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https://www.readbyqxmd.com/read/28185633/expression-profile-of-biomarkers-altered-in-papillary-and-anaplastic-thyroid-carcinoma-contribution-of-tunisian-patients
#1
Asma Fourati, Olfa El Amine, Wided Ben Ayoub, Imen Cherni, Aida Goucha, Michèle Véronique El May, Amor Gamoudi, Ahmed El May
AIMS: The objective of this study was to compare the protein expression profile between well-differentiated (papillary) and undifferentiated (anaplastic) thyroid carcinoma in Tunisian patients. METHODS: This first Tunisian retrospective study concerned data of 38 thyroid cancer cases (19 papillary carcinoma PTC and 19 anaplastic carcinoma ATC) collected at Salah Azaiez Institute of Tunisia. Immunohistochemistry was used to evaluate tumor expression of different molecular markers (p53, Ki67, E-cadherin, cyclin D1, bcl2, S100 and Her-2)...
February 6, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/28048979/adult-hippocampal-neurogenesis-is-impaired-by-transient-and-moderate-developmental-thyroid-hormone-disruption
#2
M E Gilbert, J H Goodman, J Gomez, A F M Johnstone, R L Ramos
The hippocampus maintains a capacity for neurogenesis throughout life, a capacity that is reduced in models of adult onset hypothyroidism. The effects of developmental thyroid hormone (TH) insufficiency on neurogenesis in the adult hippocampus, however, has not been examined. Graded degrees of TH insufficiency were induced in pregnant rat dams by administration of 0, 3 or 10ppm of 6-propylthiouracil (PTU) in drinking water from gestational day (GD) 6 until weaning. Body, brain, and hippocampal weight were reduced on postnatal day (PN) 14, 21, 78 and hippocampal volume was smaller at the 10 but not 3ppm dose level...
December 31, 2016: Neurotoxicology
https://www.readbyqxmd.com/read/28036290/yes-associated-protein-1-promotes-papillary-thyroid-cancer-cell-proliferation-by-activating-the-erk-mapk-signaling-pathway
#3
Tian Liao, Duo Wen, Ben Ma, Jia-Qian Hu, Ning Qu, Rong-Liang Shi, Liang Liu, Qing Guan, Duan-Shu Li, Qing-Hai Ji
Yes-associated protein 1 (YAP1) stimulates cell proliferation, epithelial-to-mesenchymal transition, invasion and metastasis in several cancers. Here, we investigated the involvement of YAP1 in papillary thyroid carcinoma (PTC) by assessing YAP1 mRNA and protein levels in PTC tissues and matched normal thyroid epithelial tissues from 50 patients. YAP1 mRNA and protein levels were higher in PTC tumor tissues than in control tissues, and correlated positively with the levels of proliferation-related genes (KI67 and c-MYC)...
December 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27892665/thyroid-function-after-postoperative-radiation-therapy-in-patients-with-breast-cancer
#4
Edyta Wolny-Rokicka, Andrzej Tukiendorf, Jerzy Wydmański, Danuta Roszkowska, Bogusław Staniul, Agnieszka Zembroń-Łacny
Objective: The aim of this study was to assess thyroid function in breast cancer patients exposed to therapeutic external beam radiation. The focus was on possible progressive changes and any relationships between the incidence of primary hypothyroidism, the time required to become hypothyroid, and factors such as chemotherapy, hormonotherapy and immunotherapy. Materials and Methods: Seventy females undergoing 3D conformal and IMRT radiation therapy for breast cancers were enrolled in a non-randomized prospective study...
1, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27624298/breast-cancer-and-thyroid-diseases-analysis-of-867-consecutive-cases
#5
C Chiappa, F Rovera, S Rausei, S Del Ferraro, A Fachinetti, M Lavazza, V Marchionini, V Arlant, M L Tanda, E Piantanida, H Y Kim, A Anuwong, G Dionigi
INTRODUCTION: The aim of this study was to evaluate the association of breast cancer with thyroid diseases. Many authors have already studied the possible relationship between these two diseases, but the results are nowadays conflicting. MATERIALS AND METHODS: Our study examining 867 patients with breast cancer (862 women and 5 men, average age = 61 years old) of whom 141 also had thyroid disease evaluated the recurrence of thyroid diseases and their association with different types of breast cancer...
