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low level laser therapy burn inflammation

Sophie Seité, René-Jean Bensadoun, Jean-Michel Mazer
More than half the number of patients with cancer, who are treated with radiotherapy, will have radiodermatitis at some point during their treatment. Radiodermatitis either occurs early on in the treatment period or appears months or up to several years later. Acute radiodermatitis is a burn injury that varies in severity according to both treatment and inherent patient factors. Most acute radiodermatitis reactions resolve after several weeks but some reactions persist and can cause complications. Late-onset radiodermatitis is characterized by telangiectasia that forms on atrophic and fragile skin...
2017: Breast Cancer: Targets and Therapy
Mozhgan Rezaei Kanavi, Faraj Tabeie, Farzin Sahebjam, Nima Poursani, Nazanin Jahanbakhsh, Pouya Paymanpour, Sasha AfsarAski
This study was conducted to investigate the effect of combining extremely low frequency-pulsed electromagnetic field (ELF-PEMF) and low-level laser therapy (LLLT) on alkali-burned rabbit corneas. Fifty alkali-burned corneas of 50 rabbits were categorized into five groups: ELF-PEMF therapy with 2 mT intensity (ELF 2) for 2 h daily; LLLT for 30 min twice daily; combined ELF-PEMF and LLLT (ELF + LLLT); medical therapy (MT); and control (i.e., no treatment). Clinical examination and digital photography of the corneas were performed on days 0, 2, 7, and 14...
April 2016: Experimental Eye Research
Asheesh Gupta, Gaurav K Keshri, Anju Yadav, Shefali Gola, Satish Chauhan, Ashok K Salhan, Shashi Bala Singh
Low-level laser therapy (LLLT) using superpulsed near-infrared light can penetrate deeper in the injured tissue and could allow non-pharmacological treatment for chronic wound healing. This study investigated the effects of superpulsed laser (Ga-As 904 nm, 200 ns pulse width; 100 Hz; 0.7 mW mean output power; 0.4 mW/cm(2) average irradiance; 0.2 J/cm(2) total fluence) on the healing of burn wounds in rats, and further explored the probable associated mechanisms of action. Irradiated group exhibited enhanced DNA, total protein, hydroxyproline and hexosamine contents compared to the control and silver sulfadiazine (reference care) treated groups...
June 2015: Journal of Biophotonics
Pinar Avci, Asheesh Gupta, Magesh Sadasivam, Daniela Vecchio, Zeev Pam, Nadav Pam, Michael R Hamblin
Low-level laser (light) therapy (LLLT) is a fast-growing technology used to treat a multitude of conditions that require stimulation of healing, relief of pain and inflammation, and restoration of function. Although skin is naturally exposed to light more than any other organ, it still responds well to red and near-infrared wavelengths. The photons are absorbed by mitochondrial chromophores in skin cells. Consequently, electron transport, adenosine triphosphate nitric oxide release, blood flow, reactive oxygen species increase, and diverse signaling pathways are activated...
March 2013: Seminars in Cutaneous Medicine and Surgery
Franciane B Fiório, Regiane Albertini, Ernesto Cesar Pinto Leal-Junior, Paulo de Tarso Camillo de Carvalho
Low-level laser therapy (LLLT) has been increasingly used to accelerate wound healing in third-degree burns. This study investigated the effects of lasers on the tissue repair process of third-degree burns. Burns were produced on the backs of male Wistar rats. The animals were divided into four groups (n = 12): control, injury, LLLT 3 J/cm(2), and LLLT 4 J/cm(2). Each group was further divided into two subgroups; the rats in one subgroup were killed on day 8 and those in the other, on day 16 after injury. The animals in LLLT 3 J/cm(2) and LLLT 4 J/cm(2) were irradiated 1 h after injury, and irradiation was repeated every 48 h...
January 2014: Lasers in Medical Science
Juliana Medeiros de Moraes, Diego Eterno de Oliveira Mendonça, Vânia Beatriz L Moura, Milton Adriano Pelli Oliveira, Cristina Lopes Afonso, Marina Clare Vinaud, Maria Márcia Bachion, Ruy de Souza Lino
Third-degree burn wounds are considered severe injuries because they destroy all the skin layers and may affect subcutaneous tissues, fasciae, muscles, and bones. To favor the healing process of the injured tissues, it is very useful to diminish the occurrence of the inflammatory process. The present study was aimed at comparing the effect of different energetic densities of AlGaInP laser on the inflammatory process and in the healing of third-degree burn wounds in Wistar rats. This study was approved by the Ethics Committee, in which 36 adult male rats were selected and suffered the induction of third-degree burn injury...
