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low level laser therapy systemic inflammatory response

Akira Aoki, Koji Mizutani, Frank Schwarz, Anton Sculean, Raymond A Yukna, Aristeo A Takasaki, Georgios E Romanos, Yoichi Taniguchi, Katia M Sasaki, Jorge L Zeredo, Geena Koshy, Donald J Coluzzi, Joel M White, Yoshimitsu Abiko, Isao Ishikawa, Yuichi Izumi
Laser irradiation has numerous favorable characteristics, such as ablation or vaporization, hemostasis, biostimulation (photobiomodulation) and microbial inhibition and destruction, which induce various beneficial therapeutic effects and biological responses. Therefore, the use of lasers is considered effective and suitable for treating a variety of inflammatory and infectious oral conditions. The CO2 , neodymium-doped yttrium-aluminium-garnet (Nd:YAG) and diode lasers have mainly been used for periodontal soft-tissue management...
June 2015: Periodontology 2000
Matías Mantineo, João P Pinheiro, António M Morgado
We evaluated the effect of different irradiation parameters in low-level laser therapy (LLLT) for treating inflammation induced in the gastrocnemius muscle of rats through cytokines concentration in systemic blood and analysis of muscle tissue. We used continuous (830 and 980 nm) and pulsed illuminations (830 nm). Animals were divided into five groups per wavelength (10, 20, 30, 40, and 50 mW), and a control group. LLLT was applied during 5 days with a constant irradiation time and area. TNF-α, IL-1β, IL-2, and IL-6 cytokines were quantified by ELISA...
September 2014: Journal of Biomedical Optics
Róbert Kilík, Lucia Lakyová, Ján Sabo, Peter Kruzliak, Kamila Lacjaková, Tomáš Vasilenko, Martina Vidová, František Longauer, Jozef Radoňak
BACKGROUND AND OBJECTIVE: Despite the fact that the molecular mechanism of low-level laser therapy (LLLT) is not yet known, the exploitation of phototherapy in clinical medicine and surgery is of great interest. The present study investigates the effects of LLLT on open skin wound healing in normal and diabetic rats. MATERIALS AND METHODS: Four round full-thickness skin wounds on dorsum were performed in male adult nondiabetic (n = 24) and diabetic (n = 24) Sprague-Dawley rats...
2014: BioMed Research International
Antonio Carlos Guimarães Prianti, José Antonio Silva, Regiane Feliciano Dos Santos, Isabela Bueno Rosseti, Maricilia Silva Costa
In the classical model of edema formation and hyperalgesia induced by carrageenan administration in rat paw, the increase in prostaglandin E2 (PGE2) production in the central nervous system (CNS) contributes to the severity of the inflammatory and pain responses. Prostaglandins are generated by the cyclooxygenase (COX). There are two distinct COX isoforms, COX-1 and COX-2. In inflammatory tissues, COX-2 is greatly expressed producing proinflammatory prostaglandins (PGs). Low-level laser therapy (LLLT) has been used in the treatment of inflammatory pathologies, reducing both pain and acute inflammatory process...
July 2014: Lasers in Medical Science
S R Barretto, G C de Melo, J C dos Santos, M G B de Oliveira, R N Pereira-Filho, A V F Alves, M A G Ribeiro, I B Lima-Verde, L J Quintans Júnior, R L C de Albuquerque-Júnior, L R Bonjardim
The aim of this study was to investigate the analgesic and anti-inflammatory activity of low-level laser therapy (LLLT) on the nociceptive behavioral as well as histomorphological aspects induced by injection of formalin and carrageenan into the rat temporomandibular joint. The 2.5% formalin injection (FRG group) induced behavioral responses characterized by rubbing the orofacial region and flinching the head quickly, which were quantified for 45 min. The pretreatment with systemic administration of diclofenac sodium-DFN group (10 mg/kg i...
