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https://www.readbyqxmd.com/read/28329786/religious-affiliation-among-older-age-groups-worldwide-estimates-for-2010-and-projections-until-2050
#1
Vegard Skirbekk, Michaela Potancoková, Conrad Hackett, Marcin Stonawski
Objectives: The religious landscape of older adults around the world is changing profoundly. Yet until now, no study has chronicled these changes or compared expected aging patterns of religious groups. Differential aging among religious groups can have important economic and social consequences. This study estimates and projects the future religious composition by age at the global and regional levels. Method: This study presents estimates of age structures by religion for 2010 and projections until 2050...
November 9, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28329141/frequent-spread-of-plasmodium-vivax-malaria-maintains-high-genetic-diversity-at-the-myanmar-china-border-without-distance-and-landscape-barriers
#2
Eugenia Lo, Nancy Lam, Elizabeth Hemming-Schroeder, Jennifer Nguyen, Guofa Zhou, Ming-Chieh Lee, Zhaoqing Yang, Liwang Cui, Guiyun Yan
Background.: In Myanmar, civil unrest and the establishment of internally displaced persons (IDP) settlements along the Myanmar-China border have impacted malaria transmission. Methods.: Microsatellite markers were used to examine source-sink dynamics for Plasmodium vivax between IDP and surrounding villages in the border region. Genotypic structure and diversity were compared across the three years following the establishment of IDP in order to infer demographic history...
March 3, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28328543/challenges-in-describing-ribosome-dynamics
#3
Kien Nguyen, Paul Charles Whitford
For decades, protein folding and functional dynamics have been described in terms of diffusive motion across an underlying energy landscape. With continued advances in structural biology and high-performance computing, the field is positioned to extend these approaches to large biomolecular assemblies. Through the application of energy landscape techniques to the ribosome, one may work towards establishing a comprehensive description of the dynamics, which will bridge theoretical concepts and experimental observations...
March 22, 2017: Physical Biology
https://www.readbyqxmd.com/read/28323041/quantitative-analyses-of-the-3d-nuclear-landscape-recorded-with-super-resolved-fluorescence-microscopy
#4
Volker J Schmid, Marion Cremer, Thomas Cremer
Recent advancements of super-resolved fluorescence microscopy have revolutionized microscopic studies of cells, including the exceedingly complex structural organization of cell nuclei in space and time. In this paper we describe and discuss tools for (semi-) automated, quantitative 3D analyses of the spatial nuclear organization. These tools allow the quantitative assessment of highly resolved different chromatin compaction levels in individual cell nuclei, which reflect functionally different regions or sub-compartments of the 3D nuclear landscape, and measurements of absolute distances between sites of different chromatin compaction...
March 18, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28320902/a-global-optimization-perspective-on-molecular-clusters
#5
REVIEW
J M C Marques, F B Pereira, J L Llanio-Trujillo, P E Abreu, M Albertí, A Aguilar, F Pirani, M Bartolomei
Although there is a long history behind the idea of chemical structure, this is a key concept that continues to challenge chemists. Chemical structure is fundamental to understanding most of the properties of matter and its knowledge for complex systems requires the use of state-of-the-art techniques, either experimental or theoretical. From the theoretical view point, one needs to establish the interaction potential among the atoms or molecules of the system, which contains all the information regarding the energy landscape, and employ optimization algorithms to discover the relevant stationary points...
April 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/28319704/assessing-the-drivers-shaping-global-patterns-of-urban-vegetation-landscape-structure
#6
C Dobbs, C Nitschke, D Kendal
Vegetation is one of the main resources involve in ecosystem functioning and providing ecosystem services in urban areas. Little is known on the landscape structure patterns of vegetation existing in urban areas at the global scale and the drivers of these patterns. We studied the landscape structure of one hundred cities around the globe, and their relation to demography (population), socioeconomic factors (GDP, Gini Index), climate factors (temperature and rain) and topographic characteristics (altitude, variation in altitude)...
March 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28319179/biophysical-comparison-of-atp-driven-proton-pumping-mechanisms-suggests-a-kinetic-advantage-for-the-rotary-process-depending-on-coupling-ratio
#7
Ramu Anandakrishnan, Daniel M Zuckerman
ATP-driven proton pumps, which are critical to the operation of a cell, maintain cytosolic and organellar pH levels within a narrow functional range. These pumps employ two very different mechanisms: an elaborate rotary mechanism used by V-ATPase H+ pumps, and a simpler alternating access mechanism used by P-ATPase H+ pumps. Why are two different mechanisms used to perform the same function? Systematic analysis, without parameter fitting, of kinetic models of the rotary, alternating access and other possible mechanisms suggest that, when the ratio of protons transported per ATP hydrolyzed exceeds one, the one-at-a-time proton transport by the rotary mechanism is faster than other possible mechanisms across a wide range of driving conditions...
