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https://www.readbyqxmd.com/read/28813037/concomitant-bladder-cancer-and-prostate-cancer-challenges-and-controversies
#1
REVIEW
Antonio Lopez-Beltran, Liang Cheng, Francesco Montorsi, Maria Scarpelli, Maria R Raspollini, Rodolfo Montironi
Radical cystoprostatectomy (RCP) followed by bilateral pelvic lymphadenectomy and urinary diversion remains the gold-standard therapy for men with localized muscle-invasive bladder cancer (MIBC). Prostate cancer might be incidentally detected at the time of RCP with a reported prevalence of 24-51%. Typically, these patients are considered to have clinically insignificant disease, but data from emerging series challenge this assumption and suggest that some of these tumours might be aggressive, or somehow increase the aggressiveness of the associated MIBC, and can negatively influence the patient's overall survival outcomes...
August 16, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28813018/biophysical-and-computational-studies-of-the-vcci-vmip-ii-complex
#2
Anna F Nguyen, Nai-Wei Kuo, Laura J Showalter, Ricardo Ramos, Cynthia M Dupureur, Michael E Colvin, Patricia J LiWang
Certain viruses have the ability to subvert the mammalian immune response, including interference in the chemokine system. Poxviruses produce the chemokine binding protein vCCI (viral CC chemokine inhibitor; also called 35K), which tightly binds to CC chemokines. To facilitate the study of vCCI, we first provide a protocol to produce folded vCCI from Escherichia coli (E. coli.) It is shown here that vCCI binds with unusually high affinity to viral Macrophage Inflammatory Protein-II (vMIP-II), a chemokine analog produced by the virus, human herpesvirus 8 (HHV-8)...
August 16, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28813007/the-efficacy-of-bifidobacterium-longum-bori-and-lactobacillus-acidophilus-ad031-probiotic-treatment-in-infants-with-rotavirus-infection
#3
Myeong Soo Park, Bin Kwon, Seockmo Ku, Geun Eog Ji
A total of 57 infants hospitalized with rotavirus disease were included in this study. The children were randomly divided into the study's two treatment groups: three days of the oral administration of (i) a probiotics formula containing both Bifidobacterium longum BORI and Lactobacillus acidophilus AD031 (N = 28); or (ii) a placebo (probiotic-free skim milk, N = 29) and the standard therapy for diarrhea. There were no differences in age, sex, or blood characteristics between the two groups. When the 57 cases completed the protocol, the duration of the patients' diarrhea was significantly shorter in the probiotics group (4...
August 16, 2017: Nutrients
https://www.readbyqxmd.com/read/28812983/a-microfluidic-platform-for-modeling-metastatic-cancer-cell-matrix-invasion
#4
Laura Blaha, Chentian Zhang, Mario Cabodi, Joyce Y Wong
Invasion of the extracellular matrix is a critical step in the colonization of metastatic tumors. The invasion process is thought to be driven by both chemokine signaling and interactions between invading cancer cells and physical components of the metastatic niche, including endothelial cells that line capillary walls and serve as a barrier to both diffusion and invasion of the underlying tissue. Transwell chambers, a tool for generating artificial chemokine gradients to induce cell migration, have facilitated recent work to investigate the chemokine contributions to matrix invasion...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812982/quantitative-criteria-to-benchmark-new-and-existing-bio-inks-for-cell-compatibility
#5
Karen Dubbin, Anthony Tabet, Sarah Heilshorn
Recent advancements in 3D bioprinting have led to the fabrication of more complex, more precise, and larger printed tissue constructs. As the field continues to advance, it is critical to develop quantitative benchmarks to compare different bio-inks for key cell-biomaterial interactions, including (1) cell sedimentation within the ink cartridge, (2) cell viability during extrusion, and (3) cell viability after ink curing. Here we develop three simple protocols for quantitative analysis of bio-ink performance...
