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https://www.readbyqxmd.com/read/27922118/mining-visualizing-and-comparing-multidimensional-biomolecular-data-using-the-genomics-data-miner-gmine-web-server
#1
Carla Proietti, Martha Zakrzewski, Thomas S Watkins, Bernard Berger, Shihab Hasan, Champa N Ratnatunga, Marie-Jo Brion, Peter D Crompton, John J Miles, Denise L Doolan, Lutz Krause
Genomics Data Miner (GMine) is a user-friendly online software that allows non-experts to mine, cluster and compare multidimensional biomolecular datasets. Various powerful visualization techniques are provided, generating high quality figures that can be directly incorporated into scientific publications. Robust and comprehensive analyses are provided via a broad range of data-mining techniques, including univariate and multivariate statistical analysis, supervised learning, correlation networks, clustering and multivariable regression...
December 6, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27920781/inoculation-of-schizolobium-parahyba-with-mycorrhizal-fungi-and-plant-growth-promoting-rhizobacteria-increases-wood-yield-under-field-conditions
#2
Martha V T Cely, Marco A Siviero, Janaina Emiliano, Flávia R Spago, Vanessa F Freitas, André R Barazetti, Erika T Goya, Gustavo de Souza Lamberti, Igor M O Dos Santos, Admilton G De Oliveira, Galdino Andrade
Schizolobium parahyba var. amazonicum (Huber ex Ducke) occurs naturally in the Brazilian Amazon. Currently, it is being planted extensively because of its fast growth and excellent use in forestry. Consequently, there is great interest in new strategies to increase wood production. The interaction between soil microorganisms and plants, specifically in the roots, provides essential nutrients for plant growth. These interactions can have growth-promoting effects. In this way, this study assessed the effect of the inoculation with arbuscular mycorrhizal fungi (AMF) and plant growth-promoting rhizobacteria (PGPR) on growth of S...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27920763/microbial-activity-response-to-solar-radiation-across-contrasting-environmental-conditions-in-salar-de-huasco-northern-chilean-altiplano
#3
Klaudia L Hernández, Beatriz Yannicelli, Lasse M Olsen, Cristina Dorador, Eduardo J Menschel, Verónica Molina, Francisco Remonsellez, Martha B Hengst, Wade H Jeffrey
In high altitude environments, extreme levels of solar radiation and important differences of ionic concentrations over narrow spatial scales may modulate microbial activity. In Salar de Huasco, a high-altitude wetland in the Andean mountains, the high diversity of microbial communities has been characterized and associated with strong environmental variability. Communities that differed in light history and environmental conditions, such as nutrient concentrations and salinity from different spatial locations, were assessed for bacterial secondary production (BSP, (3)H-leucine incorporation) response from short-term exposures to solar radiation...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27920354/welcome-to-2017-the-year-of-the-fiery-rooster
#4
Martha B Baird
No abstract text is available yet for this article.
January 2017: Journal of Transcultural Nursing: Official Journal of the Transcultural Nursing Society
https://www.readbyqxmd.com/read/27920090/islet-derived-cd4-t-cells-targeting-proinsulin-in-human-autoimmune-diabetes
#5
Aaron W Michels, Laurie G Landry, Kristen A McDaniel, Liping Yu, Martha Campbell-Thompson, William W Kwok, Kenneth L Jones, Peter A Gottlieb, John W Kappler, Qizhi Tang, Bart O Roep, Mark A Atkinson, Clayton E Mathews, Maki Nakayama
Type 1 diabetes results from chronic autoimmune destruction of insulin-producing beta cells within pancreatic islets. While insulin is a critical self-antigen in animal models of autoimmune diabetes, due to extremely limited access to pancreas samples, little is known about human antigenic targets for islet-infiltrating T-cells. Here we show that proinsulin peptides are targeted by islet-infiltrating T-cells from type 1 diabetes patients. We identified hundreds of T-cells from inflamed pancreatic islets of three young type 1 diabetes organ donors with a short disease duration with high risk HLA genes using a direct T-cell receptor (TCR) sequencing approach without long-term cell culture...
