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Y Smadi, C Deb, J Bornstein, S Safder, K Horvath, D Mehta
Patients with eosinophilic esophagitis (EoE) require frequent evaluation of mucosal inflammation via endoscopy. Instead of endoscopy, mucosal evaluation in adults with esophageal cancer and candidiasis is achieved using a cytology brush inserted through a nasogastric tube (NGT). We conducted a prospective cross-sectional study in children and young adults scheduled for routine esophagogastroduodenoscopy (EGD) where in Phase 1, we performed esophageal brushing through the endoscope under direct visualization and in Phase 2, we inserted the brush through a Cortrak® NGT prior to endoscopy...
June 14, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Richard S Kwon, Raquel E Davila, Daniel K Mullady, Mohammad A Al-Haddad, Ji Young Bang, Juliane Bingener-Casey, Brian P Bosworth, Jennifer A Christie, Gregory A Cote, Sarah Diamond, Jennifer Jorgensen, Thomas E Kowalski, Nisa Kubiliun, Joanna K Law, Keith L Obstein, Waqar A Qureshi, Francisco C Ramirez, Robert E Sedlack, Franklin Tsai, Shivakumar Vignesh, Mihir S Wagh, Daniel Zanchetti, Walter J Coyle, Jonathan Cohen
No abstract text is available yet for this article.
July 2017: VideoGIE: an official video journal of the American Society for Gastrointestinal Endoscopy
Ren Mao, Rui-Han Tang, Yun Qiu, Bai-Li Chen, Jing Guo, Sheng-Hong Zhang, Xue-Hua Li, Rui Feng, Yao He, Zi-Ping Li, Zhi-Rong Zeng, Rami Eliakim, Shomron Ben-Horin, Min-Hu Chen
Background: The Montreal classification defines L4 Crohn's disease (CD) as any disease location proximal to the terminal ileum, which anatomically includes L4-esophagogastroduodenal (EGD), L4-jejunal, and L4-proximal ileal involvement. L4-jejunal disease was established to be associated with poor prognosis. However, the outcome of patients with L4-proximal ileal disease or L4-EGD remains to be clarified. Our study aimed to investigate whether the outcome differs among CD patients with L4-EGD, L4-jejunal, and L4-proximal ileal disease...
2018: Therapeutic Advances in Gastroenterology
Zhan He, Hang Wang, Xiao Han, Tiantian Ma, Yi Hang, Huifei Yu, Fangfang Wei, Jing Sun, Yongchun Yang, Changyong Cheng, Houhui Song
We aimed to obtain the recombinant aminopeptidase encoded by Listeria monocytogenes (L. monocytogenes) gene lmo1711, and characterized the enzyme. First, the amino acid sequences of Lmo1711 from L. monocytogenes EGD-e and its homologues in other microbial species were aligned and the putative active sites were analyzed. The putative model of Lmo1711 was constructed through the SWISS-MODEL Workspace. Then, the plasmid pET30a-Lmo1711 was constructed and transformed into E. coli for expression of the recombinant Lmo1711...
May 25, 2018: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
Vadim G Krivoshapkin, Sergei I Semenov, Svetlana S Maximova, Nadegda N Tihonova, Anna I Sivtseva, Snegana S Sleptsova
OBJECTIVE: Inrtroduction: The epidemiological situation for hepatitis D has changed significantly. Reduced population authors infection due to a sharp decline in hospitalizations from Central Asia regions, the Caucasus and Moldova, which are known to be endemic for hepatitis D. Currently, the incidence of chronic hepatitis D (HGD) in Russia is 1%, while in the countries of Central Asia, and in particular in Turkmenistan, the share of HGD among chronic viral hepatitis is 8%. The aim of research was to establish the clinical features, depending on the activity of the replication of hepatitis viruses B and D...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
Stephen J Hjerpe, Umar Rahim, Muhammad Shariq Usman, Amna Ansari, Waliul Chowdhury, Muhammad Uzair Lodhi, Mustafa Rahim
High-grade neuroendocrine carcinoma (NEC) of the esophagus is an extremely aggressive and rare disease, which is still not well understood. In this case report, we discuss a 73-year-old male patient that presented with the sole complaint of dysphagia to solid foods. During our evaluation of the patient, a six-centimeter esophageal mass was found on esophagogastroduodenoscopy (EGD). A diagnosis of poorly differentiated (high-grade) non-small cell neuroendocrine carcinoma was made after a histological analysis and immunostaining...
April 3, 2018: Curēus
Yu Hatano, Ken Haruma, Tomoari Kamada, Akiko Shiotani, Kosuke Takahari, Masatoshi Matsumoto, Osamu Uchida
BACKGROUND/AIMS: Previous studies have reported a possible relevance between proton pump inhibitor (PPI) use and 3 new gastric mucosal changes: black spots (BSs), white flat elevated mucosa (WFEM), and cobblestone-like mucosa (CLM). The aim of this study was to investigate the association between these mucosal changes and multiple factors including PPI use. METHODS: All subjects who underwent a routine esophagogastroduodenoscopy (EGD) were successively enrolled...
