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https://www.readbyqxmd.com/read/29777902/chemical-characterization-and-cerebroprotective-effect-of-methanolic-root-extract-of-colebrookea-oppositifolia-in-rats
#1
Gollapalle Lakshminarayanashastry Viswanatha, Marikunte V Venkataranganna, Nunna Bheema Lingeswara Prasad, Shylaja Hanumanthappa
ETHNOPHARMACOLOGICAL RELEVANCE: Colebrookea oppositifolia Smith is one of the extensively used plants to treat neurological conditions such as epilepsy by the various ethnic communities in sub-Himalayan regions of India such as Bhoxa, Tharu and nomadic Gujjars. AIM OF THE STUDY: This study was conducted to evaluate the cerebroprotective effect of C. oppositifolia methanolic root (MeCO) extract in Wistar rats. MATERIALS AND METHODS: The MeCO was characterized for total phenolic content and later subjected for detailed liquid chromatography-mass spectrometry analysis...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29774505/mitigating-peroxynitrite-mediated-mitochondrial-dysfunction-in-aged-rat-brain-by-mitochondria-targeted-antioxidant-mitoq
#2
Arpan Kumar Maiti, B C Spoorthi, Nimai Chandra Saha, Ashis Kumar Panigrahi
Although reactive oxygen species mediated oxidative stress is a well-documented mechanism of aging, recent evidences indicate involvement of nitrosative stress in the same. As mitochondrial dysfunction is considered as one of the primary features of aging, the present study was designed to understand the involvement of nitrosative stress by studying the impact of a mitochondria-targeted antioxidant MitoQ, a peroxynitrite (ONOO- ) scavenger, on mitochondrial functions. Four groups of rats were included in this study: Group I: Young-6 months (-MitoQ), Group II: Aged-22 months (- MitoQ), Group III: Young-6 months (+ MitoQ), Group IV: Aged-22 months (+ MitoQ)...
May 17, 2018: Biogerontology
https://www.readbyqxmd.com/read/29769067/antioxidant-capacity-of-cinnamon-extract-for-palm-oil-stability
#3
Muhammad Zia Shahid, Hafiza Saima, Adeela Yasmin, Muhammad Tahir Nadeem, Muhammad Imran, Muhammad Afzaal
BACKGROUND: Spices and their bioactive components are more promising attractions for their inclusion in diet-based regimes to improve human health. These are sources of natural antioxidants and play an important role in the chemoprevention of diseases and aging. The aim of the current study was to explore the antioxidant potential of cinnamon; a widely used spice throughout the world. METHODS: The current research was aimed to investigate the antioxidant potential of cinnamon extract...
May 16, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29761542/ameliorative-effect-of-resveratrol-on-testicular-oxidative-stress-spermatological-parameters-and-dna-damage-in-glyphosate-based-herbicide-exposed-rats
#4
F Avdatek, Y O Birdane, R Türkmen, H H Demirel
In this study, the reproductive impacts of being exposed to glyphosate (GLF) and the protective impacts of resveratrol (RES) were assessed in 28 Wistar male rats, which were equally separated into four groups. Control group were fed normal diet without GLF or RES, group II received normal feed containing 20 mg kg-1 daily-1 RES, group III received normal feed containing 375 mg kg-1 daily-1 GLF, and group IV received normal feed containing 375 mg kg-1 daily-1 GLF+20 mg kg-1 daily-1 RES. GLF administration decreased sperm motility, sperm plasma membrane integrity, glutathione level and superoxide dismutase in the testicular tissue of rats...
May 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29757051/weight-regain-but-not-weight-loss-is-related-to-competitive-success-in-real-life-mixed-martial-arts-competition
#5
Victor Silveira Coswig, Bianca Miarka, Daniel Alvarez Pires, Levy Mendes da Silva, Charles Bartel, Fabrício Boscolo Del Vecchio
We aimed to describe the nutritional and behavioural strategies for rapid weight loss (RWL), investigate the effects of RWL and weight regain (WRG) in winners and losers and verify mood state and technical-tactical/time-motion parameters in Mixed Martial Arts (MMA). The sample consisted of MMA athletes after a single real match and was separated into two groups: Winners (n=8, age: 25.4±6.1yo., height: 173.9±0.2cm, habitual body mass (BM): 89.9±17.3kg) and Losers (n=7, age: 24.4±6.8yo., height: 178.4±0...
