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https://www.readbyqxmd.com/read/28343318/prevalence-of-thyroid-dysfunction-and-its-impact-on-cognition-in-older-mexican-adults-sadem-study
#1
T Juárez-Cedillo, L Basurto-Acevedo, S Vega-García, A Sánchez-Rodríguez Martha, R Retana-Ugalde, E Juárez-Cedillo, C Gonzalez-Melendez Roberto, J Escobedo-de-la-Peña
INTRODUCTION: Subclinical thyroid dysfunction is a possible risk factor for cognitive impairment in old age, but results are inconsistent. Aim of the present study was to evaluate the prevalence of thyroid dysfunction among older community-dwelling adults and to see whether thyroid function impacts the cognitive status of the elderly. METHODS: We included 1750 participants from the Study on Aging and Dementia in Mexico (SADEM). All subjects were evaluated clinically via specific interviews...
March 25, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28342576/biological-co2-mitigation-from-coal-power-plant-by-chlorella-fusca-and-spirulina-sp
#2
Jessica Hartwig Duarte, Etiele Greque de Morais, Elisângela Martha Radmann, Jorge Alberto Vieira Costa
CO2 biofixation by microalgae and cyanobacteria is an environmentally sustainable way to mitigate coal burn gas emissions. In this work the microalga Chlorella fusca LEB 111 and the cyanobacteria Spirulina sp. LEB 18 were cultivated using CO2 from coal flue gas as a carbon source. The intermittent flue gas injection in the cultures enable the cells growth and CO2 biofixation by these microorganisms. The Chlorella fusca isolated from a coal power plant could fix 2.6 times more CO2 than Spirulina sp. The maximum daily CO2 from coal flue gas biofixation was obtained with Chlorella fusca (360...
March 12, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28340179/open-label-pilot-study-to-compare-the-safety-and-immunogenicity-of-pentavalent-rotavirus-vaccine-rv5-administered-on-an-early-alternative-dosing-schedule-with-those-of-rv5-administered-on-the-recommended-standard-schedule
#3
Ezzeldin Saleh, Brian Eichner, Douglas W Clark, Martha E Gagliano, James M Troutman, Lynn Harrington, Monica McNeal, Dennis Clements
This study compares the safety and immunogenicity of pentavalent rotavirus vaccine (RV5) administered on an alternative schedule (initiated at 2-5 weeks of age) with those of RV5 administered on the recommended standard schedule. Our findings support the future conduct of larger clinical trials to confirm the safety and efficacy of rotavirus vaccination in the neonatal period.
March 3, 2017: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28339637/provider-perspectives-on-the-implementation-of-psychosocial-risk-screening-in-pediatric-cancer
#4
Anne E Kazak, Lamia P Barakat, Martha A Askins, Maureen McCafferty, Alyssa Lattomus, Nicole Ruppe, Janet Deatrick
Objective:  Psychosocial risk screening is an important initial step in delivering evidence-based care. This qualitative descriptive study identified how multidisciplinary pediatric oncology health-care providers perceive psychosocial risk screening to identify factors in uptake and implementation. Methods:  A script guided digitally recorded (transcribed) interviews regarding psychosocial screening and challenges to facilitators of screening. Participants were 15 multidisciplinary staff (physicians, nurses, social workers, psychologists, physician assistant) at nine sites, three using the Psychosocial Assessment Tool© for research and six for clinical care...
February 16, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/28339114/cervical-length-in-patients-at-risk-for-placenta-accreta
#5
Martha W F Rac, Donald D McIntire, C Edward Wells, Elysia Moschos, Diane D Twickler
OBJECTIVES: To evaluate cervical length measurements in women with placenta accreta compared to women with a nonadherent low-lying placenta or placenta previa and evaluate this relationship in terms of vaginal bleeding, preterm labor, and preterm birth. METHODS: We conducted a retrospective cohort study between 1997 and 2011 of gravidas with more than 1 prior cesarean delivery who had a transvaginal ultrasound examination between 24 and 34 weeks for a low-lying placenta or placenta previa...
