keyword
https://read.qxmd.com/read/38536887/endothelial-and-inflammatory-pathophysiology-in-dengue-shock-new-insights-from-a-prospective-cohort-study-in-vietnam
#1
JOURNAL ARTICLE
Angela McBride, Huynh Thi Le Duyen, Nguyen Lam Vuong, Phan Vinh Tho, Luong Thi Hue Tai, Nguyen Thanh Phong, Nguyen Thanh Ngoc, Lam Minh Yen, Phung Tran Huy Nhat, Tran Thuy Vi, Martin J Llewelyn, Louise Thwaites, Nguyen Van Hao, Sophie Yacoub
Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapies and host immune modulators are needed. With the aim of prioritising potential therapeutics, we conducted a prospective observational study of adults (≥16 years) with DS in Vietnam from 2019-2022, comparing the pathophysiology underlying circulatory failure with patients with septic shock (SS), and investigating the association of biomarkers with clinical severity (SOFA score, ICU admission, mortality) and pulmonary vascular leak (daily lung ultrasound for interstitial and pleural fluid)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38530675/early-physician-gestalt-versus-usual-screening-tools-for-the-prediction-of-sepsis-in-critically-ill-emergency-patients
#2
JOURNAL ARTICLE
Sarah K S Knack, Nathaniel Scott, Brian E Driver, Matthew E Prekker, Lauren Page Black, Charlotte Hopson, Ellen Maruggi, Olivia Kaus, Walker Tordsen, Michael A Puskarich
STUDY OBJECTIVE: Compare physician gestalt to existing screening tools for identifying sepsis in the initial minutes of presentation when time-sensitive treatments must be initiated. METHODS: This prospective observational study conducted with consecutive encounter sampling took place in the emergency department (ED) of an academic, urban, safety net hospital between September 2020 and May 2022. The study population included ED patients who were critically ill, excluding traumas, transfers, and self-evident diagnoses...
March 25, 2024: Annals of Emergency Medicine
https://read.qxmd.com/read/38529068/the-role-of-aggf1-in-the-classification-and-evaluating-prognosis-of-adult-septic-patients-an-observational-study
#3
JOURNAL ARTICLE
Wenqing Ji, Tiantian Wan, Fang Zhang, Shubin Guo, Xue Mei
PURPOSE: Angiogenic factor with G patch and FHA domains 1 (AGGF1) is a crucial angiogenic factor that is involved in a variety of diseases and in the regulation of inflammatory responses. However, its role in sepsis is poorly understood. We have investigated the role of AGGF1 in the classification and prognostic evaluation of adult septic patients in a clinical context. PATIENTS AND METHODS: A total of 126 septic patients who visited the Emergency Department of Beijing Chao-Yang Hospital and 76 non-sepsis patients visiting the Physical Examination Center of Beijing Chao-Yang Hospital were enrolled...
2024: Infection and Drug Resistance
https://read.qxmd.com/read/38526296/prognostic-value-of-poly-microorganisms-detected-by-droplet-digital-pcr-and-pathogen-load-kinetics-in-sepsis-patients-a-multi-center-prospective-cohort-study
#4
JOURNAL ARTICLE
Yuanhan Zhao, Ke Lin, Haocheng Zhang, Yanliang Zhang, Shaling Li, Shengguo Zhang, Wei Zhang, Aiming Zhou, Yangyang Zhuang, Jie Chen, Caixia Wu, Wei Zhou, Xiaoju He, Qiaoyan Yue, Meng Zhang, Yan Huang, Liang Li, Liang Hong, Fujing Cai, Lisu Huang, Zhengshang Ruan, Shanshan Xu, Yan Zhang, Xiaohua Chen, Jie Chen, Ying Ye, Tingting Bian, Jiabin Li, Jun Yin, Xiang Li, Lijing Jiang, Chen Lei, Jun Liu, Ying Zhang, Jialin Jin, Jingwen Ai, Jingye Pan, Wenhong Zhang
This study aimed to investigate the prognostic value of a novel droplet digital polymerase chain reaction (DDPCR) assay in sepsis patients. In this prospective cohort study, univariable and multivariable Cox regressions were used to assess risk factors for 28-day mortality. We also monitored pathogen load together with clinical indicators in a subgroup of the cohort. A total of 107 sepsis patients with positive baseline DDPCR results were included. Detection of poly-microorganisms [adjusted hazard ratio (HR) = 3...