June 5, 2018: Digestion
Nobuaki Matsui, Kento Imajo, Masato Yoneda, Takaomi Kessoku, Yasushi Honda, Yuji Ogawa, Wataru Tomeno, Nobutaka Fujisawa, Toshihiro Misumi, Kubota Kazumi, Satoru Saito, Atsushi Nakajima
BACKGROUND & AIMS: The Baveno VI criteria enable non-invasive screening for esophageal varices (EV). However, these criteria were established based on studies examining a large proportion of patients with viral hepatitis and relatively few patients with nonalcoholic fatty liver disease (NAFLD). Furthermore, because vibration-controlled transient elastography (VCTE) has a high incidence of measurement error, improved criteria are needed. We aimed to develop criteria based on magnetic resonance elastography (MRE) even among patients with NAFLD...
June 4, 2018: Journal of Gastroenterology and Hepatology
He Suyu, Yijun Liu, Xu Jianyu, Guiquan Luo, Lipeng Cao, Xiaoqi Long
Background: Gastroesophageal reflux disease (GERD) without symptoms or silent GERD can be easily missed in patients with hypertension. We aimed to investigate the prevalence of GERD, specifically the prevalence of silent GERD in hypertensive patients, and to explore its possible predictors. Methods: Consecutive patients with hypertension referred to the cardiovascular clinic of Suining Central Hospital in 2016 were screened for this study. A Reflux Disease Questionnaire (RDQ) and an esophagogastroduodenoscopy (EGD) were employed for the evaluation of silent GERD...
2018: Gastroenterology Research and Practice
Alessandra Invento, Sara Mirandola, Francesca Pellini, Giovanni Paolo Pellino, Daniela Grigolato
INTRODUCTION: Invasive lobular cancer (ILC) is the second most common type of a heterogeneous group of different histological types of invasive breast carcinoma. Breast cancer can metastatize anywhere, the most common sites are bones, liver, lungs and brain. Gastrointestinal tract (GI) metastases observed in autopsy studies account for about 6% to 18% of the overall metastases from breast cancer. OBJECTIVE: We describe a 54-year old woman with recurrent ILC in the contralateral breast...
2018: Annali Italiani di Chirurgia
Jing-Yang Liou, Mei-Yung Tsou, Shinju Obara, Lu Yu, Chien-Kun Ting
BACKGROUND: Sedation for esophagogastroduodenoscopy (EGD) and colonoscopy is characterized by rapid patient induction and emergence. The drugs midazolam and alfentanil have long been used for procedural sedation; however, the relationship between plasma or effect-site concentrations (Cp or Ce, respectively) and emergence remains unclear. The aim of this study is to develop patient wake-up prediction models for both Cp and Ce using response surface modeling, a pharmacodynamics tool for assessing patients' responses...
May 23, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
Salvatore Petta, Giada Sebastiani, Elisabetta Bugianesi, Mauro Viganò, Vincent Wai-Sun Wong, Annalisa Berzigotti, Anna Ludovica Fracanzani, Quentin M Anstee, Fabio Marra, Marco Barbara, Vincenza Calvaruso, Calogero Cammà, Vito Di Marco, Antonio Craxì, Victor de Ledinghen
BACKGROUND/AIM: Baveno VI and expanded Baveno VI criteria can avoid the need for esophagogastroduodenoscopy(EGD) to screen for varices needing treatment(VNT) in a substantial proportion of compensated patients with viral and/or alcoholic cirrhosis. This multicenter, cross-sectional study aims to validate these criteria in patients with compensated cirrhosis due to nonalcoholic fatty liver disease(NAFLD), accounting for possible differences in liver stiffness measurement(LSM) values between M and XL probes...
May 23, 2018: Journal of Hepatology
Oren Ledder, Peter Church, Ruth Cytter-Kuint, Maria Martínez-León, Malgorzata Sladek, Eva Coppenrath, Batia Weiss, Baruch Yerushalmi, Javier Martin de Carpi, Larisa Duchano, Alexander Towbin, Amit Assa, Ron Shaoul, M L Mearin, George Alex, Anne Griffiths, Dan Turner
Objective: There is no standardized endoscopic description of upper gastrointestinal (UGI) disease in Crohn's disease (CD). We prospectively applied the Simple Endoscopic Score for CD (SES-CD) to the UGI tract as a planned sub-study of the multicenter prospective ImageKids study. We aimed to assess the utility of the UGI-SES-CD and its clinical significance in pediatric CD. Design: Patients underwent an esophagogastroduodenoscopy (EGD), ileocolonoscopy and magnetic resonance enterography (MRE) with explicit clinical data recorded...
