Wei Cao, Mingyu Sun, K N Yu, Lele Zhao, Yue Feng, Chunhua Tan, Miaomiao Yang, Ying Wang, Fengqin Zhu, Lianjun Chen, Lili Nie, Ye Zhao, Guodong Chen, Wei Han
The gas therapy is drawing increasing attention in the treatment of many diseases including cancer. As one of gas signaling molecules, carbon monoxide (CO) has been proved to exert anti-cancer effects via triggering multiple cell death types, such as autophagy, apoptosis and necrosis. Here, we showed that low concentration CO delivered from CO-releasing molecule 3 (CORM-3) effectively induced ferroptosis, known as a novel proinflammatory programmed cell death, in vitro and in vivo. Mechanistically, we found that CO triggered ferroptosis by modulating the ROS/GSK3β/GPX4 signaling pathway, resulting in the accumulation of lipid hydroperoxides and the occurrence of ferroptosis...
January 23, 2024: Cell Death Discovery