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https://www.readbyqxmd.com/read/28340405/population-pharmacokinetic-modeling-of-furosemide-in-patients-with-hypertension-and-fluid-overload-conditions
#1
Devender Kodati, Narsimhareddy Yellu
BACKGROUND: Furosemide is a loop diuretic drug frequently indicated in hypertension and fluid overload conditions such as congestive heart failure and hepatic cirrhosis. OBJECTIVE: The purpose of the study was to establish a population pharmacokinetic model for furosemide in Indian hypertensive and fluid overload patients, and to evaluate effects of covariates on the volume of distribution (V/F) and oral clearance (CL/F) of furosemide. METHODS: A total of 188 furosemide plasma sample concentrations from 63 patients with hypertension or fluid overload conditions were collected in this study...
January 15, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28339984/the-link-between-phenotype-and-fatty-acid-metabolism-in-advanced-chronic-kidney-disease
#2
Dan-Qian Chen, Hua Chen, Lin Chen, Nosratola D Vaziri, Ming Wang, Xiang-Ri Li, Ying-Yong Zhao
Background.: The kidney plays a central role in elimination of metabolic waste products and regulation of low-molecular weight metabolites via glomerular filtration, tubular secretion and reabsorption. Disruption of these processes results in profound changes in the biochemical milieu of the body fluids, which contribute to complications of chronic kidney disease (CKD) by inducing cytotoxicity and inflammation. Insight into the changes of the composition of metabolites and dysregulation of target genes and proteins enhances the understanding of the pathophysiology of CKD and its complications, and the development of novel therapeutic strategies...
March 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339737/a-novel-chronic-opioid-monitoring-tool-to-assess-prescription-drug-steady-state-levels-in-oral-fluid
#3
Naum Shaparin, Neel Mehta, Frank Kunkel, Richard Stripp, Damon Borg, Elizabeth Kolb
Objective. : Interpretation limitations of urine drug testing and the invasiveness of blood toxicology have motivated the desire for the development of simpler methods to assess biologically active drug levels on an individualized patient basis. Oral fluid is a matrix well-suited for the challenge because collections are based on simple noninvasive procedures and drug concentrations better correlate to blood drug levels as oral fluid is a filtrate of the blood. Well-established pharmacokinetic models were utilized to generate oral fluid steady state concentration ranges to assess the interpretive value of the alternative matrix to monitor steady state plasma oxycodone levels...
February 23, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28338408/clofazimine-encapsulation-in-nanoporous-silica-particles-for-the-oral-treatment-of-antibiotic-resistant-mycobacterium-tuberculosis-infections
#4
Sabrina Valetti, Xin Xia, Joana Costa-Gouveia, Priscille Brodin, Marie-Françoise Bernet-Camard, Margareta Andersson, Adam Feiler
AIM: First extensive reformulation of clofazimine (CLZ) in nanoporous silica particles (NSPs) for tackling antibiotic-resistant tuberculosis (TB) infections. MATERIALS & METHODS: Solid-state characterization of several CLZ-encapsulated NSP formulations was followed by in vitro drug solubility, Caco-2 intestinal cells drug permeability and TB antibacterial activity. RESULTS: NSPs stabilize the amorphous state of CLZ (shelf stability >6 months) and dramatically increase the drug solubility in simulated gastric fluid (up to 20-fold) with different dissolution kinetics depending on the NSPs used...
March 24, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28338391/modifications-in-human-oral-fibroblast-ultrastructure-collagen-production-and-lysosomal-compartment-in-response-to-e-cigarette-fluids
#5
Silvia Sancilio, Marialucia Gallorini, Amelia Cataldi, Laura Sancillo, Rosa Alba Rana, Viviana di Giacomo
Background Many smokers have recently turned to electronic cigarettes (e-cigarettes) because they have been marketed as a cheaper and safer smokeless alternative to traditional cigarettes, and a possible smoking cessation tool. Even though the safety of these electronic devices is still not fully known, there is evidence of their cytotoxicity on cells which belong to the oral cavity. In a previous paper the increase of reactive oxygen production and Bax expression, followed by the occurrence of apoptosis, were demonstrated in human gingival fibroblasts...
