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https://www.readbyqxmd.com/read/29782303/clindamycin-induced-maculopapular-exanthema-with-preferential-involvement-of-striae-distensae-a-koebner-phenomenon
#1
Benigno Monteagudo, Miguel Cabanillas, Pilar Iriarte, Aquilina Ramírez-Santos, Elvira León-Muinos, Daniel González-Vilas, Óscar Suárez-Amor
Clindamycin is a lincomycin-derived antibiotic useful for the treatment of anaerobic and Gram-positive aerobic bacterial infections. Cutaneous adverse reactions are usually maculopapular exanthemas, although hypersensitivity syndrome, acute generalized exanthematous pustulosis, and Stevens-Johnson syndrome have also been reported (1). We report the case of a patient with a maculopapular rash triggered by clindamycin who developed cutaneous lesions on striae distensae (SD). A 47-year-old woman was referred to our clinic for pruritic cutaneous lesions which had started 6 days earlier...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29780064/systemic-lupus-erythematosus-and-sj%C3%A3-gren-s-syndrome-complicated-by-conversion-disorder-a-case-report
#2
Misa Nakamura, Seiji Tanaka, Tadashi Inoue, Yasuto Maeda, Kiyohito Okumiya, Takuya Esaki, G O Shimomura, Kenji Masunaga, Shinichiro Nagamitsu, Yushiro Yamashita
Conversion disorder (CD) is sometimes accompanied by motor and sensory impairments, such as muscle weakness, paralysis, sensory hypersensitivity, and sensory loss. Sjögren's syndrome (SS) complicates 5-10% of cases of systemic lupus erythematosus (SLE). Patients with SS or SLE present with various neurological symptoms and psychiatric manifestations. When neurological symptoms are present, it is important to distinguish whether the symptoms are caused by a neurological or a mental disorder because the former requires early intensive intervention, such as methylprednisolone pulse therapy (MPT), whereas psychotherapy or antidepressant drugs are recommended for mental disorders...
May 21, 2018: Kurume Medical Journal
https://www.readbyqxmd.com/read/29779928/the-diagnosis-and-clinical-management-of-the-catastrophic-antiphospholipid-syndrome-a-comprehensive-review
#3
REVIEW
Ricard Cervera, Ignasi Rodríguez-Pintó, Gerard Espinosa
The catastrophic antiphospholipid syndrome (CAPS) is a life-threating variant of the antiphospholipid syndrome characterized by the development of multiple thrombosis in a short period of time, usually ending up in the failure of function of several vital organs. Most CAPS episodes are related to a prothrombotic situation or precipitating factor such as infections, surgical procedures or malignant diseases. In patients with CAPS, the development of multiple thrombosis leads to an important cytokine release that worsens the already critical patient's situation...
May 17, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29779436/early-lupus-project-one-year-follow-up-of-an-italian-cohort-of-patients-with-systemic-lupus-erythematosus-of-recent-onset
#4
G D Sebastiani, I Prevete, A Iuliano, M Piga, F Iannone, L Coladonato, M Govoni, A Bortoluzzi, M Mosca, C Tani, A Doria, L Iaccarino, A Tincani, M Fredi, F Conti, F R Spinelli, M Galeazzi, F Bellisai, A Zanetti, G Carrara, C A Scirè, A Mathieu
Objective To describe the clinical and serological features of a prospectively followed cohort of early diagnosed systemic lupus erythematosus (SLE) patients during a one-year follow-up period. Methods SLE patients with disease duration less than 12 months were consecutively enrolled in a multicentre, prospective study. At study entry and then every 6 months, a large panel of data was recorded. Results Of 260 patients enrolled, 185 had at least 12 months of follow-up; of these, 84.3% were female, 92.4% were Caucasians...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29775619/proteomic-approach-to-profiling-immune-complex-antigens-in-cerebrospinal-fluid-samples-from-patients-with-central-nervous-system-autoimmune-diseases
#5
Nozomi Aibara, Kunihiro Ichinose, Miyako Baba, Hideki Nakajima, Katsuya Satoh, Ryuichiro Atarashi, Naoya Kishikawa, Noriyuki Nishida, Atsushi Kawakami, Naotaka Kuroda, Kaname Ohyama
BACKGROUND: Immune complexes (ICs) may clearly reflect immunological abnormalities caused by disease, especially for autoimmune diseases. Although ICs have been detected in cerebrospinal fluid (CSF) from patients with CNS autoimmune diseases, identities of antigens in such ICs have not been comprehensively determined. METHODS: We used immune complexome analysis, in which nano-liquid chromatography-tandem mass spectrometry is employed to comprehensively identify antigens incorporated into ICs in biological fluids, to characterize ICs in CSF samples from patients with CNS autoimmune diseases, and to find disease-specific IC antigen to a certain CNS autoimmune disease...
