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https://www.readbyqxmd.com/read/29025970/the-arf-gef-gbf1-and-arf4-synergize-with-the-sensory-receptor-cargo-rhodopsin-to-regulate-ciliary-membrane-trafficking
#1
Jing Wang, Theresa Fresquez, Vasundhara Kandachar, Dusanka Deretic
The small GTPase Arf4 and the Arf GTPase activating protein (GAP) ASAP1 cooperatively sequester sensory receptor cargo into transport carriers targeted to primary cilia, but the input that drives Arf4 activation in this process remains unknown. Here, we show that during the carrier biogenesis from the photoreceptor Golgi/trans-Golgi network (TGN) a functional complex is formed between Arf4, the Arf guanine nucleotide exchange factor (GEF) GBF1 and the light-sensing receptor, rhodopsin. Rhodopsin and Arf4 bind the regulatory N-terminal DCB-HUS domain of GBF1...
October 12, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29024279/computed-tomographic-lymphography-as-a-complementary-technique-for-lymph-node-staging-in-dogs-with-malignant-tumors-of-various-sites
#2
Federica Rossi, Maximilian Körner, José Suárez, Gregorio Carozzi, Valeria S Meier, Malgorzata Roos, Carla Rohrer Bley
Locoregional lymph nodes are routinely examined in order to define the spatial extent of neoplastic disease. As draining patterns of certain tumor types can be divergent from expected anatomical distribution, it is critical to sample the lymph nodes truly representing the draining area. The aim of this bicenter prospective pilot study was to describe the technique of computed tomographic (CT)-lymphography for primary draining lymph node mapping in tumor staging in dogs. Forty-five dogs with macro- or microscopic tumors in specified localizations were evaluated...
October 11, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28992232/development-of-a-minipig-physical-phantom-from-ct-data
#3
Sooyeun Park, Pilsoo Lee, Wi-Ho Ha, Han Sung Kim, Byeong Ryong Park, Jae Seok Kim, Sehwan Shim, Sunhoo Park, Young-Su Kim, Chan Hyeong Kim, Young-Woo Jin
Quantification of pathological progression of radiation-induced injury is essential in development of treatment methods, and a proper animal model is necessary for relevant radiological and medical studies. A minipig is a current animal model selected because of its similarities to humans in anatomy and pathology. In the present study, a minipig physical phantom was developed using computed tomography (CT) data. For dosimetry purposes, the minipig physical phantom was constructed on a slice-by-slice basis, with an array of holes to accommodate dosimeters...
July 28, 2017: Journal of Radiation Research
https://www.readbyqxmd.com/read/28986730/acute-hantavirus-infection-presenting-as-haemolytic-uraemic-syndrome-hus-the-importance-of-early-clinical-diagnosis
#4
J Clement, A P K Lee, G A Verpooten, L Laenen, V Vergote, H De Samblanx, Z N Berneman, M Van Ranst, P Maes
The European prototype of hantavirus, Puumala virus (PUUV), isolated from a common wild rodent, the bank vole (Myodes glareolus), causes nephropathia epidemica (NE). NE can perfectly mimic haemolytic-uraemic syndrome (HUS), progressing from an aspecific flu-like syndrome to acute kidney injury with thrombocytopaenia, and presenting with some signs of haemolytic anaemia and/or coagulopathy. Moreover, both NE and HUS can occur in local outbreaks. We report an isolated case of NE, initially referred for plasmapheresis for suspected HUS, although signs of overt haemolysis were lacking...
October 6, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28983018/phase-1-study-of-the-anti-cd22-immunotoxin-moxetumomab-pasudotox-for-childhood-acute-lymphoblastic-leukemia
#5
MULTICENTER STUDY
Alan S Wayne, Nirali N Shah, Deepa Bhojwani, Lewis B Silverman, James A Whitlock, Maryalice Stetler-Stevenson, Weili Sun, Meina Liang, Jie Yang, Robert J Kreitman, Mark C Lanasa, Ira Pastan
Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter phase 1 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (N = 55). Moxetumomab pasudotox was administered as a 30-minute IV infusion at doses of 5 to 50 µg/kg every other day for 6 (cohorts A and B) or 10 (cohort C) doses in 21-day cycles...
