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Brian Gibbs, Lincoln Shenje, Peter Andersen, Matthew Miyamoto, Chulan Kwon
Proper control of multipotent/stem cell number and fate is essential for ensuing organ formation during development. β1-integrin, a subfamily of cell surface receptors, has a conserved role in maintenance of multipotent/stem cells, including renal progenitor cells, follicle stem cells, epidermal stem cells and neural stem cells. However, it remains unclear whether β1-integrin has a role in cardiac progenitor cell (CPC) development. Here we show that a mesodermal deletion of β1-integrin decreases Isl1+ cell number in the second pharyngeal arch (PA2), where CPCs undergo renewal and expansion...
April 10, 2018: Biochemical and Biophysical Research Communications
Beth Lincoln
No abstract text is available yet for this article.
May 2018: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
Lana E Greene, Richard Lincoln, Gonzalo Cosa
Lipid peroxidation of polyunsaturated fatty acids in cells may occur via their catalytic autoxidation through peroxyl radicals under oxidative stress conditions. Lipid peroxidation is related to a number of pathologies, and may be invoked in new forms of regulated cell death, yet it may also have beneficial roles in cell signaling cascades. Antioxidants are a natural line of defense against lipid peroxidation, and may accordingly impact the biological outcome associated with the redox chemistry of lipid peroxidation...
April 9, 2018: Free Radical Biology & Medicine
Anna K F Mårtensson, Per Lincoln
Isothermal titration calorimetry (ITC) has been utilized to investigate the effect of methyl substituents on the intercalating dppz ligand of the enantiomers of the parent complex Ru(phen)2dppz2+ (phen = 1,10-phenanthroline; dppz = dipyrido[3,2-a:2',3'-c]phenazine) on DNA binding thermodynamics. The methylated complexes (10-methyl-dppz and 11,12-dimethyl-dppz) have large, concentration-dependent, positive heats of dilution, and a strong endothermic background is also apparent in the ITC-profiles from titration of methylated complexes into poly(dAdT)2, which make direct comparison between complexes difficult...
April 12, 2018: Physical Chemistry Chemical Physics: PCCP
Graham Seow-Hng Goh, Ming Han Lincoln Liow, Hee-Nee Pang, Darren Keng-Jin Tay, Ngai-Nung Lo, Seng-Jin Yeo
BACKGROUND: The relationship between mental health and outcomes of unicompartmental knee arthroplasty (UKA) remains unclear. Poor preoperative mental health may be caused by pain and functional limitations associated with knee arthritis. We aimed at (1) investigating the effect of preoperative mental health on early outcomes and (2) assessing whether mental health improves after UKA. METHODS: Prospectively collected registry data of 1473 medial UKAs performed at a single institution in 2007-2014 were reviewed...
February 26, 2018: Journal of Arthroplasty
Lutz Wartberg, Levente Kriston, Matthias Zieglmeier, Tania Lincoln, Rudolf Kammerl
BACKGROUND: In 2013, Internet gaming disorder (IGD) was incorporated in the current version of the DSM-5. IGD refers to a problematic use of video games. Longitudinal studies on the etiology of IGD are lacking. Furthermore, it is currently unclear to which extent associated psychopathological problems are causes or consequences of IGD. In the present survey, longitudinal associations between IGD and adolescent and parental mental health were investigated for the first time, as well as the temporal stability of IGD...
April 6, 2018: Psychological Medicine
Amir H Kashani, Jane S Lebkowski, Firas M Rahhal, Robert L Avery, Hani Salehi-Had, Wei Dang, Chih-Min Lin, Debbie Mitra, Danhong Zhu, Biju B Thomas, Sherry T Hikita, Britney O Pennington, Lincoln V Johnson, Dennis O Clegg, David R Hinton, Mark S Humayun
Retinal pigment epithelium (RPE) dysfunction and loss are a hallmark of non-neovascular age-related macular degeneration (NNAMD). Without the RPE, a majority of overlying photoreceptors ultimately degenerate, leading to severe, progressive vision loss. Clinical and histological studies suggest that RPE replacement strategies may delay disease progression or restore vision. A prospective, interventional, U.S. Food and Drug Administration-cleared, phase 1/2a study is being conducted to assess the safety and efficacy of a composite subretinal implant in subjects with advanced NNAMD...
