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https://www.readbyqxmd.com/read/29781923/going-beyond-clinical-care-to-reduce-health-care-spending-findings-from-the-j-chip-community-based-population-health-management-program-evaluation
#1
Shannon M E Murphy, Douglas E Hough, Martha L Sylvia, Melissa Sherry, Linda J Dunbar, Raymond Zollinger, Regina Richardson, Scott A Berkowitz, Kevin D Frick
BACKGROUND: Addressing both clinical and nonclinical determinants of health is essential for improving population health outcomes. In 2012, the Johns Hopkins Community Health Partnership (J-CHiP) implemented innovative population health management programs across acute and community environments. The community-based program involved multidisciplinary teams [ie, physicians, care managers (CM), health behavior specialists (HBS), community health workers, neighborhood navigators] and collaboration with community-based organizations to address social determinants...
May 17, 2018: Medical Care
https://www.readbyqxmd.com/read/29780875/amyloid-%C3%AE-peptides-are-differentially-vulnerable-to-preanalytical-surface-exposure-an-effect-incompletely-mitigated-by-the-use-of-ratios
#2
Jamie Toombs, Martha S Foiani, Henrietta Wellington, Ross W Paterson, Charles Arber, Amanda Heslegrave, Michael P Lunn, Jonathan M Schott, Selina Wray, Henrik Zetterberg
Introduction: We tested the hypothesis that the amyloid β (Aβ) peptide ratios are more stable than Aβ42 alone when biofluids are exposed to two preanalytical conditions known to modify measurable Aβ concentration. Methods: Human cerebrospinal fluid (CSF) and culture media (CM) from human cortical neurons were exposed to a series of volumes and polypropylene surfaces. Aβ42 , Aβ40 , and Aβ38 peptide concentrations were measured using a multiplexed electrochemiluminescence immunoassay...
2018: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/29780657/characterizing-cellular-mechanical-phenotypes-with-mechano-node-pore-sensing
#3
Junghyun Kim, Sewoon Han, Andy Lei, Masaru Miyano, Jessica Bloom, Vasudha Srivastava, Martha M Stampfer, Zev J Gartner, Mark A LaBarge, Lydia L Sohn
The mechanical properties of cells change with their differentiation, chronological age, and malignant progression. Consequently, these properties may be useful label-free biomarkers of various functional or clinically relevant cell states. Here, we demonstrate mechano-node-pore sensing (mechano-NPS), a multi-parametric single-cell-analysis method that utilizes a four-terminal measurement of the current across a microfluidic channel to quantify simultaneously cell diameter, resistance to compressive deformation, transverse deformation under constant strain, and recovery time after deformation...
2018: Microsystems & Nanoengineering
https://www.readbyqxmd.com/read/29779764/experimental-animal-models-of-central-nervous-system-tuberculosis-a-historical-review
#4
REVIEW
Carlos Sánchez-Garibay, María Elena Hernández-Campos, Martha Lilia Tena-Suck, Citlaltepetl Salinas-Lara
Animal models are and will remain valuable tools in medical research because their use enables a deeper understanding of disease development, thus generating important knowledge for developing disease control strategies. Central nervous system tuberculosis (CNS TB) is the most devastating disease in humans. Moreover, as the variability of signs and symptoms delay a timely diagnosis, patients usually arrive at the hospital suffering from late stage disease. Therefore, it is impossible to obtain fresh human tissue for research before an autopsy...
May 2018: Tuberculosis
https://www.readbyqxmd.com/read/29779546/state-legislative-approach-to-enumerating-behavioral-health-workforce-shortages-lessons-learned-in-new-mexico
#5
Deborah B Altschul, Caroline A Bonham, Martha J Faulkner, Amy W Farnbach Pearson, Jessica Reno, Wayne Lindstrom, Shelley M Alonso-Marsden, Annette Crisanti, Julie G Salvador, Richard Larson
Nationally, the behavioral health workforce is in crisis because of a lack of resources, culturally responsive services, quality clinical supervision, sufficient training in evidence-based practices, and targeted recruitment and retention. Disparities in access to behavioral health care are particularly significant in New Mexico, where 25% of the population live in rural areas, and behavioral health shortages are among the highest in the nation. Additionally, as a Medicaid expansion state, New Mexico providers experience increased demand for services at a time when the state is challenged with limited workforce capacity...
