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https://www.readbyqxmd.com/read/28738542/protective-effects-of-tannic-acid-on-acute-doxorubicin-induced-cardiotoxicity-involvement-of-suppression-in-oxidative-stress-inflammation-and-apoptosis
#1
Jianping Zhang, Lijing Cui, Xue Han, Yuanyuan Zhang, Xuan Zhang, Xi Chu, Fenghua Zhang, Ying Zhang, Li Chu
Doxorubicin (DOX) is a highly effective drug, but its cardiotoxicity restricts its therapeutic index. Oxidative stress is the major etiopathological factor in DOX-induced cardiotoxicity. Tannic acid (TA) has various anti-cancer, antioxidant, and anti-inflammatory activities. The purpose of the study was to survey the possible effects of TA against acute DOX-induced cardiotoxicity. Male Sprague-Dawleyrats were randomly divided into five groups: control, DOX (10mg/kg) alone, DOX with TA (20 and 40mg/kg), or DOX withcaptopril (30mg/kg) treatments...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738532/genipin-attenuates-cisplatin-induced-nephrotoxicity-by-counteracting-oxidative-stress-inflammation-and-apoptosis
#2
Eglal Mahgoub, Shanmugam Muthu Kumaraswamy, Kamal Hassan Kader, Balaji Venkataraman, Shreesh Ojha, Ernest Adeghate, Mohanraj Rajesh
Cisplatin (CP) is a potent and widely used chemotherapeutic agent. However, the clinical benefits of CP are compromised because it elicits nephrotoxicity and ototoxicity. In this study, we investigated the nephroprotective effects of the phytochemical genipin (GP) isolated from the gardenia (Gardenia jasminoides) fruit, using a murine model of CP-induced nephropathy. GP pretreatment attenuated the CP-induced renal tissue injury by diminishing the serum blood urea nitrogen, creatinine, and cystatin C levels, as well as those of kidney injury molecule-1...
July 20, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738497/oeanolic-acid-protects-against-the-hepatotoxicity-of-d-galactosame-plus-endotoxin-in-mice
#3
Xiao-Li Wan, Yuan-Fu Lu, Shang-Fu Xu, Qin Wu, Jie Liu
Oleanolic acid (OA) is a triterpenoid contained in many herbal medicines. The aim of this study was to investigate the protective effect of OA against D-galactosame plus lipopolysaccharides (D-GalN/LPS)-induced acute liver injury and the underling mechanisms. Mice were randomly divided into normal control with vehicles only (corn oil), D-GalN/LPS only (700mg/10μg/kg, ip), OA-po (200μmol/kg in corn oil, po) plus D-GalN/LPS, and OA-sc (50μmol/kg in 2% tween 80, sc) plus D-GalN/LPS groups. OA pretreatment was conducted twice daily for 4 consecutive days...
July 18, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28738323/the-role-of-exogenous-hydrogen-sulfide-in-free-fatty-acids-induced-inflammation-in-macrophages
#4
Zhu-Lin Luo, Jian-Dong Ren, Zhu Huang, Tao Wang, Ke Xiang, Long Cheng, Li-Jun Tang
BACKGROUND: This study aimed to investigate whether exogenous hydrogen sulfide (H2S) can protect the RAW264.7 macrophages against the inflammation induced by free fatty acids (FFA) by blunting NLRP3 inflammasome activation via a specific TLR4/NF-κB pathway. METHODS: RAW264.7 macrophages were exposed to increasing concentrations of FFA for up to 3 days to induce FFA-induced inflammation. The cells were pretreated with NaHS (a donor of H2S) before exposure to FFA...
July 24, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28738277/new-ruthenium-compounds-bearing-semicarbazone-2-formylopyridine-moiety-playing-with-auxiliary-ligands-for-tuning-the-mechanism-of-biological-activity
#5
Michał Łomzik, Olga Mazuryk, Dorota Rutkowska-Zbik, Grażyna Stochel, Philippe C Gros, Małgorzata Brindell
Two ruthenium(II) complexes Ru1 and Ru2 bearing as a one ligand 2,2'-bipyridine substituted by a semicarbazone 2-formylopyridine moiety (bpySC: 5-(4-{4'-methyl-[2,2'-bipyridine]-4-yl}but-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone) and as the others 2,2'-bipyridine (bpy) and 4,7-diphenyl-1,10-phenanthroline (dip), respectively, as auxiliary ligands have been prepared. Their biological activity has been studied on murine colon carcinoma (CT26) and human lung adenocarcinoma (A549) cell lines. The anti-proliferative activity was dependent on the presence of bpy or dip in the complex, with one order of magnitude higher cytotoxicity for Ru2 (dip ligands)...
