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https://www.readbyqxmd.com/read/29034866/the-health-effects-of-aluminum-exposure
#1
Katrin Klotz, Wobbeke Weistenhöfer, Frauke Neff, Andrea Hartwig, Christoph van Thriel, Hans Drexler
BACKGROUND: Aluminum is regularly taken up with the daily diet. It is also used in antiperspirants, as an adjuvant for vaccination, and in desensitization procedures. In this review, we present the scientifically documented harmful effects of aluminum on health and the threshold values associated with them. METHODS: This review is based on publications retrieved by a selective search of the PubMed and SCOPUS databases on the topic of aluminum in connection with neurotoxicity, Alzheimer's disease, and breast cancer, as well as on the authors' personal experience in occupational and environmental medicine...
September 29, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/29031119/index-analysis-and-human-health-risk-model-application-for-evaluating-ambient-air-heavy-metal-contamination-in-chemical-valley-sarnia
#2
Richard Olawoyin, Linda Schweitzer, Kuangyuan Zhang, Oladapo Okareh, Kevin Slates
The impacts of air emissions as a consequence of industrial activities around communities of human habitation have been extensively reported. This study is the first to assess potential adverse human health effects in the Chemical Valley Sarnia (CVS) area, around the St. Clair River, using health risk models, ecological and pollution indices. Large quantities of particulate matters (PM) are generated from anthropogenic activities, which contain several heavy metals in trace quantities with potentially adverse effects to humans and environmental health...
October 11, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29027046/contamination-levels-and-human-health-risk-assessment-of-toxic-heavy-metals-in-street-dust-in-an-industrial-city-in-northwest-china
#3
Yufeng Jiang, Leiping Shi, A-Long Guang, Zhongfeng Mu, Huiying Zhan, Yingqin Wu
This study investigated the content, distribution, and contamination levels of toxic metals (Cd, Cr, Cu, Pb, and Zn) in street dust in Lanzhou, an industrial city in Northwest China. Meanwhile, the risk these metals posed to the urban ecosystem and human health was also evaluated using the potential ecological risk index and human exposure model. Results showed that concentrations of these metals in the dust are higher than the background value of local soil, with Cu having the highest levels. The districts of Anning and Xigu had the most extreme levels of contamination, while Chengguan and Qilihe districts were lightly contaminated, which can be partly attributed to human activities and traffic densities...
October 12, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/29025048/meta-analysis-of-occupational-exposures-in-the-rubber-manufacturing-industry-and-risk-of-cancer
#4
Mathieu Boniol, Alice Koechlin, Peter Boyle
Background: : Occupational exposures in the rubber manufacturing industry showed an increased risk of cancer and have been classified as a group 1 carcinogen, largely from studies on workers employed before 1950s. Cancer sites considered as causally associated are bladder, lung and stomach, and leukaemia. Recent studies did not report an increased risk of cancer. Methods: A meta-analysis was conducted on observational studies published until April 2016 on occupational exposures in the rubber manufacturing industry and risk of cancer...
July 26, 2017: International Journal of Epidemiology
https://www.readbyqxmd.com/read/28991219/distributions-and-sources-of-polycyclic-aromatic-hydrocarbons-pahs-in-soils-around-a-chemical-plant-in-shanxi-china
#5
Haihua Jiao, Qi Wang, Nana Zhao, Bo Jin, Xuliang Zhuang, Zhihui Bai
Background: Yearly the Shanxi coal chemical industry extracts many coal resources, producing at the same time many polycyclic aromatic hydrocarbons (PAHs) that are emitted as by-products of coal incomplete combustion. Methods: Sixty-six soil samples collected from 0 to 100 cm vertical sections of three different agricultural (AS), roadside (RS) and park (PS) functional soils around a chemical plant in Shanxi, China were analyzed for the presence of the 16 priority control PAHs. Results: The total concentrations (∑16PAHs) varied in a range of 35...
