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Christina Petersson, Ramona Fust, Carina Hagstedt, Per Vågström, Åsa Nilsdotter-Augustinsson
AIMS AND OBJECTIVES: To evaluate patient-reported experiences of facilitated subcutaneous immunoglobulin treatment in adults with primary or secondary immunodeficiency. BACKGROUND: Decreased levels of circulating antibodies (humoral immunodeficiency) are often associated with higher infection rates which cause problems in daily living, for example symptoms of severe and recurrent bacterial infections that may cause chronic lung diseases. For some diagnoses, treatment with immunoglobulin becomes critical and life-long...
June 19, 2018: Journal of Clinical Nursing
Rupak Desai, Sandeep Singh, Maryam Baikpour, Hemant Goyal, Abhijeet Dhoble, Abhishek Deshmukh, Gautam Kumar, Rajesh Sachdeva
BACKGROUND: It is well known that obesity can lead to increased oxidative stress, which is one of the proposed mechanisms in the etiopathogenesis of Takotsubo Cardiomyopathy (TCM). However, it is unknown if the presence of obesity affects the outcomes in patients with TCM. METHODS: We queried the National Inpatient Sample database from 2010-2014 to identify adult patients who admitted with a principal diagnosis of TCM with and without obesity. We compared the categorical and continuous variables by Pearson's chi-square and Student's t-test respectively in propensity-score matched cohorts...
June 19, 2018: Clinical Cardiology
Katrien Jaeken, Maria Cadenas de Llano-Pérula, Jurgen Lemiere, Anna Verdonck, Steffen Fieuws, Guy Willems
Objectives: To investigate the changes in oral health-related quality of life (OHRQoL) before, during, and after orthodontic treatment, determine the relationship with the original treatment need and evaluate the influence of self-esteem (SE). Materials and methods: OHRQoL questionnaires were used in an ongoing observational prospective cohort study at baseline (T0), 1 year after start (T1), and 1 month after the end of active orthodontic treatment (T2). Participants were 11-16-year-old at baseline and 215 complete cases were obtained from a total of 498...
June 18, 2018: European Journal of Orthodontics
M Diossy, L Reiniger, Z Sztupinszki, M Krzystanek, K M Timms, C Neff, C Solimeno, D Pruss, A C Eklund, E Tóth, O Kiss, O Rusz, G Cserni, T Zombori, B Székely, J Tímár, I Csabai, Z Szallasi
Background: Based on its mechanism of action, PARP inhibitor therapy is expected to benefit mainly tumor cases with homologous recombination deficiency (HRD). Therefore, identification of tumor types with increased HRD is important for the optimal use of this class of therapeutic agents. HRD levels can be estimated using various mutational signatures from next generation sequencing data and we used this approach to determine whether breast cancer brain metastases show altered levels of HRD scores relative to their corresponding primary tumor...
June 18, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
Tolga Onay, Seyit A Gümüştaş, Said E Baykan, Ahmet H Akgülle, Bülent Erol, Kaan S Irgit
BACKGROUND: Capitellum fractures are rare in adolescents, and information in literature is still limited. The purpose of this study was to report the mid-term and long-term functional and radiographic results of 13 surgically treated adolescent capitellum fractures in a level I trauma center. METHODS: This retrospective study included patients aged 10 to 16 years, who underwent surgery for a capitellum fracture and were followed up for at least 12 months. Fractures were classified according to the McKee modification of the Bryan and Morrey classification, and elbow arthritis was classified using the Broberg and Morrey system...
June 18, 2018: Journal of Pediatric Orthopedics
Empar Lurbe, María Isabel Torro, Julio Alvarez-Pitti, Josep Redon, Claudio Borghi, Pau Redon
OBJECTIVE: Observational studies have indicated that high levels of serum uric acid are associated with the risk of cardiovascular disease. The aim of the present study is to investigate the association of uric acid with individual cardiometabolic risk factors, as well as their degree of clustering, in overweight and moderate obese youth. METHODS: Three hundred and thirty-three Caucasians of both sexes (149 women), from 5-18 years of age from those who underwent an assessment of overweight/obesity...
June 18, 2018: Journal of Hypertension
Matthias Kreppel, Martin Kauke, Andrea Grandoch, Ali-Farid Safi, Hans-Joachim Nickenig, Joachim Zöller
BACKGROUND: For successful reshaping of the cranial vault in terms of corrective fronto-orbital advancement (FOA) efficient and reliable internal fixation systems for stabilization of bone fragments are indispensable. The rate of complications and feasibility of corrective FOA with the usage of titanium-based rigid fixation systems is rarely analyzed and discussed. METHODS: The authors retrospectively reviewed the medical records of 42 patients who received corrective FOA with the implementation of titanium internal rigid fixation and consecutive secondary surgery for removal...