July 14, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/28737827/cytotoxic-and-chemosensitization-effects-of-scutellarin-from-traditional-chinese-herb-scutellaria%C3%A2-altissima%C3%A2-l-in-human-prostate-cancer-cells
#6
Chen Gao, Yinglu Zhou, Zhongling Jiang, Yuan Zhao, Dongjun Zhang, Xia Cong, Rongfeng Cao, Huatao Li, Wenru Tian
Scutellaria altissima L. is a common traditional Chinese medicine used to treat inflammation in some countries. Scutellarin, an active major flavone glycoside isolated from the traditional Chinese medicine Scutellaria altissima L., has been shown to offer various beneficial biochemical effects on cerebrovascular diseases and inflammation. However, the antiproliferative effects of Scutellarin in prostate cancer and the underlying mechanism are not fully elucidated. In the present study, we aimed to ascertain whether Scutellarin inhibits cancer cell growth and to further explore the molecular mechanism...
July 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28737823/overexpression-of-non%C3%A2-smc-condensin%C3%A2-i-complex-subunit%C3%A2-g-serves-as-a-promising-prognostic-marker-and-therapeutic-target-for-hepatocellular-carcinoma
#7
Wanwei Liu, Bo Liang, Hongliang Liu, Yong Huang, Xiangbao Yin, Fan Zhou, Xin Yu, Qian Feng, Enliang Li, Zhenhong Zou, Linquan Wu
The non‑SMC condensin I complex subunit G (NCAPG) that organizes the coiling topology of individual chromatids, represents an overexpressed antigen in various types of cancer, and also contributes to restructuring chromatin into rod‑shaped mitotic chromosomes and ensuring the segregation of sister chromatid during cell division. In this study, we investigated the association between NCAPG expression and the biological behavior of hepatocellular carcinoma (HCC) to further explore the potential of NCAPG as a therapeutic target...
July 24, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/28737158/gastric-lesions-in-dolphins-stranded-along-the-eastern-adriatic-coast
#8
Jerko Hrabar, Ivana Bočina, Andrea Gudan Kurilj, Martina Đuras, Ivona Mladineo
Stranded cetaceans are often found with gastric lesions associated with the presence of parasites; most frequently, nematodes of the genus Anisakis and the heterophyd digenean trematode Pholeter gastrophilus. In this study, we present histopathology mainly (but not exclusively) related to these 2 parasite species. Macroscopically, lesions associated with the presence of Anisakis spp. were characterised by the presence of ulcers within the gastric mucosa, while the digenean P. gastrophilus was found within large submucosal fibrotic nodules in the gastric wall...
July 24, 2017: Diseases of Aquatic Organisms
https://www.readbyqxmd.com/read/28736996/phytochemical-investigation-antitumor-activity-and-hepatoprotective-effects-of-acrocarpus-fraxinifolius-leaf-extract
#9
Heba A S El-Nashar, Omayma A Eldahshan, Omama E Elshawi, Abdel Nasser B Singab
Preclinical Research Nine known phenolic compounds were isolated from an aqueous methanolic extract of Acrocarpus fraxinifolius Weight and Arn leaves (AFL) family Fabaceae. This extract of AFL contained approximately 169 mg gallic acid/g as assessed by HPLC. The AFL extract had marginal antitumor activity (IC50  > 200 µL/mL) but showed a concentration-dependent hepatoprotective effect against CCl4 -induced hepatotoxicity in vitro. Cell viability was increased, ALT and AST activity declined and reduced GSH concentration and SOD activity were restored as compared with silymarin...
July 24, 2017: Drug Development Research
https://www.readbyqxmd.com/read/28736504/pleomorphism-and-drug-resistant-cancer-stem-cells-are-characteristic-of-aggressive-primary-meningioma-cell-lines
#10
Ishaq Khan, Saleh Baeesa, Mohammed Bangash, Hans-Juergen Schulten, Fahad Alghamdi, Hanadi Qashqari, Nawal Madkhali, Angel Carracedo, Mohamad Saka, Awatif Jamal, Jaudah Al-Maghrabi, Mohammed AlQahtani, Saleh Al-Karim, Ghazi Damanhouri, Kulvinder Saini, Adeel Chaudhary, Adel Abuzenadah, Deema Hussein
BACKGROUND: Meningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) tumors worldwide. Up to 20% of grade I meningioma tumors reoccur and currently predictive cancer stem cells (CSCs) markers for aggressive and drug resistant meningiomas are scarce. METHODS: Meningioma tissues and primary cell lines were investigated using whole transcriptome microarray analysis, immunofluorescence staining of CSCs markers (including CD133, Sox2, Nestin, and Frizzled 9), and drug treatment with cisplatin or etoposide...