March 25, 2024: Microbiology Spectrum
https://read.qxmd.com/read/38524548/sequential-respiratory-support-in-septic-patients-undergoing-continuous-renal-replacement-therapy-a-study-based-on-mimic-iii-database
#5
JOURNAL ARTICLE
Chunxia Wang, Jianli Zheng, Yilin Zhao, Tiantian Liu, Yucai Zhang
OBJECTIVE: Oxygen and hemodynamic management are important for providing a sufficient adequate oxygen-containing blood to the organs for septic patients. In present study, we aimed to explore the application of sequential respiratory support (SRS) and the association of SRS with the outcome of septic patients who needed continuous renal replacement therapy (CRRT). METHODS: We extracted the medical information of septic patients who received CRRT within 24 h of intensive care unit (ICU) admission from the MIMIC-III v1...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38517232/development-and-validation-of-a-nomogram-for-predicting-28-day-in-hospital-mortality-in-sepsis-patients-based-on-an-optimized-apache-ii-score
#6
JOURNAL ARTICLE
Yamin Yuan, Yanfei Meng, Yihui Li, Jinquan Zhou, Jiaqi Wang, Yujing Jiang, Li Ma
PURPOSE: The objective of this study is to establish a nomogram that correlates optimized APACHE II score with sepsis-related indicators, aiming to provide a robust model for early prediction of sepsis prognosis in clinical practice and serve as a valuable reference for improved diagnosis and treatment strategies. METHODS: This retrospective study extracted sepsis patients meeting the inclusion criteria from the MIMIC-IV database to form the training group. An optimized Acute Physiology and Chronic Health Evaluation (APACHE) II score integrated with relevant indicators was developed using a nomogram for predicting the prognosis of sepsis patients...
February 5, 2024: Shock
https://read.qxmd.com/read/38514401/impact-of-intraoperative-haemoadsorption-on-outcomes-of-patients-undergoing-aortic-surgery-a-single-centre-prospective-observational-study
#7
JOURNAL ARTICLE
Yatin Mehta, Ajmer Singh, Mandeep Singh, Anil Bhan, Naresh Trehan
TITLE: Impact of Intraoperative Haemoadsorption on Outcomes of Patients undergoing Aortic Surgery: A Single-Centre, Prospective, Observational Study. OBJECTIVES: To investigate the impact of a cytokine haemoadsorption device (CytoSorb®) on inflammatory markers and patients' outcome during aortic root surgery. METHODS: Prospective, observational study including all-comers with quasi-randomisation by strictly alternating inclusion (1:1 basis)...
March 21, 2024: Interdiscip Cardiovasc Thorac Surg
https://read.qxmd.com/read/38514345/-establishment-and-verification-of-invasion-syndrome-prediction-model-in-patients-with-diabetes-complicated-with-klebsiella-pneumoniae-liver-abscess
#8
JOURNAL ARTICLE
C Y Feng, L W Zhang, T Liu, S F Jiang, X M Li, J Di
Objective: To analyze the correlative factors of invasion syndrome in patients with diabetes complicated with Klebsiella pneumoniae liver abscess, and to construct and verify the online nomographic prediction model. Methods: A case control study. The clinical data of 213 diabetic patients with Klebsiella pneumoniae liver abscess admitted to the Third Affiliated Hospital of Soochow University from January 1, 2015 to December 31, 2021 were retrospectively analyzed. The patients were divided into the training set (149 cases) and the test set (64 cases) by stratified random sampling method at a ratio of 7∶3...
