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https://www.readbyqxmd.com/read/28924116/transient-left-ventricular-contractile-dysfunction-during-the-treatment-of-rhabdomyolysis-a-case-report-and-literature-review
#1
Toshihiro Tsuruda, Nozomi Shinohara, Miyuki Ogata, Kazuo Kitamura, Hidenobu Ochiai
Transient left ventricular contractile dysfunction (TLVCD) is often observed as a result of stress-related cardiomyopathy; however, recent reports suggest that rhabdomyolysis and eating disorders can also induce the development of TLVCD. We report a 52-year-old malnourished man who developed acute heart failure on day 4 of treatment for rhabdomyolysis. Transthoracic echocardiogram revealed severe hypokinesis at the apical and mid-ventricular segments, except for the basal segments of the left ventricular wall, which recovered within one week...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28923819/geriatric-anorexia-nervosa
#2
Moaweya Zayed, Joseph P Garry
Eating disorders are not commonly diagnosed in individuals aged >50 years, yet they are associated with significant psychiatric comorbidities and overall morbidity. Anorexia nervosa is the most common eating disorder among this age group, and women are affected most often. We present the fatal case of a 66-year old woman with severe malnutrition and newly diagnosed anorexia nervosa. Inpatient refeeding was unsuccessful, and she succumbed to multisystem organ failure. The timely recognition of eating disorders among older people is important for family physicians who care for patients across the life spectrum...
September 2017: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/28919842/international-society-of-sports-nutrition-position-stand-nutrient-timing
#3
REVIEW
Chad M Kerksick, Shawn Arent, Brad J Schoenfeld, Jeffrey R Stout, Bill Campbell, Colin D Wilborn, Lem Taylor, Doug Kalman, Abbie E Smith-Ryan, Richard B Kreider, Darryn Willoughby, Paul J Arciero, Trisha A VanDusseldorp, Michael J Ormsbee, Robert Wildman, Mike Greenwood, Tim N Ziegenfuss, Alan A Aragon, Jose Antonio
The International Society of Sports Nutrition (ISSN) provides an objective and critical review regarding the timing of macronutrients in reference to healthy, exercising adults and in particular highly trained individuals on exercise performance and body composition. The following points summarize the position of the ISSN:Nutrient timing incorporates the use of methodical planning and eating of whole foods, fortified foods and dietary supplements. The timing of energy intake and the ratio of certain ingested macronutrients may enhance recovery and tissue repair, augment muscle protein synthesis (MPS), and improve mood states following high-volume or intense exercise...
2017: Journal of the International Society of Sports Nutrition
https://www.readbyqxmd.com/read/28913658/liver-specific-reconstitution-of-ceacam1-reverses-the-metabolic-abnormalities-caused-by-its-global-deletion-in-male-mice
#4
Lucia Russo, Harrison T Muturi, Hilda E Ghadieh, Simona S Ghanem, Thomas A Bowman, Hye Lim Noh, Sezin Dagdeviren, Godwin Y Dogbey, Jason K Kim, Garrett Heinrich, Sonia M Najjar
AIMS/HYPOTHESIS: The carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) promotes insulin clearance. Mice with global null mutation (Cc1 (-/-)) or with liver-specific inactivation (L-SACC1) of Cc1 (also known as Ceacam1) gene display hyperinsulinaemia resulting from impaired insulin clearance, insulin resistance, steatohepatitis and obesity. Because increased lipolysis contributes to the metabolic phenotype caused by transgenic inactivation of CEACAM1 in the liver, we aimed to further investigate the primary role of hepatic CEACAM1-dependent insulin clearance in insulin and lipid homeostasis...
September 14, 2017: Diabetologia
https://www.readbyqxmd.com/read/28905406/thiamine-content-of-f-75-therapeutic-milk-for-complicated-severe-acute-malnutrition-time-for-a-change
#5
Laurent Hiffler, Bola Adamolekun, Philip R Fischer, Aviva Fattal-Vavleski
Since community-based management of severe acute malnutrition has become the standard of care, the clinical profile of severe acutely malnourished patients admitted to hospitals or inpatient therapeutic feeding centers has changed significantly. These patients are usually very ill and often present with several comorbidities, such as shock, sepsis, and pneumonia. Complicated severe acute malnutrition patients are at risk of thiamine insufficiency, and critically ill patients have higher thiamine requirements...
