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Estrogen receptor beta

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https://www.readbyqxmd.com/read/28208754/gypenoside-xvii-prevents-atherosclerosis-by-attenuating-endothelial-apoptosis-and-oxidative-stress-insight-into-the-er%C3%AE-mediated-pi3k-akt-pathway
#1
Ke Yang, Haijing Zhang, Yun Luo, Jingyi Zhang, Min Wang, Ping Liao, Li Cao, Peng Guo, Guibo Sun, Xiaobo Sun
Phytoestrogens are estrogen-like compounds of plant origin. The pharmacological activities of phytoestrogens are predominantly due to their antioxidant, anti-inflammatory and lipid-lowering properties, which are mediated via the estrogen receptors (ERs): estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ) and possibly G protein-coupled estrogen receptor 1 (GPER). Gypenoside XVII (GP-17) is a phytoestrogen that is widely used to prevent cardiovascular disease, including atherosclerosis, but the mechanism underlying these therapeutic effects is largely unclear...
February 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28195088/serotonin-receptor-4-5-hydroxytryptamine-receptor-type-4-regulates-expression-of-estrogen-receptor-beta-and-cell-migration-in-hormone-naive-prostate-cancer
#2
Yasuhiro Nakamura, Kazue Ise, Yuto Yamazaki, Fumiyoshi Fujishima, Keely M McNamara, Hironobu Sasano
BACKGROUND: Estrogens are considered to potentially play some roles in the development and progression of prostate cancer through estrogen receptor beta (ERβ). However, additional factors which could influence the clinical outcome of the patients through modulating these steroid signalings have also been proposed. Among these, increased expression of serotonin receptor especially that of 5-hydroxytryptamine receptor Type 4 (5-HTR4) has been recently proposed to be involved in autocrine/paracrine mechanisms of castration-resistant prostate cancer, but the presence and clinical significance of 5-HTR4 in hormone-naive prostate cancer (HNPC) and its interaction with hormonal signaling pathways have remained virtually unknown...
January 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28183459/corrigendum-to-comprehensive-assessment-of-estrogen-receptor-beta-antibodies-in-cancer-cell-line-models-and-tissue-reveals-critical-limitations-in-reagent-specificity-mol-cell-endocrinol-440-2016-138-150
#3
A W Nelson, A J Groen, J L Miller, A Y Warren, K A Holmes, G A Tarulli, W D Tilley, B S Katzenellenbogen, J R Hawse, V J Gnanapragasam, J S Carroll
No abstract text is available yet for this article.
March 5, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28130335/development-of-dilated-cardiomyopathy-and-impaired-calcium-homeostasis-with-cardiac-specific-deletion-of-esrr%C3%AE
#4
Glenn C Rowe, Angeliki Asimaki, Evan L Graham, Kimberly D Martin, Kenneth B Margulies, Saumya Das, Jeffrey E Saffitz, Zoltan Arany
Mechanisms underlying the development of Idiopathic Dilated Cardiomyopathy (DCM) remain poorly understood. Using transcription factor expression profiling, we identified estrogen-related receptor beta (ESRRβ), a member of the nuclear receptor family of transcription factors, as highly expressed in murine hearts and other highly oxidative striated muscle beds. Mice bearing cardiac-specific deletion of ESRRβ (MHC-ERRB KO) develop dilated cardiomyopathy and sudden death at approximately 10 months of age. Isolated adult cardiomyocytes from the MHC-ERRB KO mice showed an increase in calcium sensitivity and impaired cardiomyocyte contractility, which preceded echocardiographic cardiac remodeling and dysfunction by several months...
January 27, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28119050/targeted-basic-research-to-highlight-the-role-of-estrogen-and-estrogen-receptors-in-the-cardiovascular-system
#5
REVIEW
Elke Dworatzek, Shokoufeh Mahmoodzadeh
Epidemiological, clinical and animal studies revealed that sex differences exist in the manifestation and outcome of cardiovascular disease (CVD). The underlying molecular mechanisms implicated in these sex differences are not fully understood. The reasons for sex differences in CVD are definitely multifactorial, but major evidence points to the contribution of sex steroid hormone, 17β-estradiol (E2), and its receptors, estrogen receptor alpha (ERα) and estrogen receptor beta (ERβ). In this review, we summarize past and present studies that implicate E2 and ER as important determinants of sexual dimorphism in the physiology and pathophysiology of the heart...
January 21, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28109853/variants-of-estrogen-receptor-alpha-and-beta-genes-modify-the-severity-of-sporadic-breast-cancer
#6
Luciana Montes Rezende, Fernando Augusto Lima Marson, Carmen Sílvia Passos Lima, Carmen Sílvia Bertuzzo
INTRODUCTION: Reproductive factors pose a risk for sporadic breast cancer(BC) development owing to the lifetime exposure to estrogen, a hormone responsible for cell proliferation in the breast. Because variants of the estrogen receptor(ER) alpha and beta genes have been associated with BC risk in numerous populations, the objective of the study was to determine whether the risk and severity of sporadic BC was associated with the rs2228480(ESR1) and rs4986938(ESR2) variants in a Brazilian population...
