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stress related neuropathy

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https://www.readbyqxmd.com/read/27906945/ganglion-cyst-at-the-proximal-tibiofibular-joint-in-a-patient-with-painless-foot-drop
#1
Abdulmuhsen Alsahhaf, Waleed Renno
Entrapment neuropathies of the fibular nerve and its branches are often underdiagnosed due to the lack of reliable diagnosis using clinical examination and electrophysiologic evaluation. Most fibular nerve compressions may be classified into 2 broad categories: (a) mechanical causes, which occur at fibrous or fibro-osseous tunnels, and (b) dynamic causes related to nerve injury during specific limb positioning. Foot drop resulting from weakness of the dorsiflexor muscles of the foot is a relatively uncommon presentation and closely related to L5 neuropathy caused by a disc herniation...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27855625/therapeutic-potential-of-caffeic-acid-phenethyl-ester-cape-in-diabetes
#2
Valeria Pittala, Loredana Salerno, Giuseppe Romeo, Rosaria Acquaviva, Claudia Di Giacomo, Valeria Sorrenti
Diabetes mellitus is a complex metabolic disease characterized by high blood sugar levels. Different pathogenic processes are involved in the etiology of the disease. Indeed, chronic diabetes hyperglycemia is often associated with severe long-term complications including cardiovascular symptoms, retinopathy, nephropathy, and neuropathy. Although the precise molecular mechanisms underlying diabetes are not yet clear, it is widely accepted that increased levels of oxidative stress are involved in the onset, development and progression of diabetes and its related complications...
November 18, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27834877/sugar-composition-analysis-of-fuzi-polysaccharides-by-hplc-ms-n-and-their-protective-effects-on-schwann-cells-exposed-to-high-glucose
#3
Bei-Bei Wang, Jia-Li Wang, Jiang Yuan, Qing-Hua Quan, Rui-Fang Ji, Peng Tan, Jing Han, Yong-Gang Liu
Fuzi has been used to treat diabetic complications for many years in china. In a previous study, we have shown that Fuzi aqueous extract can attenuate Diabetic peripheral neuropathy (DPN) in rats and protect Schwann cells from injury. Thus, the protective effect of Fuzi polysaccharides (FPS) on high glucose-induced SCs and the preliminary mechanism were investigated. Firstly, the FPS were obtained and their monose composition was analyzed by the combination of pre-column derivatization and high performance liquid chromatography coupled with electrospray ionization multi-tandem mass spectrometry (HPLC/ESI-MS(n))...
November 9, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27830156/administration-of-traditional-chinese-blood-circulation-activating-drugs-for-microvascular-complications-in-patients-with-type-2-diabetes-mellitus
#4
REVIEW
Lisha He, Han Wang, Chengjuan Gu, Xinhui He, Linhua Zhao, Xiaolin Tong
Traditional Chinese medicine (TCM) is an important complementary strategy for treating diabetes mellitus (DM) in China. Traditional Chinese blood circulation activating drugs are intended to guide an overall approach to the prevention and treatment of microvascular complications of DM. The core mechanism is related to the protection of the vascular endothelium and the basement membrane. Here, we reviewed the scientific evidence underpinning the use of blood circulation activating drugs to prevent and treat DM-induced microvascular complications, including diabetic nephropathy (DN), diabetic peripheral neuropathy (DPN), and diabetic retinopathy (DR)...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27807175/ablation-of-perk-in-schwann-cells-improves-myelination-in-the-s63del-charcot-marie-tooth-1b-mouse
#5
Mariapaola Sidoli, Nicolò Musner, Nicholas Silvestri, Daniela Ungaro, Maurizio D'Antonio, Douglas R Cavener, M Laura Feltri, Lawrence Wrabetz
: In factory cells, the accumulation of misfolded protein provokes the unfolded protein response (UPR). For example, deletion of serine 63 (S63del) in myelin protein zero (P0) induces P0 accumulation in the endoplasmic reticulum (ER) of Schwann cells and a persistent UPR associated with Charcot-Marie-Tooth 1B (CMT1B) demyelinating peripheral neuropathy in human and mouse. PERK (protein kinase RNA-like ER kinase) is the ER stress sensor that attenuates global translation by phosphorylating eIF2α...
