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https://www.readbyqxmd.com/read/27909106/refeeding-syndrome
#1
Christian D Pulcini, Stacey Zettle, Arvind Srinath
No abstract text is available yet for this article.
December 2016: Pediatrics in Review
https://www.readbyqxmd.com/read/27901033/impact-of-dietary-glycemic-challenge-on-fuel-partitioning
#2
REVIEW
A Bosy-Westphal, F Hägele, A Nas
The 'carbohydrate-insulin theory of obesity' is used to justify popular health claims stating that carbohydrates make you fat or a high glycemic load and consumption of sugar-sweetened beverages (SSBs) and breakfast skipping increase fat gain. According to this theory, the elevated postprandial insulin secretion to a high glycemic challenge is blamed as a causal mechanism by directing nutrients away from oxidation in muscle towards storage in adipose tissue. Scientific evidence is however largely disagreeing with an adverse effect of postprandial hyperinsulinemia on fuel partitioning...
November 30, 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27894065/evaluation-of-csf-and-plasma-biomarkers-of-brain-melanocortin-activity-in-response-to-caloric-restriction-in-humans
#3
Gabrielle Page-Wilson, Kim T Nguyen, Deniz Atalayer, Kana Meece, Heather A Bainbridge, Judith Korner, Rebecca J Gordon, Sunil K Panigrahi, Anne White, Richard Smiley, Sharon L Wardlaw
The melanocortin neuronal system, comprised of hypothalamic proopiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, is a leptin target that regulates energy balance and metabolism, but studies in humans are limited by lack of reliable biomarkers for brain melanocortin activity. The objective of this study was to measure the POMC prohormone and its processed peptide, ß-endorphin (ß-EP), in cerebrospinal fluid (CSF) and AgRP in CSF and plasma after calorie restriction to validate their utility as biomarkers of brain melanocortin activity...
November 15, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27878283/hes5-promotes-cellular-proliferation-of-non-small-cell-lung-cancer-through-stat3-signaling
#4
Shudong Gu, Rui Zhang, Jun Gu, Xia Li, Liting Lv, Jingting Jiang, Zhen Xu, Shuo Wang, Cui Shi, Dan Ping Wang, Changping Wu
HES5 is a transcription factor activated downstream of the Notch pathway and regulates cell differentiation in multiple tissues. Disruption of its normal expression has been associated with developmental diseases and cancer. But its role in non-small cell lung cancer (NSCLC) remains elusive. Western blot analysis and immunohistochemistry assays demonstrated that HES5 expression was frequently increased in NSCLC tumor tissues and cell lines. Moreover, immunohistochemistry analysis revealed that upregulation of HES5 expression was positively correlated with a more invasive tumor phenotype and poor prognosis...
November 22, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27875284/parenteral-nutrition-electrolyte-abnormalities-and-associated-factors-before-and-after-nutrition-support-team-initiation
#5
Katie Braun, Anne Utech, Maria Eugenia Velez, Renee Walker
BACKGROUND: Studied since the 1940s, refeeding syndrome still has no universal definition, thus making comparison of studies difficult. Negative outcomes (eg, metabolic abnormalities) may occur with the use of specialized nutrition, such as parenteral nutrition (PN). Less than half of medical institutions have a nutrition support team (NST) managing PN. Interdisciplinary team management of PN may reduce negative outcomes of PN. The objective of this study was to show the value of the NST by measuring differences in PN variables, especially electrolyte abnormalities (EAs), before and after NST initiation at a large medical center and to identify factors associated with EAs among adult subjects receiving PN...
