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https://www.readbyqxmd.com/read/27904235/management-of-acute-work-related-shoulder-injuries-by-an-early-shoulder-assessment-program-efficiency-of-imaging-investigations
#1
Helen Razmjou, Sandra Lincoln, Christopher Geddes, Dragana Boljanovic, Iona Macritchie, Caterina Virdo-Cristello, Danielle Medeiros, Robin R Richards
Purpose: There has been a significant increase in the number of costly investigations of the shoulder joint over the past decade. The purposes of this study were to (1) describe the diagnostic imaging investigations ordered for injured workers seen at an Early Shoulder Physician Assessment (ESPA) program, (2) evaluate the impact of these investigations on final diagnosis and management, and (3) examine how efficient the program was by determining the appropriateness of referrals and whether costly imaging was justified...
2016: Physiotherapy Canada. Physiothérapie Canada
https://www.readbyqxmd.com/read/27899382/a-metastatic-mouse-model-identifies-genes-that-regulate-neuroblastoma-metastasis
#2
Bo Kyung Alex Seong, Kelly E Fathers, Robin M Hallett, Christina K Yung, Lincoln D Stein, Samar Mouaaz, Lynn Kee, Cynthia Hawkins, Meredith S Irwin, David R Kaplan
Metastatic relapse is the major cause of death in pediatric neuroblastoma (NB), where there remains a lack of therapies to target this stage of disease. To understand the molecular mechanisms mediating NB metastasis, we developed a mouse model using intracardiac injection and in vivo selection to isolate malignant cell subpopulations with a higher propensity for metastasis to bone and the central nervous system. Gene expression profiling revealed primary and metastatic cells as two distinct cell populations defined by differential expression 412 genes and multiple pathways, including CADM1, SPHK1 and YAP/TAZ whose expression independently predicted survival...
November 29, 2016: Cancer Research
https://www.readbyqxmd.com/read/27896972/data-sharing-and-reproducible-clinical-genetic-testing-successes-and-challenges
#3
Shan Yang, Melissa Cline, Can Zhang, Benedict Paten, Stephen E Lincoln
Open sharing of clinical genetic data promises to both monitor and eventually improve the reproducibility of variant interpretation among clinical testing laboratories. A significant public data resource has been developed by the NIH ClinVar initiative, which includes submissions from hundreds of laboratories and clinics worldwide. We analyzed a subset of ClinVar data focused on specific clinical areas and we find high reproducibility (>90% concordance) among labs, although challenges for the community are clearly identified in this dataset...
2016: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/27888303/dual-energy-ct-workflow-multi-institutional-consensus-on-standardization-of-abdominopelvic-mdct-protocols
#4
Bhavik N Patel, Lauren Alexander, Brian Allen, Lincoln Berland, Amir Borhani, Achille Mileto, Courtney Moreno, Desiree Morgan, Dushyant Sahani, William Shuman, Eric Tamm, Mitchell Tublin, Benjamin Yeh, Daniele Marin
PURPOSE: To standardize workflow for dual-energy computed tomography (DECT) involving common abdominopelvic exam protocols. MATERIALS AND METHODS: 9 institutions (4 rsDECT, 1 dsDECT, 4 both) with 32 participants [average # years (range) in practice and DECT experience, 12.3 (1-35) and 4.6 (1-14), respectively] filled out a single survey (n = 9). A five-point agreement scale (0, 1, 2, 3, 4-contra-, not, mildly, moderately, strongly indicated, respectively) and utilization scale (0-not performing and shouldn't; 1-performing but not clinically useful; 2-performing but not sure if clinically useful; 3-not performing it but would like to; 4-performing and clinically useful) were used...
November 25, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27876480/noise-dosimetry-for-tactical-environments
#5
Christopher J Smalt, Joe Lacirignola, Shakti K Davis, Paul T Calamia, Paula P Collins
Noise exposure and the subsequent hearing loss are well documented aspects of military life. Numerous studies have indicated high rates of noise-induced hearing injury (NIHI) in active-duty service men and women, and recent statistics from the U.S. Department of Veterans Affairs indicate a population of veterans with hearing loss that is growing at an increasing rate. In an effort to minimize hearing loss, the U.S. Department of Defense (DoD) updated its Hearing Conservation Program in 2010, and also has recently revised the DoD Design Criteria Standard Noise Limits (MIL-STD-1474E) which defines allowable noise levels in the design of all military acquisitions including weapons and vehicles...
