent a risk to workers. Occupational exposure during these operations should therefore be assessed. Methods: In this study, the PAH-related carcinogenic risk associated with furnace maintenance was assessed by monitoring atmospheric levels of benzo[a]pyrene (BaP), a representative marker, alongside urinary levels of 3-hydroxybenzo[a]pyrene (3-OHBaP), one of its metabolites...
January 9, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28336966/an-integrated-h-g-scheme-identifying-areas-for-soil-remediation-and-primary-heavy-metal-contributors-a-risk-perspective
#20
Bin Zou, Xiaolu Jiang, Xiaoli Duan, Xiuge Zhao, Jing Zhang, Jingwen Tang, Guoqing Sun
Traditional sampling for soil pollution evaluation is cost intensive and has limited representativeness. Therefore, developing methods that can accurately and rapidly identify at-risk areas and the contributing pollutants is imperative for soil remediation. In this study, we propose an innovative integrated H-G scheme combining human health risk assessment and geographical detector methods that was based on geographical information system technology and validated its feasibility in a renewable resource industrial park in mainland China...
March 23, 2017: Scientific Reports
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