November 2, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27742903/levels-of-heavy-and-essential-trace-metals-and-their-correlation-with-antioxidant-and-health-status-in-individuals-occupationally-exposed-to-municipal-solid-wastes
#6
Adesina O Odewabi, Martins Ekor
Recent studies have indicated an increased incidence of toxic neuropathies among waste management workers (WMW) possibly linked to increased detection of heavy metals in municipal solid wastes. The present study evaluated serum levels of some heavy and essential trace metals in relation to oxidant/antioxidant status of WMW. One hundred and twenty-six WMW and 84 non-WMW (control) were recruited. Metal/element concentration was measured by atomic absorption spectrophotometry and oxidant/antioxidant markers were determined using standard procedures...
October 13, 2016: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/27712995/combination-strategy-of-parp-inhibitor-with-antioxidant-prevent-bioenergetic-deficits-and-inflammatory-changes-in-cci-induced-neuropathy
#7
Prashanth Komirishetty, Aparna Areti, Ranadeep Gogoi, Ramakrishna Sistla, Ashutosh Kumar
Neuropathic pain, a debilitating pain condition and the underlying pathogenic mechanisms are complex and interwoven amongst each other and still there is scant information available regarding therapies which promise to treat the condition. Evidence indicate that oxidative/nitrosative stress induced poly (ADP-ribose) polymerase (PARP) overactivation initiate neuroinflammation and bioenergetic crisis culminating into neurodegenerative changes following nerve injury. Hence, we investigated the therapeutic effect of combining an antioxidant, quercetin and a PARP inhibitor, 4-amino 1, 8-naphthalimide (4-ANI) on the hallmark deficits induced by chronic constriction injury (CCI) of sciatic nerve in rats...
October 3, 2016: Neuropharmacology
https://www.readbyqxmd.com/read/27697454/nerve-stress-during-reverse-total-shoulder-arthroplasty-a-cadaveric-study
#8
Hubert Lenoir, Louis Dagneaux, François Canovas, Thomas Waitzenegger, Thuy Trang Pham, Michel Chammas
BACKGROUND: Neurologic lesions are relatively common after total shoulder arthroplasty. These injuries are mostly due to traction. We aimed to identify the arm manipulations and steps during reverse total shoulder arthroplasty (RTSA) that affect nerve stress. METHODS: Stress was measured in 10 shoulders of 5 cadavers by use of a tensiometer on each nerve from the brachial plexus, with shoulders in different arm positions and during different surgical steps of RTSA...
September 30, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27642327/the-aqueous-extract-of-portulaca-oleracea-ameliorates-neurobehavioral-dysfunction-and-hyperglycemia-related-to-streptozotocin-diabetes-induced-in-ovariectomized-rats
#9
Seyed Reza Fatemi Tabatabaei, Masome Rashno, Shahab Ghaderi, Majid Askaripour
Diabetes mellitus is one of the most common causes of neuropathy. Although antioxidant and antidiabetic effects of the aqueous extract of purslane (Portulaca oleracea) (AEOP) have been demonstrated before by other researchers, we did not find any study that assessed the psychobiological effects of AEOP in diabetes induced animals. Thirty ovariectomized (OVX) female Wistar rats were randomly divided into 3 groups of control, Dia and Dia+AEOP. The latter group was orally treated by 300 mg/kg of AEOP for 35 days...
2016: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/27633772/the-metabolomic-signature-of-leber-s-hereditary-optic-neuropathy-reveals-endoplasmic-reticulum-stress
#10
Juan Manuel Chao de la Barca, Gilles Simard, Patrizia Amati-Bonneau, Zainab Safiedeen, Delphine Prunier-Mirebeau, Stéphanie Chupin, Cédric Gadras, Lydie Tessier, Naïg Gueguen, Arnaud Chevrollier, Valérie Desquiret-Dumas, Marc Ferré, Céline Bris, Judith Kouassi Nzoughet, Cinzia Bocca, Stéphanie Leruez, Christophe Verny, Dan Miléa, Dominique Bonneau, Guy Lenaers, M Carmen Martinez, Vincent Procaccio, Pascal Reynier
Leber's hereditary optic neuropathy (MIM#535000), the commonest mitochondrial DNA-related disease, is caused by mutations affecting mitochondrial complex I. The clinical expression of the disorder, usually occurring in young adults, is typically characterized by subacute, usually sequential, bilateral visual loss, resulting from the degeneration of retinal ganglion cells. As the precise action of mitochondrial DNA mutations on the overall cell metabolism in Leber's hereditary optic neuropathy is unknown, we investigated the metabolomic profile of the disease...