October 9, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28973557/high-throughput-functional-genomics-identifies-modulators-of-tce-metabolite-genotoxicity-and-candidate-susceptibility-genes
#6
Vanessa Y De La Rosa, Jonathan Asfaha, Michael Fasullo, Alex Loguinov, Peng Li, Lee E Moore, Nathaniel Rothman, Jun Nakamura, James Swenberg, Ghislaine Scelo, Luoping Zhang, Martyn T Smith, Chris D Vulpe
Trichloroethylene (TCE), an industrial chemical and environmental contaminant, is a human carcinogen. Reactive metabolites are implicated in renal carcinogenesis associated with TCE exposure, yet the toxicity mechanisms of these metabolites and their contribution to cancer and other adverse effects remain unclear. We employed an integrated functional genomics approach that combined functional profiling studies in yeast and avian DT40 cell models to provide new insights into the specific mechanisms contributing to toxicity associated with TCE metabolites...
August 21, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28968200/effects-of-alpha-lipoic-acid-on-acrylamide-induced-hepatotoxicity-in-rats
#7
F A Al-Qahtani, M Arafah, B Sharma, N J Siddiqi
Acrylamide (ACR) is a neurotoxicant, reproductive toxicant, and carcinogen in animal species.  It is used in many industries and has been found to form naturally in foods cooked at high temperatures. Alpha-lipoic acid (ALA) is a naturally occurring antioxidant whose therapeutic effect has been related to its antioxidant activity.  This study was carried out to study the protective effect of alpha lipoic acid on acrylamide induced perturbations in rat liver.  Four groups of rats were studied viz., control rats, acrylamide treated rats, alpha lipoic acid treated rats, and alpha lipoic acid plus acrylamide treated rats...
July 31, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28956229/evaluating-the-health-risks-of-potentially-toxic-elements-through-wheat-consumption-in-multi-industrial-metropolis-of-faisalabad-pakistan
#8
Qumber Abbas, Balal Yousaf, Guijian Liu, Muhammad Zia-Ur-Rehman, Muhammad Ubaid Ali, Mehr Ahmed Mujtaba Munir, Syed Arif Hussain
Potentially toxic elements (PTEs) pollution is the fastest growing concern around the entire globe especially in developing countries. Rapid industrialization and urbanization are the dominant sources of anthropogenic soil-food chain contamination with PTEs. The intent of current study was to investigate the interactive levels of Cu, Fe, Mn, Ni, Pb, and Zn in soil and their accumulation in wheat (Triticum aestivum L.) samples collected from 96 sites including industrial, urban, and peri-urban areas of a leading multi-industrialized center (Faisalabad) of Pakistan...
September 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28954055/the-impact-of-tobacco-additives-on-cigarette-smoke-toxicity-a-critical-appraisal-of-tobacco-industry-studies
#9
REVIEW
Francisco José Roma Paumgartten, Maria Regina Gomes-Carneiro, Ana Cecilia Amado Xavier de Oliveira
Cigarette production involves a number of substances and materials other than just tobacco, paper and a filter. Tobacco additives include flavorings, enhancers, humectants, sugars, and ammonium compounds. Although companies maintain that tobacco additives do not enhance smoke toxicity and do not make cigarettes more attractive or addictive, these claims are questioned by independent researchers. This study reviewed the studies on the effects of tobacco additives on smoke chemistry and toxicity. Tobacco additives lead to higher levels of formaldehyde and minor changes in other smoke analytes...
September 21, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/28951802/cancer-risks-among-welders-and-occasional-welders-in-a-national-population-based-cohort-study-canadian-census-health-and-environmental-cohort
#10
Jill S MacLeod, M Anne Harris, Michael Tjepkema, Paul A Peters, Paul A Demers
BACKGROUND: Welders are exposed to many known and suspected carcinogens. An excess lung cancer risk among welders is well established, but whether this is attributable to welding fumes is unclear. Excess risks of other cancers have been suggested, but not established. We investigated welding cancer risks in the population-based Canadian Census Health and Environmental Cohort. METHODS: Among 1.1 million male workers, 12,845 welders were identified using Standard Occupational Classification codes and followed through retrospective linkage of 1991 Canadian Long Form Census and Canadian Cancer Registry (1992-2010) records...
