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Screening colonoscopy

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https://www.readbyqxmd.com/read/28328936/polyp-detection-rate-in-transverse-and-sigmoid-colon-significantly-increases-with-longer-withdrawal-time-during-screening-colonoscopy
#1
Kazuhiro Kashiwagi, Nagamu Inoue, Toshifumi Yoshida, Rieko Bessyo, Kazuaki Yoneno, Hiroyuki Imaeda, Haruhiko Ogata, Takanori Kanai, Yoshinori Sugino, Yasushi Iwao
BACKGROUND: The guidelines for colonoscopy present withdrawal time (WT) and adenoma detection rate (ADR) as the quality indicator. The purpose of this retrospective study is to analyze the predicting factors with polyp detection rate (PDR) as a surrogate for ADR by using comprehensive health checkup data, and assess the correlation between PDR per each colonic segment and WT, and factors influencing WT. METHODS: One thousand and thirty six consecutive health checkup cases from April 2015 to March 2016 were enrolled in this study, and 880 subjects who undertook colonoscopy without polyp removal or biopsy were divided into the two groups (polyp not detected group vs polyp detected group)...
2017: PloS One
https://www.readbyqxmd.com/read/28321304/gastric-heterotopia-in-rectum-a-literature-review-and-its-diagnostic-pitfall
#2
Peyman Dinarvand, Ashley A Vareedayah, Nancy J Phillips, Christine Hachem, Jinping Lai
OBJECTIVES: The term heterotopia, in pathology, refers to the presence of normal tissues at foreign sites. Gastric heterotopia has been reported anywhere in the gastrointestinal tract. However, the presence of gastric heterotopia in the rectum is very rare. METHODS: We, here, report a rare case of a localized 2-cm area of cratered mucosa with heaped-up borders in the rectum of a 51-year-old, asymptomatic woman who underwent screening colonoscopy. RESULTS: Histologic examination of the biopsy from the lesional tissue in rectum demonstrated fragments of rectal mucosa co-mingling with oxyntic- and antral-type gastric mucosa...
2017: SAGE open medical case reports
https://www.readbyqxmd.com/read/28317624/cap-assisted-colonoscopy-increases-detection-of-advanced-adenomas-and-polyps
#3
Mohamed O Othman, Daniel Zhang, Sherif Elhanafi, Mohamed Eloliby, Brian Davis, Richard Guererro, Luis Alvarado, Linda Sanchez, Alok Dwivedi, Marc J Zuckerman
BACKGROUND: Cap-assisted colonoscopy (CAC) has been reported to increase the adenoma detection rate (ADR) in Asian population. However, CAC trials in non-Asian population have had conflicting results. Studies in North America have shown an improvement in ADRs with the use of CAC, but it mainly included white and African American patients. Given the lack of prospective studies of CAC in Hispanics, we conducted this randomized controlled trial. MATERIALS AND METHODS: This is a randomized controlled trial comparing CAC with standard colonoscopy (SC) in patients undergoing screening or surveillance colonoscopy...
April 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28314604/a-prospective-randomised-study-comparing-double-balloon-colonoscopy-and-conventional-colonoscopy-in-pre-defined-technically-difficult-cases
#4
Edward J Despott, Alberto Murino, Masanao Nakamura, Leonidas Bourikas, Chris Fraser
BACKGROUNDS AND AIM: Technically 'difficult' (TD) colonoscopy is associated with incomplete colonoscopy, discomfort and longer procedures. Double-balloon colonoscopy (DBC) may facilitate TD colonoscopy. The primary outcome was to compare the time taken to achieve caecal intubation during conventional colonoscopy (CC) and DBC in patient with a TD colon. METHODS: We performed a prospective, randomised study comparing DBC and CC for TD colonoscopy. Patients were screened for parameters predictive of TD colonoscopy using an original scoring system and randomised to DBC or CC...