March 24, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28338690/a-viscous-solvent-enables-information-transfer-from-gene-length-nucleic-acids-in-a-model-prebiotic-replication-cycle
#6
Christine He, Isaac Gállego, Brandon Laughlin, Martha A Grover, Nicholas V Hud
Many hypotheses concerning the nature of early life assume that genetic information was once transferred through the template-directed synthesis of RNA, before the emergence of coded enzymes. However, attempts to demonstrate enzyme-free, template-directed synthesis of nucleic acids have been limited by 'strand inhibition', whereby transferring information from a template strand in the presence of its complementary strand is inhibited by the stability of the template duplex. Here, we use solvent viscosity to circumvent strand inhibition, demonstrating information transfer from a gene-length template (>300 nt) within a longer (545 bp or 3 kb) duplex...
April 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28337828/tradd-traf2-rip1-and-tak1-are-required-for-tnf-%C3%AE-induced-pro-labour-mediators-in-human-primary-myometrial-cells
#7
Ratana Lim, Gillian Barker, Martha Lappas
PROBLEM: TNF-α plays a central role in the processes of human labour and delivery. This study sought to determine the role of the adaptor proteins TNFR1-associated death domain protein (TRADD), TNF receptor-associated factor 2 (TRAF2), receptor interacting protein 1 (RIP1) and transforming growth factor beta-activated kinase 1 (TAK1) in TNF-α-induced formation of pro-labour mediators. METHOD OF STUDY: Human primary myometrial cells were transfected with siRNA against TRADD (siTRADD), TRAF2 (siTRAF2), RIP1 (siRIP1) or TAK1 (siTAK1), treated with TNF-α, and assayed for pro-inflammatory mediators expression...
March 24, 2017: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/28336600/complete-genome-sequences-before-and-after-mammalian-cell-culture-of-zika-virus-isolated-from-the-serum-of-a-symptomatic-male-patient-from-oaxaca-mexico
#8
Celia Boukadida, Jesús M Torres-Flores, Martha Yocupicio-Monroy, Elvira Piten-Isidro, Amaranta Y Rivero-Arrieta, Yara A Luna-Villalobos, Liliane Martínez-Vargas, Sofía L Alcaraz-Estrada, Klintsy J Torres, Rosalia Lira, Gustavo Reyes-Terán, Edgar E Sevilla-Reyes
Zika virus (ZIKV) is an emerging arthropod-borne flavivirus associated with severe congenital malformations and neurological complications. Although the ZIKV genome is well characterized, there is limited information regarding changes after cell isolation and culture adaptation. We isolated, and passaged in Vero cells, ZIKV from the serum of a symptomatic male patient and compared the viral genomes before and after culture. Single nucleotide polymorphisms were characteristic among serum-circulating genomes, while such diversity decreased after cell culture...
March 23, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28334952/dnmt1-mutations-found-in-hsanie-patients-affect-interaction-with-uhrf1-and-neuronal-differentiation
#9
Martha Smets, Stephanie Link, Patricia Wolf, Katrin Schneider, Veronica Solis, Joel Ryan, Daniela Meilinger, Weihua Qin, Heinrich Leonhardt
DNMT1 is recruited to substrate sites by PCNA and UHRF1 to maintain DNA methylation after replication. The cell cycle dependent recruitment of DNMT1 is mediated by the PCNA-binding domain (PBD) and the targeting sequence (TS) within the N-terminal regulatory domain. The TS domain was found to be mutated in patients suffering from hereditary sensory and autonomic neuropathies with dementia and hearing loss (HSANIE) and autosomal dominant cerebellar ataxia deafness and narcolepsy (ADCA-DN) and is associated with global hypomethylation and site specific hypermethylation...