September 2017: Safety and Health At Work
https://www.readbyqxmd.com/read/28939575/urine-cytology-screening-of-french-workers-exposed-to-occupational-urinary-tract-carcinogens-a-prospective-cohort-study-over-a-20-year-period
#11
Frederic Dutheil, Lucile Rouanet, Aurélien Mulliez, Geraldine Naughton, Luc Fontana, Michel Druet-Cabanac, Farès Moustafa, Alain Chamoux
OBJECTIVES: To demonstrate that urine cytology screening can provide relevant epidemiological data for earlier detection of urothelial cancer caused by occupational exposure. DESIGN: Prospective cohort study. SETTING: Industries using urothelial carcinogens in France. Urine samples were collected on site, after a work week and were analysed at the University Hospital of Clermont-Ferrand, France. PARTICIPANTS: Participants were workers exposed to urothelial carcinogens...
September 21, 2017: BMJ Open
https://www.readbyqxmd.com/read/28933602/lactoferrin-structure-function-denaturation-and-digestion
#12
Bo Wang, Yakindra Prasad Timilsena, Ewan Blanch, Benu Adhikari
Lactoferrin (LF) is a multifunctional protein occurring in many biological secretions including milk. It possesses iron binding/transferring, antibacterial, antiviral, antifungal, anti-inflammatory and anti-carcinogenic properties. These functional properties intimately depend on the structural integrity of LF especially its higher order conformation. LF is primarily extracted from bovine milk and it is subsequently added into many commercial products such as nutritional supplements, infant formula, cosmetics and toothpaste...
September 21, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28930250/enrichment-of-animal-diets-with-essential-oils-a-great-perspective-on-improving-animal-performance-and-quality-characteristics-of-the-derived-products
#13
REVIEW
Panagiotis E Simitzis
Food industry operates in a competitive market and is continually facing challenges to retain or even increase its market share. Consistent high-quality animal products are required to maintain consumer confidence and consumption. Enrichment of foods with bioactive compounds such as the essential oils appears to improve quality characteristics of the derived products and protects consumers against oxidation and bacterial spoilage effects. Synthetic additives are nowadays questioned due to their suspected carcinogenic potential, and therefore extensive research has been undertaken to identify safe and efficient alternatives...
June 2, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929262/status-source-identification-and-health-risks-of-potentially-toxic-element-concentrations-in-road-dust-in-a-medium-sized-city-in-a-developing-country
#14
S M Praveena, A Z Aris
This study aims to determine the status of potentially toxic element concentrations of road dust in a medium-sized city (Rawang, Malaysia). This study adopts source identification via enrichment factor, Pearson correlation analysis, and Fourier spectral analysis to identify sources of potentially toxic element concentrations in road dust in Rawang City, Malaysia. Health risk assessment was conducted to determine potential health risks (carcinogenic and non-carcinogenic risks) among adults and children via multiple pathways (i...
September 19, 2017: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/28926342/recent-trends-in-the-industrial-use-and-emission-of-known-and-suspected-carcinogens-in-ontario-canada
#15
Catherine E Slavik, Sheila Kalenge, Paul A Demers
BACKGROUND: In 2010, Ontario, Canada's most populous province, implemented its Toxics Reduction Act, Ontario Regulation 455/09 (TRA), which requires four major manufacturing and mineral processing industry groups that already report releases of pollutants federally to the National Pollutant Release Inventory to additionally track, account and report their use and creation. The TRA was modeled after the Massachusetts Toxics Use Reduction Act of 1989, which has been very successful and reported significant reduction in toxic use and carcinogen release...
