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https://www.readbyqxmd.com/read/29223822/exposure-to-acrylamide-induces-cardiac-developmental-toxicity-in-zebrafish-during-cardiogenesis
#1
Mengmeng Huang, Jingjing Jiao, Jun Wang, Zhidan Xia, Yu Zhang
Acrylamide (AA), an environmental pollutant, has been linked to neurotoxicity, genotoxicity and carcinogenicity. AA is widely used to synthesize polymers for industrial applications, is widely found in Western-style carbohydrate-rich foods and cigarette smoke, and can also be detected in human umbilical cord blood and breast milk. This is the first study that demonstrated the cardiac developmental toxicity of AA in zebrafish embryos. Post-fertilization exposure to AA caused a clearly deficient cardiovascular system with a shrunken heart and abortive morphogenesis and function...
December 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29217392/influence-of-traffic-on-build-up-of-polycyclic-aromatic-hydrocarbons-on-urban-road-surfaces-a-bayesian-network-modelling-approach
#2
Yingxia Li, Ziliang Jia, Buddhi Wijesiri, Ningning Song, Ashantha Goonetilleke
Due to their carcinogenic effects, Polycyclic Aromatic Hydrocarbons (PAHs) deposited on urban surfaces are a major concern in the context of stormwater pollution. However, the design of effective pollution mitigation strategies is challenging due to the lack of reliability in stormwater quality modelling outcomes. Current modelling approaches do not adequately replicate the interdependencies between pollutant processes and their influential factors. Using Bayesian Network modelling, this research study characterised the influence of vehicular traffic on the build-up of the sixteen US EPA classified priority PAHs...
December 4, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29207355/environmental-pollution-and-health-hazards-from-distillery-wastewater-and-treatment-approaches-to-combat-the-environmental-threats-a-review
#3
REVIEW
Pankaj Chowdhary, Abhay Raj, Ram Naresh Bharagava
Distillery industries are the key contributor to the world's economy, but these are also one of the major sources of environmental pollution due to the discharge of a huge volume of dark colored wastewater. This dark colored wastewater contains very high biological oxygen demand, chemical oxygen demand, total solids, sulfate, phosphate, phenolics and various toxic metals. Distillery wastewater also contains a mixture of organic and inorganic pollutants such as melanoidins, di-n-octyl phthalate, di-butyl phthalate, benzenepropanoic acid and 2-hydroxysocaproic acid and toxic metals, which are well reported as genotoxic, carcinogenic, mutagenic and endocrine disrupting in nature...
November 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29203651/development-and-validation-of-a-high-throughput-transcriptomic-biomarker-to-address-21st-century-genetic-toxicology-needs
#4
Heng-Hong Li, Renxiang Chen, Daniel R Hyduke, Andrew Williams, Roland Frötschl, Heidrun Ellinger-Ziegelbauer, Raegan O'Lone, Carole L Yauk, Jiri Aubrecht, Albert J Fornace
Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive findings (i.e., positive results in vitro that are not relevant to human cancer hazard). We developed an in vitro transcriptomic biomarker-based approach that provides biological relevance to positive genotoxicity assay data, particularly for in vitro chromosome damage assays, and propose its application for assessing the relevance of the in vitro positive results to carcinogenic hazard...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29199263/determination-of-crystalline-silica-in-respirable-dust-upon-occupational-exposure-for-egyptian-workers
#5
Sabrein H Mohamed, Aida L El-Ansary, Eman M Abd El-Aziz
Crystalline free silica is considered as a lung carcinogen and the occupational exposure to its dust is a health hazard to workers employed in industries that involve ores of mineral dust. In Egypt, thousands of people work under conditions of silica dust exposure exceeding the occupational exposure limit, as a result the monitoring of this occupational exposure to crystalline silica dust is required by government legislation. The assessment of the later is a multi-phase process, depend on workplace measurements, quantitative analyses of samples, and comparison of results with the permissible limits...
