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https://www.readbyqxmd.com/read/28647486/geographically-weighted-negative-binomial-regression-applied-to-zonal-level-safety-performance-models
#1
Marcos José Timbó Lima Gomes, Flávio Cunto, Alan Ricardo Silva
Generalized Linear Models (GLM) with negative binomial distribution for errors, have been widely used to estimate safety at the level of transportation planning. The limited ability of this technique to take spatial effects into account can be overcome through the use of local models from spatial regression techniques, such as Geographically Weighted Poisson Regression (GWPR). Although GWPR is a system that deals with spatial dependency and heterogeneity and has already been used in some road safety studies at the planning level, it fails to account for the possible overdispersion that can be found in the observations on road-traffic crashes...
June 22, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28647163/observer-based-distributed-adaptive-fault-tolerant-containment-control-of-multi-agent-systems-with-general-linear-dynamics
#2
Dan Ye, Mengmeng Chen, Kui Li
In this paper, we consider the distributed containment control problem of multi-agent systems with actuator bias faults based on observer method. The objective is to drive the followers into the convex hull spanned by the dynamic leaders, where the input is unknown but bounded. By constructing an observer to estimate the states and bias faults, an effective distributed adaptive fault-tolerant controller is developed. Different from the traditional method, an auxiliary controller gain is designed to deal with the unknown inputs and bias faults together...
June 22, 2017: ISA Transactions
https://www.readbyqxmd.com/read/28646763/deep-neural-mapping-support-vector-machines
#3
Yujian Li, Ting Zhang
The choice of kernel has an important effect on the performance of a support vector machine (SVM). The effect could be reduced by NEUROSVM, an architecture using multilayer perceptron for feature extraction and SVM for classification. In binary classification, a general linear kernel NEUROSVM can be theoretically simplified as an input layer, many hidden layers, and an SVM output layer. As a feature extractor, the sub-network composed of the input and hidden layers is first trained together with a virtual ordinary output layer by backpropagation, then with the output of its last hidden layer taken as input of the SVM classifier for further training separately...
June 21, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28646566/structural-neuroimaging-correlates-of-alcohol-and-cannabis-use-in-adolescents-and-adults
#4
Rachel E Thayer, Sophie YorkWilliams, Hollis C Karoly, Amithrupa Sabbineni, Sarah Feldstein Ewing, Angela D Bryan, Kent E Hutchison
BACKGROUND AND AIMS: Chronic alcohol use is associated with lower gray matter volume, and we recently reported that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. DESIGN AND SETTING: General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States...
June 23, 2017: Addiction
https://www.readbyqxmd.com/read/28646408/a-mechanism-based-pk-pd-model-for-hematological-toxicities-induced-by-antibody-drug-conjugates
#5
Sihem Ait-Oudhia, Weiyan Zhang, Donald E Mager
Antibody-drug conjugates (ADCs) are complex drug platforms composed of monoclonal antibodies (mAbs) conjugated to potent cytotoxic drugs (payloads) via chemical linkers, enabling selective payload delivery to neoplastic cells, resulting in improved efficacy and reduced toxicity. Brentuximab vedotin (Adcetris®, SGN-35) and adotrastuzumab emtansine (Kadcyla®, T-DM1) are the two FDA-approved and commercially available ADCs, and both drugs exhibit ADC-related thrombocytopenia and neutropenia. A pharmacokinetic/pharmacodynamic (PK/PD) model for ADCs was developed to identify the analyte from each ADC that is most associated with the observed hematopoietic toxicities and to determine the role of the apparent in vivo payload release rate on the severity of thrombocytopenia and neutropenia...
June 23, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28645285/completeness-and-timeliness-of-notifiable-disease-reporting-a-comparison-of-laboratory-and-provider-reports-submitted-to-a-large-county-health-department
#6
Brian E Dixon, Zuoyi Zhang, Patrick T S Lai, Uzay Kirbiyik, Jennifer Williams, Rebecca Hills, Debra Revere, P Joseph Gibson, Shaun J Grannis
BACKGROUND: Most public health agencies expect reporting of diseases to be initiated by hospital, laboratory or clinic staff even though so-called passive approaches are known to be burdensome for reporters and produce incomplete as well as delayed reports, which can hinder assessment of disease and delay recognition of outbreaks. In this study, we analyze patterns of reporting as well as data completeness and timeliness for traditional, passive reporting of notifiable disease by two distinct sources of information: hospital and clinic staff versus clinical laboratory staff...