October 5, 2017: Blood
https://www.readbyqxmd.com/read/28981517/a-recombinant-o-polysaccharide-protein-conjugate-approach-to-develop-highly-specific-monoclonal-antibodies-to-shiga-toxin-producing-escherichia-coli-o157-and-o145-serogroups
#6
Daniela S Castillo, Diego A Rey Serantes, Luciano J Melli, Andrés E Ciocchini, Juan E Ugalde, Diego J Comerci, Alejandro Cassola
Shiga toxin-producing Escherichia coli (STEC) is the major etiologic agent of hemolytic-uremic syndrome (HUS). The high rate of HUS emphasizes the urgency for the implementation of primary prevention strategies to reduce its public health impact. Argentina shows the highest rate of HUS worldwide, being E. coli O157 the predominant STEC-associated HUS serogroup (>70%), followed by E. coli O145 (>9%). To specifically detect these serogroups we aimed at developing highly specific monoclonal antibodies (mAbs) against the O-polysaccharide (O-PS) section of the lipopolysaccharide (LPS) of the dominant STEC-associated HUS serogroups in Argentina...
2017: PloS One
https://www.readbyqxmd.com/read/28976996/beyond-funding-acknowledgement-patterns-in-biomedical-natural-and-social-sciences
#7
Adèle Paul-Hus, Adrián A Díaz-Faes, Maxime Sainte-Marie, Nadine Desrochers, Rodrigo Costas, Vincent Larivière
For the past 50 years, acknowledgments have been studied as important paratextual traces of research practices, collaboration, and infrastructure in science. Since 2008, funding acknowledgments have been indexed by Web of Science, supporting large-scale analyses of research funding. Applying advanced linguistic methods as well as Correspondence Analysis to more than one million acknowledgments from research articles and reviews published in 2015, this paper aims to go beyond funding disclosure and study the main types of contributions found in acknowledgments on a large scale and through disciplinary comparisons...
2017: PloS One
https://www.readbyqxmd.com/read/28974864/study-of-variation-in-dose-calculation-accuracy-between-kv-cone-beam-computed-tomography-and-kv-fan-beam-computed-tomography
#8
Venkatesan Kaliyaperumal, C Jomon Raphael, K Mathew Varghese, Paul Gopu, S Sivakumar, Minu Boban, N Arunai Nambi Raj, K Senthilnathan, P Ramesh Babu
Cone-beam computed tomography (CBCT) images are presently used for geometric verification for daily patient positioning. In this work, we have compared the images of CBCT with the images of conventional fan beam CT (FBCT) in terms of image quality and Hounsfield units (HUs). We also compared the dose calculated using CBCT with that of FBCT. Homogenous RW3 plates and Catphan phantom were scanned by FBCT and CBCT. In RW3 and Catphan phantom, percentage depth dose (PDD), profiles, isodose distributions (for intensity modulated radiotherapy plans), and calculated dose volume histograms were compared...
July 2017: Journal of Medical Physics
https://www.readbyqxmd.com/read/28968817/streptococcus-pneumoniae-from-patients-with-hemolytic-uremic-syndrome-binds-human-plasminogen-via-the-surface-protein-pspc-and-uses-plasmin-to-damage-human-endothelial-cells
#9
Christian Meinel, Giuseppina Spartà, Hans-Martin Dahse, Franziska Hörhold, Rainer König, Martin Westermann, Sina M Coldewey, Zoltán Cseresnyés, Marc Thilo Figge, Sven Hammerschmidt, Christine Skerka, Peter F Zipfel
Pneumococcal hemolytic uremic syndrome (HUS) in children is caused by infections with Streptococcus pneumoniae. Because endothelial cell damage is a hallmark of HUS, we studied how HUS-inducing pneumococci derived from infant HUS patients during the acute phase disrupt the endothelial layer. HUS pneumococci efficiently bound human plasminogen. These clinical isolates of HUS pneumococci efficiently bound human plasminogen via the bacterial surface proteins Tuf and PspC. When activated to plasmin at the bacterial surface, the active protease degraded fibrinogen and cleaved C3b...
August 26, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28953996/the-role-of-gallery-forests-in-maintaining-phlebotominae-populations-potential-leishmania-spp-vectors-in-the-brazilian-savanna
#10
Tâmara Dias Oliveira Machado, Thaís Tâmara Castro Minuzzi-Souza, Tauana de Sousa Ferreira, Luciana Pereira Freire, Renata Velôzo Timbó, Tamires Emanuele Vital, Nadjar Nitz, Mariana Neiva Silva, Alcinei de Souza Santos, Nathyla Morgana Cunha Sales, Marcos Takashi Obara, Andrey José de Andrade, Rodrigo Gurgel-Gonçalves
BACKGROUND: Knowledge on synanthropic phlebotomines and their natural infection by Leishmania is necessary for the identification of potential areas for leishmaniasis occurrence. OBJECTIVE: To analyse the occurrence of Phlebotominae in gallery forests and household units (HUs) in the city of Palmas and to determine the rate of natural infection by trypanosomatids. METHODS: Gallery forests and adjacent household areas were sampled on July (dry season) and November (rainy season) in 2014...