2017: Cancer Cell International
https://www.readbyqxmd.com/read/28736376/-protective-effects-of-glycyrrhizic-acid-against-lupus-nephritis-in-mrl-lpr-mice
#11
Yuan-Yuan Wang, Hong-Tao Li, Yang Lu, Xiao-Yun Jia, Yang-Lei Li, Sheng Chen, Ji-Xia Chai, Jia-Jia Zhang, Dong Liu, Chang-Hao Xie
OBJECTIVE: To investigate protective effect of glycyrrhizic acid (GA) against lupus nephritis in MRL/lpr mice and explore its underlying mechanisms. METHODS: Forty MRL/lpr mice were randomized equally into blank control group, dexamethasone (1.5 mg/kg) group, GA (20 mg/kg) group, and GA (40 mg/kg) group with corresponding treatments for 7 days, with 10 wild-type mice as the control group. Serum levels of uric acid and creatinine and inflammatory cytokines in the serum and kidney were tested after the treatments using enzyme-linked immunosorbent assays (ELISA)...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28735741/apigenin-prevents-ultraviolet-b-radiation-induced-cyclobutane-pyrimidine-dimers-formation-in-human-dermal-fibroblasts
#12
S Mary Britto, D Shanthakumari, B Agilan, T Radhiga, G Kanimozhi, N Rajendra Prasad
Exposure to solar ultraviolet-B (UVB) radiation leads to the formation of cyclobutane pyrimidine dimers (CPDs). We investigated the protective effect of apigenin against UVB-induced CPDs formation in human dermal fibroblasts cells (HDFa). For this purpose, HDFa cells were treated with apigenin (15μM) prior to UVB irradiation (20mJ/cm(2)); DNA damage and subsequent molecular end points were observed. Exposure to UVB radiation increased significant CPDs formation in HDFa cells and the frequencies of CPDs were reduced by treatment with apigenin (15μM)...
September 2017: Mutation Research
https://www.readbyqxmd.com/read/28735240/therapeutic-effects-of-l-cysteine-in-newborn-mice-subjected-to-hypoxia-ischemia-brain-injury-via-the-cbs-h2s-system-role-of-oxidative-stress-and-endoplasmic-reticulum-stress
#13
Song Liu, Danqing Xin, Lingxiao Wang, Tiantian Zhang, Xuemei Bai, Tong Li, Yunkai Xie, Hao Xue, Shishi Bo, Dexiang Liu, Zhen Wang
Neonatal hypoxic-ischemic (HI) injury is a major cause of neonatal death and neurological dysfunction. H2S has been shown to protect against hypoxia-induced injury and apoptosis of neurons. L-Cysteine is catalyzed by cystathionine-β-synthase (CBS) in the brain and sequentially produces endogenous H2S. The present study was designed to investigate whether L-Cysteine could attenuate the acute brain injury and improve neurobehavioral outcomes following HI brain injury in neonatal mice by releasing endogenous H2S...
July 14, 2017: Redox Biology
https://www.readbyqxmd.com/read/28735143/transcranial-low-level-laser-therapy-improves-brain-mitochondrial-function-and-cognitive-impairment-in-d-galactose-induced-aging-mice
#14
Farzad Salehpour, Nahid Ahmadian, Seyed Hossein Rasta, Mehdi Farhoudi, Pouran Karimi, Saeed Sadigh-Eteghad
Mitochondrial function plays a key role in the aging-related cognitive impairment, and photoneuromodulation of mitochondria by transcranial low-level laser therapy (LLLT) may contribute to its improvement. This study focused on the transcranial LLLT effects on the D-galactose (DG)-induced mitochondrial dysfunction, apoptosis, and cognitive impairment in mice. For this purpose, red and near-infrared (NIR) laser wavelengths (660 and 810 nm) at 2 different fluencies (4 and 8 J/cm(2)) at 10-Hz pulsed wave mode were administrated transcranially 3 d/wk in DG-received (500 mg/kg/subcutaneous) mice model of aging for 6 weeks...
July 6, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28735085/minocycline-attenuates-streptomycin-induced-cochlear-hair-cell-death-by-inhibiting-protein-nitration-and-poly-adp-ribose-polymerase-activation
#15
Ping Wang, Haonan Li, Shuyuan Yu, Peng Jin, Abdurahman Hassan, Bo Du
This study aimed to elucidate the protective effect of minocycline against streptomycin-induced damage of cochlear hair cells and its mechanism. Cochlear membranes were isolated from newborn Wistar rats and randomly divided into control, 500μmol/L streptomycin, 100μmol/L minocycline, and streptomycin and minocycline treatment groups. Hair cell survival was analyzed by detecting the expression of 3-nitrotyrosine (3-NT) in cochlear hair cells by immunofluorescence and an enzyme-linked immunosorbent assay. Expression of 3-NT and inducible nitric oxide synthase (iNOS), and poly (ADP-Ribose) polymerase (PARP) and caspase-3 activation were evaluated by western blotting...
