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Selective decontamination

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https://www.readbyqxmd.com/read/29143704/identification-of-clostridium-difficile-reservoirs-in-the-patient-environment-and-efficacy-of-aerial-hydrogen-peroxide-decontamination
#1
Samuel Yui, Shanom Ali, Monika Muzslay, Annette Jeanes, A Peter R Wilson
OBJECTIVE To identify, using a novel enhanced method of recovery, environmental sites where spores of Clostridium difficile persist despite cleaning and hydrogen peroxide aerial decontamination. DESIGN Cohort study. SETTING Tertiary referral center teaching hospital. METHODS In total, 16 sites representing high-frequency contact or difficult-to-clean surfaces in a single-isolation room or bed area in patient bed bays were sampled before and after terminal or hydrogen peroxide disinfection using a sponge swab...
November 16, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29135239/advances-in-sulfidation-of-zerovalent-iron-for-water-decontamination
#2
Jinxiang Li, Xueying Zhang, Yuankui Sun, Liping Liang, Bing-Cai Pan, Weiming Zhang, Xiaohong Guan
Sulfidation has gained increasing interest in recent years for improving the sequestration of contaminants by zerovalent iron (ZVI). In view of the bright prospects of the sulfidated ZVI (S-ZVI), this review comprehensively summarized the latest developments in sulfidation of ZVI, particularly that of nanoscale ZVI (S-nZVI). The milestones in development of S-ZVI technology including its background, enlightenment, synthesis, characterization, water remediation and treatment, etc., are summarized. Under most circumstances, sulfidation can enhance the sequestration of various organic compounds and metal(loid)s by ZVI to various extents...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29119936/recent-patents-on-light-based-anti-infective-approaches
#3
Imran Ahmed, Yanyan Fang, Min Lu, Quan Yan, Ahmed Mohamed Kamel El-Hussein, Michael R Hamblin, Tianhong Dai
BACKGROUND: Antibiotic resistance is one of the most serious health threats to modern medicine. The lack of potent antibiotics puts us at a disadvantage in the fight against infectious diseases, especially those caused by antibiotic-resistant microbial strains. To this end, an urgent need to search for alternative antimicrobial approaches has arisen. In the last decade, light-based therapy has made significant strides in this fight to combat antibiotic resistance among various microbial strains...
November 7, 2017: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29119289/local-antibiotic-decontamination-to-prevent-anastomotic-leakage-short-term-outcome-in-rectal-cancer-surgery
#4
Ulrich Wirth, Susanne Rogers, Kristina Haubensak, Stefan Schopf, Thomas von Ahnen, Hans Martin Schardey
PURPOSE: Anastomotic leakage still presents an issue in rectal cancer surgery with rates of about 11%. As bacteria play a critical role, there is the concept of perioperative local decontamination to prevent anastomotic leakage. METHODS: To ascertain the effectiveness of this treatment, we performed a retrospective analysis on 206 rectal resections with primary anastomosis and routine use of a selective decontamination of the digestive tract (SDD) regimen for local decontamination...
November 8, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/29113028/restoration-of-a-healthy-intestinal-microbiota-normalizes-portal-hypertension-in-a-rat-model-of-nonalcoholic-steatohepatitis
#5
Teresa García-Lezana, Imma Raurell, Miren Bravo, Manuel Torres-Arauz, María Teresa Salcedo, Alba Santiago, Andreu Schoenenberger, Chaysavanh Manichanh, Joan Genescà, María Martell, Salvador Augustin
Portal hypertension (PH) drives most of the clinical complications in chronic liver diseases. However, its progression in nonalcoholic steatohepatitis (NASH) and its association with the intestinal microbiota (IM) has been scarcely studied. Our aim was to investigate the role of IM in the mechanisms leading to PH in early NASH. The experimental design was divided in two stages: Stage 1: Sprague-Dawley rats were fed for 8 weeks with high-fat diet and high-glucose/fructose syrup (HFGFD) or control diet/water (CD)...
