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Lipid infusion

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https://www.readbyqxmd.com/read/28341344/propofol-affinity-to-mitochondrial-membranes-does-not-alter-mitochondrial-function
#1
Luís M Félix, Fernando Correia, Pedro A Pinto, Sónia P Campos, Telma Fernandes, Romeu Videira, M Manuel Oliveira, Francisco P Peixoto, Luís M Antunes
The molecular mechanisms of hepatotoxicity after propofol anaesthesia have not been fully elucidated, although there is a relation with mitochondrial dysfunction. The action of propofol on mitochondrial hepatic functions in a rat model was evaluated by infusion for 4h with 25 and 62.5mg/kg/h propofol or 3.125ml/kg/h (vehicle). Liver mitochondrial respiratory rates were evaluated as well as mitochondrial transmembrane potential (ΔΨ), calcium fluxes, mitochondrial enzymatic activities (Complex I - V) and oxidative stress biomarkers (superoxide dismutase, catalase, glutathione reductase, glutathione S-transferase, lipid peroxidation and the oxidized/reduced glutathione ratio)...
March 21, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28339575/histaminergic-neurotransmission-as-a-gateway-for-the-cognitive-effect-of-oleoylethanolamide-in-contextual-fear-conditioning
#2
Gustavo Provensi, Roberta Fabbri, Leonardo Munari, Alessia Costa, Elisabetta Baldi, Corrado Bucherelli, Patrizio Blandina, Maria Beatrice Passani
Background: The integrity of the brain histaminergic system is necessary for the unfolding of homeostatic and cognitive processes through the recruitment of alternative circuits with distinct temporal patterns. We recently demonstrated that the fat-sensing lipid mediator oleoylethanolamide indirectly activates histaminergic neurons to exerts its hypophagic effects. The present experiments investigated whether histaminergic neurotransmission is necessary also for the modulation of emotional memory induced by oleoylethanolamide in a contextual fear conditioning paradigm...
January 19, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28331053/acetate-dose-dependently-stimulates-milk-fat-synthesis-in-lactating-dairy-cows
#3
Natalie L Urrutia, Kevin J Harvatine
Background: Acetate is a short-chain fatty acid (FA) that is especially important to cows because it is the major substrate for de novo FA synthesis. However, the effect of acetate supply on mammary lipid synthesis is not clear.Objective: The objective of this experiment was to determine the effect of increasing acetate supply on milk fat synthesis in lactating dairy cows.Methods: Six multiparous lactating Holstein cows were randomly assigned to treatments in a replicated design to investigate the effect of acetate supply on milk fat synthesis...
March 22, 2017: Journal of Nutrition
https://www.readbyqxmd.com/read/28294984/defining-the-baseline-and-oxidant-perturbed-lipidomic-profiles-of-daphnia-magna
#4
Nadine S Taylor, Thomas A White, Mark R Viant
Recent technological advancement has enabled the emergence of lipidomics as an important tool for assessing molecular stress, one which has yet to be assessed fully as an approach in an environmental toxicological context. Here we have applied a high-resolution, non-targeted, nanoelectrospray ionisation (nESI) direct infusion mass spectrometry (DIMS) technique to assess the effects of oxidative stress to Daphnia magna both in vitro (air exposure of daphniid extracts) and in vivo (Cu(2+) exposure). Multivariate and univariate statistical analyses were used to distinguish any perturbations including oxidation to the D...
March 15, 2017: Metabolites
https://www.readbyqxmd.com/read/28293389/exploring-the-effect-of-intravenous-lipid-emulsion-in-acute-methamphetamine-toxicity
#5
Ameneh Ghadiri, Leila Etemad, Mohammad Moshiri, Seyed Adel Moallem, Amir Hossein Jafarian, Farzin Hadizadeh, Mahmoud Seifi
OBJECTIVES: The increasing use of methamphetamine (METH) in the last decades has made it the second most abused drug. Advancs in the area of intravenous lipid emulsion (ILE) have led to its potential application in the treatment of poisoning. The present study aims to investigate the potential role of ILE as an antidote for acute METH poisoning. MATERIALS AND METHODS: Two groups of six male rats were treated by METH (45 mg/kg), intraperitoneally. Five to seven min later, they received an infusion of 18...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28283683/pre-pregnancy-levels-of-peripheral-natural-killer-cells-as-markers-for-immunomodulatory-treatment-in-patients-with-recurrent-miscarriage
#6
Ruben J Kuon, Franziska Müller, Kilian Vomstein, Maja Weber, Hannes Hudalla, Sabine Rösner, Thomas Strowitzki, Udo Markert, Volker Daniel, Bettina Toth
Immunological risk factors in patients with recurrent miscarriage (RM) are discussed controversially. Abnormalities of natural killer cells (NK) have been described in RM patients. Lipid infusions are known to modulate lymphocyte subsets. The aim of this study was to identify immune parameters that predict success of treatment with lipid infusions in RM patients with elevated NK. In sum, n = 341 couples with RM were screened for established risk factors and peripheral lymphocyte subpopulations as well as uterine NK cells...