October 2017: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/28948516/version-correction-via-eccentric-reaming-compromises-remaining-bone-quality-in-b2-glenoids-a-computational-study
#11
Xiang Chen, Akhil S Reddy, Andreas Kontaxis, Daniel S Choi, Timothy Wright, David M Dines, Russell F Warren, Julien Berhouet, Lawrence V Gulotta
BACKGROUND: Version correction via eccentric reaming reduces clinically important retroversion in Walch type B2 glenoids (those with substantial glenoid retroversion and a second, sclerotic neoglenoid cavity) before total shoulder arthroplasty (TSA). Clinically, an increased risk of glenoid component loosening in B2 glenoids was hypothesized to be the result of compromised glenoid bone quality attributable to eccentric reaming. However, no established guidelines exist regarding how much version correction can be applied without compromising the quality of glenoid bone...
September 25, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28947259/-hemolytic-and-uremic-syndrome-and-related-thrombotic-microangiopathies-treatment-and-prognosis
#12
C Rafat, P Coppo, F Fakhouri, V Frémeaux-Bacchi, C Loirat, J Zuber, E Rondeau
Major achievements in the understanding of thrombotic microangiopathies (TMA) have not only resulted in a reclassification of TMA but most of all they have culminated in the design of new treatments and have enabled clinicians to better delineate their prognosis. Recent multicenter studies have improved our understanding of the prognosis of atypical hemolytic and uremic syndromes (aHUS). More specifically, they have highlighted the role of genetic testing on predicting the recurrence of aHUS, the risk of chronic kidney disease and the recurrence following kidney transplantation...
September 22, 2017: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/28946963/postdiarrhoeal-haemolytic-uraemic-syndrome-without-thrombocytopenia
#13
Alejandro Balestracci, Ismael Toledo, Luciana Meni Battaglia, Leonardo de Lillo, Natalia More, Gabriel Cao, Caupolican Alvarado
BACKGROUND: Thrombocytopenia is a hallmark of postdiarrhoeal haemolytic uraemic syndrome (D+ HUS), although it can be transient and therefore undetected. There is scarce information regarding the prevalence and the course of the disease in children with D+ HUS without thrombocytopenia. OBJECTIVE: To determine the prevalence of D+ HUS without thrombocytopenia and to describe the clinical characteristics of a series of children with this condition. PATIENTS AND METHODS: The medical records of patients with D+ HUS hospitalised between 2000 and 2016 were reviewed to identify those without thrombocytopenia (>150,000mm(3))...
September 2017: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/28943538/hemolytic-uremic-syndrome-associated-encephalopathy-successfully-treated-with-corticosteroids
#14
Takashi Hosaka, Kiyotaka Nakamagoe, Akira Tamaoka
The encephalopathy that occurs in association with hemolytic uremic syndrome (HUS), which is caused by enterohemorrhagic Escherichia coli (E. coli), has a high mortality rate and patients sometimes present sequelae. We herein describe the case of a 20-year-old woman who developed encephalopathy during the convalescent stage of HUS caused by E.coli O26. Hyperintense lesions were detected in the pons, basal ganglia, and cortex on diffusion-weighted brain MRI. From the onset of HUS encephalopathy, we treated the patient with methylprednisolone (mPSL) pulse therapy alone...
September 25, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28939980/targeted-exome-sequencing-in-anti-factor-h-antibody-negative-hus-reveals-multiple-variations
#15
R W Thergaonkar, Ankita Narang, Bahadur Singh Gurjar, Pradeep Tiwari, Mamta Puraswani, Himanshi Saini, Aditi Sinha, Binuja Varma, Mitali Mukerji, Pankaj Hari, Arvind Bagga
BACKGROUND: Genetic susceptibility to atypical hemolytic uremic syndrome (aHUS) may lie within genes regulating or activating the alternate complement and related pathways converging on endothelial cell activation. METHODS: We tested 32 Indian patients of aHUS negative for antibodies to complement factor H for genetic variations in a panel of 15 genes, i.e., CFH, CFHR1-5, CFI, CFB, C3, CD46, MASP2, DGKE, ADAMTS13, THBD and PLG using next-generation DNA sequencing and for copy number variation in CFHR1-3...