December 5, 2016: Diabetes
https://www.readbyqxmd.com/read/27918836/evolvix-best-names-for-semantic-reproducibility-across-code2brain-interfaces
#6
Laurence Loewe, Katherine S Scheuer, Seth A Keel, Vaibhav Vyas, Ben Liblit, Bret Hanlon, Michael C Ferris, John Yin, Inês Dutra, Anthony Pietsch, Christine G Javid, Cecilia L Moog, Jocelyn Meyer, Jerdon Dresel, Brian McLoone, Sonya Loberger, Arezoo Movaghar, Morgaine Gilchrist-Scott, Yazeed Sabri, Dave Sescleifer, Ivan Pereda-Zorrilla, Andrew Zietlow, Rodrigo Smith, Samantha Pietenpol, Jacob Goldfinger, Sarah L Atzen, Erika Freiberg, Noah P Waters, Claire Nusbaum, Erik Nolan, Alyssa Hotz, Richard M Kliman, Ayalew Mentewab, Nathan Fregien, Martha Loewe
Names in programming are vital for understanding the meaning of code and big data. We define code2brain (C2B) interfaces as maps in compilers and brains between meaning and naming syntax, which help to understand executable code. While working toward an Evolvix syntax for general-purpose programming that makes accurate modeling easy for biologists, we observed how names affect C2B quality. To protect learning and coding investments, C2B interfaces require long-term backward compatibility and semantic reproducibility (accurate reproduction of computational meaning from coder-brains to reader-brains by code alone)...
December 5, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27918810/association-of-specific-dietary-fats-with-mortality
#7
Martha A Belury
No abstract text is available yet for this article.
December 1, 2016: JAMA Internal Medicine
https://www.readbyqxmd.com/read/27918452/light-dark-shifting-promotes-alcohol-induced-colon-carcinogenesis-possible-role-of-intestinal-inflammatory-milieu-and-microbiota
#8
Faraz Bishehsari, Abdulrahman Saadalla, Khashayarsha Khazaie, Phillip A Engen, Robin M Voigt, Brandon B Shetuni, Christopher Forsyth, Maliha Shaikh, Martha Hotz Vitaterna, Fred Turek, Ali Keshavarzian
BACKGROUND: Colorectal cancer (CRC) is associated with the modern lifestyle. Chronic alcohol consumption-a frequent habit of majority of modern societies-increases the risk of CRC. Our group showed that chronic alcohol consumption increases polyposis in a mouse mode of CRC. Here we assess the effect of circadian disruption-another modern life style habit-in promoting alcohol-associated CRC. METHOD: TS4Cre × adenomatous polyposis coli (APC)(lox468) mice underwent (a) an alcohol-containing diet while maintained on a normal 12 h light:12 h dark cycle; or (b) an alcohol-containing diet in conjunction with circadian disruption by once-weekly 12 h phase reversals of the light:dark (LD) cycle...
December 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27918218/vaccine-against-toxic-shock-syndrome-in-a-first-in-man-clinical-trial
#9
Andreas Roetzer, Bernd Jilma, Martha M Eibl
No abstract text is available yet for this article.
December 5, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27917200/sero-prevalence-and-associated-factors-of-helicobacter-pylori-infection-among-adult-patients-with-dyspepsia-attending-the-gastroenterology-unit-in-a-tertiary-hospital-in-mwanza-tanzania
#10
Hyasinta Jaka, Martha F Mushi, Mariam M Mirambo, Leonard Wilson, Jeremiah Seni, Majigo Mtebe, Stephen E Mshana
BACKGROUND: Prevalence of H.pylori infection varies greatly between populations in different countries. This study was conducted to determine the magnitude of H.pylori among adult patients with dyspepsia attending the gastroenterology unit at Bugando medical centre. METHODS: A cross sectional study involving 202 dyspeptic patients was conducted between June and July 2014. A Standardized data collection tool was used to collect socio-demographic characteristics. H...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27916474/infusion-of-exogenous-cholecystokinin-8-gastrin-releasing-peptide-29-and-their-combination-reduce-body-weight-in-diet-induced-obese-male-rats
#11
Thaer R Mhalhal, Martha C Washington, Kayla Newman, John C Heath, Ayman I Sayegh
We hypothesized that exogenous gastrin releasing peptide-29 (GRP-29), cholecystokinin-8 (CCK-8) and their combination reduce body weight (BW). To test this hypothesis, BW was measured in four groups of diet-induced obese (DIO) male rats infused in the aorta (close to the junctions of the celiac and cranial mesenteric arteries) with saline, CCK-8 (0.5 nmol/kg), GRP-29 (0.5 nmol/kg) and CCK-8+GRP-29 (0.5 nmol/kg each) once daily for a total of 23 days. We found that CCK-8, GRP-29 and CCK-8+GRP-29 reduce BW relative to saline control...