December 2, 2017: Industrial Health
https://www.readbyqxmd.com/read/29197278/land-use-and-air-quality-in-urban-environments-human-health-risk-assessment-due-to-inhalation-of-airborne-particles
#6
A C Mateos, A C Amarillo, H A Carreras, C M González
Particle matter (PM) and its associated compounds are a serious problem for urban air quality and a threat to human health. In the present study, we assessed the intraurban variation of PM, and characterized the human health risk associated to the inhalation of particles measured on PM filters, considering different land use areas in the urban area of Cordoba city (Argentina) and different age groups. To assess the intraurban variation of PM, a biomonitoring network of T. capillaris was established in 15 sampling sites with different land use and the bioaccumulation of Co, Cu, Fe, Mn, Ni, Pb and Zn was quantified...
November 29, 2017: Environmental Research
https://www.readbyqxmd.com/read/29195980/comparative-stability-and-efficacy-of-selected-chlorine-based-biocides-against-escherichia-coli-in-planktonic-and-biofilm-states
#7
Ana Meireles, Carla Ferreira, Luís Melo, Manuel Simões
Microbial contamination is an unavoidable problem in industrial processes. Sodium hypochlorite (SH) is the most common biocide used for industrial disinfection. However, in view of the current societal concerns on environmental and public health aspects, there is a trend to reduce the use of this biocide as it can lead to the formation of organochlorinated carcinogenic compounds. In this work the efficacy of SH was assessed against Escherichia coli in planktonic and biofilm states and compared with three alternative chlorine-based biocides: neutral electrolyzed oxidizing water (NEOW), chlorine dioxide (CD) and sodium dichloroisocyanurate (NaDCC)...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29195204/trace-elements-in-pm2-5-in-shandong-province-source-identification-and-health-risk-assessment
#8
Jingzhu Zhang, Xuehua Zhou, Zhe Wang, Lingxiao Yang, Jing Wang, Wenxing Wang
The chemical compositions in PM2.5 in metropolitan areas have obtained lots of attentions, of which concerns of airborne trace elements are relatively lacking. Here, PM2.5 samples were collected simultaneously in one year at four urban sites (Zibo (ZB), Zaozhuang (ZZ), Qingdao (QD) and Jinan (JN (Shandong University)), and a rural site (JN (Miaopu)) in Shandong province. 25 elements (Al, Na, Cl, Mg, Si, S, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Br, Sr, Cd, Ba and Pb) in PM2.5 were measured by wavelength dispersive X-ray fluorescence spectrometer (WDXRF)...
November 28, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29178015/spatiotemporal-variation-and-exposure-risk-to-human-health-of-potential-toxic-elements-in-suburban-vegetable-soils-of-a-megacity-sw-china-2012-2016
#9
Haijian Bing, Zhongxiang Xiang, He Zhu, Yanhong Wu
Trace element contamination in soils of vegetable fields can threat public health. Seven potential toxic elements (As, Cd, Cr, Cu, Ni, Pb, and Zn) in suburban vegetable soils of Chengdu city, Southwest China, in 2012 and 2016, were analyzed to identify their sources with the spatiotemporal variation and assess their contamination and health risk for residents. The results showed that the concentrations of soil elements did not increase significantly in 2016 compared with that in 2012, whereas their spatial distributions altered markedly...
November 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29173494/the-lymphocyte-cytokinesis-block-micronucleus-test-in-human-populations-occupationally-exposed-to-vinyl-chloride-a-systematic-review-and-meta-analysis
#10
REVIEW
Claudia Bolognesi, Marco Bruzzone, Marcello Ceppi, Micheline Kirsch-Volders
Vinyl chloride (VC) is widely used in industry in the production of polyvinyl chloride (PVC), which is used to manufacture a large variety of materials. VC was classified as a known (Group 1) human carcinogen by IARC on the basis of increased risk for liver angiosarcoma and hepatocellular cancer, and the carcinogenicity of VC was shown to be mediated by a genotoxic mechanism. Following inhalation, the compound is rapidly absorbed and metabolized in the liver to the electrophilic metabolites chloroethylene-oxide and chloroacetaldehyde, which form DNA adducts that can be processed into point mutations in cancer-related genes detected in humans and rats exposed to VC...