September 22, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/28935743/genome-sequence-for-shiga-toxin-producing-escherichia-coli-o26-h11-associated-with-a-cluster-of-hemolytic-uremic-syndrome-cases-in-south-africa-2017
#16
Anthony M Smith, Kalule J Bosco, Mark P Nicol, Jackie Kleynhans, Mignon McCulloch, Sanelisiwe T Duze, Arshad Ismail, Mushal Allam, Nomsa P Tau, Karen H Keddy
Shiga toxin-producing Escherichia coli (STEC) strains are primarily foodborne pathogens that may cause diarrheal outbreaks and are associated with severe complications, specifically hemolytic-uremic syndrome (HUS). We report here genome sequence data for STEC O26:H11, which is associated with a cluster of cases of HUS, a rarely described syndrome in South Africa.
September 21, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28925976/shiga-toxin-therapeutics-beyond-neutralization
#17
REVIEW
Gregory Hall, Shinichiro Kurosawa, Deborah J Stearns-Kurosawa
Ribotoxic Shiga toxins are the primary cause of hemolytic uremic syndrome (HUS) in patients infected with Shiga toxin-producing enterohemorrhagic Escherichia coli (STEC), a pathogen class responsible for epidemic outbreaks of gastrointestinal disease around the globe. HUS is a leading cause of pediatric renal failure in otherwise healthy children, resulting in a mortality rate of 10% and a chronic morbidity rate near 25%. There are currently no available therapeutics to prevent or treat HUS in STEC patients despite decades of work elucidating the mechanisms of Shiga toxicity in sensitive cells...
September 19, 2017: Toxins
https://www.readbyqxmd.com/read/28925349/real-time-genomic-investigation-underlying-the-public-health-response-to-a-shiga-toxin-producing-escherichia-coli-o26-h11-outbreak-in-a-nursery
#18
J Moran-Gilad, A Rokney, D Danino, M Ferdous, F Alsana, M Baum, L Dukhan, V Agmon, E Anuka, L Valinsky, R Yishay, I Grotto, J W A Rossen, M Gdalevich
Shiga toxin-producing Escherichia coli (STEC) is a significant cause of gastrointestinal infection and the haemolytic-uremic syndrome (HUS). STEC outbreaks are commonly associated with food but animal contact is increasingly being implicated in its transmission. We report an outbreak of STEC affecting young infants at a nursery in a rural community (three HUS cases, one definite case, one probable case, three possible cases and five carriers, based on the combination of clinical, epidemiological and laboratory data) identified using culture-based and molecular techniques...
October 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28920809/evaluation-of-bone-mineralization-by-computed-tomography-in-wild-and-captive-european-common-spadefoots-pelobates-fuscus-in-relation-to-exposure-to-ultraviolet-b-radiation-and-dietary-supplements
#19
Martine van Zijll Langhout, Richard P J H Struijk, Tessa Könning, Dick van Zuilen, Katalin Horvath, Hester van Bolhuis, Roelof Maarschalkerweerd, Frank Verstappen
Captive rearing programs have been initiated to save the European common spadefoot (Pelobates fuscus), a toad species in the family of Pelobatidae, from extinction in The Netherlands. Evaluating whether this species needs ultraviolet B (UVB) radiation and/or dietary supplementation for healthy bone development is crucial for its captive management and related conservation efforts. The bone mineralization in the femurs and the thickest part of the parietal bone of the skulls of European common spadefoots (n = 51) was measured in Hounsfield units (HUs) by computed tomography...
September 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28920571/recurrent-seasonal-outbreak-of-an-emerging-serotype-of-shiga-toxin-producing-escherichia-coli-stec-o55-h7-stx2a-in-the-south-west-of-england-july-2014-to-september-2015
#20
Noëleen McFarland, Nick Bundle, Claire Jenkins, Gauri Godbole, Amy Mikhail, Tim Dallman, Catherine O'Connor, Noel McCarthy, Emer O'Connell, Juli Treacy, Girija Dabke, James Mapstone, Yvette Landy, Janet Moore, Rachel Partridge, Frieda Jorgensen, Caroline Willis, Piers Mook, Chas Rawlings, Richard Acornley, Charlotte Featherstone, Sharleen Gayle, Joanne Edge, Eleanor McNamara, Jeremy Hawker, Sooria Balasegaram
The first documented British outbreak of Shiga toxin-producing Escherichia coli (STEC) O55:H7 began in the county of Dorset, England, in July 2014. Since then, there have been a total of 31 cases of which 13 presented with haemolytic uraemic syndrome (HUS). The outbreak strain had Shiga toxin (Stx) subtype 2a associated with an elevated risk of HUS. This strain had not previously been isolated from humans or animals in England. The only epidemiological link was living in or having close links to two areas in Dorset...
September 7, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
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