February 14, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28298185/general-practitioners-perceptions-of-population-based-bowel-screening-and-their-influence-on-practice-a-qualitative-study
#5
Greer Dawson, Melanie Crane, Claudine Lyons, Anna Burnham, Tara Bowman, Donna Perez, Joanne Travaglia
BACKGROUND: Although largely preventable, Australia has one of the highest rates of bowel cancer in the world. General Practitioners (GPs) have an important role to play in prevention and early detection of bowel cancer, however in Australia this is yet to be optimised and participation remains low. This study sought to understand how GPs' perceptions of bowel screening influence their attitudes to, and promotion of the faecal occult blood test (FOBT), to identify opportunities to enhance their role...
March 15, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28296927/harms-benefits-and-costs-of-fecal-immunochemical-testing-versus-guaiac-fecal-occult-blood-testing-for-colorectal-cancer-screening
#6
S Lucas Goede, Linda Rabeneck, Marjolein van Ballegooijen, Ann G Zauber, Lawrence F Paszat, Jeffrey S Hoch, Jean H E Yong, Sonja Kroep, Jill Tinmouth, Iris Lansdorp-Vogelaar
BACKGROUND: The ColonCancerCheck screening program for colorectal cancer (CRC) in Ontario, Canada, is considering switching from biennial guaiac fecal occult blood test (gFOBT) screening between age 50-74 years to the more sensitive, but also less specific fecal immunochemical test (FIT). The aim of this study is to estimate whether the additional benefits of FIT screening compared to gFOBT outweigh the additional costs and harms. METHODS: We used microsimulation modeling to estimate quality adjusted life years (QALYs) gained and costs of gFOBT and FIT, compared to no screening, in a cohort of screening participants...
2017: PloS One
https://www.readbyqxmd.com/read/28293326/line-1-is-preferentially-hypomethylated-within-adenomatous-polyps-in-the-presence-of-synchronous-colorectal-cancer
#7
Alice Chu Jiang, Lela Buckingham, William Barbanera, Amoah Yeboah Korang, Faraz Bishesari, Joshua Melson
BACKGROUND: Conventional tubular adenomas are frequently detected in patients undergoing average risk screening colonoscopy and are over-represented in patients who will develop colorectal cancer (CRC). Whether features of adenomas could serve as predictors of synchronous CRC is not known. Here, we investigate whether global methylation markers, including LINE-1, differ within adenomas in patients with and without synchronous CRC. METHODS: Colorectal tubular/tubulovillous adenomatous polyps in the absence (P group, n = 45) and in the presence of synchronous CRC (PC group, n = 32) were identified...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28289662/mucosa-associated-lymphoid-tissue-lymphoma-of-the-cecum-and-rectum-a-case-report
#8
Myung Jin Nam, Byung Chang Kim, Sung Chan Park, Chang Won Hong, Kyung Su Han, Dae Kyung Sohn, Weon Seo Park, Hee Jin Chang, Jae Hwan Oh
A colonic mucosa-associated lymphoid-tissue (MALT) lymphoma is relatively rare compared to lymphomas of the stomach or small intestine. We present a case of a MALT lymphoma in the cecum and rectum found during screening colonoscopy. A 54-year-old female, who had undergone right-breast-conserving surgery with axillary dissection due to an invasive ductal carcinoma and a left-breast excisional biopsy due to microcalcification following adjuvant chemoradiation therapy 3 years earlier, was found to have 3-mm-sized smooth elevated lesions in both the cecum and rectum...
February 2017: Annals of Coloproctology
https://www.readbyqxmd.com/read/28282689/water-exchange-for-screening-colonoscopy-increases-adenoma-detection-rate-a-multicenter-double-blinded-randomized-controlled-trial
#9
Sergio Cadoni, Přemysl Falt, Emanuele Rondonotti, Franco Radaelli, Petr Fojtik, Paolo Gallittu, Mauro Liggi, Arnaldo Amato, Silvia Paggi, Vit Smajstrla, Ondřej Urban, Matteo Erriu, Malcolm Koo, Felix W Leung
Background and study aims Single-center studies, which were retrospective and/or involved unblinded colonoscopists, have suggested that water exchange, but not water immersion, compared with air insufflation significantly increases the adenoma detection rate (ADR), particularly in the proximal and right colon. Head-to-head comparison of the three techniques with ADR as primary outcome and blinded colonoscopists has not been reported to date. In a randomized controlled trial with blinded colonoscopists, we aimed to evaluate the impact of the three insertion techniques on ADR...
