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https://www.readbyqxmd.com/read/29334615/hemodynamic-and-metabolic-responses-to-self-paced-and-ramp-graded-exercise-testing-protocols
#1
Nicholas M Beltz, Fabiano Amorim, Ann L Gibson, Jeffrey M Janot, Len Kravitz, Christine M Mermier, Nathan Cole, Terence A Moriarty, Tony P Nunez, Sam Trigg, Lance Dalleck
PURPOSE: Recent examinations have shown lower maximal oxygen uptake (VO2max) during traditional ramp (RAMP) compared to self-paced (SPV) graded exercise testing (GXT) attributed to differences in cardiac ouput. The current study examined the differences in hemodyamic and metabolic responses between RAMP and SPV during treadmill exercise. METHODS: Sixteen recreationally trained men (23.7±3.0 yrs) completed two separate treadmill GXT protocols. SPV consisted of five 2-min stages (10 min total) of increasing speed clamped by the Borg RPE6-20 scale...
January 15, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29334582/carbohydrate-mouth-rinsing-does-not-prevent-the-decline-in-maximal-strength-following-fatiguing-exercise
#2
Christopher D Black, Daniel J Schubert, Marcin K Szczyglowski, Joshua D Wren
Carbohydrate (CHO) rinsing has been shown to attenuate the decline of maximal voluntary contractions (MVC) following fatiguing exercise-perhaps via a central mechanism. This study sought to determine the effect of a CHO rinse on MVC, voluntary activation, and contractile properties following fatiguing exercise. Thirteen adults participated in a double-blind, cross-over study. MVC of the dominant knee extensors was assessed and voluntary activation (%VA) was determined using twitch-interpolation. Participants then held 50% of MVC until volitional fatigue followed by a 20s rinse with a solution of 8% maltodextrin (CHO) or placebo (PLA)...
January 12, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29334532/cost-effectiveness-and-improved-parent-and-provider-satisfaction-with-outpatient-management-of-pediatric-oncology-patients-with-low-risk-fever-and-neutropenia
#3
Abhishek Bavle, Amanda Grimes, Sibo Zhao, Daniel Zinn, Andrea Jackson, Binita Patel, Timothy Porea, Ankhi Dutta, Heidi Russell, Andras Heczey
On the basis of significant evidence for safety, the international pediatric fever and neutropenia committee recommends the identification and management of patients with "low-risk fever and neutropenia" (LRFN), outpatient with oral antibiotics, instead of traditional inpatient management. The aim of our study was to compare the cost-per-patient with these 2 strategies, and to evaluate parent and provider satisfaction with the outpatient management of LRFN. Between March 2016 and February 2017, 17 LRFN patients (median absolute neutrophil count, 90/μL) were managed at a single institution, per new guidelines...
January 12, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29334529/midterm-outcome-of-kidney-transplantation-from-donors-with-thin-basement-membrane-nephropathy
#4
Chanjoong Choi, Sanghyun Ahn, Seung-Kee Min, Jongwon Ha, Curie Ahn, Yonsu Kim, Hajeong Lee, Sang-Il Min
BACKGROUND: Thin basement membrane nephropathy (TBMN) is the most common cause of persistent glomerular hematuria. Most individuals with TBMN show a benign course, although it can be difficult to distinguish it from early stages of progressive renal diseases. However, only limited studies address the prognosis of donors with TBMN and their recipients. METHODS: From 2007 to 2016, 11 recipients received kidney grafts from donors with TBMN, and their clinical data were analyzed retrospectively...
January 12, 2018: Transplantation
https://www.readbyqxmd.com/read/29334522/themes-in-literature-related-to-incidence-risk-and-prevention-of-cancer-in-solid-organ-transplantation-recipients-on-immunosuppressive-therapy
#5
Stefanie L Rashti
BACKGROUND: Solid-organ transplants provide a second chance to thousands of critically ill patients with end-organ failure each year. Immunosuppressants are administered to patients to prevent graft rejection of a transplanted organ, such as a heart, kidney, or liver, while placing the recipient at greater risk for infection and cancer. OBJECTIVE: The literature provides evidence of various cancers that have been found to develop in patients' posttransplantation...