July 2013: Lasers in Medical Science
Silvia Cristina Núñez, Cristiane Miranda França, Daniela Fátima Teixeira Silva, Gessé Eduardo Calvo Nogueira, Renato Araujo Prates, Martha Simões Ribeiro
Low-level laser therapy (LLLT) promotes biomodulation of wound healing and literature reports that light delivery during the inflammation could play a different role compared with latter phases of the healing process. The objective of this study was to investigate whether single dose of a red laser (λ = 660 nm) is different from fractionated delivery protocol in full thickness burns. Two lesions were inflicted on the back of 36 rats. In the fractionated dose group (FG), the lesions were irradiated with 1 J/cm² on days 1, 3, 8, and 10 post-wounding...
February 2013: Lasers in Medical Science
Luca Scrimali, Giuseppe Lomeo, Corrado Nolfo, Gianluca Pompili, Serena Tamburino, Alexei Catalani, Paolo Siragò, Rosario Emanuele Perrotta
Keloids and hypertrophic scars are both abnormal wound responses in predisposed individuals but they differ in that keloids extend beyond the original wound and almost never regress, while hypertrophic scars remain within the original wound and tend to regress. How keloids grow is not totally clear because there is no animal model; in fact, keloids affect only humans. Different injuries can result in keloids, including burns, surgery, ear piercing, lacerations, abrasions, tattooing, vaccinations, injections, insect bites and any process causing skin inflammation (chicken pox, acne, folliculitis, zoster)...
October 2010: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
Valdir Gouveia Garcia, Marcos Alcântara de Lima, Tetuo Okamoto, Luís Alberto Milanezi, Erivan Clementino Gualberto Júnior, Leandro Araújo Fernandes, Juliano Milanezi de Almeida, Letícia Helena Theodoro
The aim of this study was to conduct a histological assessment of the effect of photodynamic therapy (PDT) on the repairing of third-degree-burn wounds made on the backs of rats with a heated scalpel. Ninety-six rats were divided into groups: G1, control (n = 24), cold scalpel; G2, burned, heated scalpel (n = 24); G3, low-level laser therapy (LLLT) (n = 24), on burns; and G4, photodynamic therapy (PDT) (n = 24), toluidine-O blue (100 microg/ml) and LLLT treatment on burns. The laser (685 nm) was applied in continuous mode, 50 mW, 4...
March 2010: Lasers in Medical Science
Mohammad Bayat, Mohammad Mehdi Vasheghani, Naser Razavie, Mohammad Reza Jalili
Mast cells have been shown to participate in the wound healing process. We investigated the effects of low-level laser therapy (LLLT) on mast cell number in the inflammation, proliferation, and remodeling phases of the wound healing process of experimental burns. Sixty rats subjected to third-degree burns were divided into four groups: two laser-treated, one control, and one nitrofurazone-treated group. In the two laser-treated groups, burned areas received LLLT with a helium-neon laser at energy densities of 38...
2008: Journal of Rehabilitation Research and Development
Gyselle C S Meireles, Jean N Santos, Priscila O Chagas, Adriana P Moura, Antonio L B Pinheiro
OBJECTIVE: The aim of this investigation was to compare by light microscopy the effects of laser photobiomodulation (LPBM) at lambda = 660 nm and lambda = 780 nm on third-degree burns in diabetic Wistar rats. BACKGROUND DATA: Burns are severe injuries that result in fluid loss, tissue destruction, infection, and shock, that may result in death. Diabetes is a disease that reduces the body's ability to heal properly. LPBM has been suggested as an effective method of improving wound healing...
February 2008: Photomedicine and Laser Surgery
D A Hendrick, A Meyers
Compared with scalpel wounds, CO2 laser wounds show delays in inflammation, collagen production, reepithelialization, and tensile strength in the early stages of healing. Some of these delays are similar to those seen with electrocautery and burn wounds. Later stages compensate for these early deficiencies, because scalpel and laser wounds become more similar in epithelialization and wound strength over time. Healed CO2 laser wounds tend to have less scar contraction than scalpel wounds. Débridement of initial laser wound char, tissue cooling techniques during lasering, and pulsed modes of laser delivery all seem to result in more rapid, favorable healing...
October 1995: Otolaryngologic Clinics of North America
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