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https://www.readbyqxmd.com/read/28938416/pancreatic-histopathology-of-human-monogenic-diabetes-due-to-causal-variants-in-kcnj11-hnf1a-gata6-and-lmna
#1
May Sanyoura, Laura Jacobsen, David Carmody, Daniela Del Gaudio, Gorka Alkorta-Aranburu, Kelly Arndt, Ying Ying Hu, Frances Kobiernicki, Irina Kusmartseva, Mark A Atkinson, Louis H Philipson, Desmond Schatz, Martha Campbell-Thompson, Siri Atma W Greeley
Context: Monogenic diabetes is thought to account for 2% of all diabetes cases but most patients are misdiagnosed as type 1 or type 2 diabetes. To date, little is known about the histopathological features of pancreases from patients with monogenic diabetes. Objective: Retrospective study of the JDRF Network for Pancreatic Organ donors with Diabetes biorepository was used to identify possible cases with monogenic diabetes and to compare effects of genetic variants on pancreas histology...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28937959/prenatal-fluoride-exposure-and-cognitive-outcomes-in-children-at-4-and-6-12-years-of-age-in-mexico
#2
Morteza Bashash, Deena Thomas, Howard Hu, E Angeles Martinez-Mier, Brisa N Sanchez, Niladri Basu, Karen E Peterson, Adrienne S Ettinger, Robert Wright, Zhenzhen Zhang, Yun Liu, Lourdes Schnaas, Adriana Mercado-García, Martha María Téllez-Rojo, Mauricio Hernández-Avila
BACKGROUND: Some evidence suggests that fluoride may be neurotoxic to children. Few of the epidemiologic studies have been longitudinal, had individual measures of fluoride exposure, addressed the impact of prenatal exposures or involved more than 100 participants. OBJECTIVE: Our aim was to estimate the association of prenatal exposure to fluoride with offspring neurocognitive development. METHODS: We studied participants from the Early Life Exposures in Mexico to Environmental Toxicants (ELEMENT) project...
September 19, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28934572/birth-of-a-standard-achieving-consensus-on-safe-and-effective-healthcare-technology
#3
Martha Vockley
No abstract text is available yet for this article.
2017: Biomedical Instrumentation & Technology
https://www.readbyqxmd.com/read/28934316/pathogenesis-of-oral-fiv-infection
#4
Craig Miller, Karen Boegler, Scott Carver, Martha MacMillan, Helle Bielefeldt-Ohmann, Sue VandeWoude
Feline immunodeficiency virus (FIV) is the feline analogue of human immunodeficiency virus (HIV) and features many hallmarks of HIV infection and pathogenesis, including the development of concurrent oral lesions. While HIV is typically transmitted via parenteral transmucosal contact, recent studies prove that oral transmission can occur, and that saliva from infected individuals contains significant amounts of HIV RNA and DNA. While it is accepted that FIV is primarily transmitted by biting, few studies have evaluated FIV oral infection kinetics and transmission mechanisms over the last 20 years...
2017: PloS One
https://www.readbyqxmd.com/read/28934231/principal-component-analysis-identifies-patterns-of-cytokine-expression-in-non-small-cell-lung-cancer-patients-undergoing-definitive-radiation-therapy
#5
Susannah G Ellsworth, Bryan M Rabatic, Jie Chen, Jing Zhao, Jeffrey Campbell, Weili Wang, Wenhu Pi, Paul Stanton, Martha Matuszak, Shruti Jolly, Amy Miller, Feng-Ming Kong
BACKGROUND/PURPOSE: Radiation treatment (RT) stimulates the release of many immunohumoral factors, complicating the identification of clinically significant cytokine expression patterns. This study used principal component analysis (PCA) to analyze cytokines in non-small cell lung cancer (NSCLC) patients undergoing RT and explore differences in changes after hypofractionated stereotactic body radiation therapy (SBRT) and conventionally fractionated RT (CFRT) without or with chemotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28934180/notes-from-the-field-travel-associated-melioidosis-and-resulting-laboratory-exposures-united-states-2016
#6
Patrick K Mitchell, Colin Campbell, Martha P Montgomery, Julie Paoline, Christopher Wilbur, Leah Posivak-Khouly, Kristin Garafalo, Mindy Elrod, Lindy Liu, Andre Weltman
In mid-July 2016, a Pennsylvania resident aged 15 years who had recently returned from Thailand was treated by a pediatrician for sore throat, fever, and bilateral thigh abscesses at the sites of mosquito bites (Figure). She had traveled to northeast Thailand with nine other teens as part of an 18-day service-oriented trip run by an Ohio-based youth tour company that arranges travel to Thailand for approximately 500 persons annually. This trip included construction and agricultural activities and recreational mud exposures...