September 14, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28887630/ncb5or-deficiency-in-the-cerebellum-and-midbrain-leads-to-dehydration-and-alterations-in-thirst-response-fasted-feeding-behavior-and-voluntary-exercise-in-mice
#6
Matthew A Stroh, Michelle K Winter, Kenneth E McCarson, John P Thyfault, Hao Zhu
Cytosolic NADH-cytochrome-b5-oxidoreductase (NCB5OR) is ubiquitously expressed in animal tissues. We have previously reported that global ablation of NCB5OR in mice results in early-onset lean diabetes with decreased serum leptin levels and increased metabolic and feeding activities. The conditional deletion of NCB5OR in the mouse cerebellum and midbrain (conditional knock out, CKO mice) results in local iron dyshomeostasis and altered locomotor activity. It has been established that lesion to or removal of the cerebellum leads to changes in nutrient organization, visceral response, feeding behavior, and body weight...
September 8, 2017: Cerebellum
https://www.readbyqxmd.com/read/28880351/-refeeding-syndrome-during-alcohol-detoxification
#7
J J S Rutten, H Post, G H de Weert-van Oene, V J A Buwalda
Refeeding syndrome (RS) can occur when malnourished patients are reintroduced to carbohydrates. The symptoms are caused by a combination of electrolyte shifts and fluid retention. Symptoms are wide-ranging; some patients may suffer from harmless muscle cramps, others from more severe neurological and cardiological symptoms that can even lead to death. Although alcohol dependence is a risk factor for the development of RS, little attention is being given to this problem in addiction treatment. In this article we report a case of RS that occurred during alcohol detoxification...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28878927/themes-arising-in-clinical-consultation-for-therapists-implementing-family-based-treatment-for-adolescents-with-anorexia-nervosa-a-qualitative-study
#8
J Couturier, J Lock, M Kimber, G McVey, M Barwick, A Niccols, C Webb, S Findlay, T Woodford
BACKGROUND: Our study aims to explore and describe themes arising in sessions of clinical consultation with therapists implementing Family-Based Treatment (FBT) for adolescents with Anorexia Nervosa (AN). There is currently no literature describing the content of clinical consultation for FBT. Thus, this knowledge will add to the evidence-base on what therapists need from consultants in ongoing clinical consultation. METHODS: Eight therapists at four sites participated in this study, which spanned a two-year period...
2017: Journal of Eating Disorders
https://www.readbyqxmd.com/read/28873961/transcriptome-analysis-of-the-response-of-burmese-python-to-digestion
#9
Jinjie Duan, Kristian Wejse Sanggaard, Leif Schauser, Sanne Enok Lauridsen, Jan J Enghild, Mikkel Heide Schierup, Tobias Wang
Exceptional and extreme feeding behaviour makes the Burmese python (Python bivittatus) an interesting model to study physiological remodelling and metabolic adaptation in response to refeeding after prolonged starvation. In this study, we used transcriptome sequencing of 5 visceral organs during fasting as well as 24 hours and 48 hours after ingestion of a large meal to unravel the postprandial changes in Burmese pythons. We first used the pooled data to perform a de novo assembly of the transcriptome and supplemented this with a proteomic survey of enzymes in the plasma and gastric fluid...
August 1, 2017: GigaScience
https://www.readbyqxmd.com/read/28873424/dual-specificity-phosphatase-6-deficiency-is-associated-with-impaired-systemic-glucose-tolerance-and-reversible-weight-retardation-in-mice
#10
Katrin Pfuhlmann, Paul T Pfluger, Sonja C Schriever, Timo D Müller, Matthias H Tschöp, Kerstin Stemmer
Here, we aimed to investigate the potential role of DUSP6, a dual specificity phosphatase, that specifically inactivates extracellular signal-regulated kinase (ERK), for the regulation of body weight and glucose homeostasis. We further assessed whether metabolic challenges affect Dusp6 expression in selected brain areas or white adipose tissue. Hypothalamic Dusp6 mRNA levels remained unchanged in chow-fed lean vs. high fat diet (HFD) fed obese C57Bl/6J mice, and in C57Bl/6J mice undergoing prolonged fasting or refeeding with fat free diet (FFD) or HFD...