June 23, 2017: BMC Medical Informatics and Decision Making
https://www.readbyqxmd.com/read/28645273/factors-associated-with-diabetes-related-distress-over-time-among-patients-with-t2dm-in-a-tertiary-hospital-in-singapore
#7
Maudrene L Tan, Chuen S Tan, Konstadina Griva, Yung S Lee, Jeannette Lee, E S Tai, Eric Y Khoo, Hwee-Lin Wee
BACKGROUND: Persistent diabetes-related distress (DRD) is experienced by patients with Type 2 Diabetes Mellitus. Knowing factors associated with persistent DRD will aid clinicians in prioritising interventions efforts. METHODS: A total of 216 patients were recruited from a tertiary hospital in Singapore, an Asian city state, and followed for 1.5 years (2011-2014). Data was collected by self-completed questionnaires assessing DRD (measured by the Problem Areas in Diabetes score) and other psychosocial aspects such as social support, presenteeism, depression, health-related quality of life (HRQoL) and excessive daytime sleepiness (EDS) at three time points...
June 23, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28643557/pooled-sample-testing-for-bonamia-ostreae-a-tale-of-two-sybr-green-real-time-pcr-assays
#8
Henry S Lane, J Brian Jones, Wendy L McDonald
Pooled testing of samples is a common laboratory practice to increase efficiency and reduce expenses. We investigated the efficacy of 2 published SYBR Green real-time PCR assays when used to detect the haplosporidian parasite Bonamia ostreae in pooled samples of infected oyster tissue. Each PCR targets a different gene within the B. ostreae genome: the actin 1 gene or the 18S rRNA gene. Tissue homogenates (150 mg) of the New Zealand flat oyster Ostrea chilensis were spiked with ~1.5 × 10(3) purified B. ostreae cells to create experimental pools of 3, 5, and 10...
June 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28643407/childhood-exposure-to-constricted-living-space-a-possible-environmental-threat-for-myopia-development
#9
Kai Yip Choi, Wing Yan Yu, Christie Hang I Lam, Zhe Chuang Li, Man Pan Chin, Yamunadevi Lakshmanan, Francisca Siu Yin Wong, Chi Wai Do, Paul Hong Lee, Henry Ho Lung Chan
PURPOSE: People in Hong Kong generally live in a densely populated area and their homes are smaller compared with most other cities worldwide. Interestingly, East Asian cities with high population densities seem to have higher myopia prevalence, but the association between them has not been established. This study investigated whether the crowded habitat in Hong Kong is associated with refractive error among children. METHODS: In total, 1075 subjects [Mean age (S...
June 22, 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/28643068/effects-of-barbed-suture-during-robot-assisted-radical-prostatectomy-on-postoperative-tissue-damage-and-longitudinal-changes-in-lower-urinary-tract-outcome
#10
Nobuhiro Haga, Noriaki Kurita, Tomohiko Yanagida, Soichiro Ogawa, Michihiro Yabe, Hidenori Akaihata, Junya Hata, Yuichi Sato, Kei Ishibashi, Osamu Hasegawa, Yoshiyuki Kojima
OBJECTIVE: To compare the postoperative tissue damage and longitudinal changes in functional and patient-reported outcomes after vesicourethral anastomosis with barbed suture and nonbarbed suture in robot-assisted laparoscopic radical prostatectomy (RARP). MATERIALS AND METHODS: This was a prospective cohort study involving 88 consecutive patients who underwent RARP. These patients were categorized into the barbed suture group (n = 50) and the nonbarbed suture group (n = 38)...