November 7, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29112384/efficient-capture-and-effective-sensing-of-cr2o7-2-from-water-using-a-zirconium-metal-organic-framework
#6
Zu-Jin Lin, He-Qi Zheng, Huan-Yu Zheng, Li-Ping Lin, Qin Xin, Rong Cao
Highly efficient decontamination of heavily toxic Cr2O7(2-) from water remains a serious task for public health and ecosystem protection. An easily regenerative and reused sorbent with suitable porosity may address this task. Herein, a series of water-stable and ecofriendly metal-organic frameworks (MOFs) with large surface areas were assessed for their ability to adsorb and separate Cr2O7(2-) from aqueous solutions. Among these tested MOFs, NU-1000 shows an extraordinary capability to efficiently capture (within 3 min) Cr2O7(2-) with a sorption capacity of up to 76...
November 7, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29103639/surveillance-guided-selective-digestive-decontamination-of-carbapenem-resistant-enterobacteriaceae-in-the-intensive-care-unit-a-cost-effectiveness-analysis
#7
Joyce H S You, Hong-Kiu Li, Margaret Ip
BACKGROUND: Clinical findings have shown effectiveness and safety of selective digestive decontamination (SDD) for eradication of carbapenem-resistant Enterobacteriaceae (CRE) in high-risk carriers. We aimed to evaluate the cost-effectiveness of SDD guided by CRE surveillance in the intensive care unit (ICU). METHODS: Outcomes of surveillance-guided SDD (test-guided SDD) and no screening (control) in the ICU were compared by Markov model simulations. Model outcomes were CRE infection and mortality rates, direct costs, and quality-adjusted life year (QALY) loss...
November 2, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/29101197/population-wide-survey-of-salmonella-enterica-response-to-high-pressure-processing-reveals-a-diversity-of-responses-and-tolerance-mechanisms
#8
Sandeep Tamber
High pressure processing is a non-thermal method of food preservation that uses pressure to inactivate microorganisms. To ensure the effective validation of process parameters, it is important that the design of challenge protocols consider the potential for resistance in a particular species. Herein, the response of 99 diverse Salmonella enterica strains to high pressure is reported. Members of this population belong to one of 24 serovars and were isolated from various Canadian sources over a period of 26 years...
November 3, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29066141/evaluation-of-a-shoe-sole-uvc-device-to-reduce-pathogen-colonization-on-floors-surfaces-and-patients
#9
Tasnuva Rashid, Kelley Poblete, Jonathan Amadio, Irtiza Hasan, Khurshida Begum, M Jahangir Alam, Kevin W Garey
BACKGROUND: Recently, a UVC decontamination device has become available that delivers germicidal UVC radiation to shoe soles. The objective of this study were to demonstrate that shoe soles can be vectors for healthcare associated infection and whether a UVC shoe sole decontamination device would be effective at decreasing this risk. METHODOLOGY: Three bacterial strains (Staphylococcus aureus, Enterococcus faecalis, and Escherichia coli, and a non-toxigenic strain of Clostridium difficile were spiked onto standardized rubber soled shoe soles and then randomly selected to UVC exposure or no UVC exposure...
October 21, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29058966/high-level-isolation-unit-infection-control-procedures
#10
Jocelyn J Herstein, Paul D Biddinger, Shawn G Gibbs, Aurora B Le, Katelyn C Jelden, Angela L Hewlett, John J Lowe
The 2014-2016 Ebola outbreak in West Africa prompted a select group of US hospitals to establish high-level isolation units equipped with advanced engineering controls, trained staff, and stringent protocols to safely treat highly infectious disease patients. This survey details the comprehensive infection control protocols developed by these units, including for decontamination of units, post-mortem management, liquid waste disposal, and personal protective equipment (PPE) use. In spring 2016, a survey was electronically distributed to the 56 original Centers for Disease Control and Prevention (CDC)-designated high-level isolation units...