August 16, 2017: Biofabrication
https://www.readbyqxmd.com/read/28812844/clinician-perspectives-of-barriers-to-effective-implementation-of-a-rapid-response-system-in-an-academic-health-centre-a-focus-group-study
#6
John Rihari-Thomas, Michelle DiGiacomo, Jane Phillips, Phillip Newton, Patricia M Davidson
BACKGROUND: Systemic and structural issues of rapid response system (RRS) models can hinder implementation. This study sought to understand the ways in which acute care clinicians (physicians and nurses) experience and negotiate care for deteriorating patients within the RRS. METHODS: Physicians and nurses working within an Australian academic health centre within a jurisdictional-based model of clinical governance participated in focus group interviews. Verbatim transcripts were analysed using thematic content analysis...
January 1, 2017: International Journal of Health Policy and Management
https://www.readbyqxmd.com/read/28812677/species-specific-responses-to-ocean-acidification-should-account-for-local-adaptation-and-adaptive-plasticity
#7
Cristian A Vargas, Nelson A Lagos, Marco A Lardies, Cristian Duarte, Patricio H Manríquez, Victor M Aguilera, Bernardo Broitman, Steve Widdicombe, Sam Dupont
Global stressors, such as ocean acidification, constitute a rapidly emerging and significant problem for marine organisms, ecosystem functioning and services. The coastal ecosystems of the Humboldt Current System (HCS) off Chile harbour a broad physical-chemical latitudinal and temporal gradient with considerable patchiness in local oceanographic conditions. This heterogeneity may, in turn, modulate the specific tolerances of organisms to climate stress in species with populations distributed along this environmental gradient...
March 13, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812662/spending-limited-resources-on-de-extinction-could-lead-to-net-biodiversity-loss
#8
Joseph R Bennett, Richard F Maloney, Tammy E Steeves, James Brazill-Boast, Hugh P Possingham, Philip J Seddon
There is contentious debate surrounding the merits of de-extinction as a biodiversity conservation tool. Here, we use extant analogues to predict conservation actions for potential de-extinction candidate species from New Zealand and the Australian state of New South Wales, and use a prioritization protocol to predict the impacts of reintroducing and maintaining populations of these species on conservation of extant threatened species. Even using the optimistic assumptions that resurrection of species is externally sponsored, and that actions for resurrected species can share costs with extant analogue species, public funding for conservation of resurrected species would lead to fewer extant species that could be conserved, suggesting net biodiversity loss...
March 1, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28812380/analysis-of-an-8-hour-acetylcysteine-infusion-protocol-for-repeated-supratherapeutic-ingestion-rsti-of-paracetamol
#9
Anselm Wong, Naren Gunja, Richard McNulty, Andis Graudins
OBJECTIVES: In Australia, the treatment guideline for patients with repeated supratherapeutic ingestion (RSTI) of paracetamol recommends an abbreviated acetylcysteine regimen if the paracetamol concentration is low (<10 mg/L) and alanine aminotransferase (ALT) is normal or static after 8 hours of infusion. There are currently no studies of this recommendation. METHOD: A retrospective review of paracetamol overdose presentations from October 2009 to August 2016 in two hospital toxicology networks was performed...
August 16, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28812364/catalytic-asymmetric-desymmetrization-of-cyclopentendiones-via-diels-alder-reaction-of-3-hydroxy-2-pyrones-construction-of-multifunctional-bridged-tricyclic-lactones
#10
Li-Min Shi, Wu-Wei Dong, Hai-Yan Tao, Xiu-Qin Dong, Chun-Jiang Wang
An unprecedented asymmetric Diels-Alder reaction of 3-hydroxy-2-pyrones with prochiral cyclopentene-1,3-diones via desymmetrization was efficiently realized with high stereoselective control with the aid of fine-tunable cinchona alkaloid derived bifunctional amine-thiourea catalysts bearing multiple hydrogen-bonding donors. This protocol provides an expedient access to the multifunctional-bridged tricyclic lactones featuring four contiguous stereogenic centers and one remote quaternary stereogenic center with a broad substrate scope...