March 10, 2017: Endoscopy
https://www.readbyqxmd.com/read/28277021/the-chinese-and-korean-american-immigrant-experience-a-mixed-methods-examination-of-facilitators-and-barriers-of-colorectal-cancer-screening
#10
Mary Y Jung, Cheryl L Holt, Diane Ng, Hwa J Sim, Xiaoxiao Lu, Daisy Le, Hee-Soon Juon, Jun Li, Sunmin Lee
OBJECTIVE: Among Asian Americans, colorectal cancer (CRC) is the second leading cause of cancer deaths. Despite strong evidence that screening can reduce CRC-related mortality, fewer Chinese and Koreans receive screening as compared to non-Hispanic whites and blacks. The objective of this study was to examine facilitators and barriers as well as strategies to promote CRC screening in this population. DESIGN: This study employed a mixed-methods design. We conducted 17 key informant interviews and 12 focus groups in the Washington, D...
February 25, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28271924/serological-biomarkers-in-triage-of-fit-positive-subjects
#11
Hans J Nielsen, Ib Jarle Christensen, Berit Andersen, Morten Rasmussen, Lennart J Friis-Hansen, Thomas Bygott, Jake MiCallef
FIT-based colorectal cancer screening has been implemented in many countries including Denmark, where 916 colorectal cancer and 4468 high- or medium-risk adenoma patients were identified within April-December 2014, among 16,806 subjects with a positive FIT test. Screening increases the overall requirements for colonoscopy, which may challenge the current capacity. Some countries have increased their initial FIT cut-off level in order to comply with lack of colonoscopy capacity. Many patients with neoplasia will not be detected, however, by using increased FIT cut-off levels...
March 8, 2017: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/28270869/epigenome-wide-discovery-and-evaluation-of-leukocyte-dna-methylation-markers-for-the-detection-of-colorectal-cancer-in-a-screening-setting
#12
Jonathan Alexander Heiss, Hermann Brenner
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide. If detected at an early stage, prognosis is good. Despite increasing evidence for the benefits of implemented screening programs, such as screening colonoscopy, compliance is rather low. Hence there is demand for non-invasive tests for the early detection of CRC with high acceptance in population-wide screening. The objective of this study was to identify and evaluate leukocyte DNA methylation patterns as a potential biomarker for early detection of CRC...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/28270725/a-centrally-generated-primary-care-physician-audit-report-does-not-improve-colonoscopy-uptake-after-a-positive-result-on-a-fecal-occult-blood-test-in-ontario-s-coloncancercheck-program
#13
D Stock, L Rabeneck, N N Baxter, L F Paszat, R Sutradhar, L Yun, J Tinmouth
BACKGROUND: Timely follow-up of fecal occult blood screening with colonoscopy is essential for achieving colorectal cancer mortality reduction. In the present study, we evaluated the effectiveness of centrally generated, physician-targeted audit and feedback to improve colonoscopy uptake after a positive fecal occult blood test (fobt) result within Ontario's population-wide ColonCancerCheck Program. METHODS: This prospective cohort study used data sets from Ontario's ColonCancerCheck Program (2008-2011) that were linked to provincial administrative health databases...
February 2017: Current Oncology
https://www.readbyqxmd.com/read/28266302/should-screening-colonoscopy-be-offered-from-age-50
#14
Hermann Brenner, Nadine Zwink, Leopold Ludwig, Michael Hoffmeister
BACKGROUND: The introduction of colonoscopic screening in 2002 for persons aged 55 and older was followed by a marked decline in the incidence of colon cancer in the corresponding age groups in Germany. The prevalence of colorectal neoplasia among persons aged 50 to 54 has remained unknown until now. Expert committees currently recommend colonoscopic screening for persons aged 50 and older. This option has been offered since 2014 by the AOK Baden-Württemberg and by Bosch BKK in the framework of their specialized medical care program...
