Arunima Kapoor, Aimée Gaubert, Belinda Yew, Jung Yun Jang, Shubir Dutt, Yanrong Li, John Paul M Alitin, Amy Nguyen, Jean K Ho, Anna E Blanken, Isabel J Sible, Anisa Marshall, Fatemah Shenasa, Kathleen E Rodgers, Alessandra C Martini, Elizabeth Head, Daniel A Nation
Dilation of perivascular spaces (PVS) in the brain may indicate poor fluid drainage due to the accumulation of perivascular cell debris, waste, and proteins, including amyloid-beta (Aβ). No prior study has assessed whether plasma Aβ levels are related to PVS in older adults without dementia. Independently living older adults (N = 56, mean age = 68.2 years; Standard deviation (SD) = 6.5; 30.4% male) free of dementia or clinical stroke were recruited from the community and underwent brain MRI and venipuncture...
April 14, 2023: Neurobiology of Aging