March 11, 2017: Archivum Immunologiae et Therapiae Experimentalis
https://www.readbyqxmd.com/read/28282403/chemokine-binding-protein-m3-limits-atherosclerosis-in-apolipoprotein-e-mice
#7
Dhanya Ravindran, Anisyah Ridiandries, Laura Z Vanags, Rodney Henriquez, Siân Cartland, Joanne T M Tan, Christina A Bursill
Chemokines are important in macrophage recruitment and the progression of atherosclerosis. The 'M3' chemokine binding protein inactivates key chemokines involved in atherosclerosis (e.g. CCL2, CCL5 and CX3CL1). We aimed to determine the effect of M3 on plaque development and composition. In vitro chemotaxis studies confirmed that M3 protein inhibited the activity of chemokines CCL2, CCL5 and CX3CL1 as primary human monocyte migration as well as CCR2-, CCR5- and CX3CR1-directed migration was attenuated by M3...
2017: PloS One
https://www.readbyqxmd.com/read/28279967/ezetimibe-increases-endogenous-cholesterol-excretion-in-humans
#8
Xiaobo Lin, Susan B Racette, Lina Ma, Michael Wallendorf, Richard E Ostlund
OBJECTIVE: Ezetimibe improves cardiovascular outcomes when added to optimum statin treatment. It lowers low-density lipoprotein cholesterol and percent intestinal cholesterol absorption, but the exact cardioprotective mechanism is unknown. We tested the hypothesis that the dominant effect of ezetimibe is to increase the reverse transport of cholesterol from rapidly mixing endogenous cholesterol pool into the stool. APPROACH AND RESULTS: In a randomized, placebo-controlled, double-blind parallel trial in 24 healthy subjects with low-density lipoprotein cholesterol 100 to 200 mg/dL, we measured cholesterol metabolism before and after a 6-week treatment period with ezetimibe 10 mg/d or placebo...
March 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/28271568/effect-of-ziziphus-jujube-fruit-infusion-on-lipid-profiles-glycaemic-index-and-antioxidant-status-in-type-2-diabetic-patients-a-randomized-controlled-clinical-trial
#9
Zeinab Yazdanpanah, Akram Ghadiri-Anari, Alireza Vahidi Mehrjardi, Ali Dehghani, Hadi Zare Zardini, Azadeh Nadjarzadeh
This study was designed to assess the effects of Ziziphus jujube fruit (ZJF) infusion on lipid profiles, glycaemic control and antioxidant status in patients with type 2 diabetes mellitus (T2DM). In this randomized controlled clinical trial, 116 participants with T2DM (older than 30 years) were assigned to consume a balanced diet or diet plus ZJF infusion (10 g/100 mL boiling water) three times/day before main meals for 12 weeks. Diet was designed to be energy restricted (500 kcal/day deficit from estimated energy requirements), and macronutrient content was similar in both groups (55% carbohydrate, 15% protein and 30% fat)...
March 7, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28255844/nanosomal-docetaxel-lipid-suspension-a-guide-to-its-use-in-cancer
#10
Kate McKeage
Nanosomal docetaxel lipid suspension (NDLS) [DoceAqualip] is a novel formulation of docetaxel approved in India for the treatment of breast cancer, hormone-refractory prostate cancer, locally advanced squamous cell carcinoma of the head and neck, non-small cell lung cancer and advanced gastric adenocarcinoma. The lipid-based delivery system of NDLS eliminates the need for polysorbate 80 and ethanol, which are contained in the conventional docetaxel formulation and are associated with hypersensitivity reactions and infusion-related toxicities...