January 18, 2017: Gene
https://www.readbyqxmd.com/read/28065637/the-steroid-metabolite-16-%C3%AE-oh-androstenedione-generated-by-cyp21a2-serves-as-a-substrate-for-cyp19a1
#7
J Neunzig, M Milhim, L Schiffer, Y Khatri, J Zapp, A Sánchez-Guijo, M F Hartmann, S A Wudy, R Bernhardt
The 21-hydroxylase (CYP21A2) is a steroidogenic enzyme crucial for the synthesis of mineralo- and glucocorticoids. It is described to convert progesterone as well as 17-OH-progesterone, through a hydroxylation at position C21, into 11-deoxycorticosterone (DOC) and 11-deoxycortisol (RSS), respectively. In this study we unraveled CYP21A2 to have a broader steroid substrate spectrum than assumed. Utilizing a reconstituted in vitro system, consisting of purified human CYP21A2 and human cytochrome P450 reductase (CPR) we demonstrated that CYP21A2 is capable to metabolize DOC, RSS, androstenedione (A4) and testosterone (T)...
March 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27940297/increased-levels-of-enzymes-involved-in-local-estradiol-synthesis-in-chronic-obstructive-pulmonary-disease
#8
G F J Konings, N L Reynaert, B Delvoux, F M Verhamme, K R Bracke, G G Brusselle, A Romano, J H J Vernooy
INTRODUCTION: Steroid hormones are involved in lung development, pulmonary inflammation, and lung cancer. Estrogen signaling and exposure may play a role in pulmonary disorders, including COPD. In both genders, estrogens can be generated locally in the lungs and this contributes importantly to the tissue exposure to these steroids. OBJECTIVE: To characterize and assess differences in localization of estrogen receptors and enzymes involved in the local generation of estrogens in COPD...
December 8, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27923632/puerarin-suppression-of-a%C3%AE-1-42-induced-primary-cortical-neuron-death-is-largely-dependent-on-er%C3%AE
#9
Li Li, Zuguang Xue, Lei Chen, Xueyu Chen, Heshuang Wang, Xiaobo Wang
Recent study has suggested that estrogen replacement therapy (ERT) can decrease the risk of the development of Alzheimer's disease (AD), and phytoestrogen has been proposed as a potential alternative to ERT. In this study, we investigated the protective function of puerarin (a phytoestrogen isolated from puerarin lobate) against amyloid beta (Aβ1-42)-induced toxicity in cortical neurons and established the connection between such a protection and estrogen receptor (ER) activation. Puerarin suppressed Aβ1-42-induced cortical neuron death in a concentration-dependent manner...
December 3, 2016: Brain Research
https://www.readbyqxmd.com/read/27909742/the-anti-inflammatory-effect-of-montelukast-a-cysteinyl-leukotriene-receptor-1-antagonist-against-estradiol-induced-nonbacterial-inflammation-in-the-rat-prostate
#10
Mahmoud M Said, Maarten C Bosland
There is no standard treatment of chronic nonbacterial prostatitis in humans. The current study was aimed to investigate the effect of montelukast, an antagonist of cysteinyl leukotriene receptor-1, against estrogen-induced, nonbacterial lateral lobe-specific prostate inflammation in rats. Male Wistar rats were randomized into five groups of six rats, including sham controls (group 1) and castrated rats (group 2), whereas nonbacterial prostatitis (NBP) was induced in groups 3-5 by castration followed by a daily subcutaneous injection of estradiol (0...
February 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27903449/sex-differences-in-the-estrogen-dependent-regulation-of-temporomandibular-joint-remodeling-in-altered-loading
#11
J L Robinson, K Cass, R Aronson, T Choi, M Xu, R Buttenbaum, H Drissi, H H Lu, J Chen, S Wadhwa
OBJECTIVE: Temporomandibular joint (TMJ) diseases predominantly afflict women, suggesting a role of estrogen in the disease etiology. Previously, we determined that decreased occlusal loading (DOL) inhibited collagen type II (Col2) expression in the mandibular condylar cartilage (MCC) of female wild-type (WT) mice whereas no change was observed in males. This decrease in chondrogenesis was abolished by estrogen receptor beta (ERβ) deficiency in females. Therefore, the goal of this study was to examine the role of estradiol - ERβ signaling in mediating DOL effects in male mice to further decipher sex differences...