September 2017: Health Security
https://www.readbyqxmd.com/read/29046782/assessment-of-the-potential-for-resistance-to-antimicrobial-violet-blue-light-in-staphylococcus-aureus
#11
Rachael M Tomb, Michelle Maclean, John E Coia, Scott J MacGregor, John G Anderson
BACKGROUND: Antimicrobial violet-blue light in the region of 405 nm is emerging as an alternative technology for hospital decontamination and clinical treatment. The mechanism of action is the excitation of endogenous porphyrins within exposed microorganisms, resulting in ROS generation, oxidative damage and cell death. Although resistance to 405 nm light is not thought likely, little evidence has been published to support this. This study was designed to establish if there is potential for tolerance development, using the nosocomial pathogen Staphylococcus aureus as the model organism...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29033925/caco-2-invasion-by-cronobacter-sakazakii-and-salmonella-enterica-exposed-to-drying-and-heat-treatments-in-dried-state-in-milk-powder
#12
Emilie Lang, Stéphane Guyot, Pablo Alvarez-Martin, Jean-Marie Perrier-Cornet, Patrick Gervais
Due to the ability of foodborne pathogens to survive in low moisture food, the decontamination of milk powder is an important issue in food protection. The safety of food products is, however, not always insured and the different steps in the processing of food involve physiological and metabolic changes in bacteria. Among these changes, virulence properties may also be affected. In this study, the effect of drying and successive thermal treatments on the invasion capacity of Salmonella Typhimurium, Salmonella Senftenberg, and Cronobacter sakazakii was assessed...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29030192/polyvinyl-alcohol-sodium-alginate-integrated-silver-nanoparticles-as-probable-solution-for-decontamination-of-microbes-contaminated-water
#13
M A Abu-Saied, Tarek H Taha, Nehal M El-Deeb, Elsayed E Hafez
It is well known that the pathogenic multidrug resistant microbes are highly distributed and transferred to human through contaminated food and water. Advanced technologies have been developed for controlling these microbes using synthesized nanoparticles. In this study, biosynthesized silver nanoparticles were prepared, characterized and integrated with two synthetic and natural polymers. The polymers-silver nanoparticles were characterized using SEM, FTIR and mechanical properties of the membrane synthesized from either polymers with/without nanosilver...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29029980/sol-gel-derived-flexible-silica-aerogel-as-selective-adsorbent-for-water-decontamination-from-crude-oil
#14
A Abolghasemi Mahani, S Motahari, A Mohebbi
Oil spills are the most important threat to the sea ecosystem. The present study is an attempt to investigate the effects of sol-gel parameters on seawater decontamination from crude oil by use of flexible silica aerogel. To this goal, methyltrimethoxysilane (MTMS) based silica aerogels were prepared by two-step acid-base catalyzed sol-gel process, involving ambient pressure drying (APD) method. To investigate the effects of sol-gel parameters, the aerogels were prepared under two different acidic and basic pH values (i...
October 11, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29022219/photoreduction-of-cr-vi-in-water-using-bivo4-fe3o4-nano-photocatalyst-under-visible-light-irradiation
#15
Tingling Ke, Hongguang Guo, Yongli Zhang, Yang Liu
The residuals of hexavalent chromium in the aquatic environment have raised much concern for water decontamination. In this study, BiVO4-Fe3O4 was synthesized using a solvothermal method and adopted as a photoreduction catalyst to removal of Cr(VI) in water under visible light irradiation. The physical and chemical properties of BiVO4-Fe3O4 were characterized by UV-vis-DRS, SEM, XRD, FTIR, and BET. The results demonstrated that the band gap for the obtained material is 1.74 eV with an average size of 15 nm and a specific surface area of 55...