March 3, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28333950/drug-resistant-hiv-behaviors-and-characteristics-among-los-angeles-men-who-have-sex-with-men-with-new-hiv-diagnosis
#10
Pamina M Gorbach, Marjan Javanbakht, Lorelei Bornfleth, Robert K Bolan, Martha Lewis Blum
Epidemiology of drug resistant HIV has focused on trends and less attention has been given to identification of factors, especially behaviors including substance use, in acquisition of drug-resistant HIV. From 2009 to 2012 The Metromates Study enrolled and followed for one year men who have sex with men (MSM) seeking testing for HIV in a community clinic in Los Angeles assessing those testing positive for acute and recent HIV infection. Behavioral data were collected via Computer-Assisted Self-Interview from 125 classified as newly HIV infected and 91 as chronically infected (newly HIV-diagnosed); specimens were available and viable for resistance testing for 154 of the 216 HIV positives with new diagnoses...
2017: PloS One
https://www.readbyqxmd.com/read/28333279/inhibition-of-pim1-kinase-attenuates-inflammation-induced-pro-labour-mediators-in-human-fetal-membranes-in-vitro
#11
Ratana Lim, Gillian Barker, Martha Lappas
STUDY QUESTION: Does proviral integration site for Moloney murine leukemic virus (PIM)1 kinase play a role in regulating the inflammatory processes of human labour and delivery? SUMMARY ANSWER: PIM1 kinase plays a critical role in fetal membranes in regulating pro-inflammatory and pro-labour mediators. WHAT IS KNOWN ALREADY: Infection and inflammation have strong causal links to preterm delivery by stimulating pro-inflammatory cytokines and collagen degrading enzymes, which can lead to rupture of membranes...
March 9, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333057/photocatalytic-degradation-of-tartrazine-dye-using-cuo-straw-sheaf-like-nanostructures
#12
Martha Purnachander Rao, Jerry J Wu, Abdullah M Asiri, Sambandam Anandan
Straw-sheaf-like CuO nanostructures were fruitfully synthesized using a chemical precipitation approach for the photocatalytic degradation assessment of tartrazine. Phase identification, composition, and morphological outlook of prepared CuO nanostructures were established by X-ray diffraction and scanning electron microscopy analysis. The photocatalytic performance of the synthesized CuO nanostructures was appraised in the presence of visible light and the possible intermediates formed during the photocatalytic degradation were analyzed by gas chromatography-mass spectrometry...
March 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28332011/delayed-otolith-development-does-not-impair-vestibular-circuit-formation-in-zebrafish
#13
Richard Roberts, Jeffrey Elsner, Martha W Bagnall
What is the role of normally patterned sensory signaling in development of vestibular circuits? For technical reasons, including the difficulty in depriving animals of vestibular inputs, this has been a challenging question to address. Here we take advantage of a vestibular-deficient zebrafish mutant, rock solo (AN66) , in order to examine whether normal sensory input is required for formation of vestibular-driven postural circuitry. We show that the rock solo (AN66) mutant is a splice site mutation in the secreted glycoprotein otogelin (otog), which we confirm through both whole genome sequencing and complementation with an otog early termination mutant...
March 22, 2017: Journal of the Association for Research in Otolaryngology: JARO
https://www.readbyqxmd.com/read/28331529/detection-of-braf-mutation-in-the-cytocentrifugation-supernatant-fluid-from-fine-needle-aspiration-of-thyroid-lesions-may-enhance-the-diagnostic-yield
#14
Ashley E Brown, Khin Sandar Lim, George Corpus, Martha T Hustek, Tien Anh N Tran, Chung-Che Chang
OBJECTIVE: BRAF mutations using cellular DNA from fine-needle aspiration (FNA) specimens are commonly used to support the diagnosis of papillary thyroid carcinoma (PTC). The goal of this study was to preliminarily evaluate the diagnostic utility of detecting BRAF mutations in the routinely discarded FNA specimen supernatant fluid. MATERIALS AND METHODS: Seventy-eight FNAs of thyroid lesions were evaluated for BRAF mutations using both cellular and supernatant DNA...
2017: CytoJournal
https://www.readbyqxmd.com/read/28330375/complex-p-t88n-w130r-mutation-in-the-lysozyme-gene-leading-to-hereditary-lysozyme-amyloidosis-with-biopsy-proven-cardiac-involvement
#15
Brett W Sperry, Angela Dispenzieri, Asad Ikram, Martha Grogan, Jason D Theis, Nelson Leung, W Edward Highsmith, Joseph J Maleszewski, Mazen Hanna
No abstract text is available yet for this article.