March 26, 2024: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/38510779/clinical-profile-and-predictors-of-intensive-care-admission-in-neonicotinoid-poisoning-in-a-tertiary-care-hospital-in-south-india
#9
JOURNAL ARTICLE
Lalhming Sanga, Amita Jacob, Jonathan Arul Jeevan Jayakaran, Ramya Iyadurai
BACKGROUND AND OBJECTIVES: Neonicotinoids are a newer class of pesticides that are believed to cause predominantly mild toxicity in humans. This study aimed to describe the clinical features of neonicotinoid poisoning and identify predictors of severe toxicity. MATERIALS AND METHODS: This retrospective study included all patients with neonicotinoid poisoning admitted to a Tertiary Care Center in India over an 18-year period. Clinical and laboratory features were compared against outcomes to identify predictors of the need for intensive care admission...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38510775/the-use-of-sustained-low-efficiency-dialysis-in-the-treatment-of-sepsis-associated-acute-kidney-injury-in-a-low-income-country-a-prospective-cohort-study
#10
JOURNAL ARTICLE
Abdalla Kamal Abdalla Taha, Mazin Mohammed Taha Shigidi, Nazik Mahmoud Abdulfatah, Rajabia Khidir Alsayed
BACKGROUND: Limited data are available regarding the management and outcomes of patients with sepsis-associated acute kidney injury (SA-AKI) requiring dialysis in Sudan. Continuous renal replacement therapy (CRRT) is a highly favored treatment modality in such patients. However, it stays unavailable and expensive treatment in most low-income countries. We aimed to evaluate the use of sustained low-efficiency dialysis (SLED) in the treatment of hemodynamically unstable patients with SA-AKI admitted to the intensive care unit (ICU)...
January 2024: Indian Journal of Critical Care Medicine
https://read.qxmd.com/read/38509460/association-between-trough-serum-vancomycin-concentration-and-vancomycin-associated-acute-kidney-injury-and-30-day-mortality-in-critically-ill-elderly-adults
#11
JOURNAL ARTICLE
Jialong Chen, Jing Lin, Jianzhen Weng, Yang Ju, Yanming Li
BACKGROUND: Vancomycin-associated acute kidney injury (VA-AKI) is the most clinically relevant side effect of vancomycin. The objective of this study was to investigate the association between VTC and VA-AKI as well as 30-day mortality in critically ill elderly adults. METHOD: Elderly patients with trough serum vancomycin concentration records(VTC) in the Medical Information Mart-IV (MIMIC-IV) and eICU databases were retrospectively studied. RESULTS: A total of 3,146 critically ill elderly adults were finally enrolled...
March 20, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38509095/comparison-of-mortality-and-outcomes-of-four-respiratory-viruses-in-the-intensive-care-unit-a-multicenter-retrospective-study
#12
MULTICENTER STUDY
Baptiste Grangier, Charles-Hervé Vacheron, Donatien De Marignan, Jean-Sebastien Casalegno, Sandrine Couray-Targe, Audrey Bestion, Florence Ader, Jean-Christophe Richard, Emilie Frobert, Laurent Argaud, Thomas Rimmele, Anne-Claire Lukaszewicz, Frédéric Aubrun, Frédéric Dailler, Jean-Luc Fellahi, Julien Bohe, Vincent Piriou, Bernard Allaouchiche, Arnaud Friggeri, Florent Wallet
This retrospective study aimed to compare the mortality and burden of respiratory syncytial virus (RSV group), SARS-CoV-2 (COVID-19 group), non-H1N1 (Seasonal influenza group) and H1N1 influenza (H1N1 group) in adult patients admitted to intensive care unit (ICU) with respiratory failure. A total of 807 patients were included. Mortality was compared between the four following groups: RSV, COVID-19, seasonal influenza, and H1N1 groups. Patients in the RSV group had significantly more comorbidities than the other patients...