September 15, 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27530093/carbon-disulfide-activates-p62-nrf2-keap1-pathway-in-rat-nerve-tissues
#11
Shasha Wang, Yisi Chen, Ruirui Kou, Yu Wang, Tao Zeng, Keqin Xie, Fuyong Song
Oxidative stress is associated with the pathogenesis of carbon disulfide (CS2) induced polyneuropathy. The nuclear factor erythroid 2-related factor 2 (Nrf2) plays a critical role in protecting cells against oxidative stress. However, whether there exists a Nrf2-mediated antioxidative machinery in CS2-induced neuropathy has not been elucidated. In the present study, male wistar rats were randomly divided into three experimental groups and one control group. The rats in experimental groups were treated with CS2 by gavage at dosages of 200, 400 and 600mg/kg/day respectively, six times per week for 6 weeks...
August 10, 2016: Toxicology
https://www.readbyqxmd.com/read/27496624/the-effects-of-gliclazide-methylcobalamin-and-gliclazide-methylcobalamin-combination-therapy-on-diabetic-peripheral-neuropathy-in-rats
#12
Hongping Yao, Juanyi Feng, Qiaowei Zheng, Youxia Wei, Shixiang Wang, Weiyi Feng
AIMS: This study investigated the efficacies of gliclazide (GLZ), methylcobalamin (MCA), and GLZ+MCA combination therapy on DPN by evaluating the treatment-related changes in peripheral nerve function, the polyol pathway, and oxidative stress in the sciatic nerve of streptozotocin-induced diabetic rats. MATERIALS AND METHODS: The rat model of streptozotocin-induced diabetes was orally given GLZ (25mg/kg/day), MCA (175μg/kg/day), and GLZ+MCA (25mg/kg/day+175μg/kg/day) combination therapy for 8weeks, in order to observe its effects on the motor nerve conduction velocity (MNCV), on the activities of Na(+), K(+)-ATPase, aldose reductase(AR), AR mRNA expression, on the polyol contents, antioxidative enzyme activities and peroxidation products in the sciatic never tissue...
September 15, 2016: Life Sciences
https://www.readbyqxmd.com/read/27476541/studying-neuroprotective-effect-of-atorvastatin-as-a-small-molecule-drug-on-high-glucose-induced-neurotoxicity-in-undifferentiated-pc12-cells-role-of-nadph-oxidase
#13
Samira Rayegan, Ahmad Reza Dehpour, Ali Mohammad Sharifi
Overproduction of reactive oxygen species (ROS) by NADPH oxidase (NOX) activation has been considered the essential mechanism induced by hyperglycemia in various tissues. However, there is no comprehensive study on the role of NOXs in high glucose (HG)-induced toxic effect in neural tissues. Recently, a therapeutic strategy in oxidative related pathologies has been introduced by blocking the undesirable actions of NOX enzymes by small molecules. The protective roles of Statins in ameliorating oxidative stress by NOX inhibition have been shown in some tissues except neural...
August 1, 2016: Metabolic Brain Disease
https://www.readbyqxmd.com/read/27393712/serum-adma-and-arginine-levels-predict-micro-and-macrovascular-complications-in-type-2-diabetes-mellitus
#14
Tali Ganz, Julio Wainstein, Suzan Gilad, Rona Limor, Mona Boaz, Naftali Stern
AIMS: Increased oxidative stress in diabetes increases nitric oxide (NO) oxidation and low L-arginine (Arg) could further reduce NO and impair vascular function, thus accelerating, in the long run, vascular complications. We therefore measured Arg and asymmetric dimethylarginine (ADMA) levels in patients with type 2 diabetes mellitus (T2DM) and healthy controls. Additionally, we followed the diabetic individuals over time to see if Arg and ADMA predicted T2DM complications. MATERIALS AND METHODS: We examined baseline serum Arg and ADMA levels in a cohort of 105 subjects with type 2 diabetes and compared them to an age- and weight matched non-diabetic group of 137 individuals who served as a reference population...
July 8, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/27338109/overexpression-of-protocadherin-10-in-transthyretin-related-familial-amyloidotic-polyneuropathy
#15
Nádia P Gonçalves, Diana Martins, Maria João Saraiva
Overwhelming data suggest that oncogenic and neurodegenerative pathways share several altered cellular responses to insults such as oxidative stress, extracellular matrix remodeling, inflammation, or cell dyscommunication. Protocadherin-10 (Pcdh10) is an adhesion molecule found to protect against tumorigenesis and essential for axonal elongation and actin dynamics during development. Here, by using genome microarrays we identified for the first time Pcdh10 up-regulation in tissues from transgenic mouse models, cultured Schwann cells, and human samples from a familial form of peripheral neuropathy (familial amyloidotic polyneuropathy)...