2017: PloS One
https://www.readbyqxmd.com/read/28871553/treatment-with-granulocyte-colony-stimulating-factor-in-the-refeeding-phase-of-anorexia-nervosa-complicated-with-severe-neutropenia-and-sepsis-a-case-report
#11
Haruki Komatsu, Karin Hayashi, Fukiko Higashiyama
Leukopenia is frequently observed in patients with anorexia nervosa (AN). However, serious infectious diseases are infrequent in patients with AN. We present the case of a 13-year-old girl with AN complicated with severe neutropenia and sepsis upon refeeding. Her body mass index was 11 kg/m(2) and her absolute neutrophil count (ANC) was 1555/µL on admission. After the initiation of refeeding, her ANC gradually declined to 346/µL. High fever occurred and a blood culture tested positive for Enterobacter cloacae...
September 4, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28866139/impact-of-caloric-intake-in-critically-ill-patients-with-and-without-refeeding-syndrome-a-retrospective-study
#12
Laura E Olthof, W A C Kristine Koekkoek, Coralien van Setten, Johannes C N Kars, Dick van Blokland, Arthur R H van Zanten
BACKGROUND & AIMS: Refeeding syndrome comprises metabolic disturbances that occur after the reintroduction of feeding after prolonged fasting. Standard care consists of correcting fluid and electrolytes imbalances. Energy intake during refeeding syndrome is heavily debated. This study addresses the effect of caloric intake on outcome during the management of refeeding syndrome. METHODS: A retrospective study among critically ill invasive mechanically ventilated patients admitted for >7 days to a medical-surgical ICU...
August 10, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28853614/refeeding-after-caloric-restriction-reverses-altered-liver-glucose-release
#13
Rosângela F Garcia, Isabela R Mariano, Isabela C Stolarz, Maria Montserrat D Pedrosa
CONTEXT: Caloric restriction increases liver glucose release (LGR), but it is not known if this is a permanent condition. OBJECTIVE: To investigate if refeeding after caloric restriction reverses the high LGR. MATERIALS AND METHODS: Rats were organised in six-pups litters (GC); 12-pups litters with either 50% caloric restriction from 21 to 80 days of age (GR) or fed at will from 50 to 80 days of age (GRL). Liver perfusion was made at the age of 80 days...
August 30, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28852859/neuronal-connections-of-the-central-amygdalar-nucleus-with-refeeding-activated-brain-areas-in-rats
#14
Györgyi Zséli, Barbara Vida, Anett Szilvásy-Szabó, Mónika Tóth, Ronald M Lechan, Csaba Fekete
Following fasting, satiety is accompanied by neuronal activation in brain areas including the central amygdalar nucleus (CEA). Since CEA is known to inhibit food intake, we hypothesized that CEA contributes to the termination of meal during refeeding. To better understand the organization of this satiety-related circuit, the interconnections of the CEA with refeeding-activated neuronal groups were elucidated using retrograde (cholera toxin-β subunit, CTB) and anterograde (phaseolus vulgaris leucoagglutinin, PHA-L) tracers in male rats...
August 29, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28852200/early-gestational-maternal-low-protein-diet-diminishes-hepatic-response-to-fasting-in-young-adult-male-mice
#15
Noriko Sato, Katsuko Sudo, Masayo Mori, Chihiro Imai, Masaaki Muramatsu, Masahiro Sugimoto
Maternal low-protein (MLP) diet can lead to hepatic steatosis, which only develops with ageing. It is still unclear whether the young offspring show any signs of past exposure to prenatal adverse conditions. We hypothesized that early nutritional insult would first affect the dynamic responsiveness to nutritional challenges rather than the static state. We analyzed the transcriptome and metabolome profiles of the hepatic response to fasting/refeeding in young male mice offspring to identify changes induced by early gestational MLP diet...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28835303/mitotic-index-and-morphological-characteristics-of-ovarian-small-follicles-from-goats-submitted-to-nutritionally-unbalanced-regimens
#16
Davide Rondina, Vicente J F Freitas, Jamily B Bruno, Juliana J H Celestino, Regiane R Santos
The objective of this study was to assess the influence of nutritional regimens such as adequate feeding, restricted feeding, and underfeeding-refeeding on the follicle growth and development from caprine ovaries. Goats were divided into three different groups (n = 5 per group). For 24 weeks, goats received elephant grass plus concentrate to provide 1.5 (n = 5) and 0.72 (n = 10) times the energy requirements for maintenance of live weight. Underfed goats were subsequently refed for 6 weeks with the diet of the nourished group (1...