September 22, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/28934044/surviving-the-loss-of-a-child-a-mexican-american-s-story
#7
Steven L Baumann, Martha Velasco-Whetsell
This paper tells the story of a mother's loss of her 10-year-old daughter from cancer. It is in part a pain and suffering narrative and a story of remarkable post-loss growth and transformation. It is a story told for busy parents and multitasking nurses, to all of us who need to relearn how to be attentive to others, particularly our children. The woman who tells the story is one of the authors (M.V.-W.); she is a Mexican-American. The paper is based on two interviews of M.V.-W., using questions similar to those used by one of the authors (S...
October 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28934037/middle-range-theory-coping-and-adaptation-with-active-aging
#8
Martha Elba Salazar-Barajas, Bertha Cecilia Salazar-González, Esther Carlota Gallegos-Cabriales
Various disciplines focus on a multiplicity of aspects of aging: lifestyles, personal biological factors, psychological conditions, health conditions, physical environment, and social and economic factors. The aforementioned are all related to the determinants of active aging. The aim is to describe the development of a middle-range theory based on coping and adaptation with active aging. Concepts and relationships derived from Roy's model of adaptation are included. The proposed concepts are hope, health habits, coping with aging, social relations, and active aging...
October 2017: Nursing Science Quarterly
https://www.readbyqxmd.com/read/28933930/autism-spectrum-disorder-among-us-children-2002-2010-socioeconomic-racial-and-ethnic-disparities
#9
Maureen S Durkin, Matthew J Maenner, Jon Baio, Deborah Christensen, Julie Daniels, Robert Fitzgerald, Pamela Imm, Li-Ching Lee, Laura A Schieve, Kim Van Naarden Braun, Martha S Wingate, Marshalyn Yeargin-Allsopp
OBJECTIVES: To describe the association between indicators of socioeconomic status (SES) and the prevalence of autism spectrum disorder (ASD) in the United States during the period 2002 to 2010, when overall ASD prevalence among children more than doubled, and to determine whether SES disparities account for ongoing racial and ethnic disparities in ASD prevalence. METHODS: We computed ASD prevalence and 95% confidence intervals (CIs) from population-based surveillance, census, and survey data...
September 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28933882/maternal-depressive-symptoms-mother-child-interactions-and-children-s-executive-function
#10
Noa Gueron-Sela, Marie Camerota, Michael T Willoughby, Lynne Vernon-Feagans, Martha J Cox
This study examined the independent and mediated associations between maternal depression symptoms (MDS), mother-child interaction, and child executive function (EF) in a prospective longitudinal sample of 1,037 children (50% boys) from predominantly low-income and rural communities. When children were 6, 15 and 24 months of age, mothers reported their level of depressive symptomatology. At 24 and 36 months of age, mother-child interactions during play were rated for warmth-sensitivity and harsh-intrusiveness, and dyadic joint attention and maternal language complexity were assessed from a book sharing activity...
