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Markus O Scheinhardt, Tamara Lerman, Inke R König, Georg Griesinger
STUDY QUESTION: What is the performance of previously established regression models in predicting low and high ovarian response to 150 μg corifollitropin alfa/GnRH-antagonist ovarian stimulation in an independent dataset? SUMMARY ANSWER: The outcome of ovarian stimulation with 150 μg corifollitropin alfa in a fixed, multiple dose GnRH-antagonist protocol can be validly predicted using logistic regression models with AMH being of paramount importance. WHAT IS KNOWN ALREADY: Predictors of ovarian response have been identified in FSH/GnRH agonist protocols as well as ovarian stimulation with corifollitropin alfa/GnRH-antagonist...
July 10, 2018: Human Reproduction
Yassir A Yassir, Ahmed M El-Angbawi, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare the quality of orthodontic treatment between 0.018-inch and 0.022-inch slot bracket systems. Subjects and methods: Eligible participants aged 12 years or over were allocated to the 0.018-inch or 0.022-inch slot MBT appliance (3M-Unitek, Monrovia, California, USA) using block randomization in groups of 10. Outcome measures included: 1. ABO cast-radiograph evaluation (CR-EVAL), 2. peer assessment rating (PAR) scores, 3. incisor inclination, and 4...
July 11, 2018: European Journal of Orthodontics
Gabriella Roda, Sebastiano Arnoldi, Michele Dei Cas, Valeria Ottaviano, Eleonora Casagni, Fausto Tregambe, Giacomo Luca Visconti, Fiorenza Farè, Rino Froldi, Veniero Gambaro
A man was found dead in a hotel located near Rome (Italy). The man was still holding a syringe attached to a butterfly needle inserted in his left forearm vein. The syringe contained a cloudy pinkish fluid. In the hotel room the Police found a broken propofol glass vial plus four sealed ones, an opened NaCl plastic vial and six more still sealed, and a number of packed smaller disposable syringes and needles. An opened plastic bottle containing a white crystalline powder labeled as potassium cyanide was also found...
July 1, 2018: Journal of Analytical Toxicology
Ahmed M El-Angbawi, Yassir A Yassir, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare orthodontically induced inflammatory root resorption (OIIRR) and patient perception of pain during orthodontic treatment between 0.018-inch and 0.022-inch slot bracket systems. Subjects and methods: Eligible participants aged 12 years or above were allocated to treatment with the 0.018-inch or 0.022-inch slot MBT appliance (3M Unitek, Monrovia, California, USA) using block randomization in groups of 10. OIIRR was assessed radiographically using standardized periapical radiographs before and after 9 months from the start of treatment...
July 11, 2018: European Journal of Orthodontics
Yassir A Yassir, Ahmed M El-Angbawi, Grant T McIntyre, Gavin F Revie, David R Bearn
Objective: To compare treatment duration between 0.018-inch and 0.022-inch slot systems and determine factors influencing treatment duration. Subjects and methods: Eligible participants aged 12 years or over were allocated to the 0.018-inch or 0.022-inch slot MBT appliance (3M-Unitek, Monrovia, California, USA) using block randomization in groups of 10. Outcome measures included duration of: 1. overall treatment, 2. levelling and alignment, 3. working and finishing, and 4...
July 11, 2018: European Journal of Orthodontics
Han-Yu Deng, Gang Li, Jun Luo, Guha Alai
A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was: Can definitive chemoradiotherapy (CRT) be an alternative to surgery for early-stage oesophageal cancer? A total of 622 papers were found using the reported search, of which 5 cohort studies represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated...
July 10, 2018: Interactive Cardiovascular and Thoracic Surgery
B A Rakha, M S Ansari, S Akhter, J Santiago-Moreno, E Blesbois
Egg yolk is a good external cryoprotectant of mammalian sperm and some wild bird's sperm, but, at least in domestic breeds of chicken (Gallus gallus domesticus), it may inhibit eventual fertilization of ova when high concentrations are used. We hypothesized that egg yolk can protect the sperm from cryo-induced damages providing adequate fertilization in one phylogenetic wild ancestor of current chicken breeds: the Indian red jungle fowl (Gallus gallus murghi). To test the hypothesis, the present study was designed to evaluate different concentrations of egg yolk in extender in comparison with glycerol...
