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Igfbp6

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https://www.readbyqxmd.com/read/29626982/genetic-and-microscopic-assessment-of-the-human-chemotherapy-exposed-placenta-reveals-possible-pathways-contributive-to-fetal-growth-restriction
#1
M Verheecke, A Cortès Calabuig, J Finalet Ferreiro, V Brys, R Van Bree, G Verbist, T Everaert, L Leemans, M M Gziri, I Boere, M J Halaska, J Vanhoudt, F Amant, K Van Calsteren
INTRODUCTION: Fetal growth restriction (FGR) carries an increased risk of perinatal mortality and morbidity. A major cause of FGR is placental insufficiency. After in utero chemotherapy-exposure, an increased incidence of FGR has been reported. In a prospective cohort study we aimed to explore which pathways may contribute to chemotherapy-associated FGR. METHODS: Placental biopsies were collected from 25 cancer patients treated with chemotherapy during pregnancy, and from 66 control patients...
April 2018: Placenta
https://www.readbyqxmd.com/read/29605601/identification-of-host-cellular-proteins-lage3-and-igfbp6-that-interact-with-orf-virus-protein-orfv024
#2
Mingjian Long, Yuanyuan Wang, Daxiang Chen, Yong Wang, Ruixue Wang, Daoyuan Gong, Haijian He, Daniel L Rock, Wenbo Hao, Shuhong Luo
OBJECTIVE: Orf virus (ORFV) is the pathogen causing contagious pustular dermatitis in goats, sheep and herdsmen. Evidence has confirmed that ORFV can be used as a preventive and therapeutic immunomodulatory agent in several animal models. Our previous data demonstrated that ORFV024 is able to inhibit activation of the NF-κB signaling pathway and act as an important modulator for early immune responses against viral infection. However, the molecular mechanism by which ORFV024 exerting biological function remains unclear...
March 29, 2018: Gene
https://www.readbyqxmd.com/read/29582205/in-vitro-model-for-studying-of-the-role-of-igfbp6-gene-in-breast-cancer-metastasizing
#3
S V Nikulin, M P Raigorodskaya, A A Poloznikov, G S Zakharova, U Schumacher, D Wicklein, C Stürken, K Riecken, K A Fomicheva, B Ya Alekseev, M Yu Shkurnikov
IGFBP6 gene plays an important role in the pathogenesis of breast cancer. In this work, we performed knockdown of IGFBP6 gene in MDA-MB-231 cells and obtained a stable cell line. Knockdown of IGFBP6 gene was confirmed by the real-time PCR. The influence of IGFBP6 gene on migration and proliferation of breast cancer cells was studied. Knockdown of IGFBP6 gene reduced migration activity of MDA-MB-231 cells and increased their proliferation rate. This in vitro cell model can be used for the further analysis of the role of IGFBP6 gene in the pathogenesis of breast cancer...
March 27, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29577195/role-of-igfbp6-protein-in-the-regulation-of-epithelial-mesenchymal-transition-genes
#4
S V Nikulin, M P Raigorodskaya, A A Poloznikov, G S Zakharova, U Schumacher, D Wicklein, C Stürken, K Riecken, K A Fomicheva, B Ya Alekseev, M Yu Shkurnikov
Protein IGFBP6 plays an important role in the pathogenesis of many malignant tumors, including breast cancer. The relationship between IGFBP6 protein and the expression of genes associated with the epithelial-mesenchymal transition is studied. Gene IGFBP6 knockdown does not trigger the epithelial-mesenchymal transition in MDA-MB-231 cells, but modifies significantly the expression of many genes involved in this process. A decrease of IGFBP6 expression can involve a decrease in the expression of N-cadherin and transcription factor Slug...
March 26, 2018: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29547667/comparison-of-secretome-from-osteoblasts-derived-from-sclerotic-versus-non-sclerotic-subchondral-bone-in-oa-a-pilot-study
#5
Christelle Sanchez, Gabriel Mazzucchelli, Cécile Lambert, Fanny Comblain, Edwin DePauw, Yves Henrotin
OBJECTIVE: Osteoarthritis (OA) is characterized by cartilage degradation but also by other joint tissues modifications like subchondral bone sclerosis. In this study, we used a proteomic approach to compare secretome of osteoblast isolated from sclerotic (SC) or non sclerotic (NSC) area of OA subchondral bone. DESIGN: Secretome was analyzed using differential quantitative and relative label free analysis on nanoUPLC G2 HDMS system. mRNA of the more differentially secreted proteins were quantified by RT-PCR in cell culture from 5 other patients...