January 12, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29334467/robot-assisted-upper-extremity-rehabilitation-for-cervical-spinal-cord-injuries-a-systematic-scoping-review
#6
Hardeep Singh, Janelle Unger, José Zariffa, Maureen Pakosh, Susan Jaglal, B Catharine Craven, Kristin E Musselman
Abstact Purpose: To provide an overview of the feasibility and outcomes of robotic-assisted upper extremity training for individuals with cervical spinal cord injury (SCI), and to identify gaps in current research and articulate future research directions. MATERIALS AND METHODS: A systematic search was conducted using Medline, Embase, PsycINFO, CCTR, CDSR, CINAHL and PubMed on June 7, 2017. Search terms included 3 themes: (1) robotics; (2) SCI; (3) upper extremity. Studies using robots for upper extremity rehabilitation among individuals with cervical SCI were included...
January 15, 2018: Disability and Rehabilitation. Assistive Technology
https://www.readbyqxmd.com/read/29334420/copper-catalyzed-regioselective-cleavage-of-c-x-bond-and-c-h-bond-a-strategy-for-sulfur-dioxide-fixation
#7
Daoshan Yang, Pengfei Sun, Wei Wei, Fengjuan Liu, Hui Zhang, Hua Wang
The first example of direct fixation of sulfur dioxide between heteroaryls and aryl halides has been developed via copper-catalyzed regioselective cleavage of C-X and C-H bonds under base-free and ligand-free conditions by using DABSO as a solid and bench-stable sulfur dioxide surrogate. This mild protocol results in double C-S bond-forming reactions from simple precursors in the absence of prefunctionalized organometallic reagents, arenediazonium salts, and iodonium salts which extends the still limited number of sulfur dioxide fixation strategies...
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334411/nickel-catalyzed-c-s-bond-formation-via-decarbonylative-thioetherification-of-esters-amides-and-intramolecular-recombination-fragment-coupling-of-thioesters
#8
Shao-Chi Lee, Hsuan-Hung Liao, Adisak Chatupheeraphat, Magnus Rueping
A nickel catalyzed cross-coupling protocol for the straightforward C-S bond formation has been developed. Various mercaptans and a wide range of ester and amide substrates bearing various substituents were tolerated in this process which afforded products in good to excellent yields. Furthermore, an intramolecular protocol for the synthesis of thioethers starting from thioesters has been developed. The utility of this protocol has been demonstrated in the synthesis of benzothiophene on the bench top.
January 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29334400/oolong-tea-and-lr-white-resin-a-new-method-of-plant-sample-preparation-for-transmission-electron-microscopy
#9
Xiaohua He, Fuzhen Guo, Bin Liu
Simplifying sample processing, shortening the sample preparation time, and adjusting procedures to suitable for new health and safety regulations, these issues are the current challenges which electron microscopic examinations need to face. In order to resolve these problems, new plant tissue sample processing protocols for transmission electron microscopy should be developed. In the present study, we chose the LR-White resin-assisted processing protocol for the ultrastructural observation of different types of plant tissues...
January 15, 2018: Journal of Microscopy
https://www.readbyqxmd.com/read/29334328/different-durations-within-the-method-of-best-practice-affect-the-parameters-of-the-speed-duration-relationship
#10
Christoph Triska, Bettina Karsten, Chris Beedie, Bernhard Koller-Zeisler, Alfred Nimmerichter, Harald Tschan
The aim of the study was to determine whether estimates of the speed-duration relationship are affected using different time-trial (TT) field-based testing protocols, where exhaustive times were located within the generally recommended durations of 2-15 min. Ten triathletes (mean ± SD age: 31.0 ± 5.7 years; height: 1.81 ± 0.05 m; body mass: 76.5 ± 6.8 kg) performed two randomly assigned field tests to determine critical speed (CS) and the total distance covered above CS (D´). CS and D´ were obtained using two different protocols comprising three TT that were interspersed by 60 min passive rest...