December 1, 2016: Appetite
https://www.readbyqxmd.com/read/27914363/new-insights-into-the-sar-and-drug-combination-synergy-of-2-quinolin-4-yloxy-acetamides-against-mycobacterium-tuberculosis
#12
Bruno Couto Giacobbo, Kenia Pissinate, Valnês Rodrigues-Junior, Anne Drumond Villela, Estêvão Silveira Grams, Bruno Lopes Abbadi, Fernanda Teixeira Subtil, Nathalia Sperotto, Rogério Valim Trindade, Davi Fernando Back, Maria Martha Campos, Luiz Augusto Basso, Pablo Machado, Diógenes Santiago Santos
2-(Quinolin-4-yloxy)acetamides have been described as potent and selective in vitro inhibitors of Mycobacterium tuberculosis (Mtb) growth. Herein, a new series of optimized compounds were found to demonstrate highly potent antitubercular activity, with minimum inhibitory concentration (MIC) values against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains in the submicromolar range. Furthermore, the most active compounds had no apparent toxicity to mammalian cells, and they showed intracellular activities similar to those of isoniazid and rifampin in a macrophage model of Mtb infection...
November 23, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27913904/association-between-brain-structural-anomalies-electroencephalogram-and-history-of-seizures-in-mucopolysaccharidosis-type-ii-hunter-syndrome
#13
Ramón Ernesto Jiménez-Arredondo, Aniel Jessica Leticia Brambila-Tapia, Francisco Miguel Mercado-Silva, Martha Ortiz-Aranda, Verónica Benites-Godinez, Graciela Olmos-García-de-Alba, Luis Eduardo Figuera
Mucopolysaccharidosis type II or Hunter syndrome (MPS II) is a genetic disease that can course with intellectual impairment and central nervous system (CNS) alterations. To date, no report has documented electroencephalogram (EEG) measures associated with CNS alterations, detected by imaging studies, and the history of seizures in patients with MPS II. Therefore, we decided to search this association. We included 9 patients with MPS II and performed imaging studies of the brain to detect the presence of cortico-subcortical atrophy, enlarged subarachnoid space and supratentorial ventricular size...
December 2, 2016: Neurological Sciences
https://www.readbyqxmd.com/read/27913695/a-randomized-double-blind-placebo-controlled-trial-of-coenzyme-q10-in-huntington-disease
#14
Andrew McGarry, Michael McDermott, Karl Kieburtz, Elisabeth A de Blieck, Flint Beal, Karen Marder, Christopher Ross, Ira Shoulson, Peter Gilbert, William M Mallonee, Mark Guttman, Joanne Wojcieszek, Rajeev Kumar, Mark S LeDoux, Mary Jenkins, H Diana Rosas, Martha Nance, Kevin Biglan, Peter Como, Richard M Dubinsky, Kathleen M Shannon, Padraig O'Suilleabhain, Kelvin Chou, Francis Walker, Wayne Martin, Vicki L Wheelock, Elizabeth McCusker, Joseph Jankovic, Carlos Singer, Juan Sanchez-Ramos, Burton Scott, Oksana Suchowersky, Stewart A Factor, Donald S Higgins, Eric Molho, Fredy Revilla, John N Caviness, Joseph H Friedman, Joel S Perlmutter, Andrew Feigin, Karen Anderson, Ramon Rodriguez, Nikolaus R McFarland, Russell L Margolis, Eric S Farbman, Lynn A Raymond, Valerie Suski, Sandra Kostyk, Amy Colcher, Lauren Seeberger, Eric Epping, Sherali Esmail, Nancy Diaz, Wai Lun Alan Fung, Alan Diamond, Samuel Frank, Philip Hanna, Neal Hermanowicz, Leon S Dure, Merit Cudkowicz
OBJECTIVE: To test the hypothesis that chronic treatment of early-stage Huntington disease (HD) with high-dose coenzyme Q10 (CoQ) will slow the progressive functional decline of HD. METHODS: We performed a multicenter randomized, double-blind, placebo-controlled trial. Patients with early-stage HD (n = 609) were enrolled at 48 sites in the United States, Canada, and Australia from 2008 to 2012. Patients were randomized to receive either CoQ 2,400 mg/d or matching placebo, then followed for 60 months...
December 2, 2016: Neurology
https://www.readbyqxmd.com/read/27913659/formative-research-using-a-community-based-participatory-research-approach-to-develop-an-oral-health-intervention-for-migrant-mexican-families
#15
Tracy L Finlayson, Padideh Asgari, Lisa Hoffman, Ana Palomo-Zerfas, Martha Gonzalez, Nannette Stamm, Maria-Isabel Rocha, Arcela Nunez-Alvarez
Oral health is a leading unmet health need among migrant families. This article describes the 1-year, community-based participatory research (CBPR) approach employed to plan and develop a Líder Communitario (lay community health worker)-led educational intervention for Mexican migrant adult caregivers and their families in three underserved, remote communities in North San Diego County, California. Four partner organizations collaborated, reviewed existing oral health curricula, and sought extensive input on educational topics and research design from key informants, migrant caregivers, and Líderes Communitarios...