May 15, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29771193/early-symptoms-of-systemic-lupus-erythematosus-sle-recalled-by-339-sle-patients
#6
N Leuchten, B Milke, B Winkler-Rohlfing, D Daikh, T Dörner, S R Johnson, M Aringer
Objective The European League Against Rheumatism and the American College of Rheumatology jointly embarked on a new classification criteria for systemic lupus erythematosus (SLE) project. Its first phase involved generation of a broad set of items potentially useful for classification of SLE. This study was undertaken to add the patient perspective to an expert Delphi approach and an early patient cohort study. Methods A national cross-sectional study was conducted. A self-report questionnaire was published in the "Schmetterling" (Butterfly), the quarterly journal of the German SLE patient association...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29759123/systemic-lupus-erythematosus-for-primary-care
#7
REVIEW
Ruba Kado
Systemic lupus erythematosus is a chronic autoimmune condition with variable organ system involvement; manifestations can range from mild to potentially life threatening. Early diagnosis is important, as progression of disease can be halted. Diagnosis is made by review of signs and symptoms, imaging, and serology.
June 2018: Primary Care
https://www.readbyqxmd.com/read/29759049/klinefelter-s-syndrome-with-lupus-encephalitis-and-retroperitoneal-teratoma
#8
C Ng Wq, S E Eide, Huang J, Khor Ym
We report a case of a middle-aged male who presented with pyrexia of unknown origin, oral ulcers, rash and bicytopenia. His past medical history included unexplained proteinuria, infertility and joint pain. Initial workup showed a large retroperitoneal soft tissue mass, which has appeared stable for 10 years. He subsequently developed neuropsychiatric symptoms with imaging findings of meningoencephalitis. Concurrent investigations showed elevated ANA, anti-double-stranded DNA (dsDNA) and ESR levels, as well as low complement levels...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29747124/serum-human-epididymis-protein-4-is-a-predictor-for-developing-nephritis-in-patients-with-systemic-lupus-erythematosus-a-prospective-cohort-study
#9
Yingpeng Ren, Jing Xie, Feng Lin, Wanwan Luo, Zhencheng Zhang, Panying Mao, Renqian Zhong, Yan Liang, Zaixing Yang
BACKGROUND: It has been demonstrated that serum human epididymis protein 4 (HE4) is a useful biomarker for differentiating lupus nephritis (LN) from systemic lupus erythematosus (SLE). However, it remains unclear whether HE4 can be used to predict the development of LN. METHODS: A total of 74 SLE patients without LN were recruited between August 2008 and September 2013. Serum HE4 concentrations were measured by enzyme-linked immunosorbent assay. These patients were followed up from the date of SLE diagnosis to LN development or the end of the study...
May 7, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29742693/a-successful-treatment-of-severe-systemic-lupus-erythematosus-caused-by-occult-pulmonary-infection-associated-with-hemophagocytic-syndrome-a-case-report
#10
Weihong Shi, Mingyang Duan, Ligang Jie, Weifeng Sun
RATIONALE: A 27-year-old woman with a history of systemic lupus erythaematosus (SLE) developed hemophagocytic syndrome (HPS) secondary due to an unrecognized infection that led to severe SLE with a prolonged recovery. PATIENT CONCERNS: The patient showed a high spiking fever and myalgia. Laboratory data revealed pancytopenia and immunological abnormalities. Pulse methylprednisone plus intravenous immunoglobulin (IVIG) failed to improve the clinical symptoms and laboratory data...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29740985/obesity-independently-associates-with-worse-patient-reported-outcomes-in-women-with-systemic-lupus-erythematosus
#11
Sarah L Patterson, Gabriela Schmajuk, Kashif Jafri, Jinoos Yazdany, Patricia Katz
BACKGROUND: We aimed to determine whether obesity in women with systemic lupus erythematosus (SLE) independently associates with worse patient-reported outcomes (PROs). METHODS: Data derive from a prospective study of adult women who carried a diagnosis of SLE verified by medical record review. Two established definitions for obesity were used: fat mass index (FMI) ≥ 13 kg/m2 and BMI ≥ 30 kg/m2 . Dependent variables included 4 validated PROs: disease activity via Systemic Lupus Activity Questionnaire (SLAQ), depressive symptoms via Center for Epidemiologic Studies Depression Scale (CES-D), pain via Short Form 36 Health Survey (SF-36) Pain Subscale, and fatigue via SF-36 Vitality Subscale...