March 24, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28338159/-application-of-multimodal-analgesia-in-radical-gastrectomy-for-gastric-cancer-patients-a-prospective-nonrandomized-controlled-study
#6
Wei Zhang, Ka Li, Weihan Zhang, Fei Liu, Kai Liu, Xiaohai Song, Xinzu Chen, Kun Yang, Jiankun Hu
OBJECTIVE: To compare the postoperative analgesia efficacy, rehabilitation parameters and complication between multimodal analgesia and traditional analgesia after radical gastrectomy for gastric cancer patients. METHODS: Patients with gastric cancer who underwent surgery in our hospital from October 2016 to December 2016 were enrolled in this prospective study. According to the non-randomized method, patients were assigned to multimodal analgesia group(n=32) and traditional analgesia group(n=33) in gastric cancer treatment team A and B in Department of Gastrointestinal Surgery, West China Hospital, Sichuan University...
March 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28337902/helicobacter-pylori-in-periodontal-pockets-and-saliva-a-possible-role-in-gastric-infection-relapses
#7
L Azzi, F Carinci, S Gabaglio, F Cura, F Croveri, L Tettamanti, A Tagliabue, S Segato
It has been a long time since the scientific community started to speculate upon the presence of Helicobacter pylori (HP) in periodontal pockets as an extra-gastric reservoir responsible for gastric relapses after eradication therapy. The aim of this study is to evaluate the presence of oral HP in a group of patients who underwent examination for gastric infection. Sixty patients were enrolled in the current study, subdivided into two groups: 30 patients with a positive result for HP gastric infection with C-Breath Test Urea examination, and 30 patients with a negative result for HP gastric infection...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28336238/hydropneumothorax-due-to-esophageal-rupture
#8
Joseph R Shiber, Emily Fontane, Jin H Ra, Andrew J Kerwin
BACKGROUND: A brief review of the historical aspects of esophageal rupture is presented along with a case and current recommendations for diagnostic evaluation and treatment. CASE REPORT: A 97-year-old woman complained of acute dyspnea without prior vomiting. Chest x-ray study showed a large right pneumothorax with associated effusion. A thoracostomy tube was placed with return of > 1 L turbid fluid with polymicrobial culture and elevated pleural fluid amylase level...
March 20, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28334841/oral-fluid-testing-for-cocaine-analytical-evaluation-of-two-point-of-collection-drug-screening-devices
#9
Juliana Nichterwitz Scherer, Taís Regina Fiorentin, Tanara Rosangela Vieira Sousa, Renata Pereira Limberger, Flavio Pechansky
The use of point-of-collection testing (POCT) devices for drugs of abuse in oral fluid (OF) is an advantageous tool that has been used for different purposes-particularly traffic enforcement. However, even with the widespread report of cocaine consumption, the reliability of POCT devices has been reported in different magnitudes. This study evaluated the reliability of two POCT devices for the detection of cocaine in OF samples of 110 cocaine users: (i) the DDS2™ (cutoff = 30 ng/mL) and (ii) the Multi-Drugs Multi-Line-Twist Screen Test Device™ (MDML) (cutoff = 20 ng/mL)...
February 27, 2017: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/28334434/withdrawn-nutrition-support-for-bone-marrow-transplant-patients
#10
REVIEW
Susan M Murray, Sima Pindoria
BACKGROUND: This is an update of the original Cochrane review published in Issue 2, 2002. Bone marrow transplantation involves administration of toxic chemotherapy and infusion of marrow cells. After treatment, patients can develop poor appetite, mucositis and gastrointestinal failure, leading to malnutrition. To prevent this, parenteral nutrition (PN) support is often first choice but is associated with increased risk of infection. Enteral nutrition (EN) is an alternative, as is addition of substrates...