June 28, 2018: Theriogenology
Joanna Zawitkowska, Monika Lejman, Agnieszka Zaucha-Prażmo, Katarzyna Drabko, Marcin Płonowski, Joanna Bulsa, Michał Romiszewski, Agnieszka Mizia-Malarz, Andrzej Kołtan, Katarzyna Derwich, Grażyna Karolczyk, Tomasz Ociepa, Magdalena Ćwiklińska, Joanna Trelińska, Joanna Owoc-Lempach, Maciej Niedźwiecki, Aleksandra Kiermasz, Jerzy Kowalczyk
OBJECTIVE: The aim of this study was to analyse the clinical characteristics and outcome of children diagnosed with Ph+ ALL. MATERIAL AND METHODS: A total of 2591 newly diagnosed ALL children were treated in Poland between the years 2005-2017. Of those, 44 were diagnosed with Ph(+) ALL. The patients were treated according to protocols: ALL IC - BFM 2002 and 2009 (26 patients), EsPhALL (12 patients), initially ALL IC - BFM and then EsPhALL (6 patients). RESULTS: The median of follow up in the observed group was 3 years...
July 14, 2018: European Journal of Haematology
Aravind Cherukuri, Rajil Mehta, Puneet Sood, Sundaram Hariharan
Early histological progression that associates with Delayed Graft Function (DGF) and its relationship to graft outcomes is less well understood. We systematically evaluated early acute and chronic histological changes associated with DGF through serial biopsies (protocol: 3 and 12mos; for-cause) and related them to graft outcomes. 56/294 (19.04%) of our patients had DGF. DGF was associated with a progressive increase in both Banff 't' and 'i' scores from 2 weeks to 3 and 12 months with a resultant increase in T cell mediated Rejection (TCMR) that was significantly greater than those with primary graft function (PGF)...
July 14, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Henrik Bjarke Vaegter, Kristian Kjær Petersen, Carsten Dahl Mørch, Yosuke Imai, Lars Arendt-Nielsen
Background and aims Conditioned Pain Modulation (CPM) is a well-established phenomenon and several protocols have shown acceptable between-subject reliability [based on intraclass correlation coefficient (ICC) values] in pain-free controls. Recently, it was recommended that future CPM test-retest reliability studies should explicitly report CPM reliability based on CPM responders and non-responders (within-subject reliability) based on measurement error of the test stimulus. Identification of reliable CPM paradigms based on responders and non-responders may be a step towards using CPM as a mechanistic marker in diagnosis and individualized pain management regimes...
July 14, 2018: Scandinavian Journal of Pain
Firas G Petros, Aradhana M Venkatesan, Diana Kaya, Chaan S Ng, Bryan M Fellman, Jose A Karam, Christopher G Wood, Surena F Matin
OBJECTIVES: To determine conditional survival for patients with small renal masses (SRM) undergoing active surveillance (AS). MATERIALS AND METHODS: Patients were enrolled in a prospective AS protocol at our institution between May 2005 and January 2016. Patients with SRM ≤4cm with serial cross-sectional imaging available in-house for review were included. Overall survival (OS) was estimated using Kaplan-Meier method and modeled via Cox proportional hazards models...
July 14, 2018: BJU International
Partha Basu, Farida Selmouni, Latifa Belakhel, Catherine Sauvaget, Loubna Abousselham, Eric Lucas, Richard Muwonge, Rengaswamy Sankaranarayanan, Youssef Chami Khazraji
Breast Cancer Screening Program was introduced and rolled out in Morocco in 2010. Women between 40 and 69 years are screened at the primary health centers (PHC) with clinical breast examination (CBE). A comprehensive evaluation of the program was conducted in 2016-2017 for quality assurance and mid-term course correction. The evaluation process involved: in-depth interviews of program managers; focus group discussions with service-providers of screening, diagnosis and treatment; supportive supervisory visits to randomly selected PHCs and diagnostic centers; desk review of the national guidelines and other published documents; and analysis of the performance data compiled by the program-in-charge...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
Dheeraj K Rajan, Buzz Moran, Thomas J Lobl, Murray R Asch, Andrew W Steele, Charmaine E Lok
INTRODUCTION: Dysfunctional or infected hemodialysis polyester-cuffed catheters often require removal and are dissected out. The DermaPort™, percutaneous vascular access system (PVAS) permanently integrates a titanium mesh with the skin forming a stable, sterile barrier that allows for catheter placement, adjustment, or catheter exchange. This study aimed to describe the use and clinical outcomes of the DermaPort PVAS. METHODS: Thirty-eight patients who were receiving hemodialysis via a tunneled catheter were enrolled in this prospective open-label study...