March 20, 2024: Scientific Reports
https://read.qxmd.com/read/38505014/more-attention-should-be-paid-to-omicron-associated-sepsis-a-multicenter-retrospective-study-in-south-china
#13
JOURNAL ARTICLE
Ling Sang, Yonghao Xu, Yongbo Huang, Zhengtu Li, Deliang Wen, Changbo Liu, Yichun Wang, Lewu Xian, Linling Cheng, Feng Ye, Hongkai Wu, Xilong Deng, Yueping Li, Weiyan Ye, Nanshan Zhong, Yimin Li, Shiyue Li, Xiaoqing Liu
BACKGROUND: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible but causes less severe disease compared to other variants. However, its association with sepsis incidence and outcomes is unclear. This study aimed to investigate the incidence of Omicron-associated sepsis, as per the Sepsis 3.0 definition, in hospitalized patients, and to explore its relationship with clinical characteristics and prognosis. METHODS: This multicenter retrospective study included adults hospitalized with confirmed SARS-CoV-2 infection across six tertiary hospitals in Guangzhou, China from November 2022 to January 2023...
February 29, 2024: Journal of Thoracic Disease
https://read.qxmd.com/read/38504911/post-operative-sepsis-induced-acute-respiratory-distress-syndrome-risk-factors-for-a-life-threatening-complication
#14
JOURNAL ARTICLE
Miguel Bardají-Carrillo, Marta Martín-Fernández, Rocío López-Herrero, Juan Manuel Priede-Vimbela, María Heredia-Rodríguez, Esther Gómez-Sánchez, Estefanía Gómez-Pesquera, Mario Lorenzo-López, Pablo Jorge-Monjas, Rodrigo Poves-Álvarez, Jesús Villar, Eduardo Tamayo
INTRODUCTION: Prevalence and mortality of the acute respiratory distress syndrome (ARDS) in intensive care units (ICU) are unacceptably high. There is scarce literature on post-operative sepsis-induced ARDS despite that sepsis and major surgery are conditions associated with ARDS. We aimed to examine the impact of post-operative sepsis-induced ARDS on 60-day mortality. METHODS: We performed a secondary analysis of a prospective observational study in 454 patients who underwent major surgery admitted into a single ICU...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38504695/predictive-and-prognostic-potentials-of-lymphocyte-c-reactive-protein-ratio-upon-hospitalization-in-adult-patients-with-acute-pancreatitis
#15
JOURNAL ARTICLE
Xiao-Yu Xu, Yang Gao, Chuang-Shi Yue, Yu-Jia Tang, Zhao-Jin Zhang, Feng-Jie Xie, Hong Zhang, Yu-Cheng Zhu, Yan Zhang, Qi-Qi Lai, Xin-Tong Wang, Jia-Xi Xu, Jia-Ning Zhang, Bo-Wen Liu, Jian-Nan Zhang, Kai Kang
PURPOSE: In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). METHODS: We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University between July 2019 and June 2022. These patients were categorized into three groups: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP), based on the presence and duration of organ dysfunction...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38504259/urinary-cadmium-concentration-is-associated-with-the-severity-and-clinical-outcomes-of-covid-19-a-bicenter-observational-cohort-study
#16
JOURNAL ARTICLE
Li-Chung Chiu, Chung-Shu Lee, Ping-Chih Hsu, Hsin-Hsien Li, Tien-Ming Chan, Ching-Chung Hsiao, Scott Chih-Hsi Kuo, How-Wen Ko, Shu-Min Lin, Chun-Hua Wang, Horng-Chyuan Lin, Pao-Hsien Chu, Tzung-Hai Yen
BACKGROUND: Cadmium and nickel exposure can cause oxidative stress, induce inflammation, inhibit immune function, and therefore has significant impacts on the pathogenesis and severity of many diseases. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can also provoke oxidative stress and the dysregulation of inflammatory and immune responses. This study aimed to assess the potential associations of cadmium and nickel exposure with the severity and clinical outcomes of patients with coronavirus disease 2019 (COVID-19)...
