Fabiola Diniz, Belisa Parmeggiani, Gabriela Brandão, Bruna Klippel Ferreira, Monique Fonseca Teixeira, Emilio Luiz Streck, Silvia Olivera-Bravo, Luis Hector Barbeito, Patricia Fernanda Schuck, Ricardo Augusto de Melo Reis, Gustavo Costa Ferreira
Carnosine is composed of β-alanine and L-histidine and is considered to be an important neuroprotective agent with antioxidant, metal chelating, and antisenescence properties. However, children with serum carnosinase deficiency present increased circulating carnosine and severe neurological symptoms. We here investigated the in vitro effects of carnosine on redox and mitochondrial parameters in cultured cortical astrocytes from neonatal rats. Carnosine did not alter mitochondrial content or mitochondrial membrane potential...
December 28, 2023: Molecular Neurobiology