September 21, 2017: Developmental Psychology
https://www.readbyqxmd.com/read/28933335/re-evaluating-ttf-1-immunohistochemistry-in-diffuse-gliomas-expression-is-clonedependent-and-associated-with-tumor-location
#11
Drew Pratt, Nina Afsar, Michael Allgauer, Patricia Fetsch, Maryknoll Palisoc, Stefania Pittaluga, Martha Quezado
TTF-1 is widely used as a marker in routine surgical pathology in the work-up of malignancy. Aberrant expression of TTF-1 in extrapulmonary and extrathyroidal malignancies is a frequently reported phenomenon. In addition to the recently characterized pituicyte-derived tumors of the sella, immunoreactivity has been reported in diffuse gliomas with the SPT24 clone. Here, we sought to evaluate TTF-1 expression with three commercially available clones in a large series of gliomas. Expression was compared across the newly defined diagnostic entities in the 2016 WHO Classification of CNS Tumors...
September 21, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28931580/the-biosocial-genome-interdisciplinary-perspectives-on-environmental-epigenetics-health-and-society
#12
Ruth Müller, Clare Hanson, Mark Hanson, Michael Penkler, Georgia Samaras, Luca Chiapperino, John Dupré, Martha Kenney, Christopher Kuzawa, Joanna Latimer, Stephanie Lloyd, Astrid Lunkes, Molly Macdonald, Maurizio Meloni, Brigitte Nerlich, Francesco Panese, Martyn Pickersgill, Sarah Richardson, Joëlle Rüegg, Sigrid Schmitz, Aleksandra Stelmach, Paula-Irene Villa
No abstract text is available yet for this article.
September 20, 2017: EMBO Reports
https://www.readbyqxmd.com/read/28931566/sex-differences-in-coronary-heart-disease-risk-factors-rename-it-ischaemic-heart-disease
#13
EDITORIAL
Ahmed AlBadri, Janet Wei, Puja K Mehta, Rashmee Shah, Romana Herscovici, Martha Gulati, Chrisandra Shufelt, Noel Bairey Merz
No abstract text is available yet for this article.
September 20, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28931395/effect-of-cell-permeability-and-dehydrogenase-expression-on-octane-activation-by-cyp153a6-based-whole-cell-escherichia-coli-catalysts
#14
Bronwyn E White, Caryn J Fenner, Martha S Smit, Susan T L Harrison
BACKGROUND: The regeneration of cofactors and the supply of alkane substrate are key considerations for the biocatalytic activation of hydrocarbons by cytochrome P450s. This study focused on the biotransformation of n-octane to 1-octanol using resting Escherichia coli cells expressing the CYP153A6 operon, which includes the electron transport proteins ferredoxin and ferredoxin reductase. Glycerol dehydrogenase was co-expressed with the CYP153A6 operon to investigate the effects of boosting cofactor regeneration...
September 20, 2017: Microbial Cell Factories
https://www.readbyqxmd.com/read/28931009/ndfip-allows-nedd4-nedd4l-induced-aqp2-ubiquitination-and-degradation
#15
Christiane Trimpert, Daniel Wesche, Theun de Groot, Martha M Pimentel Rodriguez, Victoria Wong, Dennis T M van den Berg, Lydie Cheval, Carolina A Ariza, Alain Doucet, Igor Stagljar, Peter M T Deen
Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas binding of vasopressin to its type-2 receptor initiates a cAMP-protein kinase A cascade and AQP2 translocation to the apical membrane, this is counteracted by protein kinase C-activating hormones, resulting in ubiquitination-dependent internalization of AQP2. The proteins targeting AQP2 for ubiquitin-mediated degradation are unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28930768/a-6-month-prospective-trial-of-a-personalized-behavioral-intervention-long-acting-injectable-antipsychotic-in-individuals-with-schizophrenia-at-risk-of-treatment-nonadherence-and-homelessness
#16
Martha Sajatovic, Luis F Ramirez, Edna Fuentes-Casiano, Jamie Cage, Curtis Tatsuoka, Michelle E Aebi, Ashley Bukach, Kristin A Cassidy, Jennifer B Levin
PURPOSE: Long-acting injectable antipsychotics (LAI) can optimize adherence for high-risk serious mental illness (SMI). This customized adherence-enhancement approach delivered by social worker interventionists was combined with LAI (CAE-L) of paliperidone palmitate for homeless, poorly adherent individuals with SMI. METHODS: This 6-month prospective, uncontrolled trial of CAE-L in 30 recently homeless individuals with SMI assessed adherence using the Tablets Routine Questionnaire, injection frequency, and SMI symptoms measured by the Positive and Negative Syndrome Scale, Brief Psychiatric Rating Scale, and Clinical Global Impressions...