December 5, 2013: Journal of Photochemistry and Photobiology. B, Biology
Ramona E von Leden, Sean J Cooney, Teresa M Ferrara, Yujia Zhao, Clifton L Dalgard, Juanita J Anders, Kimberly R Byrnes
BACKGROUND AND OBJECTIVE: Despite the success of using photobiomodulation (PBM), also known as low level light therapy, in promoting recovery after central nervous system (CNS) injury, the effect of PBM on microglia, the primary mediators of immune and inflammatory response in the CNS, remains unclear. Microglia exhibit a spectrum of responses to injury, with partial or full polarization into pro- and anti-inflammatory phenotypes. Pro-inflammatory (M1 or classically activated) microglia contribute to chronic inflammation and neuronal toxicity, while anti-inflammatory (M2 or alternatively activated) microglia play a role in wound healing and tissue repair; microglia can fall anywhere along this spectrum in response to stimulation...
April 2013: Lasers in Surgery and Medicine
Pallavi V Pople, Kamalinder K Singh
In atopic dermatitis (AD), topical anti-inflammatory therapy with skin barrier restoration to prevent repeated inflammatory episodes leads to long-term therapeutic success. Tacrolimus, although effective against AD, is a challenging molecule due to low solubility, low-penetration, poor-bioavailability, and toxicity. Part I of this paper, reported novel modified nanolipid carrier system for topical delivery of tacrolimus (T-MNLC), offering great opportunity to load low-solubility drug with improved entrapment efficiency, enhanced stability and improved skin deposition...
May 2013: European Journal of Pharmaceutics and Biopharmaceutics
Adel J Hussein, Abdalbari A Alfars, Mohsin A J Falih, Al-Nawar A Hassan
BACKGROUND: Tissue healing is a complex process that involves local and systemic responses. The use of low level laser therapy for wound healing has been shown to be effective in modulating both local and systemic response. AIM: The aim of this study was to accelerate and facilitate wound healing and reduce scar formation and wound contraction of an open wound by a low level laser. MATERIALS #ENTITYSTARTX00026; METHODS: Twenty adult male rabbits, lepus cuniculus demostica, were brought from a Basrah local market and raised under proper management conditions in Basrah Veterinary Medicine College...
April 2011: North American Journal of Medical Sciences
Maria S Moreira, Irineu T Velasco, Leila S Ferreira, Suely K K Ariga, Fatima Abatepaulo, Lea Tenenholz Grinberg, Márcia M Marques
Laser phototherapy emerges as an alternative or auxiliary therapy for acute ischemic stroke, traumatic brain injury, degenerative brain disease, spinal cord injury, and peripheral nerve regeneration, but its effects are still controversial. We have previously found that laser phototherapy immunomodulates the response to focal brain damage. Following direct cortical cryogenic injury the effects of laser phototherapy on inflammation and repair was assessed after cryogenic injury (CI) to the central nervous system (CNS) of rats...
December 2, 2011: Journal of Photochemistry and Photobiology. B, Biology
X Yang, S Askarova, W Sheng, J K Chen, A Y Sun, G Y Sun, G Yao, J C-M Lee
Oxidative stress and inflammation are important processes in the progression of Alzheimer's disease (AD). Recent studies have implicated the role of amyloid β-peptides (Aβ) in mediating these processes. In astrocytes, oligomeric Aβ induces the assembly of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complexes resulting in its activation to produce anionic superoxide. Aβ also promotes production of pro-inflammatory factors in astrocytes. Since low energy laser has previously been reported to attenuate oxidative stress and inflammation in biological systems, the objective of this study was to examine whether this type of laser light was able to abrogate the oxidative and inflammatory responses induced by Aβ...