October 11, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28980926/insufficient-decontamination-in-sewage-treatment-plants-induce-the-risk-of-artificial-selection-of-extended-spectrum-%C3%AE-lactamase-producing-escherichia-coli
#16
A Gundogdu, H Kilic, C Kurekci, E Alp
Quantitative data about extended-spectrum beta-lactamase producing E. coli (ESBLEC) in the wastewaters are scarce, especially in developing countries. These data could be useful to raise awareness about the potential risk of spreading ESBLEC strains in the community. Water samples were collected weekly over a 10-week period, from one urban sewage treatment plant (STP), one rural STP and one hospital complex's wastewater (HWW) in Turkey. Mean E. coli and ESBLEC loads were determined for each sampling point. For the 580 ESBLEC isolated, antimicrobial resistance profiles, phylogenetic grouping, presence of common beta-lactamese-typesand integrons were studied using PCR...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28957385/additional-risk-of-diabetes-exceeds-the-increased-risk-of-cancer-caused-by-radiation-exposure-after-the-fukushima-disaster
#17
Michio Murakami, Masaharu Tsubokura, Kyoko Ono, Shuhei Nomura, Tomoyoshi Oikawa
The 2011 Fukushima disaster led to increases in multiple risks (e.g., lifestyle diseases and radiation exposure) and fear among the public. Here, we assessed the additional risks of cancer caused by radiation and diabetes related to the disaster and the cost-effectiveness of countermeasures against these conditions. Our study included residents of the cities of Minamisoma and Soma (10-40 km and 35-50 km north of the Fukushima Daiichi (N° 1) Nuclear Power Station, respectively). We used the loss of life expectancy (LLE) as an indicator to compare risks between radiation exposure and diabetes...
2017: PloS One
https://www.readbyqxmd.com/read/28894438/characterization-of-enterococcus-isolates-colonizing-the-intestinal-tract-of-intensive-care-unit-patients-receiving-selective-digestive-decontamination
#18
Teresita D J Bello Gonzalez, Phu Pham, Janetta Top, Rob J L Willems, Willem van Schaik, Mark W J van Passel, Hauke Smidt
Enterococci have emerged as important opportunistic pathogens in intensive care units (ICUs). In this study, enterococcal population size and Enterococcus isolates colonizing the intestinal tract of ICU patients receiving Selective Digestive Decontamination (SDD) were investigated. All nine patients included in the study showed substantial shifts in the enterococcal 16S rRNA gene copy number in the gut microbiota during the hospitalization period. Furthermore, 41 Enterococcus spp. strains were isolated and characterized from these patients at different time points during and after ICU hospitalization, including E...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28876132/removal-of-escherichia-coli-and-enterococcus-faecalis-after-hand-washing-with-antimicrobial-and-nonantimicrobial-soap-and-persistence-of-these-bacteria-in-rinsates
#19
J Pérez-Garza, S García, N Heredia
Food handlers are important sources of contamination in the agricultural environment. This study was conducted (i) to evaluate the activity of antimicrobial soaps against Escherichia coli and Enterococcus faecalis using a hand washing model with soiled hands and (ii) to determine the survival and persistence of these bacteria in rinsates. Sterilized agricultural soil from tomato and pepper farms was inoculated with E. coli or E. faecalis at 10(3) or 10(6) CFU/g. Decontaminated hands were placed in contact with contaminated soil for 2 min and were then washed with soaps with or without antimicrobial compounds (citric extracts, chloroxylenol, triclosan, or chlorhexidine gluconate)...
October 2017: Journal of Food Protection
https://www.readbyqxmd.com/read/28870727/selective-digestive-and-oropharyngeal-decontamination-in-medical-and-surgical-icu-patients-individual-patient-data-meta-analysis
#20
N L Plantinga, A M G A de Smet, E A N Oostdijk, E de Jonge, C Camus, W A Krueger, D Bergmans, J B Reitsma, M J M Bonten
OBJECTIVES: Selective digestive decontamination (SDD) and selective oropharyngeal decontamination (SOD) improved intensive care unit (ICU), hospital and 28-day survival in ICUs with low levels of antibiotic resistance. Yet it is unclear whether the effect differs between medical and surgical ICU patients. METHODS: In an individual patient data meta-analysis, we systematically searched PubMed and included all randomized controlled studies published since 2000. We performed a two-stage meta-analysis with separate logistic regression models per study and per outcome (hospital survival and ICU survival) and subsequent pooling of main and interaction effects...
September 1, 2017: Clinical Microbiology and Infection
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