March 2, 2017: Clinical Drug Investigation
https://www.readbyqxmd.com/read/28246176/effect-of-intralipid-postconditioning-on-myocardial-injury-in-patients-undergoing-valve-replacement-surgery-a-randomised-controlled-trial
#11
Rong-Hua Zhou, Hui Yu, Xiao-Rong Yin, Qi Li, Hong Yu, Hai Yu, Chan Chen, Ji-Yue Xiong, Zhen Qin, Ming Luo, Zhao-Xia Tan, Ting Liu
OBJECTIVE: This study was conducted to determine whether the administration of intralipid just before aortic cross-unclamping would reduce myocardial injury in patients undergoing valve replacement surgery. METHODS: Seventy-three adult patients, scheduled for elective aortic or mitral valve surgery without significant coronary stenosis (>70%), were randomly assigned to the intralipid postconditioning (ILPC) group (n=37) or control group (n=36): the ILPC group received an intravenous infusion of 20% intralipid (2 mL/kg) just 10 min before aortic cross-unclamping, and the control group received an equivalent volume of normal saline...
February 28, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28241817/berberine-improves-glucogenesis-and-lipid-metabolism-in-nonalcoholic-fatty-liver-disease
#12
Li Zhao, Zhen Cang, Honglin Sun, Xiaomin Nie, Ningjian Wang, Yingli Lu
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is considered a critical hepatic manifestation of metabolic syndrome. Berberine (BBR) exerts anti-hyperglycemic and anti-dyslipidemic effects and can also ameliorate NAFLD. Thus, BBR might exert its therapeutic effect on NAFLD by improving glucolipid metabolism. Here, we investigated the aspects and extent to which glucolipid metabolism were affected by BBR in rats with NAFLD. METHODS: Three groups of Sprague-Dawley rats were studied: a control group (n = 6) fed a normal chow diet and a NAFLD group (n = 6) and a NAFLD + BBR group (n = 6) fed a high-fat diet...
February 28, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28239611/pleotropic-acute-and-chronic-effects-of-leptin-to-reverse-type-1-diabetes
#13
Rachel J Perry
Recent studies have demonstrated that leptin can prolong life chronically in rats with poorly-controlled type 1 diabetes (T1D). Multiple explanations have been proposed to explain leptin's chronic antihyperglycemic effect, including suppression of glucagon release and/or signaling, reductions in hyperphagia and ectopic lipid content, and improvements in insulin sensitivity; it is leptin's ability to reduce plasma glucose relies on all of these effects. In addition, leptin reverses hyperglycemia and diabetic ketoacidosis (DKA) acutely, within 6 hours of leptin infusion, by suppressing hypothalamic-pituitary-adrenal (HPA) axis activity in insulinopenic rats...
January 2017: Postdoc Journal: a Journal of Postdoctoral Research and Postdoctoral Affairs
https://www.readbyqxmd.com/read/28222328/effects-of-cooking-methods-and-tea-marinades-on-the-formation-of-benzo-a-pyrene-in-grilled-pork-belly-samgyeopsal
#14
Keun-Cheol Park, HeeSoo Pyo, WooSeok Kim, Ki Sun Yoon
We investigated the effects of different grilling tools, temperatures, and tea marinades on the formation of benzo[a]pyrene in grilled pork belly as well as the antioxidant capacities of tea marinades. The least amount of benzo[a]pyrene was detected in modified charcoal-grilled pork belly (1.28μg/kg). The highest risk factors for the formation of benzo[a]pyrene are direct contact with flames and fat excess on the heating source. A modified charcoal grill can be used as an alternative grilling tool to meet consumer needs for safety and taste...
February 14, 2017: Meat Science
https://www.readbyqxmd.com/read/28207959/lipoprotein-lipase-activity-does-not-predict-vldl-tg-fatty-acid-oxidation-during-exercise
#15
Esben Søndergaard, Iben R Andersen, Lars P Sørensen, Lars C Gormsen, Søren Nielsen
INTRODUCTION: Exercise lowers plasma triglyceride levels, but the physiological mechanisms remain not fully elucidated. Lipoprotein lipase (LPL) is a key enzyme in facilitating fatty acid uptake from lipoproteins. Since exercise increase the efficiency of VLDL-TG oxidation, we hypothesized that muscle LPL activity would be a rate-limiting step and predict VLDL-TG FA oxidation during exercise. METHODS: Sixteen healthy, lean subjects (8 men and 8 women) were examined before and during an acute exercise bout (90 min at 50% of VO2-max)...