2017: PloS One
https://www.readbyqxmd.com/read/28317958/the-collective-behavior-of-spring-like-motifs-tethered-to-a-dna-origami-nanostructure
#8
E-C Schöneweiß, B Saccà
Dynamic DNA nanotechnology relies on the integration of small switchable motifs at suitable positions of DNA nanostructures, thus enabling the manipulation of matter with nanometer spatial accuracy in a trigger-dependent fashion. Typical examples of such motifs are hairpins, whose elongation into duplexes can be used to perform long-range, translational movements. In this work, we used temperature-dependent FRET spectroscopy to determine the thermal stabilities of distinct sets of hairpins integrated into the central seam of a DNA origami structure...
March 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28315749/integrated-structural-biology-to-unravel-molecular-mechanisms-of-protein-rna-recognition
#9
REVIEW
Andreas Schlundt, Jan-Niklas Tants, Michael Sattler
Recent advances in RNA sequencing technologies have greatly expanded our knowledge of the RNA landscape in cells, often with spatiotemporal resolution. These techniques identified many new (often non-coding) RNA molecules. Large-scale studies have also discovered novel RNA binding proteins (RBPs), which exhibit single or multiple RNA binding domains (RBDs) for recognition of specific sequence or structured motifs in RNA. Starting from these large-scale approaches it is crucial to unravel the molecular principles of protein-RNA recognition in ribonucleoprotein complexes (RNPs) to understand the underlying mechanisms of gene regulation...
March 15, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/28314700/structural-heart-disease-intervention-the-canadian-landscape
#10
Anita W Asgar, Eric Horlick, Kevin McKenzie, Neil Brass, Warren J Cantor, Albert Chan, Anthony Della Siega, Jean Francois Gobeil, Saleem Kassam, Michael P Love, Samer Mansour, Giuseppe Martucci, Najaf Nadeem, Madhu K Natarajan, Vernon Paddock, Josep Rodés-Cabau, Mouhieddin Traboulsi, James L Velianou, Robert C Welsh, David Wood, John G Webb
Cardiovascular disease encompasses coronary artery disease and valvular heart disease, and the prevalence of both increases with age. Over the past decade, the landscape of interventional cardiology has evolved to encompass a new set of percutaneous procedures outside the coronary tree, including transcatheter aortic valve implantation, transcatheter mitral valve repair, and left atrial appendage occlusion. These interventions have sparked a new discipline within interventional cardiology referred to as structural heart disease (SHD) intervention...
December 13, 2016: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28314196/governance-and-management-dynamics-of-landscape-restoration-at-multiple-scales-learning-from-successful-environmental-managers-in-sweden
#11
Lucas Dawson, Marine Elbakidze, Per Angelstam, Johanna Gordon
Due to a long history of intensive land and water use, habitat networks for biodiversity conservation are generally degraded in Sweden. Landscape restoration (LR) is an important strategy for achieving representative and functional green infrastructures. However, outcomes of LR efforts are poorly studied, particularly the dynamics of LR governance and management. We apply systems thinking methods to a series of LR case studies to analyse the causal structures underlying LR governance and management in Sweden...
March 14, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28306748/does-landscape-connectivity-shape-local-and-global-social-network-structure-in-white-tailed-deer
#12
Erin L Koen, Marie I Tosa, Clayton K Nielsen, Eric M Schauber
Intraspecific social behavior can be influenced by both intrinsic and extrinsic factors. While much research has focused on how characteristics of individuals influence their roles in social networks, we were interested in the role that landscape structure plays in animal sociality at both individual (local) and population (global) levels. We used female white-tailed deer (Odocoileus virginianus) in Illinois, USA, to investigate the potential effect of landscape on social network structure by weighting the edges of seasonal social networks with association rate (based on proximity inferred from GPS collar data)...
2017: PloS One
https://www.readbyqxmd.com/read/28306309/thermal-fluctuations-of-ferroelectric-nanodomains-in-a-ferroelectric-dielectric-pbtio_-3-srtio_-3-superlattice
#13
Qingteng Zhang, Eric M Dufresne, Pice Chen, Joonkyu Park, Margaret P Cosgriff, Mohammed Yusuf, Yongqi Dong, Dillon D Fong, Hua Zhou, Zhonghou Cai, Ross J Harder, Sara J Callori, Matthew Dawber, Paul G Evans, Alec R Sandy
Ferroelectric-dielectric superlattices consisting of alternating layers of ferroelectric PbTiO_{3} and dielectric SrTiO_{3} exhibit a disordered striped nanodomain pattern, with characteristic length scales of 6 nm for the domain periodicity and 30 nm for the in-plane coherence of the domain pattern. Spatial disorder in the domain pattern gives rise to coherent hard x-ray scattering patterns exhibiting intensity speckles. We show here using variable-temperature Bragg-geometry x-ray photon correlation spectroscopy that x-ray scattering patterns from the disordered domains exhibit a continuous temporal decorrelation due to spontaneous domain fluctuations...