August 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/28812346/metal-free-synthesis-of-2-aminobenzothiazoles-via-iodine-catalyzed-and-oxygen-promoted-cascade-reactions-of-isothiocyanatobenzenes-with-amines
#11
Yuanshuang Xu, Bin Li, Xinying Zhang, Xuesen Fan
In this paper, a highly efficient and sustainable synthesis of 2-aminobenzothiazoles through the cascade reactions of isothiocyanatobenzenes with primary or secondary amines by using iodine as a catalyst and oxygen as an oxidant is presented. Mechanistically, the formation of the title compounds involves the in situ formation of the required benzothiourea intermediate followed by its intramolecular cross dehydrogenative coupling of a C(sp2)-H bond and a S-H bond. To our knowledge, this should be the first example in which 2-aminobenzothiazoles are efficiently prepared from simple and cheap isothiocyanates and amines under metal free conditions by using iodine as a catalyst and molecular oxygen as an oxidant with water as the byproduct...
August 16, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28812180/effect-of-continuous-positive-airway-pressure-on-glucose-metabolism-in-adults-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
REVIEW
Bingqian Zhu, Chao Ma, Jindarat Chaiard, Changgui Shi
Obstructive sleep apnea (OSA) has many serious consequences, and one of these may be the exacerbation of type 2 diabetes mellitus (T2DM). Reports on the effect of continuous positive airway pressure (CPAP) on glucose metabolism in people with T2DM and OSA are conflicting. Therefore, the purpose of this review was to examine the effect of CPAP treatment on glucose metabolism by synthesizing findings from randomized controlled trials. The PRISMA review protocol was developed and registered in PROSPERO. A systematic search of PubMed, CINAHL, Embase, Web of Science, PsycInfo, and Cochrane was conducted from inception to March 2017...
August 15, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28812123/-promoting-a%C3%A2-balanced-diet-and-physical-activity-among-children-conditions-for-the-successful-implementation-and-maintenance-of-multi-level-interventions-and-policies-results-of-two-qualitative-case-studies
#13
Berit Steenbock, Saskia Muellmann, Hajo Zeeb, Claudia R Pischke
BACKGROUND: To date, conditions for successfully implementing and maintaining multi-level interventions and policies for the promotion of a balanced diet and physical activity are not well understood from the perspective of stakeholders. OBJECTIVE: The aim of this article is to examine which factors are regarded as facilitating or impeding introduction, implementation and maintenance of multi-level interventions and policies from the standpoint of stakeholders. MATERIALS AND METHODS: Semi-structured face-to-face interviews with stakeholders of one multi-level intervention (Identification and prevention of Dietary- and lifestyle-induced health EFfects In Children and infantS [IDEFICS] for the prevention of childhood obesity, n = 4) and one policy (Federal state offices coordinating networks for the provision of healthy food options in schools, n = 3) were analysed using qualitative content analysis...
August 15, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/28812109/vibratory-perineal-stimulation-for-the-treatment-of-female-stress-urinary-incontinence-a-systematic-review
#14
Marina Petter Rodrigues, Luciana Laureano Paiva, José Geraldo Lopes Ramos, Lia Ferla
INTRODUCTION AND HYPOTHESIS: The pelvic floor muscles (PFM) play an important part in the urinary continence mechanism. Changes in their structure and functionality may lead to a predisposition to pelvic floor dysfunction such as urinary incontinence (UI), which is the involuntary loss of urine. Some techniques for conservative treatment of UI are already well documented. However, new approaches have been found that require scientific proof of their effectiveness, such as vibratory stimulation (VS)...
August 15, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28812073/controllable-access-to-multi-substituted-imidazoles-via-palladium-ii-catalyzed-c-c-coupling-and-c-n-condensation-cascade-reactions
#15
Haihua Yu, Li Xiao, Xicheng Yang, Liming Shao
A novel and efficient protocol for the synthesis of various 2,4-disubstituted, 1,2,4-trisubstituted and 1,2,4,5-tetra-substituted imidazoles via cascade palladium catalyzed C-C coupling followed by intramolecular C-N bond formation was developed. Readily accessible boronic acids and N-substituted-2-aminoacetonitriles were firstly reported as starting materials to construct di-, tri-, and tetra-substituted imidazoles in good to excellent yield.