July 13, 2018: Cardiovascular and Interventional Radiology
Mehmet Yavuz, Myrna H P Hall
New York City drinking water quality depends on retention of forest cover in its Catskill Mountains watersheds, yet multiple published analyses of temporally approximate satellite imagery derived no definitive nor agreed upon quantification of either forest cover in the watershed, or, more importantly, its rate of change over time. The objective of this work was to reduce uncertainty surrounding these estimates. We developed a five-pronged protocol that included (1) creation of a 1975-2002 time-series of land use/land cover (LULC) using Cross-Correlation Analysis (CCA); (2) a corrective post classification logic-based algorithm to correct for illogical transitions; (3) a probability-based stratified random sample accuracy assessment; (4) joint probability calculations of the "true" 2002 class proportions; and (5) verification of quantities of our LULC classification, and those of other researchers, versus the statistically derived true proportions...
July 14, 2018: Environmental Monitoring and Assessment
Masafumi Tomita, Shuji Saito, Shinichiro Makimoto, Shuntaro Yoshida, Hiroyuki Isayama, Tomonori Yamada, Takeaki Matsuzawa, Toshiyuki Enomoto, Rika Kyo, Toshio Kuwai, Nobuto Hirata, Mamoru Shimada, Tomio Hirakawa, Koichi Koizumi, Yoshihisa Saida
BACKGROUND: Self-expandable metallic stenting (SEMS) for malignant colorectal obstruction (MCO) as a bridge to elective surgery (BTS) is a widely used procedure. The aim of this study was to assess short-term outcomes of SEMS for MCO as BTS. METHODS: This study analyzed pooled data from BTS patients who were enrolled in two multicenter prospective single-arm observational clinical studies that used different stent types. Both studies were conducted by the Japan Colonic Stent Safe Procedure Research Group (JCSSPRG)...
July 13, 2018: Surgical Endoscopy
Mi Ji Lee, Sook-Yeon Lee, Soohyun Cho, Eun-Suk Kang, Chin-Sang Chung
BACKGROUND: Calcitonin gene-related peptide (CGRP) has been reported as elevated in chronic migraine. We aimed to validate the role of interictal serum CGRP concentration in peripheral blood samples as a biomarker of chronic migraine. METHODS: We prospectively recruited patients with episodic and chronic migraine and normal controls (NCs) in the Samsung Medical Center between August 2015 and May 2016. Blood samples were collected interictally from antecubital veins per prespecified protocol...
July 13, 2018: Journal of Headache and Pain
Daisuke Ino, Masamitsu Iino
To study the signaling mechanism of the development and maintenance of myelinating Schwann cells (SCs) in the peripheral nervous system, in vivo techniques for SC-selective gene manipulation are useful. The present protocol describes an in vivo electroporation method that allows efficient transfection of myelinating SCs in rodent sciatic nerves. This technique allows us to introduce the genes of interest into myelinating SCs by simply applying electric pulses to the sciatic nerve after plasmid DNA injection...
2018: Methods in Molecular Biology
Gerben Van Hameren, Sergio Gonzalez, Ruani N Fernando, Claire Perrin-Tricaud, Nicolas Tricaud
Myelinated fibers are essential for the rapid and efficient propagation of nerve information throughout the body. These fibers result from an intimate crosstalk between myelinating glia and the myelinated axons and, because it is difficult to fully reproduce these interactions in vitro, the basic molecular mechanisms that regulate myelination, demyelination, and remyelination remain unclear. Schwann cells produce myelin in the peripheral nervous system (PNS) and remain associated with the axons of peripheral neurons throughout axonal migration to the target...
2018: Methods in Molecular Biology
Miguel Tamayo Caro, Marta Palomo Irigoyen, Encarnación Pérez Andrés, Adrián Barreira Manrique, Marta Varela Rey, Ashwin Woodhoo
Autophagy is a key cellular mechanism involved in the degradation of long-lived proteins and organelles. We and others have previously shown that Schwann cells are able to degrade their own myelin by a form of selective autophagy, or myelinophagy. There is now increasing evidence that myelinophagy could also be aberrantly activated in other demyelinating diseases, including hereditary or inflammatory neuropathies, implicating this pathway in the pathogenesis of these disorders. In this chapter, we describe our protocol to monitor autophagy in peripheral nerves, using the autophagy flux assay...
2018: Methods in Molecular Biology
Yi Pang, Kimberly Simpson, José Javier Miguel-Hidalgo, Renate Savich
Myelination cell culture systems are useful tools for studying myelin biology and myelin-related disorders. Compared to a number of established protocols for dissociated pure oligodendrocyte (OL) culture, methods for myelination culture are limited. We recently developed a mixed neuron-glia coculture system that generates robust and efficient myelination. By optimizing cell culture conditions, dissociated neural progenitor cells from embryonic rat spinal cords develop into neurons and glial cells including profiles of oligodendrocyte (OL) lineage...
2018: Methods in Molecular Biology
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