March 19, 2024: Environmental Health
https://read.qxmd.com/read/38500500/development-and-validation-a-nomogram-prediction-model-for-early-diagnosis-of-bloodstream-infections-in-the-intensive-care-unit
#17
JOURNAL ARTICLE
Zhili Qi, Lei Dong, Jin Lin, Meili Duan
PURPOSE: This study aims to develop and validate a nomogram for predicting the risk of bloodstream infections (BSI) in critically ill patients based on their admission status to the Intensive Care Unit (ICU). PATIENTS AND METHODS: Patients' data were extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database (training set), the Beijing Friendship Hospital (BFH) database (validation set) and the eICU Collaborative Research Database (eICU-CRD) (validation set)...
2024: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/38499589/the-microcirculation-in-the-first-days-of-icu-admission-in-critically-ill-covid-19-patients-is-influenced-by-severity-of-disease
#18
JOURNAL ARTICLE
Fleur Brouwer, Can Ince, Jiska Pols, Zühre Uz, Matthias Peter Hilty, Mendi Sesmu Arbous
The objective of this study was to investigate the relationship between sublingual microcirculatory parameters and the severity of the disease in critically ill coronavirus disease 2019 (COVID-19) patients in the initial period of Intensive Care Unit (ICU) admission in a phase of the COVID-19 pandemic where patients were being treated with anti-inflammatory medication. In total, 35 critically ill COVID-19 patients were included. Twenty-one critically ill COVID-19 patients with a Sequential Organ Failure Assessment (SOFA) score below or equal to 7 were compared to 14 critically ill COVID-19 patients with a SOFA score exceeding 7...
March 18, 2024: Scientific Reports
https://read.qxmd.com/read/38497568/protracted-fibrinolysis-resistance-following-cardiac-surgery-with-cardiopulmonary-bypass-a-prospective-observational-study-of-clinical-associations-and-patient-outcomes
#19
JOURNAL ARTICLE
Lucy A Coupland, Kieran G Pai, Sidney J Pye, Mark T Butorac, Jennene J Miller, Philip J Crispin, David J Rabbolini, Antony H L Stewart, Anders Aneman
BACKGROUND: Surgery on cardiopulmonary bypass (CPB) elicits a pleiomorphic systemic host response which, when severe, requires prolonged intensive care support. Given the substantial cross-talk between inflammation, coagulation, and fibrinolysis, the aim of this hypothesis-generating observational study was to document the kinetics of fibrinolysis recovery post-CPB using ClotPro® point-of-care viscoelastometry. Tissue plasminogen activator-induced clot lysis time (TPA LT, s) was correlated with surgical risk, disease severity, organ dysfunction and intensive care length of stay (ICU LOS)...
March 18, 2024: Acta Anaesthesiologica Scandinavica
https://read.qxmd.com/read/38495114/prognostic-analysis-of-high-flow-nasal-cannula-therapy-and-non-invasive-ventilation-in-mild-to-moderate-hypoxemia-patients-and-construction-of-a-machine-learning-model-for-48-h-intubation-prediction-a-retrospective-analysis-of-the-mimic-database
#20
JOURNAL ARTICLE
Wei Fu, Xiaoqing Liu, Lili Guan, Zhimin Lin, Zhenfeng He, Jianyi Niu, Qiaoyun Huang, Qi Liu, Rongchang Chen
BACKGROUND: This study aims to investigate the clinical outcome between high-flow nasal cannula (HFNC) and non-invasive ventilation (NIV) therapy in mild to moderate hypoxemic patients on the first ICU day and to develop a predictive model of 48-h intubation. METHODS: The study included adult patients from the MIMIC III and IV databases who first initiated HFNC or NIV therapy due to mild to moderate hypoxemia (100 < PaO2/FiO2 ≤ 300)...
2024: Frontiers in Medicine
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