March 22, 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28329816/subjective-cognitive-decline-correlates-with-depression-symptoms-and-not-with-concurrent-objective-cognition-in-a-clinic-based-sample-of-older-adults
#16
Zvinka Z Zlatar, Martha Muniz, Douglas Galasko, David P Salmon
Objectives: Subjective cognitive decline (SCD) is common in older adults; however, its utility in clinic-based samples remains controversial given its strong associations with mood symptoms. Methods: Five hundred nineteen individuals aged 60-95 with a wide range of cognitive performance scores were referred by community health clinics for brief screening of cognitive complaints. Linear regression models examined the cross-sectional associations between SCD (5-item self-reported questions), symptoms of depression (Beck Depression Inventory [BDI]), and concurrent objective cognitive performance (Cognitive Composite) adjusting for demographics...
January 19, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28329370/sleep-characteristics-and-daytime-cortisol-levels-in-older-adults
#17
Ethan Morgan, L Philip Schumm, Martha McClintock, Linda Waite, Diane S Lauderdale
Objective: Older adults frequently report sleep problems and are at increased risk for cardiometabolic disruption. Experimental sleep restriction of younger adults has suggested that cortisol may be on the pathway between sleep restriction and cardiometabolic disease. We investigated whether the natural variation in sleep among older adults is associated with daytime cortisol level. Methods: Salivary cortisol samples and actigraphy sleep data were collected from a random subsample of participants in the National Social Life, Health and Aging Project, a nationally-representative probability sample of adults aged 62-90 (N=672)...
March 9, 2017: Sleep
https://www.readbyqxmd.com/read/28329301/association-between-non-iron-deficient-anemia-and-insomnia-symptoms-in-community-dwelling-older-adults-the-baltimore-longitudinal-study-of-aging
#18
Lenis P Chen-Edinboro, Laura E Murray-Kolb, Eleanor M Simonsick, Luigi Ferrucci, Richard Allen, Martha E Payne, Adam P Spira
Background: Anemia is associated with poorer sleep in children, and clinically, anemia is linked to insomnia. However, the association between anemia and insomnia in older adults is understudied. Methods: We examined the cross-sectional association between anemia and insomnia in 1,053 adults (71.4 ± 10.6 years) in the Baltimore Longitudinal Study of Aging. Participants were classified as nonanemic, non-iron-deficient anemic, or iron-deficient anemic based on hemoglobin, ferritin, transferrin saturation, and mean cell volume...
January 20, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329251/factors-associated-with-accelerated-hospitalization-and-re-hospitalization-among-medicare-home-health-patients
#19
Matthew C Lohman, Emily A Scherer, Karen L Whiteman, Rebecca L Greenberg, Martha L Bruce
Background: Preventing hospitalizations and re-hospitalizations of older adults receiving Medicare home health (HH) services is a key goal for patients and care providers. This study aimed to identify factors related to greater risk of and earlier hospitalizations from HH, a key step in targeting preventive efforts. Methods: Data come from Medicare mandated start-of-care assessments from 87,780 HH patients served by 132 agencies in 32 states, collected from January 2013 to March 2015...
January 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28329091/association-between-sleep-timing-obesity-diabetes-the-hispanic-community-health-study-study-of-latinos-hchs-sol-cohort-study-sleep-timing-obesity-and-diabetes
#20
Kristen L Knutson, Donghong Wu, Sanjay R Patel, Jose S Loredo, Susan Redline, Jianwen Cai, Linda C Gallo, Yasmin Mossavar-Rahmani, Alberto R Ramos, Yanping Teng, Martha L Daviglus, Phyllis C Zee
Study Objectives: Recent studies implicate inadequate sleep duration and quality in metabolic disease. Fewer studies have examined the timing of sleep, which may be important because of its potential impact on circadian rhythms of metabolic function. We examined the association between sleep timing and metabolic risk among Hispanic/Latino adults. Methods.: Cross-sectional data from community-based study of 13,429 participants aged 18-74 years. People taking diabetes medications were excluded...
January 28, 2017: Sleep
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