June 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29779184/limbic-system-structure-volumes-and-associated-neurocognitive-functioning-in-former-nfl-players
#6
Christian Lepage, Marc Muehlmann, Yorghos Tripodis, Jakob Hufschmidt, Julie Stamm, Katie Green, Pawel Wrobel, Vivian Schultz, Isabelle Weir, Michael L Alosco, Christine M Baugh, Nathan G Fritts, Brett M Martin, Christine Chaisson, Michael J Coleman, Alexander P Lin, Ofer Pasternak, Nikos Makris, Robert A Stern, Martha E Shenton, Inga K Koerte
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to repetitive head impacts. CTE has been linked to disruptions in cognition, mood, and behavior. Unfortunately, the diagnosis of CTE can only be made post-mortem. Neuropathological evidence suggests limbic structures may provide an opportunity to characterize CTE in the living. Using 3 T magnetic resonance imaging, we compared select limbic brain regional volumes - the amygdala, hippocampus, and cingulate gyrus - between symptomatic former National Football League (NFL) players (n = 86) and controls (n = 22)...
May 19, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29776479/nursing-child-assessment-satellite-training-parent-child-interaction-scales-comparing-american-and-canadian-normative-and-high-risk-samples
#7
Nicole L Letourneau, Panagiota D Tryphonopoulos, Jason Novick, J Martha Hart, Gerald Giesbrecht, Monica L Oxford
PURPOSE: Many nurses rely on the American Nursing Child Assessment Satellite Training (NCAST) Parent-Child Interaction (PCI) Teaching and Feeding Scales to identify and target interventions for families affected by severe/chronic stressors (e.g. postpartum depression (PPD), intimate partner violence (IPV), low-income). However, the NCAST Database that provides normative data for comparisons may not apply to Canadian families. The purpose of this study was to compare NCAST PCI scores in Canadian and American samples and to assess the reliability of the NCAST PCI Scales in Canadian samples...
May 2018: Journal of Pediatric Nursing
https://www.readbyqxmd.com/read/29772489/prevention-of-venous-thromboembolism-in-pregnant-patients-with-a-history-of-venous-thromboembolic-disease-a-retrospective-cohort-study
#8
Alejandro Lazo-Langner, Fatimah Al-Ani, Sarah Weisz, Camilla Rozanski, Martha Louzada, Judy Kovacs, Michael J Kovacs
BACKGROUND: Optimal prophylactic strategies in pregnant women with a history of venous thromboembolism (VTE) are unknown. PATIENTS AND METHODS: We conducted a retrospective cohort study of consecutive pregnant patients with a previous VTE history. Patients were followed until 6 weeks postpartum. Patients with a previous unprovoked event (including antepartum VTE) received antenatal prophylaxis, mostly with low dose low molecular weight heparin (LMWH). All patients received prophylaxis for six weeks after delivery...
May 5, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29771178/islet-microvasculature-alterations-with-loss-of-beta-cells-in-patients-with-type-1-diabetes
#9
Joseph S Canzano, Lith H Nasif, Elizabeth A Butterworth, Dongtao A Fu, Mark A Atkinson, Martha Campbell-Thompson
Islet microvasculature provides key architectural and functional roles, yet the morphological features of islets from patients with type 1 diabetes are poorly defined. We examined islet and exocrine microvasculature networks by multiplex immunofluorescence imaging of pancreases from organ donors with and without type 1 diabetes ( n=17 and n=16, respectively) and determined vessel diameter, density, and area. We also analyzed these variables in insulin-positive and insulin-negative islets of 7 type 1 diabetes donors...