February 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/27384681/expression-of-cdx2-in-gastric-cardia-adenocarcinoma-and-its-correlation-with-h-pylori-and-cell-proliferation
#6
Ying Zhang, Hu Wang, Chao Bi, Yinping Xiao, Zhaoyong Liu
BACKGROUND: Gastric cardia cancer (GCC) is located in the distal stomach, and strongly correlates with atrophic gastritis and Helicobacter pylori (H.pylori) infection. Caudal-related homeobox transcription factor 2 (CDX2) is homeobox gene encoding an intestine-specific transcription factor usually expressed in the intestinal epithelium cells. However, in several recent published papers, CDX2 was found to be aberrantly expressed in gastric, thyroid and ovarian cancer. RESULTS: Higher expression of CDX2 was found in GCC tissues in comparison with non-malignant cardia mucosa (p<0...
23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27384157/clinicopathological-features-of-low-grade-thyroid-like-nasopharyngeal-papillary-adenocarcinoma
#7
Minhua Li, Jiangguo Wei, Xiaofei Yao, Cheng Wang
PURPOSE: Primary low-grade thyroid-like papillary adenocarcinomas are extremely rare neoplasms that generally originate in the nasopharynx. Here, we describe a novel case of a 15-year-old Chinese girl who was diagnosed with low-grade thyroid-like papillary adenocarcinoma, including a brief review of the literature to reveal the clinicopathological features of low-grade thyroid-like nasopharyngeal papillary adenocarcinoma. MATERIALS AND METHODS: Immunohistochemistry was used to evaluate the expression of pan-cytokeratin (CKpan), cytokeratin (CK) 7, thyroid transcription factor 1 (TTF-1), vimentin, epithelial membrane antigen (EMA), thyroglobulin, CD15, S100, P40, CK20, CDX-2, glial fibrillary acidic protein (GFAP), and Ki-67...
January 2017: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/27254276/loss-of-tyrosine-phosphorylation-at-y406-abrogates-the-tumor-suppressor-functions-of-the-thyroid-hormone-receptor-%C3%AE
#8
Jeong Won Park, Li Zhao, Mark C Willingham, Sheue-Yann Cheng
We have recently identified that phosphorylation at tyrosine (Y)406 is critical for the tumor suppressor functions of the thyroid hormone receptor β1 (TRβ) in a breast cancer line. However, still unclear is whether the critical tumor suppressor role of phosphorylated Y406 of TRβ is limited to only breast cancer cells or could be extended to other cell types. In the present studies, we addressed this question by stably expressing TRβ, a mutated TRβ oncogene (PV), or a TRβ mutated at Y406 (TRβY406F) in rat PCCL3 thyroid follicular cells and evaluated their tumor characteristics in athymic mice with elevated thyroid stimulating hormone...
February 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27151693/histopathological-changes-induced-by-selective-inactivation-of-menin-on-the-thyroid-gland-in-ret%C3%A3-ptc3-and-e7-transgenic-mice-a-study-of-77-cases
#9
Oana Maria Căpraru, Nicole Berger, Nicolas Gadot, Myriam Decaussin-Petrucci, Chang Zhang, Angela Borda, Tibor Szilágyi, Françoise Borson-Chazot, Samia Selmi-Ruby
Multiple Endocrine Neoplasia Type 1 (MEN1) does not involve the thyroid gland, but animal studies have shown that mice with inactivation of menin could develop thyroid pathologies. The objective was to evaluate if the selective inactivation of menin in murine thyroid glands expressing RET÷PTC3 and E7 oncogenes, might induce an increased index of proliferation and a more rapid development of thyroid hyperplasia and÷or tumors. The thyroid glands of 77 mice aged 4-18 months (31 expressing the E7 oncogene and 25 the RET÷PTC3 oncogene) were analyzed for histological changes and Ki67 proliferation index...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/26919073/the-clinicopathological-features-of-pituicytoma-and-the-differential-diagnosis-of-sellar-glioma
#10
Junmei Wang, Zhaoxia Liu, Jiang Du, Yun Cui, Jingyi Fang, Li Xu, Guilin Li
Pituicytoma is rare and difficult to diagnose. This study explored the clinicopathological features, immunophenotype and differential diagnosis of pituicytoma. We compared 11 cases of pituicytoma and 26 cases of sellar glioma (16 pilocytic astrocytomas, four diffuse astrocytomas, three pilomyxoid astrocytomas, and three third ventricle chordoid gliomas). The 11 pituicytoma cases involved six men and five women (age: 33-65 years). Three of the 11 patients experienced recurrence due to a residual tumor, and one patient underwent three surgeries during a 6-month period...