October 18, 2016: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27851333/1698-refeeding-syndrome-in-pancreatic-exocrine-insufficiency-replacement-therapy
#6
Riley Jones, Long Vu, Haroon Ahmed, Edwin Hargitt, Kalpan Desai, Vishal Jivan
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27851272/1637-torsades-precipitated-by-refeeding-syndrome-a-case-report-abstract
#7
Joshua Da Silva
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27817168/knockdown-of-dixdc1-inhibits-the-proliferation-and-migration-of-human-glioma-cells
#8
Jianguo Chen, Chaoyan Shen, Jinlong Shi, Jianhong Shen, Wenjuan Chen, Jie Sun, Shaocheng Fan, Yuanqi Bei, Peng Xu, Hao Chang, Rui Jiang, Lu Hua, Bin Ji, Qingfeng Huang
DIX domain containing 1 (DIXDC1), the human homolog of coiled-coil-DIX1 (Ccd1), is a positive regulator of Wnt signaling pathway. Recently, it was found to act as a candidate oncogene in colon cancer, non-small-cell lung cancer, and gastric cancer. In this study, we aimed to investigate the clinical significance of DIXDC1 expression in human glioma and its biological function in glioma cells. Western blot and immunohistochemistry analysis showed that DIXDC1 was overexpressed in glioma tissues and glioma cell lines...
November 5, 2016: Cellular and Molecular Neurobiology
https://www.readbyqxmd.com/read/27815199/dietary-protein-enhances-non-specific-immunity-anti-oxidative-capability-and-resistance-to-aeromonas-hydrophila-in-labeo-rohita-fingerlings-pre-exposed-to-short-feed-deprivation-stress
#9
Sona Yengkokpam, Dipesh Debnath, N P Sahu, A K Pal, K K Jain, Kartik Baruah
Present experiment was conducted to study the effect of dietary protein levels on growth, immunity and anti-oxidative status of Labeo rohita fingerlings during feed deprivation followed by refeeding. Fish (5.44 ± 0.10 g) were deprived of feed for 3 weeks and then re-fed to satiation for 5 weeks with one of the diets containing 25 (25P), 30 (30P), 35 (35P) or 40 (40P) percent crude protein (CP) level. In addition to these groups, a control group (C) was also maintained by feeding to satiation level twice daily with a diet containing 30% CP throughout the experimental period...
December 2016: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/27814707/serum-phosphate-and-magnesium-in-children-recovering-from-severe-acute-undernutrition-in-ethiopia-an-observational-study
#10
Anne-Louise Hother, Tsinuel Girma, Maren J H Rytter, Alemseged Abdissa, Christian Ritz, Christian Mølgaard, Kim F Michaelsen, André Briend, Henrik Friis, Pernille Kæstel
BACKGROUND: Children with severe acute malnutrition (SAM) have increased requirements for phosphorus and magnesium during recovery. If requirements are not met, the children may develop refeeding hypophosphatemia and hypomagnesemia. However, little is known about the effect of current therapeutic diets (F-75 and F-100) on serum phosphate (S-phosphate) and magnesium (S-magnesium) in children with SAM. METHODS: Prospective observational study, with measurements of S-phosphate and S-magnesium at admission, prior to rehabilitation phase and at discharge in children aged 6-59 months admitted with SAM to Jimma Hospital, Ethiopia...
November 5, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27802964/chronic-hyperprolactinemia-evoked-by-disruption-of-lactotrope-dopamine-d2-receptors-impacts-on-liver-and-adipocyte-genes-related-to-glucose-and-insulin-balance
#11
Guillermina Maria Luque, Felicitas Lopez-Vicchi, Ana Maria Ornstein, Belen Brie, Catalina De Winne, Esteban Fiore, Maria Ines Perez Millan, Guillermo Mazzolini, Marcelo Rubinstein, Damasia Becu-Villalobos
We studied the impact of high prolactin titers on liver and adipocyte gene expression related to glucose and insulin homeostasis, in correlation with obesity onset. To that end we used mutant female mice that selectively lack dopamine type 2 receptors (D2Rs) from pituitary lactotropes (lacDrd2KO) which have chronic high prolactin levels associated with increased body weight, marked increments in fat depots, adipocyte size, and serum lipids, a metabolic phenotype which intensifies with age. LacDrd2KO mice of two developmental ages, 5 and 10 months were used...