June 18, 2018: Journal of Craniofacial Surgery
Luis D Medina, Linda Hirshberg, Michael J Taylor, Paul E Gilbert, Robert K Heaton
BACKGROUND/OBJECTIVE: Fibromyalgia (FM) is a chronic pain syndrome of unknown etiology that can include subjective cognitive symptoms and variable evidence of cognitive dysfunction. Rates of occurrence and severity of cognitive impairment remain unclear. Additionally, comparison of this group with other pain conditions has been limited. The current cross-sectional study sought to identify rates of clinically significant cognitive impairment in FM and rheumatoid arthritis (RA) using an automated clinical rating approach...
June 18, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Kyoung Ho Yoon, Jung Suk Kim, Soo Yeon Park, Sang Eon Park
BACKGROUND: Bone tunnel enlargement is one of the important factors that determine whether a revision anterior cruciate ligament reconstruction (ACLR) should be performed in 1 or 2 stages. The goal of this retrospective cohort study was to compare the mid-term to long-term outcomes of 1-stage revision ACLR according to the amount of preoperative tunnel enlargement. METHODS: Between January 2002 and January 2012, 88 patients who underwent revision ACLR were enrolled...
June 20, 2018: Journal of Bone and Joint Surgery. American Volume
Sarah K Sonnenschein, Carlota Betzler, Rebecca Kohnen, Johannes Krisam, Ti-Sun Kim
OBJECTIVE: To assess the oral health-related quality of life (OH-QoL) in patients under supportive periodontal therapy (SPT) and the influence of the individual periodontal risk as well as different degrees of adherence during SPT on OH-QoL. MATERIALS AND METHODS: 309 patients with at least 5 years of SPT were re-examined. Periodontal risk profile (according to Lang and Tonetti) was assessed and the adherence to SPT-appointments within the last 30(±6) months was reviewed for each patient (fully adherent: adherence to all appointments ±6 weeks, partially adherent: SPT-interval not extended more than half of the recommended interval, insufficiently adherent: SPT-interval extended more than half of the recommended interval, non-adherent: recommended SPT-interval interruption ≥12 months)...
June 19, 2018: Acta Odontologica Scandinavica
Andrea Bobbio, Anna Maria Manganelli, Silvano Cannone
OBJECTIVES: This paper addresses the moderating role of locomotion - a functional and fundamental dimension of self-regulation - in the relationship between job insecurity and subjective well-being. METHODS: A group of 205 adult Italian workers took part in the research by filling out an anonymous questionnaire that included measures of job insecurity, locomotion, satisfaction with life, positive and negative affect. RESULTS: Results showed that job insecurity was positively related to negative affect and negatively related to life satisfaction and positive affect...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
Maria Koshy, John Mathew, Reginald Alex, John Antony Jude, Ravikar Ralph, Thambu David Sudarsanam, Sowmya Sathyendra, J Visalakshi, John Victor Peter
Background & objectives: The pathological hallmark of scrub typhus infection is focal or disseminated vasculitis. As with other infections, antinuclear antibodies (ANA) have been previously described in scrub typhus. However, the underlying mechanisms and implications of this immunological phenomenon is not well understood. In the present work it was assessed whether ANA is associated with illness severity and outcomes. Methods: In this prospective study spanning one year, patients fulfilling the diagnostic criteria for scrub typhus were recruited...
January 2018: Journal of Vector Borne Diseases
G Camelia Adams, Andrew J Wrath, Xiangfei Meng
OBJECTIVE: Several studies have shown a relationship between individual attachment and various aspects of treatment utilization in individuals with medical problems as well as mental health disorders. This review systematically evaluates existing literature targeting the relationship between attachment and all aspects of treatment utilization, such as engagement, participation, and completion, in adults with mental health problems. METHOD: A computerized search of PsycINFO, Medline, Embase, PubMed, and Healthstar and a manual search were employed...
January 1, 2018: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
Siba Jneid, Hicham Jabbour, Aline Hajj, Antoine Sarkis, Hady Licha, Souheil Hallit, Lydia Rabbaa Khabbaz
OBJECTIVE: Patients with hypertension tend to have a lower health-related quality of life (HRQOL) compared to normotensive patients. This study's main objectives are to assess (1) HRQOL and factors that might impact it and (2) association between HRQOL and adherence to treatment, trust in physician, and treatment satisfaction among patients with hypertension. METHODS: A cross-sectional study enrolled 196 patients from medical-care offices in Beirut, North and South Lebanon...