November 20, 2016: Hearing Research
https://www.readbyqxmd.com/read/27875625/clinical-and-genetic-determinants-of-ovarian-metastases-from-colorectal-cancer
#6
Karuna Ganesh, Ronak H Shah, Efsevia Vakiani, Garrett M Nash, Hugh P Skottowe, Rona Yaeger, Andrea Cercek, Anne Lincoln, Christina Tran, Neil H Segal, Diane L Reidy, Anna Varghese, Andrew S Epstein, Yukio Sonoda, Dennis Chi, Jose Guillem, Larissa Temple, Philip Paty, Jaclyn Hechtman, Jinru Shia, Martin Weiser, Julio Garcia Aguilar, Nancy Kemeny, Michael F Berger, Leonard Saltz, Zsofia K Stadler
BACKGROUND: Ovarian metastases from colorectal cancer (OM-CRC) often are unresponsive to chemotherapy and are associated with poor survival. To the authors' knowledge, the clinicopathologic and genomic predictors of OM-CRC are poorly characterized and optimal clinical management remains unclear. METHODS: Women with a histopathological diagnosis of OM-CRC who were treated at Memorial Sloan Kettering Cancer Center from 1999 to 2015 were identified. Next-generation somatic mutation profiling (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets [MSK-IMPACT]) was performed on 38 OM-CRC cases, including 21 matched tumor pairs/trios...
November 22, 2016: Cancer
https://www.readbyqxmd.com/read/27869625/asymptomatic-pseudotumors-in-patients-with-taper-corrosion-of-a-dual-taper-modular-femoral-stem-mars-mri-and-metal-ion-study
#7
Young-Min Kwon, Sariah Khormaee, Ming Han Lincoln Liow, Tsung-Yuan Tsai, Andrew A Freiberg, Harry E Rubash
BACKGROUND: Modularity in total hip arthroplasty facilitates intraoperative restoration of patient anatomy. Although dual-taper modular total hip arthroplasty offers potential advantages for optimizing the hip center of rotation, it has been associated with modular taper corrosion. This corrosion has led to adverse local tissue reactions (pseudotumors) at the neck-stem junction and elevated metal-ion levels. However, the occurrence of taper-corrosion-related pseudotumors in patients who remain asymptomatic following total hip arthroplasty with a dual-taper modular femoral stem remains largely unknown...
October 19, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27869333/patient-specific-3d-flair-for-enhanced-visualization-of-brain-white-matter-lesions-in-multiple-sclerosis
#8
Refaat E Gabr, Amol S Pednekar, Koushik A Govindarajan, Xiaojun Sun, Roy F Riascos, María G Ramírez, Khader M Hasan, John A Lincoln, Flavia Nelson, Jerry S Wolinsky, Ponnada A Narayana
PURPOSE: To improve the conspicuity of white matter lesions (WMLs) in multiple sclerosis (MS) using patient-specific optimization of single-slab 3D fluid-attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI). MATERIALS AND METHODS: Sixteen MS patients were enrolled in a prospective 3.0T MRI study. FLAIR inversion time and echo time were automatically optimized for each patient during the same scan session based on measurements of the relative proton density and relaxation times of the brain tissues...
November 21, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27863515/feasibility-trial-of-a-scalable-psychological-intervention-for-women-affected-by-urban-adversity-and-gender-based-violence-in-nairobi
#9
Katie S Dawson, Alison Schafer, Dorothy Anjuri, Lincoln Ndogoni, Caroline Musyoki, Marit Sijbrandij, Mark van Ommeren, Richard A Bryant
BACKGROUND: Living in conditions of chronic adversity renders many women more vulnerable to experiencing gender-based violence (GBV). In addition to GBV's physical and social consequences, the psychological effects can be pervasive. Access to evidence-based psychological interventions that seek to support the mental health of women affected by such adversity is rare in low- and middle-income countries. METHODS: The current study evaluates a brief evidence-informed psychological intervention developed by the World Health Organization for adults impacted by adversity (Problem Management Plus; PM+)...