February 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28190990/the-translation-of-lipid-profiles-to-nutritional-biomarkers-in-the-study-of-infant-metabolism
#16
Animesh Acharjee, Philippa Prentice, Carlo Acerini, James Smith, Ieuan A Hughes, Ken Ong, Julian L Griffin, David Dunger, Albert Koulman
INTRODUCTION: Links between early life exposures and later health outcomes may, in part, be due to nutritional programming in infancy. This hypothesis is supported by observed long-term benefits associated with breastfeeding, such as better cognitive development in childhood, and lower risks of obesity and high blood pressure in later life. However, the possible underlying mechanisms are expected to be complex and may be difficult to disentangle due to the lack of understanding of the metabolic processes that differentiate breastfed infants compared to those receiving just formula feed...
2017: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/28185575/integration-of-metabolomics-lipidomics-and-clinical-data-using-a-machine-learning-method
#17
Animesh Acharjee, Zsuzsanna Ament, James A West, Elizabeth Stanley, Julian L Griffin
BACKGROUND: The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity or the subsequent pathophysiological consequences associated with excess weight gain. Certain nuclear hormone receptors (NRs) play a pivotal role in lipid and carbohydrate metabolism and have been highlighted as potential treatments for obesity. This realisation started a search for NR agonists in order to understand and successfully treat MetS and associated conditions such as insulin resistance, dyslipidaemia, hypertension, hypertriglyceridemia, obesity and cardiovascular disease...
November 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28176051/piracetam-attenuates-lps-induced-neuroinflammation-and-cognitive-impairment-in-rats
#18
Alok Tripathi, Pankaj Paliwal, Sairam Krishnamurthy
The present study was performed to investigate the effect of piracetam on neuroinflammation induced by lipopolysaccharide (LPS) and resulting changes in cognitive behavior. Neuroinflammation was induced by a single dose of LPS solution infused into each of the lateral cerebral ventricles in concentrations of 1 μg/μl, at a rate of 1 μl/min over a 5-min period, with a 5-min waiting period between the two infusions. Piracetam in doses of 50, 100, and 200 mg/kg i.p. was administered 30 min before LPS infusion and continued for 9 days...
February 7, 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/28174289/vascular-effects-of-obestatin-in-lean-and-obese-subjects
#19
Francesca Schinzari, Augusto Veneziani, Nadia Mores, Angela Barini, Nicola Di Daniele, Carmine Cardillo, Manfredi Tesauro
Obese patients have impaired vasodilator reactivity and increased endothelin (ET)-1-mediated vasoconstriction, two abnormalities contributing to vascular dysfunction. Obestatin, a product of the ghrelin gene, in addition to favorable effects on glucose and lipid metabolism, has shown nitric oxide (NO)-dependent vasodilator properties in experimental models. Given these premises, we compared the effects of exogenous obestatin on forearm flow in lean and obese subjects and assessed its influence on ET-1-dependent vasoconstrictor tone in obesity...
February 7, 2017: Diabetes
https://www.readbyqxmd.com/read/28160864/inulin-type-fructan-and-infusion-of-artemisia-vulgaris-protect-the-liver-against-carbon-tetrachloride-induced-liver-injury
#20
Marília Locatelli Corrêa-Ferreira, Maria Helena Verdan, Francislaine Aparecida Dos Reis Lívero, Larissa Favaretto Galuppo, José Ederaldo Queiroz Telles, Maria Élida Alves Stefanello, Alexandra Acco, Carmen Lúcia de Oliveira Petkowicz
BACKGROUND: Infusions of aerial parts of Artemisia vulgaris L. (Asteraceae) are used in herbal medicine to treat several disorders, including hepatosis. PURPOSE: Evaluation of in vivo hepatoprotective effects of A. vulgaris infusion (VI) and inulin (VPI; i.e., the major polysaccharide of VI). STUDY DESIGN: The hepatoprotective effect of A. vulgaris extracts on carbon tetrachloride (CCl4)-induced hepatotoxicity and the probable mechanism involved in this protection were investigated in mice...
January 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
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