June 22, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28642335/carcinoid-syndrome-and-costs-of-care-during-the-first-year-after-diagnosis-of-neuroendocrine-tumors-among-elderly-patients
#11
Chan Shen, Yiyi Chu, Daniel M Halperin, Arvind Dasari, Shouhao Zhou, Ying Xu, James C Yao, Ya-Chen Tina Shih
BACKGROUND: Neuroendocrine tumors (NETs) can secrete hormonal peptides that lead to additional symptom burdens. However, it is largely unknown whether and to what extent the additional symptom burdens translate into higher costs of care. This study aimed to examine the cost pattern of elderly NET patients during the first year of diagnosis, taking into account of the carcinoid syndrome status. METHODS: We used Surveillance, Epidemiology, and End Results Medicare data to identify elderly NET patients diagnosed between January 2003 and December 2011...
June 22, 2017: Oncologist
https://www.readbyqxmd.com/read/28641758/maternal-intake-of-fried-foods-and-risk-of-gestational-diabetes-mellitus
#12
Citlalli Osorio-Yáñez, Bizu Gelaye, Chunfang Qiu, Wei Bao, Andres Cardenas, Daniel A Enquobahrie, Michelle A Williams
PURPOSE: We examined the relationship of maternal periconceptional (i.e., before conception and early pregnancy) intake of fried foods with gestational diabetes mellitus (GDM) risk. METHODS: In a prospective birth cohort in Seattle and Tacoma, Washington State, USA, we assessed maternal periconceptional fried food intake using a food frequency questionnaire among 3414 participants. We used multivariable generalized linear regression models to derive estimates of relative risks (RRs; and 95% confidence intervals, 95% CIs) of GDM in relation to the intake of different types of fried foods (i...
June 2017: Annals of Epidemiology
https://www.readbyqxmd.com/read/28641499/a-comprehensive-model-for-heat-induced-radio-sensitization
#13
Sarah Catharina Brüningk, Jannat Ijaz, Ian Rivens, Simeon Nill, Gail Ter Haar, Uwe Oelfke
Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitization. We propose an empirical cell survival model (AlphaR model) to describe this multimodality therapy. The model is motivated by the observation that heat induced radio-sensitization may be explained by a reduction in the DNA damage repair capacity of heated cells. We assume that this repair is only possible up to a threshold level above which survival will decrease exponentially with dose...
June 23, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28641259/face-hallucination-using-linear-models-of-coupled-sparse-support
#14
Reuben A Farrugia, Christine Guillemot
Most face super-resolution methods assume that low- and high-resolution manifolds have similar local geometrical structure, hence learn local models on the low-resolution manifold (e.g. sparse or locally linear embedding models), which are then applied on the high- resolution manifold. However, the low-resolution manifold is distorted by the one-to-many relationship between low- and high- resolution patches. This paper presents the Linear Model of Coupled Sparse Support (LM-CSS) method which learns linear models based on the local geometrical structure on the high-resolution manifold rather than on the low-resolution manifold...
June 19, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28640818/ankylosing-spondylitis-patients-at-risk-of-poor-radiographic-outcome-show-diminishing-spinal-radiographic-progression-during-long-term-treatment-with-tnf-%C3%AE-inhibitors
#15
Fiona Maas, Suzanne Arends, Freke R Wink, Reinhard Bos, Hendrika Bootsma, Elisabeth Brouwer, Anneke Spoorenberg
OBJECTIVE: To investigate the influence of patient characteristics on the course of spinal radiographic progression in a large prospective longitudinal cohort study of ankylosing spondylitis (AS) patients treated long-term with TNF-α inhibitors. METHODS: Consecutive patients from the Groningen Leeuwarden AS (GLAS) cohort starting TNF-α inhibitors with spinal radiographs at least available at baseline and 6 years of follow-up were included. Radiographs were scored using mSASSS by two independent readers...