November 18, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27863311/concordance-of-self-and-observer-rated-motivation-and-pleasure-in-patients-with-negative-symptoms-and-healthy-controls
#10
Maike Engel, Tania M Lincoln
This study examined the validity of using a self-rating scale for assessing the motivation and pleasure domain of negative symptoms in the general population by examining the concordance of self- and observer-rated negative symptoms in a healthy sample and by comparing it with a patient sample. The motivation and pleasure domain of negative symptoms was assessed using the observer-rated Clinical Assessment Interview for Negative Symptoms (CAINS) and the self-rated Motivation and Pleasure Scale-Self-Report (MAP-SR)...
November 11, 2016: Psychiatry Research
https://www.readbyqxmd.com/read/27862088/prognostic-dilemmas-and-genetic-counseling-for-prenatally-detected-fragile-x-gene-expansions
#11
Brenda Finucane, Sharyn Lincoln, Lindsay Bailey, Christa Lese Martin
With widespread adoption of fragile X carrier screening in pregnant women, the number of expectant couples receiving news of an unanticipated Fragile X Mental Retardation 1 (FMR1) gene expansion has increased. The most common abnormal result from maternal FMR1 testing involves an intermediate allele, also known as a gray zone result, which requires genetic counseling but poses minimal risk for an adverse developmental outcome. By contrast, the finding of a maternal FMR1 pre- or full mutation during pregnancy has important implications for the woman herself, her unborn child, and her extended family...
November 11, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27851734/erratum-a-renewed-model-of-pancreatic-cancer-evolution-based-on-genomic-rearrangement-patterns
#12
Faiyaz Notta, Michelle Chan-Seng-Yue, Mathieu Lemire, Yilong Li, Gavin W Wilson, Ashton A Connor, Robert E Denroche, Sheng-Ben Liang, Andrew M K Brown, Jaeseung C Kim, Tao Wang, Jared T Simpson, Timothy Beck, Ayelet Borgida, Nicholas Buchner, Dianne Chadwick, Sara Hafezi-Bakhtiari, John E Dick, Lawrence Heisler, Michael A Hollingsworth, Emin Ibrahimov, Gun Ho Jang, Jeremy Johns, Lars G T Jorgensen, Calvin Law, Olga Ludkovski, Ilinca Lungu, Karen Ng, Danielle Pasternack, Gloria M Petersen, Liran I Shlush, Lee Timms, Ming-Sound Tsao, Julie M Wilson, Christina K Yung, George Zogopoulos, John M S Bartlett, Ludmil B Alexandrov, Francisco X Real, Sean P Cleary, Michael H Roehrl, John D McPherson, Lincoln D Stein, Thomas J Hudson, Peter J Campbell, Steven Gallinger
No abstract text is available yet for this article.
November 16, 2016: Nature
https://www.readbyqxmd.com/read/27850712/1074-severity-of-hemodynamic-instability-around-high-dose-vasoactive-syringe-changes-in-the-picu
#13
Roman Gusztak, Susan Hamilton, Mary-Jeanne Manning, Patricia Lincoln, Brian Walsh, Daniel Kohane, Nilesh Mehta
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850594/956-a-mortality-prediction-model-for-pediatric-acute-respiratory-distress-syndrome
#14
Robinder Khemani, Lincoln Smith, Kaushik Parvathaneni, Nelson Sanchez-Pinto, Christopher Newth
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27832920/piezoelectric-compared-with-conventional-rotary-osteotomy-for-the-prevention-of-postoperative-sequelae-and-complications-after-surgical-extraction-of-mandibular-third-molars-a-systematic-review-and-meta-analysis
#15
REVIEW
E K Badenoch-Jones, M David, T Lincoln
The purpose of this review was to determine if postoperative sequelae (facial swelling, trismus, pain) and neurological complications are reduced when mandibular third molars are surgically extracted using a piezoelectric device for osteotomy compared with conventional rotary burs, and to determine if there is a difference in operating time between the two techniques. Clinical trials were identified through a search (April 2015) on the PubMed, EMBASE, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases...