2018: PloS One
https://www.readbyqxmd.com/read/29439316/correlation-of-igfbp-6-expression-with-apoptosis-and-migration-of-colorectal-carcinoma-cells
#6
Fei Qiu, Wei Gao, Bin Wang
Colorectal cancer (CRC) is one of the most common malignant tumors in digestive tract. Previous study found close correlation between insulin-like growth factor binding proteins (IGFBPs) and occurrence of multiple tumors. This study aims to analyze the effects of IGFBP6 on the apoptosis and migration of tumor cells, and to investigate underlying mechanism. HCT-116 or SW480 cell was cultured with 1.0 mg/l, 10 mg/l and 100 mg/l IGFBP-6. MTT assay was employed to test the proliferation activity of tumor cells after differential treatment...
February 2, 2018: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29080277/proteomic-profiling-of-follicle-fluids-after-superstimulation-in-one-month-old-lambs
#7
Y Wu, J Lin, B Han, L Wang, Y Chen, M Liu, J Huang
Follicular fluid (FF) accumulates in the antrum of the ovarian follicle. In addition, FF provides the microenvironment for oocyte development, oocyte maturation and competence, which are acquired during follicular development. Superstimulatory treatment of 1-month-old lambs can achieve synchronous development of numerous growing follicles. However, these growing follicles are unable to completely mature and ovulate. Furthermore, the oocytes exhibit lower competence compared with those of ewes. In this study, we utilized an isobaric tag for relative and absolute quantification (iTRAQ)-based proteomics analysis and compare protein composition between pre-pubertal and adult superstimulated follicle FF in sheep...
February 2018: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28977828/human-monocyte-derived-dendritic-cells-exposed-to-hyperthermia-show-a-distinct-gene-expression-profile-and-selective-upregulation-of-igfbp6
#8
Arcangelo Liso, Stefano Castellani, Francesca Massenzio, Rosa Trotta, Alessandra Pucciarini, Barbara Bigerna, Pasquale De Luca, Pietro Zoppoli, Filippo Castiglione, Maria Concetta Palumbo, Fabrizio Stracci, Matteo Landriscina, Giorgina Specchia, Leon A Bach, Massimo Conese, Brunangelo Falini
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal temperature (37°C) for 180 minutes...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28864782/ozone-oil-promotes-wound-healing-by-increasing-the-migration-of-fibroblasts-via-pi3k-akt-mtor-signaling-pathway
#9
Weirong Xiao, Hua Tang, Meng Wu, Yangying Liao, Ke Li, Lan Li, Xiaopeng Xu
Skin injury affects millions of people via the uncontrolled inflammation and infection. Many cellular components including fibroblasts and signaling pathways such as transforming growth factor-β (TGF-β) were activated to facilitate the wound healing to repair injured tissues. C57BL/6 female mice were divided into control and ozone oil treated groups. Excisional wounds were made on the dorsal skin and the fibroblasts were isolated from granulation tissues. The skin injured mouse model revealed that ozone oil could significantly decrease the wound area and accelerate wound healing compared with control group...
December 22, 2017: Bioscience Reports
https://www.readbyqxmd.com/read/28829625/whole-exome-sequencing-identified-a-novel-igfbp6-variant-in-a-disc-degeneration-pedigree
#10
Sun Fu, Wang Lei, Dai Lanlan, Yuan Qi-Ling, Liu Liang, Zhou Hanlin, Zhang Jianguo, Zhang Yin-Gang
OBJECTIVE: To identify the likely causal mutation that results in disc degeneration in a pedigree with a high incidence of disc degeneration. MATERIALS AND METHODS: A large pedigree with a high incidence of disc degeneration was recruited for this study. Exome sequencing was completed on four family members with disc degeneration to screen for potential causal gene variants. Detected variants were filtered against the 1000 Genomes Project, the Short Genetic Variations database (dbSNP), and the Beijing Genomics Institute (BGI) in-house database...
