Liping Wang, Dongliang Liang, Yinyin Huang, Yunxin Chen, Xiaocong Yang, Zhijun Huang, Yiqin Jiang, Hanfu Su, Lijing Wang, Janak L Pathak, Linhu Ge
INTRODUCTION: Serum amyloid P component (SAP) regulates the innate immune system and microbial diseases. Periodontitis is an inflammatory oral disease developed by the host immune system's interaction with the dysbiotic oral microbiome, thereby SAP could play a role in periodontitis pathogenicity. OBJECTIVES: To investigate the role of SAP in oral microbiome modulation and peridontitis pathogenicity. METHODS: In this study, wildtype and SAP-knockout (KO) mice were used...
October 12, 2022: Journal of Advanced Research