May 1, 2018: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29769572/large-positive-linear-magnetoresistance-in-the-two-dimensional-t-2g-electron-gas-at-the-euo-srtio-3-interface
#10
Kristy J Kormondy, Lingyuan Gao, Xiang Li, Sirong Lu, Agham B Posadas, Shida Shen, Maxim Tsoi, Martha R McCartney, David J Smith, Jianshi Zhou, Leonid L Lev, Marius-Adrian Husanu, Vladimir N Strocov, Alexander A Demkov
The development of novel nano-oxide spintronic devices would benefit greatly from interfacing with emergent phenomena at oxide interfaces. In this paper, we integrate highly spin-split ferromagnetic semiconductor EuO onto perovskite SrTiO3 (001). A careful deposition of Eu metal by molecular beam epitaxy results in EuO growth via oxygen out-diffusion from SrTiO3 . This in turn leaves behind a highly conductive interfacial layer through generation of oxygen vacancies. Below the Curie temperature of 70 K of EuO, this spin-polarized two-dimensional t 2g electron gas at the EuO/SrTiO3 interface displays very large positive linear magnetoresistance (MR)...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769145/phylogenetic-relationships-stage-specific-expression-and-localisation-of-a-unique-family-of-inactive-cysteine-proteases-in-sarcoptes-scabiei
#11
Deepani D Fernando, Simone L Reynolds, Martha Zakrzewski, Ehtesham Mofiz, Anthony T Papenfuss, Deborah Holt, Katja Fischer
BACKGROUND: Scabies is worldwide one of the most common, yet neglected, parasitic skin infections, affecting a wide range of mammals including humans. Limited treatment options and evidence of emerging mite resistance against the currently used drugs drive our research to explore new therapeutic candidates. Previously, we discovered a multicopy family of genes encoding cysteine proteases with their catalytic sites inactivated by mutation (SMIPP-Cs). This protein family is unique in parasitic scabies mites and is absent in related non-burrowing mites...
May 16, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29767459/long-term-effects-of-patiromer-for-hyperkalaemia-treatment-in-patients-with-mild-heart-failure-and-diabetic-nephropathy-on-angiotensin-converting-enzymes-angiotensin-receptor-blockers-results-from-amethyst-dn
#12
Bertram Pitt, George L Bakris, Matthew R Weir, Mason W Freeman, Mitja Lainscak, Martha R Mayo, Dahlia Garza, Rezi Zawadzki, Lance Berman, David A Bushinsky
AIMS: Chronic kidney disease (CKD) in heart failure (HF) increases the risk of hyperkalaemia (HK), limiting angiotensin-converting enzyme inhibitor (ACE-I) or angiotensin receptor blocker (ARB) use. Patiromer is a sodium-free, non-absorbed potassium binder approved for HK treatment. We retrospectively evaluated patiromer's long-term safety and efficacy in HF patients from AMETHYST-DN. METHODS AND RESULTS: Patients with Type 2 diabetes, CKD, and HK [baseline serum potassium >5...
May 16, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29765933/a-pilot-study-of-inhaled-co-therapy-in-neonatal-hypoxia-ischemia-carboxyhemoglobin-concentrations-and-brain-volumes
#13
Martha Douglas-Escobar, Monique Mendes, Candace Rossignol, Nikolay Bliznyuk, Ariana Faraji, Abdullah S Ahmad, Sylvain Doré, Michael D Weiss
Objective: The objective of this pilot study was to start evaluating the efficacy and the safety (i.e., carboxyhemoglobin concentration of carbon monoxide (CO)) as a putative neuroprotective therapy in neonates. Study Design: Neonatal C57BL/6 mice were exposed to CO at a concentration of either 200 or 250 ppm for a period of 1 h. The pups were then sacrificed at 0, 10, 20, 60, 120, 180, and 240 min after exposure to either concentration of CO, and blood was collected for analysis of carboxyhemoglobin. Following the safety study, 7-day-old pups underwent a unilateral carotid ligation...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29765778/reflections-on-family-medicine-and-primary-healthcare-in-sub-saharan-africa
#14
EDITORIAL
Robert Mash, Amanda Howe, Osa Olayemi, Martha Makwero, Sunanda Ray, Meseret Zerihun, Abraham Gyuse, Felicity Goodyear-Smith
No abstract text is available yet for this article.
2018: BMJ Global Health
https://www.readbyqxmd.com/read/29765596/an-evolutionary-perspective-on-night-terrors
#15
Sean D Boyden, Martha Pott, Philip T Starks
Night terrors, also known as sleep terrors, are an early childhood parasomnia characterized by screams or cries, behavioral manifestations of extreme fear, difficulty waking and inconsolability upon awakening. The mechanism causing night terrors is unknown, and a consistently successful treatment has yet to be documented. Here, we argue that cultural practices have moved us away from an ultimate solution: cosleeping. Cosleeping is the norm for closely related primates and for humans in non-Western cultures...