October 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28673325/maternal-intake-of-high-n-6-polyunsaturated-fatty-acid-diet-during-pregnancy-causes-transgenerational-increase-in-mammary-cancer-risk-in-mice
#11
Nguyen M Nguyen, Fabia de Oliveira Andrade, Lu Jin, Xiyuan Zhang, Madisa Macon, M Idalia Cruz, Carlos Benitez, Bryan Wehrenberg, Chao Yin, Xiao Wang, Jianhua Xuan, Sonia de Assis, Leena Hilakivi-Clarke
BACKGROUND: Maternal and paternal high-fat (HF) diet intake before and/or during pregnancy increases mammary cancer risk in several preclinical models. We studied if maternal consumption of a HF diet that began at a time when the fetal primordial germ cells travel to the genital ridge and start differentiating into germ cells would result in a transgenerational inheritance of increased mammary cancer risk. METHODS: Pregnant C57BL/6NTac mouse dams were fed either a control AIN93G or isocaloric HF diet composed of corn oil high in n-6 polyunsaturated fatty acids between gestational days 10 and 20...
July 3, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28621669/human-monocyte-derived-dendritic-cells-exposed-to-hyperthermia-show-a-distinct-gene-expression-profile-and-selective-upregulation-of-igfbp6
#12
Arcangelo Liso, Stefano Castellani, Francesca Massenzio, Rosa Trotta, Alessandra Pucciarini, Barbara Bigerna, Pasquale De Luca, Pietro Zoppoli, Filippo Castiglione, Maria Concetta Palumbo, Fabrizio Stracci, Matteo Landriscina, Giorgina Specchia, Leon A Bach, Massimo Conese, Brunangelo Falini
Fever plays a role in activating innate immunity while its relevance in activating adaptive immunity is less clear. Even brief exposure to elevated temperatures significantly impacts on the immunostimulatory capacity of dendritic cells (DCs), but the consequences on immune response remain unclear. To address this issue, we analyzed the gene expression profiles of normal human monocyte-derived DCs from nine healthy adults subjected either to fever-like thermal conditions (39°C) or to normal temperature (37°C) for 180 minutes...
June 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28572803/insulin-like-growth-factor-binding-protein-6-in-rheumatoid-arthritis-a-possible-novel-chemotactic-factor
#13
Alessia Alunno, Onelia Bistoni, Mirko Manetti, Giacomo Cafaro, Valentina Valentini, Elena Bartoloni, Roberto Gerli, Arcangelo Liso
OBJECTIVES: Immune cell migration from the bloodstream to target tissues is a hallmark of rheumatoid arthritis (RA) pathogenesis. The role of chemoattractants, mainly chemokines, and their possible targeting for therapeutic purposes have been under intense investigation over the last few years but the results were not as satisfactory as expected. The insulin-like growth factor binding protein 6 (IGFBP6), a direct inhibitor of insulin-like growth factor (IGF)-II, also exerts IGF-independent effects including tumor cell migration in vitro...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28284700/effects-of-dietary-neutral-detergent-fiber-and-starch-ratio-on-rumen-epithelial-cell-morphological-structure-and-gene-expression-in-dairy-cows
#14
L Ma, M Zhao, L S Zhao, J C Xu, J J Loor, D P Bu
This study was designed to investigate the effect of dietary neutral detergent fiber to starch ratio on rumen epithelial morphological structure and gene expression. Eight primiparous dairy cows including 4 ruminally fistulated cows were assigned to 4 total mixed rations with neutral detergent fiber to starch ratios of 0.86, 1.18, 1.63, and 2.34 in a replicated 4 × 4 Latin square design. The duration of each period was 21 d including 14 d for adaptation and 7 d for sampling. Rumen epithelial papillae were collected from the ruminally fistulated cows for morphological structure examination and mRNA expression analysis using quantitative real-time PCR of several genes related to volatile fatty acid absorption and metabolism, and cellular growth...
May 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/27888466/the-expression-of-igfbp6-after-spinal-cord-injury-implications-for-neuronal-apoptosis
#15
Song Wang, Yonghua Liu, Chunshuai Wu, Weijuan Zhao, Jinlong Zhang, Guofeng Bao, Guanhua Xu, Yuyu Sun, Jiajia Chen, Zhiming Cui
IGFBP6, a member of the insulin-like growth factor-binding proteins family that contains six high affinity IGFBPs, modulates insulin-like growth factor (IGF) activity and also showed an independent effect of IGF, such as growth inhibition and apoptosis. However, the role of IGFBP6 in spinal cord injury (SCI) remains largely elusive. In this study, we have performed an acute SCI model in adult rats and investigated the dynamic changes of IGFBP6 expression in the spinal cord. Our results showed that IGFBP6 was upregulated significantly after SCI, which was paralleled with the levels of apoptotic proteins p53 and active caspase-3...