November 1, 2016: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27798779/expanding-the-differential-diagnosis-for-transaminitis-in-patients-with-anorexia-nervosa
#12
Adam C Nadelson, Victor D Babatunde, Eric U Yee, Vilas R Patwardhan
Aminotransferase elevations have been described in patients with anorexia nervosa. Hypothesized etiologies have included ischemic hepatitis, refeeding-induced transaminitis, and the process of autophagy. Supervised enteral nutrition is the mainstay of treatment for severe anorexia, but an increase in aminotransferase levels after initiation of enteral feeding presents clinicians with a diagnostic dilemma. We present a 31-year-old woman with anorexia nervosa (body mass index [BMI] of 13.5 kg/m(2)) who experienced a worsening of aminotransferase elevations even after the initiation of enteral feeding...
October 31, 2016: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/27765466/-wasting-in-chronic-kidney-disease-refeeding-techniques-and-artificial-nutrition-practices
#13
Céline Pasian, Raymond Azar, Denis Fouque
Protein energy wasting (PEW) is an independent factor associated with morbi-mortality in chronic kidney disease. Wasting is particularly common in chronic diseases of organs such as kidney disease with a major impact at the stage of dialysis. It covers 20 to 70% of patients diagnosed with chronic kidney disease according to the degree of evolution of the disease and the diagnostic method used patients. Mechanisms of PEW are based mainly on anorexia and metabolic abnormalities caused by kidney disease. Nutritional treatment differs depending on the stage of the kidney disease acute or chronic treated whether or not by dialysis...
October 17, 2016: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/27735945/liver-ubiquitome-uncovers-nutrient-stress-mediated-trafficking-and-secretion-of-complement-c3
#14
Helena de Fatima Magliarelli, Mariette Matondo, Gergő Mészáros, Alexander Goginashvili, Eric Erbs, Zhirong Zhang, Michael Mihlan, Christian Wolfrum, Ruedi Aebersold, Izabela Sumara, Romeo Ricci
Adaptation to changes in nutrient availability is crucial for cells and organisms. Posttranslational modifications of signaling proteins are very dynamic and are therefore key to promptly respond to nutrient deprivation or overload. Herein we screened for ubiquitylation of proteins in the livers of fasted and refed mice using a comprehensive systemic proteomic approach. Among 1641 identified proteins, 117 were differentially ubiquitylated upon fasting or refeeding. Endoplasmic reticulum (ER) and secretory proteins were enriched in the livers of refed mice in part owing to an ER-stress-mediated response engaging retro-translocation and ubiquitylation of proteins from the ER...
October 13, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27733761/cdc2-like-kinase-2-clk2-in-the-hypothalamus-is-necessary-to-maintain-energy-homeostasis
#15
P G F Quaresma, L Weissmann, T M Zanotto, A C Santos, A H B de Matos, I C Furigo, F M Simabuco, J D Junior, J C Bittencourt, I Lopes-Cendes, P O Prada
OBJECTIVE: To investigate whether the Cdc2-like Kinase 2 (CLK2) is expressed in hypothalamic neurons and if it is, whether the hypothalamic CLK2 has a role in the regulation of energy balance. SUBJECTS: Swiss mice on chow or high fat diet (HFD) and db/db mice on chow diet were used to address the role of CLK2 in the hypothalamus. RESULTS: Hypothalamic CLK2(Thr343) phosphorylation, which induces CLK2 activity, is regulated in vivo by refeeding, insulin and leptin, in a PI3K dependent manner...