January 15, 2018: European Journal of Sport Science
https://www.readbyqxmd.com/read/29334309/effects-of-resisted-sprint-training-on-sprinting-ability-and-change-of-direction-speed-in-professional-soccer-players
#11
Saulo Gil, Renato Barroso, Everton Crivoi do Carmo, Irineu Loturco, Ronaldo Kobal, Valmor Tricoli, Carlos Ugrinowitsch, Hamilton Roschel
Resisted sprint training consists of performing overloaded sprints, which may produce greater effects than traditional sprint training. We compared a resisted sprint training with overload control versus an unresisted sprint training program on performance in soccer players. Eighteen elite athletes were randomly assigned to resisted (RST) or unresisted sprint training protocol (UR). Before and after a 6-week training period, sprinting ability, change of direction speed (COD), vertical jumps (SJ and CMJ), mean power (MP) and mean propulsive power (MPP) at distinct loads were assessed...
January 15, 2018: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29334292/safety-and-effectiveness-of-fascial-therapy-in-adult-patients-with-hemophilic-arthropathy-a-pilot-study
#12
Elena Donoso-Úbeda, Javier Meroño-Gallut, José Antonio López-Pina, Rubén Cuesta-Barriuso
BACKGROUND: The primary clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Fascial therapy is one of the most used physiotherapy techniques today to improve joint dysfunctions and chronic pain. OBJECTIVE: To assess the safety and efficacy of fascial therapy treatment in patients with hemophilic arthropathy of ankle and knee. DESIGN: Non-randomized, controlled clinical trial...
January 15, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29334275/laparoscopic-ovarian-drilling-versus-gnrh-antagonist-combined-with-cabergoline-as-a-prophylaxis-against-the-re-development-of-ovarian-hyperstimulation-syndrome
#13
Emaduldin Seyam, Enas Hefzy
OBJECTIVE: The aim of this work was to investigate the value of laparoscopic ovarian drilling (LOD) compared with GnRH antagonist flexible protocol combined with cabergoline (Cb), as a prophylaxis against the re-development of ovarian hyperstimulation syndrome (OHSS) in women with clomiphene citrate-resistant polycystic ovary disease (CCR-PCOD) who had severe OHSS before in a previous ICSI cycle. STUDY DESIGN: It is a prospective controlled study, where 250 CCR-PCOD women (n = 250) with a history of severe OHSS before, had been recruited for the study...
January 15, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29334236/wb-mri-and-oncology-recent-major-advances
#14
Vassiliki Pasoglou, Nicolas Michoux, Ahmed Larbi, Van Nieuwenhove Sandy, Frédéric Lecouvet
Magnetic Resonance Imaging (MRI) is a very attractive approach for tumor detection and oncological staging with its absence of ionizing radiation, high soft tissue contrast and spatial resolution. Less than ten years ago the use of Whole Body MRI (WB-MRI) protocols was uncommon due to many limitations, such as the long acquisition times and limited availability. This decade has marked substantial progress in WB-MRI protocols. This very promising technique is rapidly arising from the research world and is becoming a commonly used exam for tumor detection, due to recent technological developments and validation of WB-MRI by multiple studies and consensus papers...
January 15, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29334222/on-line-preconcentration-in-capillaries-by-multiple-large-volume-sample-stacking-an-alternative-to-immunoassays-for-quantification-of-amyloid-beta-peptides-biomarkers-in-cerebrospinal-fluid
#15
Cedric Crosnier de Lassichere, Thanh Duc Mai, Markus Otto, Myriam Taverna
A novel electrokinetic preconcentration approach, so-called multiple pressure-assisted large-volume sample stacking with an electroosmotic flow pump (M-PA-LVSEP), was developed to allow in-capillary enrichment and separation of analytes from unlimited sample volumes. With this approach, the inherent limitation of in-capillary electrokinetic preconcentrations to the separation capillary volume can be overcome. The M-PA-LVSEP protocol relies on repeated cycles of pressure-assisted electroosmotic pumping and injection of extremely large sample volumes for analyte stacking and sample matrix removal...
