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https://www.readbyqxmd.com/read/29148927/flat-serrated-polyps-at-ct-colonography-relevance-appearance-and-optimizing-interpretation
#1
David H Kim, Meghan G Lubner, Ashley R Cahoon, B Dustin Pooler, Perry J Pickhardt
Serrated polyps are a recently recognized family of colonic polyps with subgroups that harbor future malignant potential. In the past, the significance of these lesions to the colorectal cancer carcinogenesis pathway was not recognized nor well understood. It is now known that serrated polyps account for approximately one-fourth of all sporadic colorectal cancers. The sessile serrated polyp (SSP) (also known as a sessile serrated adenoma [SSA]) is the main lesion of interest given its prevalence and subtle presentation...
November 17, 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29147109/colorectal-cancer-blood-based-biomarkers
#2
REVIEW
Nina Hauptman, Damjan Glavač
Mortality and morbidity associated with colorectal cancer (CRC) are increasing globally, partly due to lack of early detection of the disease. The screening is usually performed with colonoscopy, which is invasive and unpleasant, discouraging participation in the screening. As a source of noninvasive and easily accessible biomarkers, liquid biopsies are emerging. Blood-based biomarkers have the potential as diagnostic and prognostic tool in CRC. Early stage detection of CRC with high sensitivity and specificity would likely lead to higher participation in the screening test...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/29145325/perforated-appendicitis-after-colonoscopy-cause-or-coincidence-a-rare-case-report-and-literature-review
#3
Xiao-Cong Zhou, Chun-Wei Huang, Yan-Yan Dai, Zhi-Yang Huang, Zheng Lou
RATIONALE: Colonoscopy is a relatively safe and common procedure with low risks of complications, and acute appendicitis with perforation is an extremely rare complication of colonoscopy. The current study presents an unusual case of acute gangrenous appendicitis with perforation following a screening colonoscopy. PATIENT CONCERNS: A 73-year-old man presented to our emergency department with lower right abdominal pain 3 days after a routine screening colonoscopy...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29142519/high-c-reactive-protein-level-is-associated-with-high-risk-adenoma
#4
Hyae Min Lee, Jae Myung Cha, Jung Lok Lee, Jung Won Jeon, Hyun Phil Shin, Kwang Ro Joo, Jin Young Yoon, Joung Il Lee
Background/Aims: There is substantial evidence supporting a role of inflammation in the pathogenesis of colorectal cancer; however, little is known about the association between serum C-reactive protein (CRP) and the risk of colorectal adenoma. This study was conducted to investigate the association between serum CRP and colorectal adenoma risk. Methods: A retrospective cross-sectional study was performed on first-time screening colonoscopies in asymptomatic subjects who also had their serum CRP level measured during a routine health check-up between September 2006 and September 2009 in Korea...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29142517/is-methylation-analysis-of-sfrp2-tfpi2-ndrg4-and-bmp3-promoters-suitable-for-colorectal-cancer-screening-in-the-korean-population
#5
Soo-Kyung Park, Hae Lim Baek, Junghee Yu, Ji Yeon Kim, Hyo-Joon Yang, Yoon Suk Jung, Kyu Yong Choi, Hungdai Kim, Hyung Ook Kim, Kyung Uk Jeong, Ho-Kyung Chun, Kyungeun Kim, Dong Il Park
Background/Aims: Colorectal cancer (CRC) screening using stool DNA was recently found to yield good detection rates. A multi-target stool DNA test (Cologuard®, Exact Sciences), including methylated genes has been recently approved by the U.S. Food and Drug Administration. The aim of this study was to validate these aberrantly methylated genes as stool-based DNA markers for detecting CRC and colorectal advanced adenoma (AA) in the Korean population. Methods: A single-center study was conducted in 36 patients with AA; 35 patients with CRC; and 40 endoscopically diagnosed healthy controls using CRC screening colonoscopy...