May 14, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29747667/protective-effect-of-grape-seed-and-skin-extract-against-high-fat-diet-induced-dyshomeostasis-of-energetic-metabolism-in-rat-lung
#6
Mohamed El Ayed, Safwen Kadri, Maha Mabrouk, Ezzedine Aouani, Salem Elkahoui
BACKGROUND: Obesity is currently one of the major epidemics of this millennium and affects poeples throughout the world. It causes multiple systemic complications as it significantly interferes with respiratory function. OBJECTIVE: We aimed in the present work to study the effect of high fat diet (HFD) on lung oxidative stress and energy metabolism alterations, as well as the putative protection afforded by grape seed and skin extract (GSSE). METHODS: We started by characterizing the GSSE and its composition using gas chromatography coupled to mass spectrometry (GC-MS)...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29744485/platinum-iv-prodrugs-with-long-lipid-chains-for-drug-delivery-and-overcoming-cisplatin-resistance
#7
Qiling Chen, Yuanyuan Yang, Xun Lin, Wen Ma, Gui Chen, Wenliang Li, Xuefeng Wang, Zhiqiang Yu
Platinum(iv) prodrugs of clinically used cisplatin and oxaliplatin with two axial long lipid chains were developed for nanoparticle delivery to combat cisplatin resistance.
May 10, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29743860/ameliorative-effects-of-spirulina-platensis-against-lead-induced-nephrotoxicity-in-newborn-rats-modulation-of-oxidative-stress-and-histopathological-changes
#8
Manel Gargouri, Ahlem Soussi, Amel Akrouti, Christian Magné, Abdelfattah El Feki
Our experimental work was aimed at evaluating the safety and protective effects of dietary spirulina supplementation on the kidney of newborn rats, the offspring of lead contaminated lactating mothers. Female rats were randomly divided into four groups: group I (control) was given a normal diet, group II (positive control, S) received a diet enriched with spirulina , group III received only lead through drinking water (Pb), and group IV received both a diet enriched with spirulina and lead contaminated water (S Pb)...
2018: EXCLI journal
https://www.readbyqxmd.com/read/29741759/anionic-nanoliposomes-reduced-atherosclerosis-progression-in-low-density-lipoprotein-receptor-ldlr-deficient-mice-fed-a-high-fat-diet
#9
Smriti M Krishna, Joseph V Moxon, Roby J Jose, Jiaze Li, Amirhossein Sahebkar, Mahmoud R Jaafari, Mahdi Hatamipour, Dawie Liu, Jonathan Golledge
Atherosclerosis is a systemic disease characterized by the deposition of cholesterol and inflammatory cells within the arterial wall. Removal of cholesterol from the vessel wall may have an impact on the size and composition of atherosclerotic lesions. Anionic phospholipids or liposome vesicles composed of a lipid bilayer such as nanoliposomes have been suggested as treatments for dyslipidemia. In this study, we investigated the effect of anionic nanoliposomes on atherosclerosis in a mouse model. Low-density lipoprotein receptor knockout mice (Ldlr-/- ) were fed with an atherosclerosis promoting high fat and cholesterol (HFC) diet for 12 weeks...
May 9, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29739324/zinc-and-linoleic-acid-pre-treatment-attenuates-biochemical-and-histological-changes-in-the-midbrain-of-rats-with-rotenone-induced-parkinsonism
#10
Ngala Elvis Mbiydzenyuy, Herbert Izo Ninsiima, Miriela Betancourt Valladares, Constant Anatole Pieme
BACKGROUND: Studies have suggested the supplementation of Zinc and Linoleic acid in the management of neurodegenerative disorders but none has investigated the combined effects. Little is known about the neuroprotective effects of either Zinc or Linoleic acid or their combination against development of Parkinsonism. This study was designed to investigate the neuroprotective effects of Zinc and Linoleic acid in rotenone-induced Parkinsonism in rats. METHODS: Thirty-six young adult female rats weighing 100-150 g divided into six groups were used...
May 9, 2018: BMC Neuroscience
https://www.readbyqxmd.com/read/29735797/modulatory-effect-of-dietary-inclusion-of-aegle-marmelos-fruits-against-cisplatin-induced-hepatotoxicity-in-wistar-rats
#11
Saket S Chandel, Mrunal Shirsat, Ram K Sahu, Siva S Nayak
INTRODUCTION AND AIM: Aegle marmelos is an important traditional herbal medicine used in India. The dietary inclusion of the plant has never exposed earlier for its hepatoprotective activity. This study aimed to investigate the modulator efficacy of dietary inclusion of Aegle marmelos against Cisplatin - induced hepatotoxicity in Wistar albino rats. MATERIAL AND METHODS: Animals were divided into five different groups; Group I was given basal diets only, Group II was fed basal diets with Aegle marmelos in 4% concentration, while Group III was fed basal diets co-administered with Cisplatin...