September 19, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/28930314/concerted-double-proton-transfer-electron-transfer-between-catechol-and-superoxide-radical-anion
#17
Jorge Quintero-Saumeth, David A Rincón, Markus Doerr, Martha C Daza
We have carried out a computational study on the reactivity of catechol (1,2-dihydroxybenzene) towards superoxide radical anion (O2˙(-)) in water, N,N-dimethylformamide (DMF), pentyl ethanoate (PEA) and vacuum using density functional theory and the coupled cluster method. Five reaction mechanisms were studied: (i) sequential proton transfer followed by hydrogen atom transfer (PT-HT), (ii) sequential hydrogen atom transfer followed by proton transfer (HT-PT), (iii) single electron transfer (SET), (iv) radical adduct formation (RAF) and (v) concerted double proton-transfer electron-transfer (denoted as global reaction, GR)...
September 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28929291/evaluation-of-an-advance-care-planning-web-based-resource-applicability-for-cancer-treatment-patients
#18
Martha A Cresswell, Carole A Robinson, Gillian Fyles, Joan L Bottorff, Rebecca Sudore
PURPOSE: The purpose of this study was to explore the acceptability, applicability, and understandability of a promising advance care planning (ACP) web-based resource for use with oncology patients, and determine whether revisions to the website would be necessary before implementation into oncology care. The resource is called PREPARE ( www.prepareforyourcare.org ) and it had not been tested for use within oncology, but had previously been shown to influence the readiness of older, community-dwelling adults to engage in ACP behaviors...
September 19, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28928269/perturbed-cd8-t-cell-immunity-across-universal-influenza-epitopes-in-the-elderly
#19
Thi H O Nguyen, Sneha Sant, Nicola L Bird, Emma J Grant, E Bridie Clemens, Marios Koutsakos, Sophie A Valkenburg, Stephanie Gras, Martha Lappas, Anthony Jaworowski, Jane Crowe, Liyen Loh, Katherine Kedzierska
Influenza epidemics lead to severe illness, life-threatening complications, and deaths, especially in the elderly. As CD8(+) T cells are associated with rapid recovery from influenza, we investigated the effects of aging on antigen-specific CD8(+) T cells across the universal influenza epitopes in humans. We show that aging is characterized by altered frequencies in T cell subsets, with naive T cells being partially replaced by activated effector/memory populations. Although we observed no striking differences in TCR signaling capacity, T cells in the elderly had increased expression of transcription factors Eomes and T-bet, and such changes were most apparent in CD8(+) T cells...
September 19, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28928111/personalized-hypertension-management-using-patient-generated-health-data-integrated-with-electronic-health-records-empower-h-six-month-pre-post-study
#20
Nan Lv, Lan Xiao, Martha L Simmons, Lisa G Rosas, Albert Chan, Martin Entwistle
BACKGROUND: EMPOWER-H (Engaging and Motivating Patients Online With Enhanced Resources-Hypertension) is a personalized-care model facilitating engagement in hypertension self-management utilizing an interactive Web-based disease management system integrated with the electronic health record. The model is designed to support timely patient-provider interaction by incorporating decision support technology to individualize care and provide personalized feedback for patients with chronic disease...
September 19, 2017: Journal of Medical Internet Research
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