October 2017: Mutation Research
https://www.readbyqxmd.com/read/29173038/state-of-the-art-of-the-environmental-behaviour-and-removal-techniques-of-the-endocrine-disruptor-3-4-dichloroaniline
#11
Andrea Luca Tasca, Ashleigh Fletcher
In recent years, the presence of Endocrine Disrupting Chemicals (EDCs) in wastewater discharges from agricultural and industrial sources, [1] fresh- and estuarine-waters, as well as soils, has been reported in the literature. [2] Studies of adverse changes in wildlife, linked to environmental exposure to these substances, and the suggestion that humans could also be at similar risk of adverse health effects, [3-5] have raised concern for urgent action to understand and reduce such risks. 3,4-Dichloroaniline (3,4-DCA) has been recognized as an EDC, with regards to endocrine disruption data for both wildlife populations and human health...
November 27, 2017: Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering
https://www.readbyqxmd.com/read/29167790/engineered-nickel-oxide-nanoparticle-causes-substantial-physicochemical-perturbation-in-plants
#12
Indrani Manna, Maumita Bandyopadhyay
Concentration of engineered nickel oxide nanoparticle (NiO-NP) in nature is on the rise, owing to large scale industrial uses, which have accreted the scope of its exposure to plants, the primary producers of the ecosystem. Though an essential micronutrient for the animal system, supported by numerous studies confirming its toxicity at higher dosages, nickel oxide is graded as a human carcinogen by WHO. A few studies do depict toxicity and bioaccumulation of nickel in plants; however, interaction of NiO-NP with plants is not well-elucidated...
2017: Frontiers in Chemistry
https://www.readbyqxmd.com/read/29161267/sugar-industry-sponsorship-of-germ-free-rodent-studies-linking-sucrose-to-hyperlipidemia-and-cancer-an-historical-analysis-of-internal-documents
#13
Cristin E Kearns, Dorie Apollonio, Stanton A Glantz
In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal of Medicine that discounted evidence linking sucrose consumption to blood lipid levels and hence coronary heart disease (CHD). SRF subsequently funded animal research to evaluate sucrose's CHD risks. The objective of this study was to examine the planning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary Carbohydrate and Blood Lipids in Germ-Free Rats," led by Dr. W...
November 2017: PLoS Biology
https://www.readbyqxmd.com/read/29141963/current-and-new-challenges-in-occupational-lung-diseases
#14
REVIEW
Sara De Matteis, Dick Heederik, Alex Burdorf, Claudio Colosio, Paul Cullinan, Paul K Henneberger, Ann Olsson, Anne Raynal, Jos Rooijackers, Tiina Santonen, Joaquin Sastre, Vivi Schlünssen, Martie van Tongeren, Torben Sigsgaard
Occupational lung diseases are an important public health issue and are avoidable through preventive interventions in the workplace. Up-to-date knowledge about changes in exposure to occupational hazards as a result of technological and industrial developments is essential to the design and implementation of efficient and effective workplace preventive measures. New occupational agents with unknown respiratory health effects are constantly introduced to the market and require periodic health surveillance among exposed workers to detect early signs of adverse respiratory effects...
December 31, 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/29141474/assessment-of-immunotoxicity-in-female-fischer-344-n-and-sprague-dawley-rats-and-female-b6c3f1-mice-exposed-to-hexavalent-chromium-via-the-drinking-water
#15
Kelly A Shipkowski, Christopher M Sheth, Matthew J Smith, Michelle J Hooth, Kimber L White, Dori R Germolec
Sodium dichromate dihydrate (SDD), an inorganic compound containing hexavalent chromium (Cr(VI)), is a common environmental contaminant of groundwater sources due to widespread industrial use. There are indications in the literature that Cr(VI) may induce immunotoxic effects following dermal exposure, including acting as both an irritant and a sensitizer; however, the potential immunomodulatory effects of Cr(VI) following oral exposure are relatively unknown. Following the detection of Cr(VI) in drinking water sources, the National Toxicology Program (NTP) conducted extensive evaluations of the toxicity and carcinogenicity of SDD following drinking water exposure, including studies to assess the potential for Cr(VI) to modulate immune function...