February 2017: Neurochemical Research
https://www.readbyqxmd.com/read/27650075/igfbp6-regulates-cell-apoptosis-and-migration-in-glioma
#16
Yuanqi Bei, Qingfeng Huang, Jianhong Shen, Jinlong Shi, Chaoyan Shen, Peng Xu, Hao Chang, Xiaojie Xia, Li Xu, Bin Ji, JianGuo Chen
The insulin-like growth factor binding protein 6 (IGFBP6), as an inhibitor of IGF-II actions, plays an important role in inhibiting survival and migration of tumor cells. In our study, we intended to demonstrate the biological function of IGFBP6 in the development of glioma and its clinical significance. Firstly, Western blot and immunohistochemistry revealed that the expression of IGFBP6 inversely correlated with glioma grade. Secondly, multivariate analysis with the Cox proportional hazards model and Kaplan-Meier analysis indicated that IGFBP6 could be an independent prognostic factor for the survival of glioma patients...
July 2017: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27623076/igfbp6-is-a-novel-nasopharyngeal-carcinoma-prognostic-biomarker
#17
Qiuyan Chen, Siyuan Qin, Yang Liu, Minghuang Hong, Chao-Nan Qian, Evan T Keller, Jian Zhang, Yi Lu
Insulin-like growth factor binding proteins (IGFBPs) play critical roles in carcinogenesis. This study assessed the impact of IGFBP6 on the progression of nasopharyngeal carcinoma (NPC). Using immunohistochemical analysis, we found that IGFBP6 was differentially expressed in primary malignant NPC tissues. Clinical samples were divided into two groups: IGFBP6(+) and IGFBP6(-). Five years of follow-up revealed that overall survival and distant metastasis-free survival rates were significantly higher in the IGFBP6(+) than IGFBP6(-) group...
October 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27517731/genome-wide-analysis-identifies-differential-promoter-methylation-of-leprel2-foxf1-mmp25-igfbp6-and-peg12-in-murine-tendinopathy
#18
Katie J Trella, Jun Li, Eleni Stylianou, Vincent M Wang, Jonathan M Frank, Jorge Galante, John D Sandy, Anna Plaas, Robert Wysocki
We have used a murine Achilles tendinopathy model to investigate whether tissue changes (such as collagen disorganization, chondroid metaplasia, and loss of tensile properties) which are broadly characteristic of human tendinopathies, are accompanied by changes in the expression of chromatin-modifying enzymes and the methylation status of promoter regions of tendon cell DNA. Tendinopathy was induced by two intra-tendinous TGF-β1 injections followed by cage activity or treadmill running for up to 28 days. Activation of DNA methyltransferases occurred at 3 days after the TGF-β1 injections and also at 14 days, but only with treadmill activity...
May 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/27141097/a-contra-capture-protein-array-platform-for-studying-post-translationally-modified-ptm-auto-antigenomes
#19
Kailash Karthikeyan, Kristi Barker, Yanyang Tang, Peter Kahn, Peter Wiktor, Al Brunner, Vinicius Knabben, Bharath Takulapalli, Jane Buckner, Gerald Nepom, Joshua LaBaer, Ji Qiu
Aberrant modifications of proteins occur during disease development and elicit disease-specific antibody responses. We have developed a protein array platform that enables the modification of many proteins in parallel and assesses their immunogenicity without the need to express, purify, and modify proteins individually. We used anticitrullinated protein antibodies (ACPAs) in rheumatoid arthritis (RA) as a model modification and profiled antibody responses to ∼190 citrullinated proteins in 20 RA patients...
July 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27025059/effect-of-hypoxia-on-the-expression-of-genes-that-encode-some-igfbp-and-ccn-proteins-in-u87-glioma-cells-depends-on-ire1-signaling
#20
O H Minchenko, A P Kharkova, D O Minchenko, L L Karbovskyi
We have studied hypoxic regulation of the expression of different insulin-like growth factor binding protein genes in U87 glioma cells in relation to inhibition of IRE1 (inositol requiring enzyme-1), a central mediator of endoplasmic reticulum stress, which controls cell proliferation and tumor growth. We have demonstrated that hypoxia leads to up-regulation of the expression of IGFBP6, IGFBP7, IGFBP10/CYR61, WISP1, and WISP2 genes and down-regulation--of IGFBP9/NOV gene at the mRNA level in control glioma cells, being more signifcant changes for IGFBP10/CYR61 and WISP2 genes...
November 2015: Ukrainian Biochemical Journal
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