2017: PloS One
https://www.readbyqxmd.com/read/28640810/lassim-a-network-inference-toolbox-for-genome-wide-mechanistic-modeling
#16
Rasmus Magnusson, Guido Pio Mariotti, Mattias Köpsén, William Lövfors, Danuta R Gawel, Rebecka Jörnsten, Jörg Linde, Torbjörn Nordling, Elin Nyman, Sylvie Schulze, Colm E Nestor, Huan Zhang, Gunnar Cedersund, Mikael Benson, Andreas Tjärnberg, Mika Gustafsson
Recent technological advancements have made time-resolved, quantitative, multi-omics data available for many model systems, which could be integrated for systems pharmacokinetic use. Here, we present large-scale simulation modeling (LASSIM), which is a novel mathematical tool for performing large-scale inference using mechanistically defined ordinary differential equations (ODE) for gene regulatory networks (GRNs). LASSIM integrates structural knowledge about regulatory interactions and non-linear equations with multiple steady state and dynamic response expression datasets...
June 22, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28640520/helicobacter-pylori-seropositivity-and-childhood-neurodevelopment-the-rhea-birth-cohort-in-crete-greece
#17
Marianna Karachaliou, Leda Chatzi, Angelika Michel, Andriani Kyriklaki, Mariza Kampouri, Katerina Koutra, Theano Roumeliotaki, Georgia Chalkiadaki, Eftichia Stiakaki, Michael Pawlita, Tim Waterboer, Manolis Kogevinas, Silvia de Sanjose
BACKGROUND: Limited evidence exists on the association between exposure to Helicobacter pylori infection early in life, including fetal life, and neurodevelopment in childhood. METHODS: We used prospective data on 352 mother-child pairs and cross-sectional data on 674 children to assess the association of maternal and child's H. pylori seropositivity correspondingly on child's neurodevelopment at age four in the Rhea birth cohort in Crete, Greece. Blood levels of immunoglobulin G antibodies to 12 H...
June 22, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28638993/discrepancy-in-socioeconomic-status-does-not-fully-explain-the-variation-in-diet-quality-between-consumers-of-different-coffee-types
#18
Tommy Hon Ting Wong, Zhixian Sui, Anna Rangan, Jimmy Chun Yu Louie
PURPOSE: Habitual consumers of different coffee types may vary in socioeconomic status (SES), which is an important determinant of diet quality. Nonetheless, research on diet quality among coffee consumers was scarce. We aimed to compare the diet quality of coffee consumers with different preferences towards coffee type and additive usage. METHODS: In this cross-sectional analysis, intake data of food, coffee, and additive usage from the adult respondents of the 2011-2012 Australian Health Survey were used...
June 21, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28638703/childhood-trauma-and-negative-memory-bias-as-shared-risk-factors-for-psychopathology-and-comorbidity-in-a-naturalistic-psychiatric-patient-sample
#19
Janna N Vrijsen, Camiel T van Amen, Bauke Koekkoek, Iris van Oostrom, Aart H Schene, Indira Tendolkar
BACKGROUND: Both childhood trauma and negative memory bias are associated with the onset and severity level of several psychiatric disorders, such as depression and anxiety disorders. Studies on these risk factors, however, generally use homogeneous noncomorbid samples. Hence, studies in naturalistic psychiatric samples are lacking. Moreover, we know little about the quantitative relationship between the frequency of traumatic childhood events, strength of memory bias and number of comorbid psychiatric disorders; the latter being an index of severity...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28638611/does-size-matter-kidney-transplant-donor-size-determines-kidney-function-among-living-donors
#20
Meenakshi Narasimhamurthy, Lachlan M Smith, Jason T Machan, Steven E Reinert, Reginald Y Gohh, Lance D Dworkin, Basma Merhi, Nikunjkumar Patel, Michael D Beland, Susie L Hu
BACKGROUND: Kidney donor outcomes are gaining attention, particularly as donor eligibility criteria continue to expand. Kidney size, a useful predictor of recipient kidney function, also likely correlates with donor outcomes. Although donor evaluation includes donor kidney size measurements, the association between kidney size and outcomes are poorly defined. METHODS: We examined the relationship between kidney size (body surface area-adjusted total volume, cortical volume and length) and renal outcomes (post-operative recovery and longer-term kidney function) among 85 kidney donors using general linear models and time-to-chronic kidney disease data...
February 2017: Clinical Kidney Journal
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