December 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/29136412/combining-lead-exposure-measurements-and-experts-judgment-through-a-bayesian-framework
#16
Dong-Hee Koh, Ju-Hyun Park, Sang-Gil Lee, Hwan-Cheol Kim, Sangjun Choi, Hyejung Jung, Dong-Uk Park
Objectives: CARcinogen EXposure (CAREX) is a carcinogen-surveillance system employed in many countries. To develop Korean CAREX, the intensity of exposure to lead, as an example, was estimated across industries. Methods: Airborne-lead measurement records were extracted from the work-environment measurement database (WEMD), which is a nationwide workplace-monitoring database. Lead measurements were log-transformed; then, the log-transformed geometric means (LGMs) and log-transformed geometric standard deviations (LGSDs) were calculated for each industry...
November 10, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29134530/a-review-of-heavy-metal-pollution-levels-and-health-risk-assessment-of-urban-soils-in-chinese-cities
#17
Libo Pan, Yue Wang, Jin Ma, Yu Hu, Benying Su, Guangling Fang, Lei Wang, Bao Xiang
This study assessed literature-based data for the period 2006-2016 regarding heavy metal (As, Cd, Cr, Cu, Pb, Ni, Zn, and Hg) concentrations in soils from 32 Chinese cities and the associated human health risks. The mean concentrations of the eight metals were lower than the soil environmental quality standards in China, but were much higher than the background values for most cities. The enrichment factor (EF) and geoaccumulation index (I geo) values showed moderate pollution levels, possibly influenced by anthropogenic activity for Cd, Hg, Pb, and Zn...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29127835/spatial-variations-source-apportionment-and-potential-ecological-risks-of-polycyclic-aromatic-hydrocarbons-and-synthetic-musks-in-river-sediments-in-shanghai-china
#18
Xue-Tong Wang, Bao-Ping Hu, Hang-Xin Cheng, Hao-Hao Jia, Ying Zhou
The aims of this study were to investigate the levels, possible sources and potential ecological risks of 26 polycyclic aromatic hydrocarbons (PAHs) including highly carcinogenic dibenzopyrene (DBP) isomers and 4 synthetic musks (SMs) in river sediments from Shanghai. 74 sediment samples were collected from the Huangpu River and its main tributaries. The total concentrations ranged from 52.0 to 11400 ng g(-1) for Σ26PAHs, 25.1-9910 ng g(-1) for 16 USEPA priority PAHs (Σ16PAHs), 0.769-384 ng g(-1) for Σ4DBPs, and 0...
October 28, 2017: Chemosphere
https://www.readbyqxmd.com/read/29114957/sinonasal-cancer-in-the-italian-national-surveillance-system-epidemiology-occupation-and-public-health-implications
#19
Alessandra Binazzi, Marisa Corfiati, Davide Di Marzio, Anna M Cacciatore, Jana Zajacovà, Carolina Mensi, Paolo Galli, Lucia Miligi, Roberto Calisti, Elisa Romeo, Alessandro Franchi, Alessandro Marinaccio
BACKGROUND: Sinonasal cancer (SNC) is a rare tumor with predominant occupational etiology associated with exposures to specific carcinogens. The aim of this study is to describe SNC cases recorded in Italy in the period 2000-2016. METHODS: Clinical information, occupational history, and lifestyle habits of SNC cases collected in the Italian Sinonasal Cancer Register were examined. Age-standardized rates were estimated. RESULTS: Overall, 1529 cases were recorded...
November 7, 2017: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29108694/outdoor-air-1-3-butadiene-monitoring-near-a-petrochemical-industry-tarragona-region-and-in-several-catalan-urban-areas-using-active-multi-sorbent-bed-tubes-and-analysis-through-td-gc-ms
#20
Eva Gallego, Francisco Javier Roca, José Francisco Perales, Enrique Gadea
1,3-Butadiene is a carcinogenic compound that can be emitted to the atmosphere from several sources, such as the combustion of organic matter or traffic. However, petrochemical industry is one of the main origins of this compound. Several campaigns (2013-2017) were conducted in twelve Catalan urban areas to determine 1,3-butadiene concentrations in outdoor air, five of which were close to Tarragona petrochemical region. 1,3-Butadiene was dynamically sampled in multi-sorbent bed tubes (Carbotrap, Carbopack X and Carboxen 569) using portable pump equipment...
November 4, 2017: Science of the Total Environment
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