April 9, 2018: Annals of Hepatology
https://www.readbyqxmd.com/read/29730972/the-protective-effect-of-extra-virgin-olive-oil-in-the-experimental-model-of-multiple-sclerosis-in-the-rat
#12
C Conde, B M Escribano, E Luque, M Aguilar-Luque, M Feijóo, J J Ochoa, M LaTorre, A I Giraldo, R Lillo, E Agüera, A Santamaría, I Túnez
This study has evaluated the effect of EVOO (Extra-Virgin olive oil), OA (oleic acid) and HT (hydroxytyrosol) in an induced model of MS through experimental autoimmune encephalomyelitis (EAE). Dark Agouti 2-month old rats (25 males) were divided into five groups: (i) control group, (ii) EAE group, (iii) EAE+EVOO, (iv) EAE+HT, and (v) EAE+OA. At 65 days, the animals were sacrificed and the glutathione redox system and bacterial lipopolysaccharide (LPS) and LPS-binding protein (LBP) products of the microbiota in brain, spinal cord, and blood were evaluated...
May 5, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29716870/role-of-leptin-and-dyslipidemia-in-chronic-kidney-disease
#13
Sabeela Noor, Faiza Alam, Syeda Sadia Fatima, Mahnur Khan, Rehana Rehman
Chronic kidney disease (CKD) patients are at an increased risk of cardiovascular complications and plasma leptin level is elevated in cardio renal syndrome. We wanted to explore leptin levels in patients with different stages of CKD and find its association with risk of cardiovascular disease. This cross-sectional study was conducted in Nephrology Department of Jinnah Post Graduate Medical Centre (JPMC) from January 2014 to September 2014. Group I comprised of controls (GFR=116±8.3, n = 44) acquired from general population, CKD patients were grouped as II, III and IV respectively with GFR; 85...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29713279/astragaloside-iv-inhibits-triglyceride-accumulation-in-insulin-resistant-hepg2-cells-via-ampk-induced-srebp-1c-phosphorylation
#14
Chunyi Wang, Yan Li, Mengjiao Hao, Weimin Li
Objective: Insulin resistance (IR) is a risk factor for non-alcoholic fatty liver disease (NAFLD), which is characterized by lipid accumulation in hepatocytes. AMP-activated protein kinase (AMPK)-induced sterol regulatory element binding protein-1c (SREBP-1c) phosphorylation is crucial for proper regulation of lipid metabolism in the liver. Astragaloside IV (AST-IV) was found to decrease lipid accumulation in hepatocytes by activating AMPK, which is required to regulate lipid metabolism in liver tissue by inducing SREBP-1c phosphorylation...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29710513/alterations-in-oxidative-stress-markers-and-its-correlation-with-clinical-findings-in-schizophrenic-patients-consuming-perphenazine-clozapine-and-risperidone
#15
Narjes Hendouei, Samaneh Farnia, Farhad Mohseni, Azadeh Salehi, Maedeh Bagheri, Faezeh Shadfar, Fatemeh Barzegar, Seyed Davood Hoseini, Jamshid Yazdani Charati, Fatemeh Shaki
BACKGROUND AND OBJECTIVE: Today, the role of oxidative stress in development of schizophrenia has gained attention. Also, some atypical antipsychotic agents showed antioxidant properties. Therefore, in this study, we evaluated the level of oxidative stress parameters between patients treated with perphenazine, clozapine and risperidone and their relationship with schizophrenia symptoms' severity. MATERIALS AND METHODS: This was a descriptive study on 100 patients with chronic schizophrenia...