April 4, 2018: Science Translational Medicine
Lincoln L Berland, Nancy W Berland, Matthew W Berland
Changes in the certification program of the ABR were first described in some detail in 2008 and have since undergone refinements. Controversies surrounding these changes have included the relevance of test questions, costs, effects of altering the examination scheduling, residency program curriculum changes, and issues related to preparing for the examinations. However, the role of psychometric testing in radiology itself, as the technical foundation for the new ABR Core and Certification Examinations, has undergone less scrutiny...
March 31, 2018: Journal of the American College of Radiology: JACR
Arash Kamali, Roy F Riascos, Jay J Pillai, Haris I Sair, Rajan Patel, Flavia M Nelson, John A Lincoln, Nitin Tandon, Saeedeh Mirbagheri, Pejman Rabiei, Zafer Keser, Khader M Hasan
Although the thalamus is not considered primarily as a limbic structure, abundant evidence indicates the essential role of the thalamus as a modulator of limbic functions indirectly through the amygdala. The amygdala is a central component of the limbic system and serves an essential role in modulating the core processes including the memory, decision-making, and emotional reactions. The amygdalothalamic pathway is the largest direct amygdalo-diencephalic connection in the primates including the human brain...
April 1, 2018: Journal of Neuroscience Research
Ho Yee Tiong, Benjamin Yen Seow Goh, Edmund Chiong, Lincoln Guan Lim Tan, Anatharaman Vathsala
Robotic-assisted kidney transplantation (RKT) with the Da Vinci (Intuitive, USA) platform has been recently developed to improve outcomes by decreasing surgical site complications and morbidity, especially in obese patients. This potential paradigm shift in the surgical technique of kidney transplantation is performed in only a few centers. For wider adoption of this high stake complex operation, we aimed to develop a procedure-specific simulation platform in a porcine model for the training of robotic intracorporeal vascular anastomosis and evaluating vascular anastomoses patency...
March 31, 2018: Journal of Robotic Surgery
James E Lincoln, Juan P Sanchez, Kristina Zumstein, David G Gilchrist
A role for programmed cell death (PCD) has been established as the basis for plant-microbe interactions. A functional plant-based cDNA library screen identified possible anti-PCD genes including one member of the PR1 family, designated P14a from tomato. Members of the PR1 family have been subject to extensive research in view of their possible role in resistance against pathogens. The PR1 family is represented in every plant species studied to date and homologs have been found in animals, fungi and insects...
March 30, 2018: Molecular Plant Pathology
Zafer Keser, Khader M Hasan, Benson Mwangi, Kyan Younes, Mahsa Khayat-Khoei, Arash Kamali, John A Lincoln, Flavia M Nelson
Background and objective: Cognitive impairment (CI) is common in multiple sclerosis (MS), but underlying mechanisms and their imaging correlates are not completely understood. The gray and white matter structures of the limbic system (LS) play crucial roles in different aspects of cognition. To investigate their role in MS related CI, and since a detailed evaluations are lacking in the literature, we used a comprehensive neuroimaging approach to evaluate CI's correlations with the main components of the LS...
2018: Frontiers in Neurology
Arash Kamali, Caroline C Zhang, Roy F Riascos, Nitin Tandon, Eliana E Bonafante-Mejia, Rajan Patel, John A Lincoln, Pejman Rabiei, Laura Ocasio, Kyan Younes, Khader M Hasan
The mammillary bodies as part of the hypothalamic nuclei are in the central limbic circuitry of the human brain. The mammillary bodies are shown to be directly or indirectly connected to the amygdala, hippocampus, and thalami as the major gray matter structures of the human limbic system. Although it is not primarily considered as part of the human limbic system, the thalamus is shown to be involved in many limbic functions of the human brain. The major direct connection of the thalami with the hypothalamic nuclei is known to be through the mammillothalamic tract...
March 27, 2018: Scientific Reports
Lewis T O Cheung, Ching Yee Lui, Lincoln Fok
A total of 60 flathead grey mullets were examined for microplastic ingestion. Thirty wild mullets were captured from the eastern coast of Hong Kong and 30 captive mullets were obtained from fish farms. Microplastic ingestion was detected in 60% of the wild mullets, with an average of 4.3 plastic items per mullet, while only 16.7% of captive mullets were found to have ingested microplastics, with an average of 0.2 items per mullet. The results suggested that wild mullets have a higher risk of microplastic ingestion than their captive counterparts...
