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industrial carcinogens

Mélanie Bertin, Annie Thébaud-Mony, Emilie Counil
Complex exposure situations are frequent at the workplace, but few studies have characterized multiple occupational carcinogenic exposures (MOCE) and their gendered differences across jobs' characteristics. We assessed MOCE separately in male and female jobs and identified patterns of MOCE at job level. Participants (834 men and 183 women) were cancer patients recruited between March 2002 and December 2010 in the ongoing SCOP93 cohort study, Seine-Saint-Denis department, France. Job histories were collected through personal interviews, and carcinogenic exposures were assessed by a multidisciplinary expert committee using a list of 53 carcinogens...
February 17, 2018: Annals of Work Exposures and Health
Gholamreza Goudarzi, Nadali Alavi, Sahar Geravandi, Esmaeil Idani, Hamid Reza Adeli Behrooz, Ali Akbar Babaei, Farzaneh Aslanpour Alamdari, Sina Dobaradaran, Majid Farhadi, Mohammad Javad Mohammadi
Heavy metals (HM) are one of the main components of urban air pollution. Today, megacities and industrial regions in southwest of Iran are frequently suffering from severe haze episodes, which essentially caused by PM10 -bound heavy metals. The purpose of this study was to evaluate the health risk assessment on human exposed to heavy metals (Cr, Ni, Pb, and Zn) in the ambient air PM10 in Ahvaz, southwest Iran. In this study, we estimated healthy people from the following scenarios: (S3) residential site; (S2) high-traffic site; (S1) industrial site in Ahvaz metropolitan during autumn and winter...
February 20, 2018: International Journal of Biometeorology
Yu-Fang Huang, Chih-Chun Jean Huang, Chensheng Alex Lu, Mei-Lien Chen, Saou-Hsing Liou, Su-Yin Chiang, Kuen-Yuh Wu
Acrylamide (AA), a probable human carcinogen, is a widely-used industrial chemical but is also present in tobacco smoke and carbohydrate-rich foods processed at high temperatures. AA is metabolized to glycidamide (GA) to cause the formation of DNA adducts. N7-(2-carbamoyl-2-hydroxyethyl) guanine (N7-GAG), the most abundant DNA adduct induced by GA, was recently detected in urine of smokers and non-smokers. In this study, we assessed the variability of AA exposure and biomarkers of AA exposure in urine samples repeatedly collected from AA-exposed workers and explored the half-life of N7-GAG...
February 20, 2018: Journal of Exposure Science & Environmental Epidemiology
Fraser P Filice, Michelle S M Li, Jonathan M Wong, Zhifeng Ding
Chromium is a useful heavy metal which has been employed in numerous industry and house applications. However, there are several known health risks associated with its uses. Cr (VI) is a toxic heavy metal format which serves no essential biological role in humans. It has been associated with oxidative stress, cytotoxicity, and carcinogenicity. Contamination of groundwater or soil due to improper handling lead to long term environmental damage. This study explores the effects of long duration chronic exposure to Cr (VI) on live human cells...
February 10, 2018: Journal of Inorganic Biochemistry
Jian Gao, Jie Zhang, Hong Li, Lei Li, Linghong Xu, Yujie Zhang, Zhanshan Wang, Xuezhong Wang, Weiqi Zhang, Yizhen Chen, Xi Cheng, Hao Zhang, Liang Peng, Fahe Chai, Yongjie Wei
Volatile organic compounds (VOCs) can react with atmospheric radicals while being transported after being emitted, resulting in substantial losses. Using only observed VOC mixing ratios to assess VOC pollution, is therefore problematic. The observed mixing ratios and initial mixing ratios taking chemical loss into consideration were performed using data for 90 VOCs in the atmosphere in a typical urban area in Beijing in winter 2013 to gain a more accurate view of VOC pollution. The VOC sources, ambient VOC mixing ratios and compositions, variability and influencing factors, contributions to near-ground-ozone and health risks posed were assessed...
February 15, 2018: Science of the Total Environment
Henriqueta Louro
The manufactured nanomaterials (NMs) have specific physicochemical properties that confer unique mechanical, optical, electrical and magnetic characteristics that are beneficial for biomedical and industrial applications. However, recent studies have suggested that such specific physicochemical properties of the NMs may define nano-bio interactions thereby determining their toxic potential.One of the major concerns about NMs is the potential to induce cancer, suggested by some experimental studies, as seen for titanium dioxide nanomaterials or carbon nanotubes...