September 19, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28919126/low-dose-ct-for-the-diagnosis-of-appendicitis-in-adolescents-and-young-adults-locat-a-pragmatic-multicentre-randomised-controlled-non-inferiority-trial
#16
(no author information available yet)
BACKGROUND: CT radiation is arguably carcinogenic. Results from single-centre studies, mostly retrospective, have advocated lowering the CT radiation dose for the diagnosis of appendicitis. However, adoption of low-dose CT has been slow. We aimed to assess the effectiveness of low-dose CT compared with standard-dose CT in the diagnosis of appendicitis in adolescents and young adults. METHODS: We did this pragmatic, multicentre, randomised controlled non-inferiority trial at 20 South Korean teaching hospitals with little experience with low-dose CT...
November 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28900691/quantification-of-n-phenyl-2-naphthylamine-by-gas-chromatography-and-isotope-dilution-mass-spectrometry-and-its-percutaneous-absorption-ex-vivo-under-workplace-conditions
#17
Eike Maximilian Marek, Stephan Koslitz, Tobias Weiss, Manigé Fartasch, Gerhard Schlüter, Heiko Udo Käfferlein, Thomas Brüning
N-Phenyl-2-naphthylamine (P2NA) is an antioxidant used to protect rubbers from flex-cracking. P2NA can be converted in vivo to 2NA, one of the most potent bladder carcinogens. Here, we report the specific and ultra-sensitive quantification of P2NA in the receptor fluid of Franz diffusion cells by gas chromatography and isotope-dilution tandem-mass spectroscopy (GC-MS/MS). The experimental conditions were optimized to minimize losses of P2NA due to surface absorption on glass, plastic, and rubber material, and subsequently validated...
September 12, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28899767/effects-of-hexavalent-chromium-on-mouse-splenic-t-lymphocytes
#18
Lu Dai, Wenhua Xu, Hui Li, Jacqueline A Frank, Caigu He, Zhuo Zhang, Gang Chen
Hexavalent chromium [Cr(VI)] is widely used in various industrial processes and has been recognized as a carcinogen. As the first line of host defense system, the immune system can be a primary target of Cr(VI). T cell population represents a major arm of the immune system that plays a critical role in host anti-tumor immunity. Dysfunction of T cells, such as exhaustion under the persistent presence of tumor antigen, compromise host anti-tumor immunity resulting in oncogenesis. Previous studies have shown Cr(VI) exposure alters the phenotype of human peripheral blood lymphocytes...
December 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28889025/industrial-pollution-and-cancer-in-spain-an-important-public-health-issue
#19
Pablo Fernández-Navarro, Javier García-Pérez, Rebeca Ramis, Elena Boldo, Gonzalo López-Abente
Cancer can be caused by exposure to air pollution released by industrial facilities. The European Pollutant Release and Transfer Register (E-PRTR) has made it possible to study exposure to industrial pollution. This study seeks to describe the industrial emissions in the vicinity of Spanish towns and their temporal changes, and review our experience studying industrial pollution and cancer. Data on industrial pollutant sources (2007-2010) were obtained from the E-PRTR registries. Population exposure was estimated by the distance from towns to industrial facilities...
November 2017: Environmental Research
https://www.readbyqxmd.com/read/28888116/comprehensive-review-on-toxicity-of-persistent-organic-pollutants-from-petroleum-refinery-waste-and-their-degradation-by-microorganisms
#20
Sunita J Varjani, Edgard Gnansounou, Ashok Pandey
Control and prevention of environmental pollution has become a worldwide issue of concern. Aromatic hydrocarbons including benzene, toluene, ethyl benzene, xylene (BTEX) and polyaromatic hydrocarbons (PAHs) are persistent organic pollutants (POPs), released into the environment mainly by exploration activities of petroleum industry. These pollutants are mutagenic, carcinogenic, immunotoxic and teratogenic to lower and higher forms of life i.e. microorganisms to humans. According to the International Agency for Research on Cancer (IARC) and United States Environmental Protection Agency (U...
September 4, 2017: Chemosphere
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