December 15, 2010: Neuroscience
Paulo Cesar Lock Silveira, Luciano A Silva, Tiago P Freitas, Alexandra Latini, Ricardo A Pinho
Gallium-arsenide (GaAs) and helium-neon (HeNe) lasers are the most commonly used low-energy lasers in physiotherapy for promoting wound healing and pain modulation. The aim of this study was investigate the effect of low-power laser irradiation (LPLI) at different wavelengths and doses on oxidative stress and fibrogenesis parameters in an animal model of wound healing. The animals were randomly divided into five groups (n=6): Controls (skin injured animals without local or systemic treatment), skin injury treated with HeNe 1 J/cm(2) (two seg); skin injury treated with HeNe 3 J/cm(2) (six seg); skin injury treated with GaAs 1 J/cm(2) (three seg); skin injury treated with GaAs 3 J/cm(2) (nine seg)...
January 2011: Lasers in Medical Science
David F Driscoll, Pei-Ra Ling, Charlotte Andersson, Bruce R Bistrian
BACKGROUND: Use of lipid emulsions in parenteral nutrition therapy is an important source of daily energy in substitution of potentially harmful glucose calories when given in excess in the intensive care unit. When added to parenteral nutrition (PN) admixtures as a total nutrient admixture (TNA), the stability and safety of the emulsion may be compromised. Development of a rat model of a stable vs unstable lipid infusion would enable a study of the potential risk. DESIGN: Prospective, randomized, controlled study...
May 2009: JPEN. Journal of Parenteral and Enteral Nutrition
Basil M Hantash, Anan Abu Ubeid, Hong Chang, Reza Kafi, Bradley Renton
BACKGROUND: We recently introduced Renesis, a novel minimally invasive radiofrequency (RF) device, for the treatment of human skin. The wound healing response post-fractional RF (FRF) treatment was examined in human subjects. STUDY DESIGN: The FRF system delivered RF energy directly within the dermis via 5 micro-needle electrode pairs. Tissue temperature was held at 72 degrees C for 4 seconds using an intelligent feedback system. The wound healing response was evaluated histologically and by RT-PCR up to 10 weeks post-RF treatment...
January 2009: Lasers in Surgery and Medicine
Zsanett Csoma, Ferenc Ignacz, Zsolt Bor, Gabor Szabo, Laszlo Bodai, Attila Dobozy, Lajos Kemeny
We earlier reported that the 308 nm xenon chloride (XeCl) ultraviolet B (UVB) laser is highly effective for the treatment of inflammatory skin diseases. Since UVB irradiation has been shown to exert both local and systemic immunosuppression, we investigated the clinical efficacy of UVB irradiation in allergic rhinitis. In an open study, groups of patients with severe allergic rhinitis received intranasal irradiation with a 308 nm XeCl UVB excimer laser for two weeks. In the low-dose group (n=10), treatment was given twice weekly, starting with 0...
September 8, 2004: Journal of Photochemistry and Photobiology. B, Biology
C L Goh
OBJECTIVE: To investigate the safety and effectiveness of a long pulsed Nd:YAG (1064nm) laser compared to a shorter wavelength intense pulse light system for assisted hair removal in volunteers with skin type 1V, V and VI. METHODS: Eleven patients of Fitzpatrick skin type IV-VI were recruited into the study. The area treated included the face (upper lips, chin and jaw area), axillae and legs. One half of the body was treated with the long pulse Nd:YAG laser and the other half was treated with the IPL system randomly under topical anesthesia...
December 2003: Journal of Dermatological Treatment
Lidija Kandolf-Sekulovic, Milena Kataranovski, Milos D Pavlovic
BACKGROUND/PURPOSE: Contact hypersensitivity (CHS) reaction is a useful model for studying the skin immune system and inflammatory reactions in the skin. In this study, an experimental model of CHS reaction was employed to assess immunomodulatory effects of near-infrared (near-IR) low-intensity laser (LIL) irradiation, which is used as adjuvant therapy in dermatology, physical medicine, rheumatology, etc., because of its declared anti-inflammatory, biostimulative and analgesic effects...
August 2003: Photodermatology, Photoimmunology & Photomedicine
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