July 19, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28734981/apigenin-attenuates-patulin-induced-apoptosis-in-hek293-cells-by-modulating-ros-mediated-mitochondrial-dysfunction-and-caspase-signal-pathway
#16
Yujie Zhong, Chengni Jin, Jing Gan, Xiaorui Wang, Zhenqiang Shi, Xiaodong Xia, Xiaoli Peng
Mycotoxins like patulin (PAT) are among the most significant food contaminant with regard to public health. This study aimed to evaluate the protective effect of apigenin (API), one of the most bioactive flavonoids in plant-derived food, on PAT-induced apoptosis in HEK293 cells. Cells were treated under basic conditions, 8 μM PAT without or with API (2.5, 5 and 10 μM) concomitantly for 10 h. API exerted renoprotective effect by inhibiting intracellular reactive oxygen species (ROS) accumulation, modulating oxidative phosphorylation especially elevating the expression of ATP synthase, re-establishing mitochondrial membrane potential (MMP) and maintaining higher intracellular ATP level, accompanied by p53, Bax downregulation and Bcl-2 upregulation...
July 19, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28734673/somatostatin-protects-human-retinal-pericytes-from-inflammation-mediated-by-microglia
#17
Aurora Mazzeo, Ana I Arroba, Elena Beltramo, Angela M Valverde, Massimo Porta
Diabetic retinopathy (DR) is usually considered a microvascular disease. However, involvement of the neuroretina in the early stages of DR has recently gained major credit. Inflammatory processes, leading to glial activation and neuronal apoptosis, develop early in the retina of diabetic subjects. Pericytes constitute a link between the vascular and the neural retina, play a central role in blood-retinal barrier maintenance, and may influence neuroinflammation. Somatostatin (SST) is a potent neuroprotective factor, which is down-regulated during early DR...
July 19, 2017: Experimental Eye Research
https://www.readbyqxmd.com/read/28734215/dna-damage-and-cytotoxicity-induced-on-common-carp-by-pollutants-in-water-from-an-urban-reservoir-mad%C3%A3-n-reservoir-a-case-study
#18
I Pérez-Coyotl, C Martínez-Vieyra, M Galar-Martínez, L M Gómez-Oliván, S García-Medina, H Islas-Flores, R Pérez-Pasten Borja, E Gasca-Pérez, K A Novoa-Luna, O Dublán-García
Madín Reservoir provides a substantial amount of drinking water to two municipalities close to Mexico City metropolitan area. However, it receives untreated wastewater discharges from domestic sources in the towns of Nuevo Madín and others, as well as diverse pollutants which are hauled by the Río Tlalnepantla from its upper reaches, so that the xenobiotics in the reservoir are highly diverse in terms of type and quantity. Previous studies showed that MR is contaminated with xenobiotics such as Al, Hg and Fe, as well as NSAIDs, at concentrations exceeding the limits established for aquatic life protection...
July 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28734031/downregulation-of-dec1-contributes-to-the-neurotoxicity-induced-by-mpp-by-suppressing-pi3k-akt-gsk3%C3%AE-pathway
#19
Zhu Zhu, Yu-Wen Wang, Ding-Hao Ge, Ming Lu, Wei Liu, Jing Xiong, Gang Hu, Xiao-Ping Li, Jian Yang
AIM: Differentiated embryonic chondrocyte gene 1 (DEC1) is involved in the neuronal differentiation and development. The aim of this study is to investigate the role of DEC1 in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPP(+) )-induced PD model. METHODS: The location of DEC1 and tyrosine hydroxylase (TH)-positive neurons were detected by immunofluorescence. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse subacute model of PD was established to evaluate the change of DEC1 expression in midbrain...
July 21, 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28733879/anticancer-activity-of-salicin-and-fenofibrate
#20
Marwa Sabaa, Hassan M ELFayoumi, Shimaa Elshazly, Mahmoud Youns, Waleed Barakat
Cancer refers to a disorder of cell proliferation that leads to tumor production. Cancer is usually treated by surgery, chemotherapeutic drugs, and radiation. Despite the presence of many anticancer drugs, cancer is still an uncontrolled disease and is a major cause of death worldwide. In addition, most anticancer drugs have severe side effects that can limit their use in some patients. This study aims to investigate the possible anticancer activity of two clinically used drugs: a natural antioxidant agent (salicin) and an antihyperlipidemic agent (fenofibrate) against two breast cancer models (in vivo EAC and in vitro MCF7) and the pancreatic cancer cell line (Panc-1)...
July 21, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
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