August 24, 2017: Zygote: the Biology of Gametes and Early Embryos
https://www.readbyqxmd.com/read/28812578/throw-caution-to-the-wind-is-refeeding-syndrome-really-a-cause-of-death-in-acute-care
#17
K L Matthews, S M Capra, M A Palmer
BACKGROUND/OBJECTIVES: Refeeding syndrome (RFS), a life-threatening medical condition, is commonly associated with acute or chronic starvation. While the prevalence of patients at risk of RFS in hospital reportedly ranges from 0 to 80%, the prevalence and types of patients who die as a result of RFS is unknown. We aimed to measure the prevalence rate and examine the case histories of patients who passed away with RFS listed as a cause of death. SUBJECTS/METHODS: Patients were eligible for inclusion provided their death occurred within a Queensland hospital...
August 16, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28798045/global-mrna-polarization-regulates-translation-efficiency-in-the-intestinal-epithelium
#18
Andreas E Moor, Matan Golan, Efi E Massasa, Doron Lemze, Tomer Weizman, Rom Shenhav, Shaked Baydatch, Orel Mizrahi, Roni Winkler, Ofra Golani, Noam Stern-Ginossar, Shalev Itzkovitz
Asymmetric mRNA localization facilitates efficient translation in cells such as neurons and fibroblasts. However, the extent and significance of mRNA polarization in epithelial tissues are unclear. Here, we used single molecule transcript imaging and subcellular transcriptomics to uncover global apical-basal intracellular polarization of mRNA in the mouse intestinal epithelium. The localization of mRNAs did not generally overlap protein localization. Instead, ribosomes were more abundant on the apical sides, and apical transcripts were consequently more efficiently translated...
August 10, 2017: Science
https://www.readbyqxmd.com/read/28793989/early-enteral-tube-feeding-in-optimizing-treatment-of-hyperemesis-gravidarum-the-maternal-and-offspring-outcomes-after-treatment-of-hyperemesis-by-refeeding-mother-randomized-controlled-trial
#19
RANDOMIZED CONTROLLED TRIAL
Iris J Grooten, Marjette H Koot, Joris Am van der Post, Joke Mj Bais, Carrie Ris-Stalpers, Christiana Naaktgeboren, Henk A Bremer, David P van der Ham, Wieteke M Heidema, Anjoke Huisjes, Gunilla Kleiverda, Simone Kuppens, Judith Oeh van Laar, Josje Langenveld, Flip van der Made, Mariëlle G van Pampus, Dimitri Papatsonis, Marie-José Pelinck, Paula J Pernet, Leonie van Rheenen, Robbert J Rijnders, Hubertina Cj Scheepers, Tatjana E Vogelvang, Ben W Mol, Tessa J Roseboom, Rebecca C Painter
Background: Hyperemesis gravidarum (HG) leads to dehydration, poor nutritional intake, and weight loss. HG has been associated with adverse pregnancy outcomes such as low birth weight. Information about the potential effectiveness of treatments for HG is limited.Objective: We hypothesized that in women with HG, early enteral tube feeding in addition to standard care improves birth weight.Design: We performed a multicenter, open-label randomized controlled trial [Maternal and Offspring outcomes after Treatment of HyperEmesis by Refeeding (MOTHER)] in 19 hospitals in the Netherlands...
September 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28777106/treatment-of-eating-disorders-in-child-and-adolescent-psychiatry
#20
Beate Herpertz-Dahlmann
PURPOSE OF REVIEW: Recent research on the multimodal treatment of eating disorders in child and adolescent psychiatry has yielded a significant increase in randomized controlled trials and systematic reviews. This review aims to present relevant findings published during the last 2 years related to medical and psychological treatment of anorexia nervosa, bulimia nervosa and avoidant/restrictive food intake disorder (ARFID). RECENT FINDINGS: For anorexia nervosa, recent reports described the efficacy of different treatment settings, lengths of hospital stay and high vs...
August 24, 2017: Current Opinion in Psychiatry
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