March 26, 2018: International Journal of Environmental Research and Public Health
Simon Blockley, Ian Candy, Ian Matthews, Pete Langdon, Cath Langdon, Adrian Palmer, Paul Lincoln, Ashley Abrook, Barry Taylor, Chantal Conneller, Alex Bayliss, Alison MacLeod, Laura Deeprose, Chris Darvill, Rebecca Kearney, Nancy Beavan, Richard Staff, Michael Bamforth, Maisie Taylor, Nicky Milner
Understanding the resilience of early societies to climate change is an essential part of exploring the environmental sensitivity of human populations. There is significant interest in the role of abrupt climate events as a driver of early Holocene human activity, but there are very few well-dated records directly compared with local climate archives. Here, we present evidence from the internationally important Mesolithic site of Star Carr showing occupation during the early Holocene, which is directly compared with a high-resolution palaeoclimate record from neighbouring lake beds...
March 26, 2018: Nature Ecology & Evolution
Martin Friedl, Kristopher Kristopher Cerveny, Pirmin Weigele, Gözde Tütüncüoglu, Sara Marti-Sanchez, Chunyi Huang, Taras Patlatiuk, Heidi Potts, Zhiyuan Sun, Megan O Hill, Lucas Güniat, Wonjong Kim, Mahdi Zamani, Vladimir G Dubrovskii, Jordi Arbiol, Lincoln J Lauhon, Dominik Max Zumbühl, Anna Fontcuberta I Morral
Topological qubits based on Majorana fermions have the potential to revolutionize the emerging field of quantum computing by making information processing significantly more robust to decoherence. Nanowires (NWs) are a promising medium for hosting these kinds of qubits, though branched NWs are needed to perform qubit manipulations.3 Here we report gold-free templated growth of III-V NWs by molecular beam epitaxy using an approach that enables patternable and highly regular branched NW arrays on a far greater scale than what has been reported thus far...
March 26, 2018: Nano Letters
Nicholas Morelli, Jason Fogler, Sahil Tembulkar, Kelsey Graber, Sarah H Lincoln, Michelle Bosquet Enlow, Joseph Gonzalez-Heydrich, Eugene J D'Angelo
AIM: Previous research has demonstrated a strong association between early trauma exposure and the development of psychotic symptoms. However, few of these studies have included young adolescents and children. This study investigated rates and number of potentially traumatic experiences (PTEs) among typically developing youth (TD; n = 21), youth at clinical high risk for psychosis (CHR; n = 38), and youth with a psychotic disorder (PD; n = 28) between 7 and 18 years of age. CHR participants were further evaluated to determine whether a history of PTEs was associated with prodromal symptom severity...
March 25, 2018: Early Intervention in Psychiatry
Juliana Naldoni, Antônio A M Maia, Lincoln L Correa, Marcia R M da Silva, Edson A Adriano
Myxozoans are a diverse group of parasitic cnidarians, with some species recognized as serious pathogens to their hosts. The present study describes 2 new myxobolid species (Myxobolus figueirae sp. nov. and Henneguya santarenensis sp. nov.) infecting skin and gill filaments of the Amazonian pimelodid fish Phractocephalus hemioliopterus, based on ultrastructural, histology and phylogenetic analysis. The fish were caught in the Amazon River, Pará, Brazil. The plasmodial development of M. figueirae sp. nov. was in the dermis and those of H...
March 22, 2018: Diseases of Aquatic Organisms
Nathalia Saber de Andrade, Ana Maria Félix André, Victor Hugo Perches Ferreira, Lincoln Eduardo Villela Vieira de Castro Ferreira
BACKGROUND: - Conventional esophagogastroduodenoscopy is the best method for evaluation of the upper gastrointestinal tract, but it has limitations for the identification of the major duodenal papilla, even after the use of the straightening maneuver. Side-viewing duodenoscope is recommended for optimal examination of major duodenal papilla in patients at high risk for lesions in this region. OBJECTIVE: To evaluate the use of the biopsy forceps during conventional esophagogastroduodenoscopy as an additional tool to the straightening maneuver, in the evaluation of the major duodenal papilla...
January 2018: Arquivos de Gastroenterologia
Lisanna Lamb, Nadja Affenzeller, Lynn Hewison, Kevin James McPeake, Helen Zulch, Daniel S Mills
Adherence to the advice of medical practitioners is critical to successful treatment outcomes and has been much researched in human health, but is less well studied in the veterinary and clinical animal behavior fields. Given that the management of behavior problems often requires substantial change in established client behavior, it is likely that adherence is a substantive issue affecting success. However, little is known about the relationships between relevant factors, and there is no established way of assessing these...
2018: Frontiers in Veterinary Science
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