February 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28266301/screening-for-bowel-cancer-increasing-participation-via-personal-invitation
#15
Michael Hoffmeister, Bernd Holleczek, Nadine Zwink, Christian Stock, Christa Stegmaier, Hermann Brenner
BACKGROUND: Participation rates in bowel cancer screening programs in Germany continue to be low. In a model project, a logistically simple procedure for inviting patients to participate was tested as a means of increasing participation. METHODS: A randomized trial was performed involving persons residing in the German federal state of Saarland who had either their 50th or their 55th birthday in the year beginning on 1 April 2012 (18 560 and 16 824 persons, respectively)...
February 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28266300/colonoscopy-in-germany-important-steps-towards-a-national-screening-program
#16
EDITORIAL
Stefanie J Klug
No abstract text is available yet for this article.
February 10, 2017: Deutsches Ärzteblatt International
https://www.readbyqxmd.com/read/28265285/accuracy-of-colon-capsule-endoscopy-in-detecting-colorectal-polyps-in-individuals-with-familial-colorectal-cancer-could-we-avoid-colonoscopies
#17
Cristina Alvarez-Urturi, Gloria Fernández-Esparrach, Inés Ana Ibáñez, Cristina Rodríguez De Miguel, Josep Maria Dedeu, Xavier Bessa, Henry Córdova, Maria Pellisé, Francesc Balaguer, Angels Ginés, Luis Barranco, Isis K Araujo, Montserrat Andreu, Josep Llach, Antoni Castells, Begoña González-Suarez
Background. Individuals with a family history of colorectal cancer (CRC) have an increased risk of CRC. We evaluated the diagnostic yield of CCE in the detection of lesions and also two different colon preparations. Methods. A prospective multicenter study was designed to assess CCE diagnostic yield in a cohort of asymptomatic individuals with a family history of CRC. CCE and colonoscopy were performed on the same day by 2 endoscopists who were blinded to the results of the other procedure. Results. Fifty-three participants were enrolled...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28260941/is-there-evidence-that-we-should-screen-the-general-population-for-lynch-syndrome-with-genetic-testing-a-systematic-review
#18
REVIEW
Anya E R Prince, R Jean Cadigan, Gail E Henderson, James P Evans, Michael Adams, Emmanuel Coker-Schwimmer, Dolly C Penn, Marcia Van Riper, Giselle Corbie-Smith, Daniel E Jonas
BACKGROUND: The emerging dual imperatives of personalized medicine and technologic advances make population screening for preventable conditions resulting from genetic alterations a realistic possibility. Lynch syndrome is a potential screening target due to its prevalence, penetrance, and the availability of well-established, preventive interventions. However, while population screening may lower incidence of preventable conditions, implementation without evidence may lead to unintentional harms...
2017: Pharmacogenomics and Personalized Medicine
https://www.readbyqxmd.com/read/28257545/effects-of-starting-a-gastroenterology-fellowship-training-program-on-quality-measures-of-colonoscopy
#19
Sherif Elhanafi, Rahul Chhana, Indika Mallawaarachchi, Wynee Lou, Gabriela Rangel, Hongfei Fang, Rinkal Patel, Alok Kumar Dwivedi, Marc J Zuckerman, Mohamed O Othman
OBJECTIVES: Adenoma detection rate (ADR) is the most established indicator of the quality of screening colonoscopy. The effect of gastroenterology (GI) fellows on the quality of screening colonoscopies has been evaluated previously; however, the effect of starting a new GI fellowship program on the quality of screening colonoscopies has not been studied. The aim of our study was to assess the effects of starting a GI fellowship program and the participation of fellows in screening colonoscopies on ADR and other measures of quality...
March 2017: Southern Medical Journal
https://www.readbyqxmd.com/read/28256484/cecal-intubation-rate-during-colonoscopy-at-a-tertiary-hospital-in-south-west-nigeria-how-frequent-and-what-affects-completion-rate
#20
A Akere, K O Akande
BACKGROUND: Colonoscopy is useful in the diagnosis, treatment of colorectal diseases, and for colorectal cancer screening program. Complete colonoscopy is therefore crucial for the success of any screening program. One important measure of the quality of colonoscopy is the cecal intubation rate (CIR). AIM: This was to assess the CIR at our endoscopy unit and evaluate the factors responsible for uncompleted cases. PATIENTS AND METHODS: This was a prospective study at the endoscopy unit of the University College Hospital, Ibadan...
March 2017: Nigerian Journal of Clinical Practice
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