May 25, 2018: Journal of Crohn's & Colitis
J Bill, S Rajagopal, V Kushnir, C P Gyawali
Evaluation of dysphagia typically starts with esophagogastroduodenoscopy (EGD); further testing is pursued if this is negative. When no mucosal, structural, or motor esophageal disorders are identified with persisting symptoms, functional dysphagia is considered. We evaluated outcomes in patients undergoing EGD for dysphagia, and estimated prevalence of functional dysphagia. The endoscopy database at single tertiary care center was interrogated to identify EGDs performed for an indication of 'dysphagia' over a 12-month period (2008-09)...
May 24, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Yang-Yang Qian, Shu-Guang Zhu, Xi Hou, Wei Zhou, Wei An, Xiao-Ju Su, Mark Edward McAlindon, Zhao-Shen Li, Zhuan Liao
BACKGROUND: Magnetically controlled capsule gastroscopy (MCCG) is a newly developed non-invasive method designed for gastric examination. Although favorable diagnostic accuracy has been reported, there is little if any data about its ability to diagnose gastric cancer. AIMS: To compare the detectability of superficial gastric neoplasia by MCCG and gastroscopy. METHODS: This study was a self-controlled comparison study. Ten subjects diagnosed with superficial gastric neoplasia and scheduled to undergo endoscopic submucosal dissection (ESD) at a tertiary hospital were prospectively invited for an MCCG examination...
April 24, 2018: Digestive and Liver Disease
Monica Saumoy, Yecheskel Schneider, Nicole Shen, Michel Kahaleh, Reem Z Sharaiha, Shailja C Shah
BACKGROUND & AIMS: There are marked racial and ethnic differences in noncardia gastric cancer prevalence within the United States (US). Although gastric cancer screening is recommended in regions of high prevalence, screening is not routinely performed in the US. Our objective was to determine whether selected noncardia gastric cancer screening for high-risk races and ethnicities within the US is cost effective. METHODS: We developed a decision analytic Markov model with the base case of a 50-year-old person of non-Hispanic white, non-Hispanic black, Hispanic, or Asian race or ethnicity...
May 17, 2018: Gastroenterology
Tsung-Hsing Chen, Chen-Ming Hsu, Hao-Tsai Cheng, Yin-Yi Chu, Ming-Yao Su, Jun-Te Hsu, Ta-Sen Yeh, Chang-Fu Kuo, Cheng-Tang Chiu
BACKGROUND: Esophagogastroduodenoscopy (EGD) is a standard tool for detection of mucosal and submucosal lesions. However, identification of Helicobacter pylori (H. P) infection using EGD alone is limited in accuracy. Linked color imaging (LCI) is a novel tool to capture real-time image with sufficient contrast to observe mucosal microstructure. METHODS: This study aims to evaluate the applicability of LCI in the identification of H. pylori infection. Consecutive 122 patients scheduled for EGD were included...
May 16, 2018: Journal of the Chinese Medical Association: JCMA
Brian Johnson, Marc D Basson
BACKGROUND: There is no clarity with regard to the occurrence of serious complications from EGD-driven mucosal biopsy. This is important for considering both clinically indicated procedures and mucosal sampling for research. METHODS: We sought to quantify rates of serious complications from esophagogastroduodenoscopy (EGD) with biopsy. We studied 13,233 patients undergoing outpatient EGD with biopsy over 5 years in 2 North Dakota community hospitals, based on the reasoning that serious complications would cause hospitalization within 30 days...
May 15, 2018: Digestive Diseases
Bruno P Chumpitazi, Claudia C Robayo-Torres, Cynthia M Tsai, Antone R Opekun, Susan S Baker, Buford L Nichols, Mark A Gilger
BACKGROUND: A subset of children with functional gastrointestinal disorders (FGIDs), which includes functional dyspepsia, may have duodenal disaccharidase deficiencies. OBJECTIVES: To determine the frequency, demographics, and clinical characteristics associated with duodenal disaccharidase deficiencies in children with functional dyspepsia. METHODS: Children ages 4 to 18 years undergoing esophagogastroduodenoscopy (EGD) evaluation for dyspepsia were enrolled in either a retrospective (study 1) or prospective (study 2) evaluation...
June 2018: Journal of Pediatric Gastroenterology and Nutrition
Hirotoshi Takiyama, Tsuyoshi Ozawa, Soichiro Ishihara, Mitsuhiro Fujishiro, Satoki Shichijo, Shuhei Nomura, Motoi Miura, Tomohiro Tada
The use of convolutional neural networks (CNNs) has dramatically advanced our ability to recognize images with machine learning methods. We aimed to construct a CNN that could recognize the anatomical location of esophagogastroduodenoscopy (EGD) images in an appropriate manner. A CNN-based diagnostic program was constructed based on GoogLeNet architecture, and was trained with 27,335 EGD images that were categorized into four major anatomical locations (larynx, esophagus, stomach and duodenum) and three subsequent sub-classifications for stomach images (upper, middle, and lower regions)...
May 14, 2018: Scientific Reports
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