October 2017: Intestinal Research
https://www.readbyqxmd.com/read/29142356/clinically-occult-rectal-carcinoma-identified-in-a-case-of-streptococcus-bovis-endocarditis-on-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-a-case-report-and-review-of-literature
#6
Piyush Chandra, Satish Nath, Senthil Kumar
Numerous studies over past four decades have implicated a strong association of Streptoccus bovis infection with colorectal carcinomas. Strong is this association that a screening colonoscopy for identifying malignancy is considered mandatory in patients whose blood/fecal cultures show growth of this particular pathogen. Here, we report an interesting case of a 61-year-old female patient who presented with pyrexia of unknown origin for 3 weeks. Positron emission tomography/computed tomography, in addition to helping diagnose mitral valve endocarditis, also identified a clinically occult T2N0 rectal carcinoma...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29133254/characteristics-and-progression-of-preclinical-inflammatory-bowel-disease
#7
Iago Rodríguez-Lago, Olga Merino, Irene Azagra, Ainara Maiz, Eva Zapata, Rebeca Higuera, Isabel Montalvo, María Fernández-Calderón, Paz Arreba, Juan Carrascosa, Ainara Iriarte, Isabel Portillo, Urko Aguirre, Manuel Barreiro-de Acosta, Miguel Muñoz-Navas, José Luis Cabriada
BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a chronic disease usually diagnosed after the appearance of gastrointestinal symptoms. Little is known about IBD progression during its early and even preclinical phases. We aimed to determine the number of new incidental diagnoses of IBD in an older population, and evaluate disease progression from its early stages. METHODS: We performed a retrospective analysis of 31,005 colonoscopies performed during colorectal cancer screening of patients with positive results from fecal immunochemical tests, at 11 centers in the Basque Country (Spain) from 2009 through 2014...
November 10, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29129158/practical-gastrointestinal-investigation-of-iron-deficiency-anaemia
#8
Anjan K Banerjee, Valerio Celentano, Jim Khan, Gaius Longcroft-Wheaton, Amanda Quine, Pradeep Bhandari
About 10% of oesophagogastroduodenoscopies (OGDs) and colonoscopies are done for investigation of iron deficiency anemia (IDA) . Much of the existing guidance on investigation of IDA predates CRC screening, which has driven significant improvements in colonoscopy quality and completion rates, as well as a reduction in Helicobacter pylori prevalence and increase in PPI usage, and therefore probably needs re-consideration. New investigations, e.g. CT colonography, enteroscopy and capsule endoscopy have also been introduced...
November 13, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29125240/tumor-associated-dna-mutation-detection-in-individuals-undergoing-colonoscopy
#9
Phillip Fleshner, Glenn D Braunstein, Gayane Ovsepyan, Theresa R Tonozzi, Anja Kammesheidt
The majority of colorectal cancers (CRC) harbor somatic mutations and epigenetic modifications in the tumor tissue, and some of these mutations can be detected in plasma as circulating tumor DNA (ctDNA). Precancerous colorectal lesions also contain many of these same mutations. This study examined plasma for ctDNA from patients undergoing a screening or diagnostic colonoscopy to determine the sensitivity and specificity of the ctDNA panel for detecting CRC and precancerous lesions. Two hundred patients without a history of nonskin cancer had blood drawn before a colonoscopy...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29120461/risk-of-colorectal-cancer-for-carriers-of-a-germ-line-mutation-in-pole-or-pold1
#10
Daniel D Buchanan, Jenna R Stewart, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Bernard J Pope, Mark A Jenkins, John L Hopper, Melissa C Southey, Finlay A Macrae, Ingrid M Winship, Aung Ko Win
BackgroundGerm-line mutations in the exonuclease domains of the POLE and POLD1 genes are associated with an increased, but yet unquantified, risk of colorectal cancer (CRC).MethodsWe identified families with POLE or POLD1 variants by searching PubMed for relevant studies prior to October 2016 and by genotyping 669 population-based CRC cases diagnosed in patients under 60 years of age, from the Australasian Colorectal Cancer Family Registry. We estimated the age-specific cumulative risks (penetrance) using a modified segregation analysis...