January 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29334202/lifestyle-related-factors-associated-with-reproductive-health-in-couples-seeking-fertility-treatments-results-of-a-pilot-study
#16
Marie-Lou Piché, Véronique Babineau, Julie Robitaille, Émilie Lachance, Stephanie-May Ruchat
Background: The objective of this pilot study was to evaluate the feasibility of conducting a larger prospective cohort study, which will aim at determining the independent contribution of male and female lifestyle-related factors to assisted reproductive technology (ART) success. The study also examined whether couples seeking fertility treatments present lifestyle-related factors that may interfere with their reproductive health. MATERIALS AND METHODS: This prospective pilot study was conducted in a fertility clinic between May 2015 and February 2016...
April 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29334197/increased-non-aids-mortality-among-persons-with-aids-defining-events-after-antiretroviral-therapy-initiation
#17
April C Pettit, Mark J Giganti, Suzanne M Ingle, Margaret T May, Bryan E Shepherd, Michael J Gill, Gerd Fätkenheuer, Sophie Abgrall, Michael S Saag, Julia Del Amo, Amy C Justice, Jose M Miro, Matthias Cavasinni, François Dabis, Antonella D Monforte, Peter Reiss, Jodie Guest, David Moore, Leah Shepherd, Niels Obel, Heidi M Crane, Colette Smith, Ramon Teira, Robert Zangerle, Jonathan Ac Sterne, Timothy R Sterling
INTRODUCTION: HIV-1 infection leads to chronic inflammation and to an increased risk of non-AIDS mortality. Our objective was to determine whether AIDS-defining events (ADEs) were associated with increased overall and cause-specific non-AIDS related mortality after antiretroviral therapy (ART) initiation. METHODS: We included HIV treatment-naïve adults from the Antiretroviral Therapy Cohort Collaboration (ART-CC) who initiated ART from 1996 to 2014. Causes of death were assigned using the Coding Causes of Death in HIV (CoDe) protocol...
January 2018: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/29334139/interleaved-susceptibility-weighted-and-flair-mri-for-imaging-lesion-penetrating-veins-in-multiple-sclerosis
#18
Refaat E Gabr, Amol S Pednekar, Arash Kamali, John A Lincoln, Flavia M Nelson, Jerry S Wolinsky, Ponnada A Narayana
PURPOSE: To simultaneously image brain lesions and veins in multiple sclerosis. METHODS: An interleaved sequence was developed to simultaneously acquire 3-dimensional T2*-weighted (or susceptibility-weighted (SW)) and fluid-attenuated inversion recovery (FLAIR) images on a 3T MRI system. The pulse sequence parameters were calculated to minimize signal perturbation from steady state while maintaining acceptable image contrast and scan time. Fifteen multiple sclerosis patients were enrolled in this prospective study and underwent a standard multiple sclerosis imaging protocol...
January 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29334131/a-bayesian-method-for-accelerated-magnetic-resonance-elastography-of-the-liver
#19
Christopher Ebersole, Rizwan Ahmad, Adam V Rich, Lee C Potter, Huiming Dong, Arunark Kolipaka
PURPOSE: Magnetic resonance elastography is a noninvasive tool for quantifying soft tissue stiffness. Magnetic resonance elastography has been adopted as a clinical method for staging liver fibrosis. However, the application of liver magnetic resonance elastography requires multiple lengthy breath-holds. We propose a new data acquisition and processing method to reduce magnetic resonance elastography scan time. METHODS: A Bayesian image reconstruction method that uses transform sparsity and magnitude consistency across different phase offsets to recover images from highly undersampled data is proposed...
January 15, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29334034/improved-exogenous-dna-uptake-in-bovine-spermatozoa-and-gene-expression-in-embryos-using-membrane-destabilizing-agents-in-icsi-smgt
#20
Esther Sánchez-Villalba, María Elena Arias, Fabiola Zambrano, Pía Loren, Ricardo Felmer
Sperm-mediated gene transfer (SMGT) is a simple, fast, and economical biotechnological tool for producing transgenic animals. However, transgene expression with this technique in bovine embryos is still inefficient due to low uptake and binding of exogenous DNA in spermatozoa. The present study evaluated the effects of sperm membrane destabilization on the binding capacity, location and quantity of bound exogenous DNA in cryopreserved bovine spermatozoa using Triton X-100 (TX-100), lysolecithin (LL) and sodium hydroxide (NaOH)...
January 15, 2018: Zygote: the Biology of Gametes and Early Embryos
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