July 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27330020/treatment-of-human-immunodeficiency-virus-related-peripheral-neuropathy-with-scrambler-therapy-a-case-report
#16
Thomas J Smith, Paul Auwaerter, Amy Knowlton, Deanna Saylor, Justin McArthur
Peripheral neuropathy is one of the most common neurological complications of HIV infection with a 30-60% lifetime prevalence. Newer HIV drugs cause less peripheral neuropathy, but patients are now living long enough to develop concomitant diabetes-related, vascular-related, and chemotherapy-related neuropathy so it continues as a major debilitating issue. Recent national CDC guidelines have stressed the importance of non-opioid therapies, especially in this population that may have had drug abuse problems...
June 21, 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27184051/nmnat-1-a-security-guard-of-retinal-ganglion-cells-rgcs-in-response-to-high-glucose-stress
#17
Rong-Mei Zhou, Yi Shen, Jin Yao, Hong Yang, Kun Shan, Xiu-Miao Li, Qin Jiang, Biao Yan
BACKGROUND/AIMS: Retinal neurodegeneration is an early event in the pathological process of diabetic retinopathy (DR). Retinal ganglion cell (RGC) injury is an important pathological feature during neurodegenerative process. Protecting RGCs from high glucose-induced injury is a promising strategy for delaying or hindering diabetes mellitus-related retinal neuropathy. This study aims to investigate the role of Nmnat1, an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD), in high glucose-induced RGC injury...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27152884/involvement-of-oxidative-stress-and-impaired-lysosomal-degradation-in-amiodarone-induced-schwannopathy
#18
Naoko Niimi, Hideji Yako, Masami Tsukamoto, Shizuka Takaku, Junji Yamauchi, Emiko Kawakami, Hiroko Yanagisawa, Kazuhiko Watabe, Kazunori Utsunomiya, Kazunori Sango
Amiodarone hydrochloride (AMD), an anti-arrhythmic agent, has been shown to cause peripheral neuropathy; however, its pathogenesis remains unknown. We examined the toxic effects of AMD on an immortalized adult rat Schwann cell line, IFRS1, and cocultures of IFRS1 cells and adult rat dorsal root ganglion neurons or nerve growth factor-primed PC12 cells. Treatment with AMD (1, 5, and 10 μm) induced time- and dose-dependent cell death, accumulation of phospholipids and neutral lipids, upregulation of the expression of gangliosides, and oxidative stress (increased nuclear factor E2-related factor in nuclear extracts and reduced GSH/GSSG ratios) in IFRS1 cells...
July 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27134857/ischemia-modified-albumin-ima-a-marker-of-glycaemic-control-and-vascular-complications-in-type-2-diabetes-mellitus
#19
Rajinder Chawla, Rinchu Loomba, Deepak Guru, Vikas Loomba
INTRODUCTION: Ischemia modified albumin (IMA) has emerged as a marker for ischemic injury and oxidative damage, particularly in myocardial infarction. There are very few studies on the significance of IMA in other conditions associated with ischemia. The complications of diabetes mellitus (DM) arising out of poor glycaemic control have an underlying ischemic aetiology. AIM: To evaluate correlation of IMA with glycaemic control in type 2 DM (T2DM). Secondary aim was to assess the utility of IMA as a marker for vascular complications in T2DM...
March 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27025193/sulforaphane-ameliorates-the-insulin-responsiveness-and-the-lipid-profile-but-does-not-alter-the-antioxidant-response-in-diabetic-rats
#20
Carolina Guerini de Souza, Leonardo Lisbôa da Motta, Adriano Martimbianco de Assis, Anderson Rech, Ricardo Bruch, Fábio Klamt, Diogo Onofre Souza
Diabetes is one of the most prevalent chronic non-communicable diseases and is characterized by hyperglycemia and increased oxidative stress. These two alterations are also responsible for the main diabetic complications: cardiovascular disease, retinopathy, nephropathy and peripheral neuropathy. Diabetes progression is governed by pancreatic β-cell failure, and recent studies showed that sulforaphane (SFN) might be able to prevent this change, preserving insulin production. Consequently, our goal was to test the effects of SFN on metabolic parameters related to diabetic complications and antioxidant defenses (superoxide dismutase, catalase and sulfhydryl groups) in the pancreas, liver and kidney of non-diabetic and diabetic rats...
April 2016: Food & Function
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