November 7, 2016: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/27829783/peptide-redesign-for-inhibition-of-the-complement-system-targeting-age-related-macular-degeneration
#16
Rohith R Mohan, Andrea P Cabrera, Reed E S Harrison, Ronald D Gorham, Lincoln V Johnson, Kaustabh Ghosh, Dimitrios Morikis
PURPOSE: To redesign a complement-inhibiting peptide with the potential to become a therapeutic for dry and wet age-related macular degeneration (AMD). METHODS: We present a new potent peptide (Peptide 2) of the compstatin family. The peptide is developed by rational design, based on a mechanistic binding hypothesis, and structural and physicochemical properties derived from molecular dynamics (MD) simulation. The inhibitory activity, efficacy, and solubility of Peptide 2 are evaluated using a hemolytic assay, a human RPE cell-based assay, and ultraviolet (UV) absorption properties, respectively, and compared to the respective properties of its parent peptide (Peptide 1)...
2016: Molecular Vision
https://www.readbyqxmd.com/read/27824670/white-paper-of-the-society-of-computed-body-tomography-and-magnetic-resonance-on-dual-energy-ct-part-4-abdominal-and-pelvic-applications
#17
Carlo N De Cecco, Daniel T Boll, David N Bolus, W Dennis Foley, Ravi K Kaza, Desiree E Morgan, Neil M Rofsky, Dushyant V Sahani, U Joseph Schoepf, William P Shuman, Marilyn J Siegel, Terri J Vrtiska, Benjamin M Yeh, Lincoln L Berland
This is the fourth of a series of 4 white papers that represent expert consensus documents developed by the Society of Computed Body Tomography and Magnetic Resonance through its task force on dual-energy computed tomography. This article, part 4, discusses DECT for abdominal and pelvic applications and, at the end of each, will offer our consensus opinions on the current clinical utility of the application and opportunities for further research.
November 7, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27803569/structural-challenges-of-providing-palliative-care-for-patients-with-breast-cancer
#18
Tahereh Alsadat Khoubbin Khoshnazar, Maryam Rassouli, Mohammad Esmaeil Akbari, Farah Lotfi-Kashani, Syrus Momenzadeh, Shahpar Haghighat, Moosa Sajjadi
INTRODUCTION: To establish a palliative care system (PCS) in Iran, it is necessary to identify the potential barriers. AIM: This study aims to highlight the views of stakeholders to know the challenges of providing palliative care for women with breast cancer. MATERIALS AND METHODS: Semi-structured in-depth interviews are used with purposeful sampling conducted in Tehran, Iran; from January to June 2015. Twenty participants were included in the study: nine patients with breast cancer and ten health-care providers...
October 2016: Indian Journal of Palliative Care
https://www.readbyqxmd.com/read/27803356/bullying-mediates-between-attention-deficit-hyperactivity-disorder-in-childhood-and-psychotic-experiences-in-early-adolescence
#19
Timo Hennig, Edo S Jaya, Tania M Lincoln
Although a childhood diagnosis of attention-deficit/hyperactivity disorder (ADHD) is known to be linked to psychotic experiences and psychotic disorders in later life, the developmental trajectories that could explain this association are unknown. Using a sample from the prospective population-based Avon Longitudinal Study of Parents and Children (ALSPAC) (N = 8247), we hypothesized that the previously reported association of ADHD combined subtype in childhood and psychotic experiences in early adolescence is mediated by traumatic events and by involvement in bullying...
November 1, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27800468/effectiveness-of-chitosan-films-impregnated-with-ciprofloxacin-for-the-prophylaxis-of-osteomyelitis-in-open-fractures-an-experimental-study-in-rats
#20
Lincoln Paiva Costa, Luiz Eduardo Moreira Teixeira, Gustavo Silame Maranhão Lima, Marcelo Mendes Ferreira, Mateus Antunes de Andrade, Paula Vieira Teixeira Vidigal, André Augusto Gomes Faraco, Eduardo Frois Temponi, Ivana Duval de Araújo
BACKGROUND: The systemic antimicrobial prophylaxis is the standard treatment in the prevention of osteomyelitis after open fractures, with topical application of antimicrobials as an alternative due to their high concentrations at the site of the fracture, low systemic concentrations and fewer side effects. OBJECTIVES: This study aimed to evaluate the effectiveness of prophylaxis of osteomyelitis through experimental model of open fractures with the use of chitosan films, whether or not impregnated with ciprofloxacin...
September 2016: Archives of Trauma Research
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