December 1, 2016: Health Promotion Practice
https://www.readbyqxmd.com/read/27913397/prospective-study-of-ultraviolet-radiation-exposure-and-thyroid-cancer-risk-in-the-united-states
#16
Rachel D Zamoiski, Elizabeth K Cahoon, D Michal Freedman, Martha S Linet, Cari M Kitahara
BACKGROUND: Thyroid cancer incidence has tripled in the past three decades, yet relatively few risk factors have been identified. Some studies have suggested that ultraviolet radiation (UVR) may affect thyroid cancer risk. METHODS: We conducted a prospective analysis of 44,039 participants in the United States Radiologic Technologists study (153 thyroid cancer cases) from all 50 states. We examined the association between risk of thyroid cancer and exposure to UVR, estimated by ambient UVR, time outdoors, and a combined variable...
December 2, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27910378/development-and-characterization-of-an-interferometer-for-calorimeter-based-absorbed-dose-to-water-measurements-in-a-medical-linear-accelerator
#17
Everardo Flores-Martinez, Martha J Malin, Larry A DeWerd
The quantity of relevance for external beam radiotherapy is absorbed dose to water (ADW). An interferometer was built, characterized, and tested to measure ADW within the dose range of interest for external beam radiotherapy using the temperature dependence of the refractive index of water. The interferometer was used to measure radiation-induced phase shifts of a laser beam passing through a (10 × 10 × 10) cm(3) water-filled glass phantom, irradiated with a 6 MV photon beam from a medical linear accelerator...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27910247/auditory-processing-in-noise-is-associated-with-complex-patterns-of-disrupted-functional-connectivity-in-autism-spectrum-disorder
#18
Fahimeh Mamashli, Sheraz Khan, Hari Bharadwaj, Konstantinos Michmizos, Santosh Ganesan, Keri-Lee A Garel, Javeria Ali Hashmi, Martha R Herbert, Matti Hämäläinen, Tal Kenet
Autism spectrum disorder (ASD) is associated with difficulty in processing speech in a noisy background, but the neural mechanisms that underlie this deficit have not been mapped. To address this question, we used magnetoencephalography to compare the cortical responses between ASD and typically developing (TD) individuals to a passive mismatch paradigm. We repeated the paradigm twice, once in a quiet background, and once in the presence of background noise. We focused on both the evoked mismatch field (MMF) response in temporal and frontal cortical locations, and functional connectivity with spectral specificity between those locations...
December 2, 2016: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/27909794/prescription-of-oral-antidiabetic-drugs-in-tyrol-data-from-the-tyrol-diabetes-registry-2012-2015
#19
Lukas Lunger, Andreas Melmer, Willi Oberaigner, Marco Leo, Martin Juchum, Karin Pölzl, Johannes Gänzer, Martha Innerebner, Egon Eisendle, Gertrud Beck, Hermann Kathrein, Bernhard Heindl, Hans Robert Schönherr, Monika Lechleitner, Herbert Tilg, Christoph Ebenbichler
Diabetes mellitus affects 9% of the adult population worldwide and the economic burden of the disease is growing exponentially. In type 2 diabetes mellitus (T2DM), when life style interventions fail to achieve treatment targets, oral antidiabetic drugs are prescribed to improve glycemic control. Several new oral antidiabetics have been launched in the last few years, which enlarged the spectrum of available treatment options in T2DM. The present study aimed to examine T2DM treatment patterns in a cohort of 7769 patients recruited from the Diabetes Registry Tyrol (DRT) with at least one visit from 2012-2015...
December 1, 2016: Wiener Klinische Wochenschrift
https://www.readbyqxmd.com/read/27909430/bacterial-active-community-cycling-in-response-to-solar-radiation-and-their-influence-on-nutrient-changes-in-a-high-altitude-wetland
#20
Verónica Molina, Klaudia Hernández, Cristina Dorador, Yoanna Eissler, Martha Hengst, Vilma Pérez, Chris Harrod
Microbial communities inhabiting high-altitude spring ecosystems are subjected to extreme changes in solar irradiance and temperature throughout the diel cycle. Here, using 16S rRNA gene tag pyrosequencing (cDNA) we determined the composition of actively transcribing bacteria from spring waters experimentally exposed through the day (morning, noon, and afternoon) to variable levels of solar radiation and light quality, and evaluated their influence on nutrient recycling. Solar irradiance, temperature, and changes in nutrient dynamics were associated with changes in the active bacterial community structure, predominantly by Cyanobacteria, Verrucomicrobia, Proteobacteria, and 35 other Phyla, including the recently described Candidate Phyla Radiation (e...
2016: Frontiers in Microbiology
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