August 16, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28812035/bioabsorbable-versus-metal-screw-in-the-fixation-of-tibial-tubercle-transfer-a-cadaveric-biomechanical-study
#16
Janne T Nurmi, Ari Itälä, Raine Sihvonen, Petri Sillanpää, Pekka Kannus, Harri Sievänen, Teppo L N Järvinen
BACKGROUND: In tibial tubercle transfer (TTT) procedures, the osteotomized and transferred tibial tubercle is usually fixed into the host bone using metal screws. PURPOSE: To compare the strength of fixation provided by a single bioabsorbable screw versus a metal screw for TTT. STUDY DESIGN: Controlled laboratory study. METHODS: Twenty-two pairs of human cadaveric tibiae were used to compare the fixation strength of a single 4...
July 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28812019/whole-body-spect-ct-versus-planar-bone-scan-with-targeted-spect-ct-for-metastatic-workup
#17
Olivier Rager, René Nkoulou, Nadia Exquis, Valentina Garibotto, Claire Tabouret-Viaud, Habib Zaidi, Gaël Amzalag, Stephanie Anne Lee-Felker, Thomas Zilli, Osman Ratib
PURPOSE: The use of SPECT/CT in bone scans has been widespread in recent years, but there are no specific guidelines concerning the optimal acquisition protocol. Two strategies have been proposed: targeted SPECT/CT for equivocal lesions detected on planar images or systematic whole-body SPECT/CT. Our aim was to compare the diagnostic accuracy of the two approaches. METHODS: 212 consecutive patients with a history of cancer were referred for bone scans to detect bone metastases...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28811999/quantitative-analysis-of-epicardial-fat-volume-effects-of-scanning-protocol-and-reproducibility-of-measurements-in-non-contrast-cardiac-ct-vs-coronary-ct-angiography
#18
Luigia D'Errico, Francesco Salituri, Marco Ciardetti, Riccardo Favilla, Alessandro Mazzarisi, Giuseppe Coppini, Carlo Bartolozzi, Paoli Marraccini
BACKGROUND: Several studies have focused on the role of epicardial fat in the pathogenesis of cardiovascular disease (CVD). The main purpose of the study was to evaluate a computerized method for the quantitative analysis of epicardial fat volume (EFV) by non-contrast cardiac CT (NCT) for coronary calcium scan and coronary CT angiography (coronary CTA). METHODS: Thirty patients (61±12.5 years, 73% male, body mass index (BMI) =25.9±6.3 kg/m(2)) referred to our Institution for suspected coronary artery disease (CAD) underwent NCT and coronary CTA...
June 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/28811968/il-32%C3%AE-induced-inflammation-constitutes-a-link-between-obesity-and-colon-cancer
#19
Victoria Catalán, Javier Gómez-Ambrosi, Amaia Rodríguez, Beatriz Ramírez, Victor A Ortega, José Luis Hernández-Lizoain, Jorge Baixauli, Sara Becerril, Fernando Rotellar, Víctor Valentí, Rafael Moncada, Camilo Silva, Javier Salvador, Gema Frühbeck
Growing evidence indicates that adipose tissue inflammation is an important mechanism whereby obesity promotes cancer risk and progression. Since IL-32 is an important inflammatory and remodeling factor in obesity and is also related to colon cancer (CC) development, the aim of this study was to explore whether IL-32 could function as an inflammatory factor in human obesity-associated CC promoting a microenvironment favorable for tumor growth. Samples obtained from 84 subjects [27 lean (LN) and 57 obese (OB)] were used in the study...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811926/postinjection-delirium-sedation-syndrome-in-patients-with-schizophrenia-receiving-olanzapine-long-acting-injection-results-from-a-large-observational-study
#20
Kristin J Meyers, Himanshu P Upadhyaya, John L Landry, Rashna Chhabra-Khanna, Deborah M Falk, Balasubramanya Seetharama Rao, Meghan E Jones
BACKGROUND: Postinjection delirium/sedation syndrome (PDSS) has been reported uncommonly during treatment with olanzapine long-acting injection (LAI), a sustained-release formulation of olanzapine. AIMS: The primary aim of the study was to estimate the incidence per injection and per patient of PDSS events in adult patients with schizophrenia who were receiving olanzapine LAI in real-world clinical practice. Secondary aims were to further characterise the clinical presentation of PDSS events, to identify potential risk factors associated with PDSS events and to characterise hospitalisations at baseline and post-baseline...
July 2017: BJPsych Open
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