November 9, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29112048/results-of-a-community-based-randomized-study-comparing-a-clear-liquid-diet-with-a-low-residue-diet-using-a-magnesium-citrate-preparation-for-screening-and-surveillance-colonoscopies
#11
Chandrashekhar Thukral, Sumeet K Tewani, Adam J Lake, Aaron J Shiels, Kathy Geissler, Sara Popejoy, Megan Stafford, Joseph J Vicari
BACKGROUND: Current bowel preparations for colonoscopy include a clear liquid diet (CLD) along with consumption of a laxative. This dietary restriction along with large volume bowel preparations are barriers to compliance and willingness among patients in scheduling screening examinations. The aim of our study was to compare the efficacy and tolerability of a low-volume split dose magnesium citrate bowel preparation in patients on a low-residue diet (LRD) with those on a CLD. METHODS: In this single center, single blinded, randomized controlled trial, patients scheduled for outpatient colonoscopies were assigned to either a CLD or a LRD 1 day before the examination...
November 3, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29109496/no-results-no-problem-why-we-are-publishing-methods-of-a-landmark-study-with-results-still-pending
#12
Brian E Lacy, Brennan Spiegel
Colorectal cancer (CRC) is the third most commonly diagnosed cancer in both men and women in the United States, and screening for CRC is a national health-care priority. In this issue, investigators from the CONFIRM study group report on the aims and study design of a large, multicenter, randomized prospective study of whether screening colonoscopy is superior to an annual fecal immunochemical test (FIT). CONFRIM hopes to enroll 50,000 individuals, aged 50-75 years, from 46 Veterans Affairs Medical Centers and monitor them for 10 years...
November 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29109391/occult-spigelian-hernia-presenting-as-inability-to-complete-colon-cancer-screening-in-a-patient-with-a-history-of-rectal-cancer
#13
Daniel Persinger, Marc D Basson
BACKGROUND While it is well known that abdominal wall hernias can pose obstacles for colonoscopy, these may not be obvious in obese patients, particularly when the hernia is in an unusual place. CASE REPORT A 62-year-old man presented with inability to complete colon cancer screening by means of colonoscopy or barium enema. On exam, he was noted to have a Spigelian hernia present in his left lower quadrant abdominal wall. CT colonography identified incarcerated sigmoid colon within the hernia accounting for his inability to complete colonoscopy or barium enema...
November 7, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/29102616/cost-effectiveness-of-screening-individuals-with-cystic-fibrosis-for-colorectal-cancer
#14
Andrea Gini, Ann G Zauber, Dayna R Cenin, Amir-Houshang Omidvari, Sarah E Hempstead, Aliza K Fink, Albert B Lowenfels, Iris Lansdorp-Vogelaar
BACKGROUND & AIMS: Individuals with cystic fibrosis are at increased risk of colorectal cancer (CRC) compared to the general population, and risk is higher among those who received an organ transplant. We performed a cost-effectiveness analysis to determine optimal CRC screening strategies for patients with cystic fibrosis. METHODS: We adjusted the existing MISCAN-Colon microsimulation model to reflect increased CRC risk and lower life-expectancy in patients with cystic fibrosis...
November 1, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29101688/racial-disparities-and-factors-affecting-michigan-colorectal-cancer-screening
#15
Vincent Grzywacz, Nasir Hussain, Neli Ragina
INTRODUCTION: The objective of this study was to investigate the various factors that influence colorectal cancer screening in Michigan using 6091 participants in the Michigan Behavioral Risk Factor Surveillance System representing adults ≥ 50 years old. METHODS: Screening for colorectal cancer was assessed as fecal occult blood testing or colonoscopy/sigmoidoscopy. Full models simultaneously adjusted for alcohol use, angina/coronary heart disease, stroke, heart attack, gender, income, marital status, race, age, diabetes, disability, exercise, health care coverage, health care access, smoking, and mental health...