March 23, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28332406/continuous-glucose-monitor-interference-with-commonly-prescribed-medications
#11
Ananda Basu, Michael Q Slama, Wayne T Nicholson, Loralie Langman, Thomas Peyser, Rickey Carter, Rita Basu
BACKGROUND: Reliability of continuous glucose monitors (CGM) is a prerequisite for therapeutic dosing of insulin without the need for confirmatory blood glucose meter measurements. Interference of CGMs with commonly prescribed substances has not been extensively evaluated. METHODS: We sought to undertake a novel pilot study to determine the susceptibility of FDA-approved CGM systems (Medtronic Guardian Sof-Sensor, Dexcom G4 Platinum) to erroneous readings in the presence of common medications...
March 1, 2017: Journal of Diabetes Science and Technology
https://www.readbyqxmd.com/read/28332299/the-use-of-on-line-sfe-sfc-ms-ms-to-analyze-disease-biomarkers-in-dried-serum-spots-compared-with-serum-analysis-using-lc-ms-ms
#12
Makoto Suzuki, Shin Nishiumi, Takashi Kobayashi, Arata Sakai, Yosuke Iwata, Takato Uchikata, Yoshihiro Izumi, Takeshi Azuma, Takeshi Bamba, Masaru Yoshida
RATIONALE: The analytical stability and throughput of biomarker assays based on dried serum spots (DSS) are strongly dependent on the extraction process and determination method. In the present study, an on-line system based on supercritical fluid extraction-supercritical fluid chromatography coupled with tandem mass spectrometry (SFE-SFC/MS/MS) was established for analyzing the levels of disease biomarkers in DSS. METHODS: The chromatographic conditions were investigated using the ODS-EP, diol, and SIL-100A columns...
March 23, 2017: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/28325626/group-b-streptococcal-necrotizing-pneumonia-in-a-diabetic-adult-patient
#13
Andrea Pacha, Ramiro Luna Cian, Laura Bonofiglio, Melisa Solari, Virginia Strada, Mariana Suárez, Laura Vigliarolo, Carina Tersigni, Marta Mollerach, Horacio Lopardo
The aim of this report is to describe a rare case of necrotizing pneumonia due to group B Streptococcus serotype III in a relatively young male adult (48 years old) suffering from diabetes. The organism was isolated from his pleural fluid and was only resistant to tetracycline. The patient first received ceftazidime (2g/8h i.v.)+clindamycin (300mg/8h) for 18 days and then he was discharged home and orally treated with amoxicillin clavulanic acid (1g/12h) for 23 days with an uneventful evolution. As in the cases of invasive infection by Streptococcus pyogenes, clindamycin could prevent streptococcal toxic shock syndrome...
March 18, 2017: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/28325339/toward-novel-antiparasitic-formulations-complexes-of-albendazole-desmotropes-and-%C3%AE-cyclodextrin
#14
Ana K Chattah, Laura Y Pfund, Ariana Zoppi, Marcela R Longhi, Claudia Garnero
Novel complexes of two different solid forms of Albendazol and β-cyclodextrin were investigated in an attempt to obtain promising candidates for the preparation of alternative matrices used in pharmaceutical oral formulations. The interaction between each form of Albendazol and β-cyclodextrin was studied in solution and solid state, in order to investigate their effect on the solubility and dissolution rate of Albendazol solid forms. The solid supramolecular systems were characterized using a variety of techniques including natural-abundance (13)C cross-polarization magic-angle-spinning nuclear magnetic resonance, powder X-ray diffraction, Fourier transform-infrared spectroscopy and scanning electron microscopy...
May 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28322885/fluoride-concentration-in-saliva-and-biofilm-fluid-following-the-application-of-three-fluoride-varnishes
#15
L Al Dehailan, F Lippert, C González-Cabezas, G J Eckert, E A Martinez-Mier
OBJECTIVE: Most of the commercially available fluoride varnishes (FV) have not been evaluated for their cariostatic properties. Consequently, the aim of this in vivo study was to investigate intra-oral fluoride retention and clearance patterns from three different FV. METHODS: Eighteen subjects (7-11 years) participated in a laboratory analyst-blinded, randomized, crossover study comparing the ability of 5% sodium fluoride varnishes (CavityShield-CS, Enamel Pro-EP, Vanish-V) to enhance fluoride concentrations in biofilm fluid, centrifuged and whole saliva over a period of 48h after a single FV application...