March 3, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28304065/charge-transfer-induced-energy-storage-in-caznos-mn-insight-from-experimental-and-computational-spectroscopy
#14
Jonas J Joos, Kurt Lejaeghere, Katleen Korthout, Ang Feng, Dirk Poelman, Philippe F Smet
CaZnOS:Mn(2+) is a rare-earth-free luminescent compound with an orange broadband emission at 612 nm, featuring pressure sensing capabilities, often explained by defect levels where energy can be stored. Despite recent efforts from experimental and theoretical points of view, the underlying luminescence mechanisms in this phosphor still lack a profound understanding. By the evaluation of thermoluminescence as a function of the charging wavelength, we probe the defect levels allowing energy storage. Multiple trap depths and trapping routes are found, suggesting predominantly local trapping close to Mn(2+) impurities...
March 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28303521/assessing-the-habitat-suitability-of-agricultural-landscapes-for-characteristic-breeding-bird-guilds-using-landscape-metrics
#15
Friederike Borges, Michael Glemnitz, Alfred Schultz, Ulrich Stachow
Many of the processes behind the decline of farmland birds can be related to modifications in landscape structure (composition and configuration), which can partly be expressed quantitatively with measurable or computable indices, i.e. landscape metrics. This paper aims to identify statistical relationships between the occurrence of birds and the landscape structure. We present a method that combines two comprehensive procedures: the "landscape-centred approach" and "guild classification". Our study is based on more than 20,000 individual bird observations based on a 4-year bird monitoring approach in a typical agricultural area in the north-eastern German lowlands...
April 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28303495/genetic-landscape-and-classification-of-peripheral-t-cell-lymphomas
#16
REVIEW
Rosalind F Sandell, Rebecca L Boddicker, Andrew L Feldman
PURPOSE OF REVIEW: Peripheral T cell lymphomas (PTCLs) are markedly heterogeneous at the clinical, pathological, and molecular levels. This review will discuss genetic findings in PTCL with special emphasis on how they impact lymphoma classification. RECENT FINDINGS: Sequencing studies have identified recurrent genetic alterations in nearly every PTCL subtype. In anaplastic large cell lymphoma, these studies have revealed novel chromosomal rearrangements and mutations that have prognostic significance and may suggest new therapeutic approaches...
April 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28299651/runx1-structure-and-function-in-blood-cell-development
#17
Constanze Bonifer, Elena Levantini, Valerie Kouskoff, Georges Lacaud
RUNX transcription factors belong to a highly conserved class of transcriptional regulators which play various roles in the development of the majority of metazoans. In this review we focus on the founding member of the family, RUNX1, and its role in the transcriptional control of blood cell development in mammals. We summarize data showing that RUNX1 functions both as activator and repressor within a chromatin environment, a feature that requires its interaction with multiple other transcription factors and co-factors...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28298214/climat-het-detecting-subclonal-copy-number-alterations-and-loss-of-heterozygosity-in-heterogeneous-tumor-samples-from-whole-genome-sequencing-data
#18
Zhenhua Yu, Ao Li, Minghui Wang
BACKGROUND: Copy number alterations (CNA) and loss of heterozygosity (LOH) represent a large proportion of genetic structural variations of cancer genomes. These aberrations are continuously accumulated during the procedure of clonal evolution and patterned by phylogenetic branching. This invariably results in the emergence of multiple cell populations with distinct complement of mutational landscapes in tumor sample. With the advent of next-generation sequencing technology, inference of subclonal populations has become one of the focused interests in cancer-associated studies, and is usually based on the assessment of combinations of somatic single-nucleotide variations (SNV), CNA and LOH...
March 15, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28298102/rotational-spectra-of-two-six-membered-heterocyclic-n-methyl-piperidinol-compounds-conformations-by-oh-rotation-n-methyl-inversion-and-ring-puckering
#19
Javix Thomas, Eric Mariona, Yunjie Xu
Rotational spectra of two nitrogen containing six-membered heterocycles which are commonly used in syntheses of pharmaceuticals, namely, N-methyl-3-piperidinol (NMP3) and N-methyl-4-piperidinol (NMP4), were measured using a broadband chirped pulse and a cavity based Fourier transform microwave spectrometer. The possible conformers due to the OH rotation, N-methyl inversion, and ring puckering were investigated theoretically for these two heterocycles. The substituent position of the hydroxyl group with respective to the N atom in the heterocyclic ring has a strong influence on the preferred conformations...
March 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28297881/epidemic-spreading-on-evolving-signed-networks
#20
M Saeedian, N Azimi-Tafreshi, G R Jafari, J Kertesz
Most studies of disease spreading consider the underlying social network as obtained without the contagion, though epidemic influences people's willingness to contact others: A "friendly" contact may be turned to "unfriendly" to avoid infection. We study the susceptible-infected disease-spreading model on signed networks, in which each edge is associated with a positive or negative sign representing the friendly or unfriendly relation between its end nodes. In a signed network, according to Heider's theory, edge signs evolve such that finally a state of structural balance is achieved, corresponding to no frustration in physics terms...
February 2017: Physical Review. E
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