October 13, 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/27721832/management-of-severe-rhabdomyolysis-and-exercise-associated-hyponatremia-in-a-female-with-anorexia-nervosa-and-excessive-compulsive-exercising
#16
Marwan El Ghoch, Simona Calugi, Riccardo Dalle Grave
This case report describes the management of a 49-year-old female with restricting-type anorexia nervosa and excessive compulsive exercising associated with rhabdomyolysis, high levels of serum creatine kinase (CK) (3,238 U/L), and marked hyponatremia (Na(+): 123 mEq/L) in the absence of purging behaviours or psychogenic polydipsia; it is the first case report to describe exercise-associated hyponatremia in a patient with anorexia nervosa. The patient, who presented with a body mass index (BMI) of 13.4 kg/m(2), was successfully treated by means of an adapted inpatient version of an enhanced form of cognitive behavioural therapy (CBT-E)...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27716401/altered-gut-microbiota-in-female-mice-with-persistent-low-body-weights-following-removal-of-post-weaning-chronic-dietary-restriction
#17
Jun Chen, Yoshitaka Toyomasu, Yujiro Hayashi, David R Linden, Joseph H Szurszewski, Heidi Nelson, Gianrico Farrugia, Purna C Kashyap, Nicholas Chia, Tamas Ordog
BACKGROUND: Nutritional interventions often fail to prevent growth failure in childhood and adolescent malnutrition and the mechanisms remain unclear. Recent studies revealed altered microbiota in malnourished children and anorexia nervosa. To facilitate mechanistic studies under physiologically relevant conditions, we established a mouse model of growth failure following chronic dietary restriction and examined microbiota in relation to age, diet, body weight, and anabolic treatment...
October 3, 2016: Genome Medicine
https://www.readbyqxmd.com/read/27708756/plasticity-and-regeneration-of-gonads-in-the-annelid-pristina-leidyi
#18
B Duygu Özpolat, Emily S Sloane, Eduardo E Zattara, Alexandra E Bely
BACKGROUND: Gonads are specialized gamete-producing structures that, despite their functional importance, are generated by diverse mechanisms across groups of animals and can be among the most plastic organs of the body. Annelids, the segmented worms, are a group in which gonads have been documented to be plastic and to be able to regenerate, but little is known about what factors influence gonad development or how these structures regenerate. In this study, we aimed to identify factors that influence the presence and size of gonads and to investigate gonad regeneration in the small asexually reproducing annelid, Pristina leidyi...
2016: EvoDevo
https://www.readbyqxmd.com/read/27708682/hepatic-adaptations-to-maintain-metabolic-homeostasis-in-response-to-fasting-and-refeeding-in-mice
#19
C E Geisler, C Hepler, M R Higgins, B J Renquist
BACKGROUND: The increased incidence of obesity and associated metabolic diseases has driven research focused on genetically or pharmacologically alleviating metabolic dysfunction. These studies employ a range of fasting-refeeding models including 4-24 h fasts, "overnight" fasts, or meal feeding. Still, we lack literature that describes the physiologically relevant adaptations that accompany changes in the duration of fasting and re-feeding. Since the liver is central to whole body metabolic homeostasis, we investigated the timing of the fast-induced shift toward glycogenolysis, gluconeogenesis, and ketogenesis and the meal-induced switch toward glycogenesis and away from ketogenesis...
2016: Nutrition & Metabolism
https://www.readbyqxmd.com/read/27693627/effects-of-fasting-and-refeeding-on-gene-expression-of-slc15a1a-a-gene-encoding-an-oligopeptide-transporter-pept1-in-the-intestine-of-mozambique-tilapia
#20
Zenith Gaye A Orozco, Satoshi Soma, Toyoji Kaneko, Soichi Watanabe
The tissue distribution of slc15a1a, a gene that encodes an oligopeptide transporter, PepT1, and its response to fasting and refeeding were investigated in the intestinal epithelium of Mozambique tilapia for a better understanding of its role on nutrient absorption. The slc15a1a was predominantly expressed in the absorptive epithelia of the anterior part of the intestine, suggesting that digested oligopeptides are primarily absorbed in the anterior intestine. The response of slc15a1a to fasting was evaluated at 1, 2, 4, 7 and 14days after the last feeding...
September 30, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
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