January 1, 2018: Journal of Cardiovascular Pharmacology and Therapeutics
Stephan Uschok, Sebastian Herrmann, Stephan Pauly, Carsten Perka, Stefan Greiner
INTRODUCTION: Reverse shoulder arthroplasty shifts the rotational center of the shoulder joint caudally and medially to restore shoulder function in a rotator cuff deficient shoulder. Despite promising results in early- and mid-term follow-up, long-term loss in shoulder function has been described in the literature. A lack of exercise in elderly patients may be one reason for this loss in function. This study examines the functional benefits of physical therapy in the mid-term to long-term follow-up regarding the subjective and objective shoulder function...
June 19, 2018: Archives of Orthopaedic and Trauma Surgery
L Chadli, C Steltzlen, P Beaufils, C Toanen, N Pujol
PURPOSE: The goal of the fixation of painful osteochondritis dissecans of the femoral condyles in adults is to integrate the osteochondral fragment and thus achieve a normal hyaline cartilaginous coverage. The addition of a biological process to primary fixation may result in improved fragment integration (hybrid fixation). Osteochondral plugs may fulfil this role. The aim of this study was to evaluate long-term clinical and radiological results after hybrid fixation of unstable osteochondritis dissecans...
June 19, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
Satoshi Fukuda, Perenlei Enkhbaatar, Christina Nelson, Robert A Cox, Marla R Wolfson, Thomas H Shaffer, Robert O Williams, Soraya Hengsawas Surasarang, Sahakijpijarn Sawittree, Galina Florova, Andrey A Komissarov, Kathleen Koenig, Krishna Sarva, Harrison T Ndetan, Karan P Singh, Steven Idell
BACKGROUND: Airway fibrin casts are clinically important complications of severe inhalational smoke-induced acute lung injury (ISIALI) for which reliable evidence-based therapy is lacking. Nebulized anticoagulants or a tissue plasminogen activator; tPA, has been advocated, but airway bleeding is a known and lethal potential complication. We posited that nebulized delivery of single chain urokinase plasminogen activator, scuPA, is well-tolerated and improves physiologic outcomes in ISIALI...
June 18, 2018: Clinical and Translational Medicine
Jing Zhou, Xuemei Yi, Ying Li, Yangfeng Ding
To compare the efficacy and safety of UVA1 and narrowband UVB (NB-UVB) therapy in the treatment of scalp psoriasis. Patients with scalp psoriasis were randomly assigned to either UVA1 or NB-UVB therapy. Both treatments were performed three times weekly for 6 weeks. Clinical efficacy was evaluated by using Psoriasis Scalp Severity Index (PSSI), and patient-reported quality of life (QoL) was assessed by Dermatology Life Quality Index (DLQI). Totally 68 patients completed the study. Both UVA1 and NB-UVB phototherapy achieved a statistically significant reduction of PSSI and DLQI scores at the end of the treatment period...
June 18, 2018: Lasers in Medical Science
K J Jerzak, J G Cockburn, S K Dhesy-Thind, G R Pond, K I Pritchard, S Nofech-Mozes, P Sun, S A Narod, A Bane
PURPOSE: Preliminary data suggest that high expression of the TRβ1 tumor suppressor is associated with longer survival among women with early breast cancer. We undertook this study to validate these findings. METHODS: In this prospective cohort study, we analyzed the prognostic significance of TRβ1 protein expression in the breast tumors of 796 women who had undergone breast surgery in the Henrietta Banting Breast Cancer database. All women were recruited after undergoing primary surgical therapy at Women's College Hospital (Toronto, ON, Canada) between January 1987 and December 2000...
June 18, 2018: Breast Cancer Research and Treatment
Christian Lampl, Mirjam Rudolph, Elisabeth Bräutigam
BACKGROUND: Cluster headache (CH) is a clinically well-defined primary headache disorder, approximately 20% of cluster headache sufferers experience recurrent attacks without periods of significant remission. For the treatment of chronic cluster headache (CCH) only limited therapeutic options are available. METHODS: A potential refractory CCH patient group was identified according to the clinical definition of rCCH based on the consensus statement of the European Headache Federation (EHF)...
June 19, 2018: Journal of Headache and Pain
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