2018: Advances in Experimental Medicine and Biology
Jing Wu, JiCheng Hu, ShiJie Wang, JingXi Jin, Ran Wang, Ying Wang, Jun Jin
Polychlorinated naphthalenes (PCNs), polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), and polychlorinated biphenyls (PCBs) are of public concern worldwide because of their persistence and toxicity. To address the human health risks of these pollutants and identify possible sources, soil samples were collected from an industrial area and surrounding residential area in Shandong Province, China. The PCN, PCDD/F, and PCB levels in these samples were determined. Extremely high concentrations of PCNs were detected in two soil samples, and their congener distributions were similar to those of a PCN industrial technical product...
February 9, 2018: Chemosphere
Ernst M Bomhard
Indium oxide (In 2 O 3 ) is a technologically important semiconductor essentially used, doped with tin oxide, to form indium tin oxide (ITO). It is poorly soluble in all so far tested physiologic media. After repeated inhalation, In 2 O 3 particles accumulate in the lungs. Their mobilization can cause significant systemic exposure over long periods of time. An increasing number of cases of severe lung effects (characterized by pulmonary alveolar proteinosis, emphysema and/or interstitial fibrosis) in workers of the ITO industry warrants a review of the toxicological hazards also of In 2 O 3 ...
February 7, 2018: Environmental Toxicology and Pharmacology
Jun-Pyo Myong, Younmo Cho, Min Choi, Hyoung-Ryoul Kim
Comprehensive consideration is necessary for setting guidelines to evaluate evidence of occupational cancer in painters due to work-related exposure to carcinogens in paint (a phenomenon termed herein as "work-relatedness"). The aim of the present research is to perform a comprehensive review and to suggest criteria for the provision of compensation for occupational neoplasm among painters in Korea. In order to perform a comprehensive review, this study assessed and evaluated scientific reports of carcinogenicities from the International Agency for Research on Cancer (IARC) and the Industrial Injuries Advisory Council (IIAC), as well as reviewed the existing literature about occupational exposure among painters in Korea and the epidemiologic investigations of claimed cases of cancer among painters in Korea...
2018: Annals of Occupational and Environmental Medicine
Imen Gdara, Ines Zrafi, Catia Balducci, Angelo Cecinato, Ahmed Ghrabi
Polycyclic aromatic hydrocarbons are of great concern due to their persistence, bioaccumulation and toxic properties. The occurrence, source and ecological risk assessment of 26 polycyclic aromatic hydrocarbons in industrial and agricultural effluents affecting the Wadi El Bey watershed were investigated by means of gas chromatographic/mass spectrometric analysis (GC/MS). Total PAHs (∑ 26 PAH) ranged from 1.21 to 91.7 µg/L. The 4- and 5-ring compounds were the principal PAHs detected in most of 5 sites examined...
February 13, 2018: Environmental Geochemistry and Health
Rachit Kashyap, K S Verma, Sanjay Kr Uniyal, S K Bhardwaj
The study focused on analyzing concentrations of metal(loid)s, their geospatial distribution in groundwater around an industrial hub of northern India. Human health risk posed due to the intake of contaminated groundwater was also evaluated. For this, 240 samples were assayed using inductively coupled plasma emission spectrophotometer. For risk assessment, the methodology proposed by US Environmental Protection Agency was adopted. Geometric mean of Al, As, Mo, Cd, Co, Cr, Fe, Mn, Ni, Pb, Se, and Zn was 193...
February 12, 2018: Environmental Monitoring and Assessment
Michael Peleg, Or Nativ, Elihu D Richter
BACKGROUND AND AIM: We reexamine whether radio frequency radiation (RFR) in the occupational and military settings is a human carcinogen. METHODS: We extended an analysis of an already-reported case series of patients with cancer previously exposed to whole-body prolonged RFR, mainly from communication equipment and radar. We focused on hematolymphatic (HL) cancers. We used analysis by percentage frequency (PF) of a cancer type, which is the proportion of a specific cancer type relative to the total number of cancer cases...
February 9, 2018: Environmental Research
Mohammad W Kadi, Nadeem Ali, Hussain Mohammed Salem Ali Albar
A number of studies have reported the occurrence of phthalates and polycyclic aromatic hydrocarbons (PAHs) in indoor settled dust from different occupational and residential settings around the world but limited studies are available from public and religious places. In recent decades Kingdom of Saudi Arabia (KSA) has experienced tremendous industrial growth especially in the petroleum industries, and as result environmental issues related with such industries have also increased but scientific data is still scarce to understand the impact on public health...
January 29, 2018: Science of the Total Environment
Jungwon Kim, Sangyun Seo, Yangho Kim, Dae Hwan Kim
Background: The objective of this study is to suggest revised recognition standards for occupational disease due to chromium (VI) by reflecting recent domestic and international research works and considering domestic exposure status with respect to target organs, exposure period, and cumulative exposure dose in relation to the chromium (VI)-induced occupational disease compensation. Methods: In this study, the reports published by major international institutions such as World Health Organization (WHO) International Agency for Research on Cancer (IARC) (2012), Occupational Safety and Health Administration (OSHA) (2006), National Institute for Occupational Safety and Health (NIOSH) (2013), American Conference of Governmental Industrial Hygienists (ACGIH) (2004), National Toxicology Program (NTP) (2014), and Agency for Toxic Substances and Disease Registry (ASTDR) (2012) were reviewed and the recent research works searched by PubMed were summarized...