May 8, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29740923/long-term-renal-outcomes-in-multi-ethnic-southeast-asians-with-lupus-nephritis-a-retrospective-cohort-study
#12
Cynthia C Lim, Hui Zhuan Tan, Ying Hao, Yok Mooi Chin, Keng Thye Woo, Choong Meng Chan, Jason Cj Choo
BACKGROUND: Renal involvement is common among Asians with systemic lupus erythematosus and long-term renal outcomes have been described in homogeneous Caucasian and East Asian populations with lupus nephritis but data is scarce for other ethnicities. We aimed to evaluate the incidence and risk factors for progressive chronic kidney disease (CKD) in multi-ethnic South-east Asians with lupus nephritis. METHODS: Single-center retrospective cohort study of adults with biopsy-proven lupus nephritis diagnosed between May 2001 and May 2009...
May 9, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29739689/exome-sequencing-revealed-c1q-homozygous-mutation-in-pediatric-systemic-lupus-erythematosus
#13
S Zoghi, V Ziaee, T Hirschmugl, R Jimenez-Heredia, A Krolo, K Boztug, N Rezaei
INTRODUCTION AND OBJECTIVES: Pediatric Systemic Lupus Erythematosus (pSLE) is an autoimmune disorder of children. Early disease onset raises the probability of genetic etiology and it is more severe than adult SLE. PATIENTS AND METHODS: Herein an eight-year-old girl with pSLE from consanguineous parents is reported. RESULTS: Although she was diagnosed as pSLE since the age of two years, Whole Exome Sequencing (WES) revealed a rare stop-gained C>T mutation in C1QA gene...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29738038/pp65-antigenemia-and-cytomegalovirus-diagnosis-in-patients-with-lupus-nephritis-report-of-a-series
#14
Katia Lino, Natalia Trizzotti, Fabiana Rabe Carvalho, Rachel Ingrid Cosendey, Cintia Fernandes Souza, Evandro Mendes Klumb, Andrea Alice Silva, Jorge Reis Almeida
INTRODUCTION: In contrast to organ transplantation, few studies correlate the monitoring of pp65 antigenemia with a diagnosis of cytomegalovirus (CMV) in patients with systemic lupus erythematosus (SLE). OBJECTIVE: To highlight the importance of CMV outside transplantation, we monitored pp65 antigenemia in a series of SLE patients. METHODS: From March 2015 to March 2016, SLE patients presenting kidney involvement, fever, and an unclear infection at hospital admission were monitored through pp65 antigenemia...
April 26, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29730634/changing-patterns-in-clinical-histological-presentation-and-renal-outcome-over-the-last-five-decades-in-a-cohort-of-499-patients-with-lupus-nephritis
#15
Gabriella Moroni, Paolo Gilles Vercelloni, Silvana Quaglini, Mariele Gatto, Davide Gianfreda, Lucia Sacchi, Francesca Raffiotta, Margherita Zen, Gloria Costantini, Maria Letizia Urban, Federico Pieruzzi, Piergiorgio Messa, Augusto Vaglio, Renato Alberto Sinico, Andrea Doria
OBJECTIVES: To evaluate changes in demographic, clinical and histological presentation, and prognosis of lupus nephritis (LN) over time. PATIENTS AND METHODS: We studied a multicentre cohort of 499 patients diagnosed with LN from 1970 to 2016. The 46-year follow-up was subdivided into three periods (P): P1 1970-1985, P2 1986-2001 and P3 2002-2016, and patients accordingly grouped based on the year of LN diagnosis. Predictors of patient and renal survival were investigated by univariate and multivariate proportional hazards Cox regression analyses...