October 2016: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/26914762/clinical-manifestations-and-gene-expression-in-patients-with-conventional-papillary-thyroid-carcinoma-carrying-the-braf-v600e-mutation-and-braf-pseudogene
#11
Jiunn-Diann Lin, Shuai-Shuai Fu, Jui-Yu Chen, Chen-Hsen Lee, Wing-Keung Chau, Chao-Wen Cheng, Yuan-Hung Wang, Yuh-Feng Lin, Wen-Fang Fang, Kam-Tsun Tang
BACKGROUND: The association of BRAF(V600E) with the clinical manifestations of papillary thyroid carcinoma (PTC) remains controversial. Recent studies have shown that the BRAF pseudogene can activate the MAPK pathway and induce tumorigenesis. This study investigated the association of BRAF(V600E), the BRAF pseudogene, and their mRNA levels with clinical features and thyroid-specific gene expression in conventional PTCs. MATERIALS AND METHODS: A total of 78 specimens were collected from patients with conventional PTCs...
May 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/26848271/prognostic-implications-of-immunohistochemistry-markers-for-egfr-tki-therapy-in-chinese-patients-with-advanced-lung-adenocarcinoma-harboring-egfr-mutations
#12
Ruiguang Zhang, Yan Li, Xiu Nie, Xiaorong Dong, Gang Wu
BACKGROUND: Epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer predict dramatic clinical responses to tyrosine kinase inhibitor (TKI) treatment. The conclusion on EGFR mutation-specific antibodies by immunohistochemistry (IHC) is not consistent. We evaluated the clinical availability of EGFR mutation-specific antibodies, investigating the prediction role of mutant EGFRs and other IHC markers in TKI therapy in patients with advanced lung adenocarcinoma. MATERIALS AND METHODS: We analyzed 637 primary lung adenocarcinomas from an unselected Chinese population...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/26788274/small-cell-carcinoma-of-the-urinary-bladder-kit-and-pdgfra-gene-mutations
#13
Nuket Eliyakin, Hakan Postaci, Yasemin Baskin, Zafer Kozacioğlu
Primary small cell carcinoma of the urinary bladder is very rare. A 72-year-old was admitted to our hospital because of hematuria and dysuria. Cystoscopy revealed a bladder full of multiple, solid and papillary tumors. Biopsies from the deep and papillary tumors were taken. Histologically, tumor was pure small cell carcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin, chromo-granin, synaptophysin, neuron-specific enolase, CD56, CD117 and Ki67 (labeling 70%). The tumor cells were negative for CK7, CK20, CD3, CD20, LCA, CDX2, uroplakin, thyroid transcription factor 1, PSA and p63...
December 29, 2015: Rare Tumors
https://www.readbyqxmd.com/read/26406941/mir-204-regulates-hmga2-expression-and-inhibits-cell-proliferation-in-human-thyroid-cancer
#14
Z Y Wu, S M Wang, Z H Chen, S X Huv, K Huang, B J Huang, J L Du, C M Huang, L Peng, Z X Jian, G Zhao
BACKGROUND: Analysis using publicly available algorithms has found that high mobility group AT-hook 2 (HMGA2), a key transcriptional regulatory factor, is a potential target of microRNA-204 (miR-204). Some studies have shown that both miR-204 and HMGA2 are associated with cancer development. OBJECTIVE: We examined the possible relationship between miR-204 and HMGA2 in the development of thyroid cancer. METHODS: We assessed miR-204 expression in thyroid cancer specimens and cell lines using real-time polymerase chain reaction (PCR)...
2015: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/26341689/expression-of-tumor-related-rac1b-antagonizes-b-raf-induced-senescence-in-colorectal-cells
#15
Andreia F A Henriques, Patrícia Barros, Mary Pat Moyer, Paulo Matos, Peter Jordan
Mutations in the BRAF oncogene have been identified as a tumor-initiating genetic event in mainly melanoma, thyroid and colon cancer, resulting in an initial proliferative stimulus that is followed by a growth arrest period known as oncogene-induced senescence (OIS). It remains unknown what triggers subsequent escape from OIS to allow further tumor progression. A previous analysis revealed that around 80% of colorectal tumors carrying a mutation in BRAF also overexpress splice variant Rac1b. We used normal NCM460 colonocytes as a model to express oncogenic B-Raf-V600E in the presence or absence of co-transfected Rac1b and then analyzed the effect on expression of senescence markers...