April 24, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29705134/increase-in-liver-cytosolic-lipases-activities-and-vldl-tag-secretion-rate-do-not-prevent-the-non-alcoholic-fatty-liver-disease-in-cafeteria-diet-fed-rats
#16
Anderson Fernandes de Melo, Carolina Campos Lima Moreira, Camila Ferreira Sales, Thiago Rentz, Helena Fonseca Raposo, Maria Antonieta Rissato Garófalo, Leida Maria Botion, Isis do Carmo Kettelhut, Helena Coutinho Franco de Oliveira, Valéria Ernestânia Chaves
We have previously shown that the cafeteria diet increases body fat mass, triacylglycerol (TAG) and insulin plasma levels, glucose uptake by white and brown adipose tissues, as well as the sympathetic activity to both adipose tissues in Wistar rats. The metabolic pathways responsible for the development of non-alcoholic fatty liver disease (NAFLD) were examined in cafeteria diet-fed rats. After 3 weeks offering cafeteria diet, we evaluated: (i) activity of the sympathetic nervous system by norepinephrine turnover rates; (ii) de novo fatty acid synthesis in vivo using 3H2O; (iii) secretion of very low density lipoprotein (VLDL)-TAG secretion measuring serum TAG levels after administration of lipase lipoprotein inhibitor, (iv) liver cytosolic lipases activity and (v) liver mRNA expression of enzymes involved in lipids secretion and oxidation by RT-PCR...
April 26, 2018: Biochimie
https://www.readbyqxmd.com/read/29704992/opposing-roles-of-y-family-dna-polymerases-in-lipid-peroxide-mutagenesis-at-the-hisg46-target-in-the-ames-test
#17
Petr Grúz, Masatomi Shimizu, Masami Yamada, Kei-Ichi Sugiyama, Masamitsu Honma
DNA polymerases play a key role in mutagenesis by performing translesion DNA synthesis (TLS). The Y-family of DNA polymerases comprises several evolutionarily conserved families, specializing in TLS of different DNA adducts. Exocyclic etheno and propano DNA adducts are among the most common endogenous DNA lesions induced by lipid peroxidation reactions triggered by oxidative stress. We have investigated the participation of two enterobacterial representatives of the PolIV and PolV branches of Y-family DNA polymerases in mutagenesis by two model lipid peroxidation derived genotoxins, glyoxal and crotonaldehyde...
May 2018: Mutation Research
https://www.readbyqxmd.com/read/29702000/the-effect-of-intravenous-insulin-apheresis-and-oral-lipid-lowering-agents-on-non-fasting-hypertriglyceridemia-and-associated-pancreatitis
#18
Daniela Frankova, Kristin Melissa Olson, Brian Joseph Whyms, Maria A Guevara Hernandez, Jan Franko
BACKGROUND: There is evidence that increasing severity of hypertriglyceridemia increases the risk of acute pancreatitis. There is a debate about superiority of treatment methods and previous works have specifically called for direct comparison between IV insulin and apheresis techniques. OBJECTIVES: Identify patient characteristics predictive of lipid-lowering therapy selection in a large community hospital for treatment of hypertriglyceridemia; evaluate for a concentration-dependent relationship between hypertriglyceridemia severity and risk of acute pancreatitis; assess for differences in clinical outcomes between patients treated with IV insulin versus apheresis...
April 27, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29696662/unity-in-diversity-structural-and-functional-insights-into-the-ancient-partnerships-between-plants-and-fungi
#19
REVIEW
Katie J Field, Silvia Pressel
Contents I. II. III. IV. V. VI. VII. VIII. References SUMMARY: Mycorrhizal symbiosis is an ancient and widespread mutualism between plants and fungi that facilitated plant terrestrialisation > 500 million years ago, with key roles in ecosystem functioning at multiple scales. Central to the symbiosis is the bidirectional exchange of plant-fixed carbon for fungal-acquired nutrients. Within this unifying role of mycorrhizas, considerable diversity in structure and function reflects the diversity of the partners involved...
April 26, 2018: New Phytologist
https://www.readbyqxmd.com/read/29692651/influence-of-crocetin-on-high-cholesterol-diet-induced-atherosclerosis-in-rats-via-anti-oxidant-activity-together-with-inhibition-of-inflammatory-response-and-p38-mapk-signaling-pathway
#20
Shu-Ling Diao, Jing-Wu Sun, Bao-Xin Ma, Xiao-Mei Li, Dong Wang
The present study aimed to investigate the effect and possible mechanism of action of crocetin on the high cholesterol diet (HCD) induced atherosclerosis rat. The Wistar rats were used in the current investigation. The rats were divided into following group, Group I: control, Group II: HCD induced AS, Group III: AS + crocetin (25 mg/kg), Group IV: AS + crocetin (50 mg/kg) and Group V: AS + Simvastatin, respectively. AS was induced in the rats using the vitamin D3 and HCD. The rats received the pre-determined treatment for the 10 weeks...
March 2018: Saudi Journal of Biological Sciences
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