May 5, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29726637/sleep-disturbance-and-depression-symptoms-mediate-the-relationship-between-pain-and-cognitive-dysfunction-in-lupus-patients
#16
Teresa A Lillis, Vanessa Tirone, Nisarg Gandhi, Stacy Weinberg, Ailda Nika, Winston Sequeira, Stevan E Hobfoll, Joel A Block, Meenakshi Jolly
OBJECTIVE: The current study explored whether sleep disturbance and depression symptoms mediated the relationship between pain and Cognitive Dysfunction (CD) in a sample of 115 patients with Systemic Lupus Erythematosus (SLE). METHODS: 115 consenting SLE patients completed questionnaires on pain, perceived stress, depression, sleep, and CD. Relationships among pain, sleep, depression and CD were assessed with bootstrapped mediation models controlling for race/ethnicity, fibromyalgia diagnosis, current corticosteroid use, disease activity and damage, and perceived stress...
May 4, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29724730/metabolic-pathways-and-immunometabolism-in-rare-kidney-diseases
#17
Peter C Grayson, Sean Eddy, Jaclyn N Taroni, Yaíma L Lightfoot, Laura Mariani, Hemang Parikh, Maja T Lindenmeyer, Wenjun Ju, Casey S Greene, Brad Godfrey, Clemens D Cohen, Jeffrey Krischer, Matthias Kretzler, Peter A Merkel
OBJECTIVES: To characterise renal tissue metabolic pathway gene expression in different forms of glomerulonephritis. METHODS: Patients with nephrotic syndrome (NS), antineutrophil cytoplasmic antibody-associated vasculitis (AAV), systemic lupus erythematosus (SLE) and healthy living donors (LD) were studied. Clinically indicated renal biopsies were obtained at time of diagnosis and microdissected into glomerular and tubulointerstitial compartments. Microarray-derived differential gene expression of 88 genes representing critical enzymes of metabolic pathways and 25 genes related to immune cell markers was compared between disease groups...
May 3, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29721697/spectrum-of-systemic-lupus-erythematosus-in-oman-from-childhood-to-adulthood
#18
Asma Al Rasbi, Eiman Abdalla, Rabab Sultan, Nasreen Abdullah, Juma Al Kaabi, Ibrahim Al-Zakwani, Reem Abdwani
SLE is a disease that mainly affects women of childbearing age, however, a total of 15-20% of cases present in children. Although adult onset SLE (aSLE) and childhood onset SLE (cSLE) share the same diagnostic criteria, differences have been identified. The aim of this study is to compare the similarities and differences in between cSLE and aSLE in an Arab population from Oman. We evaluated 225 SLE patients, 139 adults and 86 children, who fulfilled the criteria for diagnosis. At disease onset, 99% of SLE cohort fulfilled the SLICC criteria; however the ACR 1997 criteria were fulfilled in 66% aSLE and 80% cSLE...
May 2, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29720035/clinical-application-of-protein-biomarkers-in-lupus-erythematosus-and-lupus-nephritis
#19
S Qi, Q Chen, D Xu, N Xie, Y Dai
Systemic lupus erythematosus (SLE) is a type of autoimmune disease that damages multiple organs, including the heart, joints, liver and kidneys. The main characteristics of SLE are the deposition of circulating autoantibodies; autoantigen complexes in the renal system; and abnormal expression of complements, cytokines and chemokines. Lupus nephritis (LN) is the most serious manifestation of SLE and is characterized by inflammation of the kidney. This review summarizes recent clinical applications of protein biomarkers including autoantibodies, complements, cytokines and chemokines and some new protein biomarkers in SLE and LN...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29719023/maximizing-the-clinical-utility-of-descriptive-lymphoid-pathology-reporting
#20
Timothy H McCalmont
Dermatopathology reporting can be both exact and inexact. Exact reporting represents the use of terminology that corresponds to a disease sui generis, such as discoid lupus erythematosus or disseminated superficial porokeratosis. Inexact reporting can vary greatly amongst various practitioners-both in terms of the exact semantics used and also stylistically-and can be used habitually by pathologists as a means to provide cover for diagnostic uncertainty or inexperience. This article explores the use of descriptive (inexact) reporting as it applies to cutaneous lymphoma and its differential diagnosis...
March 2018: Seminars in Cutaneous Medicine and Surgery
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