March 16, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28322297/standardized-herbal-formula-pm014-inhibits-radiation-induced-pulmonary-inflammation-in-mice
#16
Jee-Youn Kim, Dasom Shin, Gihyun Lee, Jin-Mo Kim, Dongwook Kim, Yong-Min An, Byung Rok Yoo, Hanna Chang, Miran Kim, Jaeho Cho, Hyunsu Bae
Radiation therapy is widely used for thoracic cancers. However, it occasionally causes radiation-induced lung injuries, including pneumonitis and fibrosis. Chung-Sang-Bo-Ha-Tang (CSBHT) has been traditionally used to treat chronic pulmonary disease in Korea. PM014, a modified herbal formula derived from CSBHT, contains medicinal herbs of seven species. In our previous studies, PM014 exhibited anti-inflammatory effects in a chronic obstructive pulmonary disease model. In this study, we have evaluated the effects of PM014 on radiation-induced lung inflammation...
March 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28321337/salivary-distinctiveness-and-modifications-in-males-with-diabetes-and-beh%C3%A3-et-s-disease
#17
Loai Aljerf, Iyad Alhaffar
Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to Behçet disease (BD) on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca(2+) and Mg(2+)) compared to healthy males and age-matched controls...
2017: Biochemistry Research International
https://www.readbyqxmd.com/read/28320354/slow-progress-in-diarrhea-case-management-in-low-and-middle-income-countries-evidence-from-cross-sectional-national-surveys-1985-2012
#18
Chandrashekhar T Sreeramareddy, Yue-Peng Low, Birger Carl Forsberg
BACKGROUND: Diarrhea remains to be a main cause of childhood mortality. Diarrhea case management indicators reflect the effectiveness of child survival interventions. We aimed to assess time trends and country-wise changes in diarrhea case management indicators among under-5 children in low-and-middle-income countries. METHODS: We analyzed aggregate data from Demographic and Health Surveys and Multiple Indicator Cluster Surveys done from 1986 to 2012 in low-and-middle-income countries...
March 21, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28320026/-alcohol-withdrawal-and-its-major-complications
#19
Klaus Junghanns, Tilman Wetterling
Delirium tremens is one of the most common complications of alcohol withdrawal. It is potentially lethal and therefore should be detected as early as possible and be monitored and treated intensively. The assessment of risk factors with the Luebeck Alcohol-Withdrawal Risk Scale short form (LARS-11) can help to predict the risk of severe withdrawal adequately. As delirium cannot be differentiated from Wernicke-Encephalopathy with sufficient certainty high parenteral doses of Vitamin B1 and Magnesium orally should be given in case of any severe withdrawal symptoms...
March 2017: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/28319546/gastric-fluid-volume-change-after-oral-rehydration-solution-intake-in-morbidly-obese-and-normal-controls-a-magnetic-resonance-imaging-based-analysis
#20
Toshie Shiraishi, Dai Kurosaki, Mitsuyo Nakamura, Taiji Yazaki, Satomi Kobinata, Yosuke Seki, Kazunori Kasama, Hideki Taniguchi
BACKGROUND: Although preoperative fluid intake 2 hours before anesthesia is generally considered safe, there are concerns about delayed gastric emptying in obese subjects. In this study, the gastric fluid volume (GFV) change in morbidly obese subjects was investigated after ingesting an oral rehydration solution (ORS) and then compared with that in nonobese subjects. METHODS: GFV change over time after the ingestion of 500 mL of ORS containing 2.5% carbohydrate (OS-1) was measured in 10 morbidly obese subjects (body mass index [BMI], >35) scheduled for bariatric surgery and 10 nonobese (BMI, 19-24) using magnetic resonance imaging...
April 2017: Anesthesia and Analgesia
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