2018: Evolution, Medicine, and Public Health
https://www.readbyqxmd.com/read/29764918/a-feed-forward-relay-integrates-the-regulatory-activities-of-bicoid-and-orthodenticle-via-sequential-binding-to-suboptimal-sites
#16
Rhea R Datta, Jia Ling, Jesse Kurland, Xiaotong Ren, Zhe Xu, Gozde Yucel, Jackie Moore, Leila Shokri, Isabel Baker, Timothy Bishop, Paolo Struffi, Rimma Levina, Martha L Bulyk, Robert J Johnston, Stephen Small
The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster , another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo patterning. Bcd is distributed as a long-range maternal gradient and activates transcription of a large number of target genes, including otd Otd and Bcd bind similar DNA sequences in vitro, but how their transcriptional activities are integrated to pattern anterior regions of the embryo is unknown...
May 15, 2018: Genes & Development
https://www.readbyqxmd.com/read/29764888/assessment-of-thyroid-cancer-risk-associated-with-radiation-dose-from-personal-diagnostic-examinations-in-a-cohort-study-of-us-radiologic-technologists-followed-1983-2014
#17
Mark P Little, Hyeyeun Lim, Melissa C Friesen, Dale L Preston, Michele M Doody, Alice J Sigurdson, Gila Neta, Bruce H Alexander, Lienard A Chang, Elizabeth K Cahoon, Steven L Simon, Martha S Linet, Cari M Kitahara
OBJECTIVE: To assess whether personal medical diagnostic procedures over life, but particularly those associated with exposure in adulthood, were associated with increased thyroid cancer risk. DESIGN: Participants from the US Radiologic Technologists Study, a large, prospective cohort, were followed from the date of first mailed questionnaire survey completed during 1983-1989 to the earliest date of self-reported diagnosis of thyroid cancer or of any other cancer than non-melanoma skin cancer (NMSC) in any of three subsequent questionnaires up to the last in 2012-2014...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29763969/hormone-replacement-therapy-for-women-previously-treated-for-endometrial-cancer
#18
REVIEW
Katharine A Edey, Stuart Rundle, Martha Hickey
BACKGROUND: Endometrial cancer is the sixth most common cancer in women worldwide and most commonly occurs after the menopause (75%) (globocan.iarc.fr). About 319,000 new cases were diagnosed worldwide in 2012. Endometrial cancer is commonly considered as a potentially 'curable cancer,' as approximately 75% of cases are diagnosed before disease has spread outside the uterus (FIGO (International Federation of Gynecology and Obstetrics) stage I). The overall five-year survival for all stages is about 86%, and, if the cancer is confined to the uterus, the five-year survival rate may increase to 97%...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29763702/immunostimulant-effects-and-potential-application-of-%C3%AE-glucans-derived-from-marine-yeast-debaryomyces-hansenii-in-goat-peripheral-blood-leucocytes
#19
Noé Medina-Córdova, Martha Reyes-Becerril, Felipe Ascencio, Thelma Castellanos, Angel I Campa-Córdova, Carlos Angulo
Debaryomyces hansenii has been described to be effective probiotic and immunostimulatory marine yeast in fish. Nonetheless, to the best of our knowledge, it has been not assayed in ruminants. This study attempts to describe the immunostimulatory effects of its β-glucan content through in vitro assays using goat peripheral blood leukocytes at 24 h of stimulation. The structural characterization of yeast glucans by proton nuclear magnetic resonance indicated structures containing (1-6)-branched (1-3)-β-D-glucan...
May 12, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29762156/preliminary-use-of-the-physical-and-neurological-examination-of-subtle-signs-for-detecting-subtle-motor-signs-in-adolescents-with-sport-related-concussion
#20
Jaclyn A Stephens, Martha B Denckla, Teri McCambridge, Beth S Slomine, E Mark Mahone, Stacy J Suskauer
Sensitive examination tools are needed to optimize evaluation after sports-related concussion. The Physical and Neurological Examination of Subtle Signs was preliminarily examined for sensitivity to motor changes in a pilot cohort of adolescents aged 13-17 yrs with sports-related concussion. A total of 15 adolescents (5 female adolescents) with sports-related concussion were evaluated up to three times: within 2 wks of injury, approximately 1 mo later (mean, 35 days between visits), and for those not recovered at the second visit, again after clinical recovery (mean, 70 days between the first and last visits for all participants)...
June 2018: American Journal of Physical Medicine & Rehabilitation
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