December 28, 2015: Cancer Letters
https://www.readbyqxmd.com/read/26300979/the-value-of-thyroperoxidase-as-a-prognostic-factor-for-differentiated-thyroid-cancer-a-long-term-follow-up-study
#16
Yurena Caballero, Eudaldo M López-Tomassetti, Julián Favre, José R Santana, Juan J Cabrera, Juan R Hernández
BACKGROUND: Thyroperoxidase (TPO) is a membrane-bound protein essential for the production of thyroid hormones; because of this, TPO expression may be impaired in selected thyroid diseases. The goal of this study is to analyze TPO immune expression in differentiated thyroid cancer, and to determine whether TPO has any prognostic value. METHODS: A total of 139 patients who required surgery due to a thyroid nodule with signs or symptoms suspicious for malignancy during their physical, ultrasound and/or cytology examination were consecutively selected for the study...
2015: Thyroid Research
https://www.readbyqxmd.com/read/26208433/simultaneous-suppression-of-the-map-kinase-and-nf-%C3%AE%C2%BAb-pathways-provides-a-robust-therapeutic-potential-for-thyroid-cancer
#17
Koji Tsumagari, Zakaria Y Abd Elmageed, Andrew B Sholl, Paul Friedlander, Mohamed Abdraboh, Mingzhao Xing, A Hamid Boulares, Emad Kandil
The MAP kinase and NF-κB signaling pathways play an important role in thyroid cancer tumorigenesis. We aimed to examine the therapeutic potential of dually targeting the two pathways using AZD6244 and Bortezomib in combination. We evaluated their effects on cell proliferation, cell-cycle progression, apoptosis, cell migration assay, and the activation of the MAPK pathway in vitro and the in vivo using tumor size and immunohistochemical changes of Ki67 and ppRB. We found inhibition of cell growth rate by 10%, 20%, and 56% (p <0...
November 1, 2015: Cancer Letters
https://www.readbyqxmd.com/read/26188382/thyroid-h%C3%A3-rthle-cell-tumors-research-of-potential-markers-of-malignancy
#18
G Donatini, A Beaulieu, M Castagnet, J-L Kraimps, P Levillain, G Fromont
INTRODUCTION: Hurthle cell tumors (HCTs) are rare thyroid neoplasia. To date, capsular and/or vascular invasion are the only findings predicting malignancy. Recently, mutation of 19p13, encoding two proteins involved in cell proliferation and apoptosis (GRIM-19 and p19), has been described. The aim of our study is to evaluate the cellular proliferation index (Ki67), GRIM-19 and p19 expression as diagnostic markers of malignancy in HCT. MATERIALS AND METHODS: Eighty patients with HCT (32 carcinomas, 48 adenomas) whom underwent surgery in our center were included...
February 2016: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/26033776/prospectively-measured-thyroid-hormones-and-thyroid-peroxidase-antibodies-in-relation-to-risk-of-different-breast-cancer-subgroups-a-malm%C3%A3-diet-and-cancer-study
#19
Jasmine Brandt, Signe Borgquist, Jonas Manjer
PURPOSE: Thyroid hormone level has been positively associated with breast cancer risk and with breast cancer cell proliferation and growth. Although breast cancer is a heterogeneous disease, this is the first study assessing pre-diagnostic levels of free triiodothyronine (fT3), free thyroxine (fT4), thyroid-stimulating hormone (TSH), and thyroid peroxidase antibodies (TPO-Ab) in relation to breast cancer subgroups and aggressiveness. METHODS: The Malmö Diet and Cancer Study collected blood samples from 17,035 women between 1991 and 1996...
August 2015: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/25974735/role-of-x-linked-inhibitor-of-apoptosis-as-a-prognostic-marker-and-therapeutic-target-in-papillary-thyroid-carcinoma
#20
Azhar R Hussain, Rong Bu, Maqbool Ahmed, Zeenath Jehan, Shaham Beg, Saif Al-Sobhi, Fouad Al-Dayel, Abdul K Siraj, Shahab Uddin, Khawla S Al-Kuraya
CONTEXT: Papillary thyroid cancer (PTC) is the second most common cancer in females in Saudi Arabia. However, the pathogenesis of PTC is still not fully elucidated. OBJECTIVE: To identify potential genes that play important role in progression of PTC, we studied the role of X-linked inhibitor of apoptosis protein (XIAP) as a potential prognostic marker and therapeutic target in a large cohort of PTC samples and cell lines. DESIGN: A DNA microarray chip was used to screen for gene copy number...
July 2015: Journal of Clinical Endocrinology and Metabolism
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