2018: Annals of Occupational and Environmental Medicine
Soon-Chan Kwon, Inah Kim, Jaechul Song, Jungsun Park
Background: The South Korean criteria for occupational diseases were amended in July 2013. These criteria included formaldehyde as a newly defined occupational carcinogen, based on cases of "leukemia or nasopharyngeal cancer caused by formaldehyde exposure". This inclusion was based on the Internal Agency for Research on Cancer classification, which classified formaldehyde as definite human carcinogen for nasopharyngeal cancer in 2004 and leukemia in 2012. Methods: We reviewed reports regarding the causal relationship between occupational exposure to formaldehyde in Korea and the development of these cancers, in order to determine whether these cases were work-related...
2018: Annals of Occupational and Environmental Medicine
Hyoung-Ryoul Kim, Boowook Kim, Bum Seak Jo, Ji-Won Lee
Crystalline silica has been classified as a definite carcinogen (Group 1) causing lung cancer by the International Agency for Research on Cancer (IARC). In Korea, crystalline silica has been the most common causal agent for workers to apply to the Korea Workers' Compensation and Welfare Service (KWCWS). We used KWCWS data to evaluate workers' crystalline silica exposure levels according to their occupations and industries, and reviewed research papers describing the dose-response relationship between cumulative exposure levels and lung cancer incidence...
2018: Annals of Occupational and Environmental Medicine
Meng Yang, Cheng Wang, Zhao-Ping Yang, Nan Yan, Feng-Ying Li, Yi-Wei Diao, Min-Dong Chen, Hui-Ming Li, Jin-Hua Wang, Xin Qian
Laboratory analysis of trace metals using inductively coupled plasma (ICP) spectroscopy is not cost effective, and the complex spatial distribution of soil trace metals makes their spatial analysis and prediction problematic. Thus, for the health risk assessment of exposure to trace metals in soils, portable X-ray fluorescence (PXRF) spectroscopy was used to replace ICP spectroscopy for metal analysis, and robust geostatistical methods were used to identify spatial outliers in trace metal concentrations and to map trace metal distributions...
February 3, 2018: Ecotoxicology and Environmental Safety
Wihan Pheiffer, Laura P Quinn, Hindrik Bouwman, Nico J Smit, Rialet Pieters
Soweto and Lenasia, the most densely populated area of South Africa, is simultaneously a thriving metropolis, with a fair share of people still living in squalor conditions directly dependant on the natural resources. Because of industrialisation the populace and environment in this urban area are exposed to various pollutants. The aquatic environment was selected as a proxy to study the effect of industrial pollution in this area. The concentrations, source identification, and various environmental risks of polycyclic aromatic hydrocarbons (PAHs) were determined in sediments of the upper reaches of the Klip River...
February 5, 2018: Ecotoxicology
Haiyan Zhang, Lei Jiang, Xin Zhou, Tao Zeng, Zhiqiao He, Xinwen Huang, Jianmeng Chen, Shuang Song
Hexachlorobutadiene (HCBD) was listed as a new controlling persistent organic pollutant in the Stockholm Convention because of its wide industrial applications and potential genotoxicity and carcinogenicity. However, only limited information exists on the release of HCBD from unintentional sources, such as waste incineration. Identification and quantification of HCBD in fly ash, one of the major outputs of waste incineration, is imperative. This work presents a simple method for determining HCBD in waste incineration fly ash based on ultrasonic extraction coupled with a silica gel-Florisil column cleanup followed by gas chromatography-mass spectrometry detection...
February 2, 2018: Analytical and Bioanalytical Chemistry
Yu Fan, Laiting Liu, Lihong Zhao, Xinping Wang, Dacai Wang, Churan Huang, Jianyun Zhang, Cheng Ji, Qiugang Ma
Aflatoxin B1 (AFB1) elicits serious threats to public health due to its widespread occurrence, as well as its teratogenic, carcinogenic and mutagenic effects. This study aimed to evaluate the toxicity of AFB1 and assess the ameliorative efficacy of Bacillus subtilis ANSB060 on aflatoxicosis in Yellow River carp. A total of 750 juvenile Yellow River carp were allocated into five dietary treatments for 60 days. Diet C0 represented for the negative control, diet M0 containing about 50 μg AFB1/kg diet represented for the positive control, and diet M0...
January 25, 2018: Food and Chemical Toxicology
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