November 3, 2017: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29101260/long-term-performance-of-colorectal-cancer-screening-programmes-based-on-the-faecal-immunochemical-test
#16
Manuel Zorzi, Cesare Hassan, Giulia Capodaglio, Chiara Fedato, Adriana Montaguti, Anna Turrin, Alberto Rosano, Daniele Monetti, Carmen Stocco, Susanna Baracco, Francesca Russo, Alessandro Repici, Massimo Rugge
BACKGROUND: The long-term performance of colorectal cancer (CRC) screening programmes based on a 2-year faecal immunochemical test (FIT) is still unclear. METHODS: In a sample of 50 to 69-year-olds repeatedly screened with the FIT (OC-Hemodia latex agglutination test; cut-off: 20 µg haemoglobin/g faeces), we examined: (1) the FIT positivity rate, the CRC and advanced adenoma detection rate and the FIT's positive predictive value (PPV) for advanced neoplasia, at each round of screening and (2) the cumulative CRC and advanced adenoma detection rate after five rounds of FIT...
November 3, 2017: Gut
https://www.readbyqxmd.com/read/29096402/risk-adjusted-colorectal-cancer-screening-using-the-fit-and-routine-screening-data-development-of-a-risk-prediction-model
#17
Jennifer Anne Cooper, Nick Parsons, Chris Stinton, Christopher Mathews, Steve Smith, Stephen P Halloran, Sue Moss, Sian Taylor-Phillips
BACKGROUND: The faecal immunochemical test (FIT) is replacing the guaiac faecal occult blood test in colorectal cancer screening. Increased uptake and FIT positivity will challenge colonoscopy services. We developed a risk prediction model combining routine screening data with FIT concentration to improve the accuracy of screening referrals. METHODS: Multivariate analysis used complete cases of those with a positive FIT (⩾20 μg g(-1)) and diagnostic outcome (n=1810; 549 cancers and advanced adenomas)...
November 2, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29095417/a-web-based-multimedia-program-before-colonoscopy-increased-knowledge-and-decreased-anxiety-sedation-requirement-and-procedure-time
#18
Siddhartha Parker, Jonathan Zipursky, Helen Ma, Geri-Lynn Baumblatt, Corey A Siegel
GOALS: Assess the impact of a web-based multimedia patient engagement program on patient anxiety, perception and knowledge about the colonoscopy in addition to procedure outcomes. BACKGROUND: The success of patients coming for a colonoscopy for colorectal cancer screening is dependent in part on patients' understanding of the preparation and of the procedure. Patients were randomized to use either our institution's standard preprocedure colonoscopy packet or a web-based multimedia patient engagement program (Emmi Solutions) before their scheduled procedure...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29095416/rolling-out-screening-volume-affecting-compliance-rate-and-waiting-time-of-fit-based-colonoscopy
#19
Hsiao-Hsuan Jen, Chen-Yang Hsu, Sam Li-Sheng Chen, Amy Ming-Fang Yen, Sherry Yueh-Hsia Chiu, Jean Ching-Yuan Fann, Yi-Chia Lee, Ming-Shiang Wu, Wen-Feng Hsu, Szu-Min Peng, Hsiu-Hsi Chen, Han-Mo Chiu
BACKGROUND AND STUDY AIMS: The population-based colorectal cancer screening program with fecal immunochemical test (FIT) from the inaugural period to the rolling-out period may create a higher demand for colonoscopies, but such a change has not been quantified. We intended to assess the change in the compliance rate and the waiting time (WT) for a colonoscopy and the associated geographic and institutional variations across the 2 periods. MATERIALS AND METHODS: Data from the Taiwanese nationwide colorectal cancer screening program were analyzed...
October 31, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/29079605/cost-effectiveness-of-the-faecal-immunochemical-test-at-a-range-of-positivity-thresholds-compared-with-the-guaiac-faecal-occult-blood-test-in-the-nhs-bowel-cancer-screening-programme-in-england
#20
Jacqueline Murphy, Stephen Halloran, Alastair Gray
OBJECTIVES: Through the National Health Service (NHS) Bowel Cancer Screening Programme (BCSP), men and women in England aged between 60 and 74 years are invited for colorectal cancer (CRC) screening every 2 years using the guaiac faecal occult blood test (gFOBT). The aim of this analysis was to estimate the cost-utility of the faecal immunochemical test for haemoglobin (FIT) compared with gFOBT for a cohort beginning screening aged 60 years at a range of FIT positivity thresholds. DESIGN: We constructed a cohort-based Markov state transition model of CRC disease progression and screening...
October 27, 2017: BMJ Open
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