November 27, 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/27899088/alternative-splicing-of-estrogen-receptor-alpha-in-hepatocellular-carcinoma
#12
Jian Zhang, Jianwei Ren, Jiamin Wei, Charing C N Chong, Dongjie Yang, Yulong He, George G Chen, Paul B S Lai
BACKGROUND: The role of estrogen receptor alpha (ERa), estrogen receptor beta (ERb) and ERa36 signaling in hepatocellular carcinoma (HCC) is not fully addressed. METHODS: In this study, three cohorts were included: (i) primary HCC patients (N = 76, cohort P), (ii) colorectal liver metastasis (mCRC) (N = 32, cohort S), and (iii) HCC from The Cancer Genome Atlas (TCGA) (N = 121). The levels of ERa36 and wtER36 were measured and their correlation with clinicopathologic features was determined...
November 30, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27892794/effects-of-repeated-9-and-30-day-exposure-to-extremely-low-frequency-electromagnetic-fields-on-social-recognition-behavior-and-estrogen-receptors-expression-in-olfactory-bulb-of-wistar-female-rats
#13
C Bernal-Mondragón, V Arriaga-Avila, E Martínez-Abundis, B Barrera-Mera, O Mercado-Gómez, R Guevara-Guzmán
OBJECTIVE: We investigated the short- and long-term effects of extremely low-frequency electromagnetic fields (EMF) on social recognition behavior and expression of α- and β-estrogen receptors (ER). METHODS: Rats were exposed to 60-Hz electromagnetic fields for 9 or 30 days and tested for social recognition behavior. Immunohistochemistry and western blot assays were performed to evaluate α- and β-ER expression in the olfactory bulb of intact, ovariectomized (OVX), and ovariectomized+estradiol (E2) replacement (OVX+E2)...
February 2017: Neurological Research
https://www.readbyqxmd.com/read/27889472/comprehensive-assessment-of-estrogen-receptor-beta-antibodies-in-cancer-cell-line-models-and-tissue-reveals-critical-limitations-in-reagent-specificity
#14
Adam W Nelson, Arnoud J Groen, Jodi L Miller, Anne Y Warren, Kelly A Holmes, Gerard A Tarulli, Wayne D Tilley, Benita S Katzenellenbogen, John R Hawse, Vincent J Gnanapragasam, Jason S Carroll
Estrogen Receptor-β (ERβ) has been implicated in many cancers. In prostate and breast cancer its function is controversial, but genetic studies implicate a role in cancer progression. Much of the confusion around ERβ stems from antibodies that are inadequately validated, yet have become standard tools for deciphering its role. Using an ERβ-inducible cell system we assessed commonly utilized ERβ antibodies and show that one of the most commonly used antibodies, NCL-ER-BETA, is non-specific for ERβ. Other antibodies have limited ERβ specificity or are only specific in one experimental modality...
January 15, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27848152/the-presence-and-impact-of-estrogen-metabolism-on-the-biology-of-triple-negative-breast-cancer
#15
Keely May McNamara, Saki Oguro, Fumiya Omata, Kyoko Kikuchi, Fouzia Guestini, Koyu Suzuki, Yang Yang, Eriko Abe, Hisashi Hirakawa, Kristy A Brown, Ishida Takanori, Noriaki Ohuchi, Hironobu Sasano
PURPOSE: While triple-negative breast cancer (TNBC) is negative for estrogen receptor alpha, a substantial proportion of carcinomas express estrogen receptor beta (ERβ); consequently, estrogen actions and metabolism may be relevant in this cancer subtype. METHODS: A cohort of 81 TNBC patients from Tohoku University Hospital, Japan were characterised with regard to the expression of estrogen receptor beta and enzymes known to modulate levels of estrogens in breast and other tissues (Aromatase, 17-beta- Hydroxysteroid dehydrogenases 1, 2 and 6)...
November 15, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27817132/inhibitory-effect-of-estrogen-receptor-beta-on-p2x3-receptors-during-inflammation-in-rats
#16
Qian Jiang, Wen-Xin Li, Jia-Run Sun, Tian-Tian Zhu, Juan Fan, Li-Hua Yu, Geoffrey Burnstock, Hua Yang, Bei Ma
Estrogen receptor beta (ERβ) has been shown to play a therapeutic role in inflammatory bowel disease (IBD). However, the mechanism underlying how ERβ exerts therapeutic effects and its relationship with P2X3 receptors (P2X3R) in rats with inflammation is not known. In our study, animal behavior tests, visceromotor reflex recording, and Western blotting were used to determine whether the therapeutic effect of ERβ in rats with inflammation was related with P2X3R. In complete Freund adjuvant (CFA)-induced chronic inflammation in rats, paw withdrawal threshold was significantly decreased which were then reversed by systemic injection of ERβ agonists, DPN or ERB-041...
November 5, 2016: Purinergic Signalling
https://www.readbyqxmd.com/read/27814578/lipid-raft-er-signalosome-malfunctions-in-menopause-and-alzheimer-s-disease
#17
Ana Canerina-Amaro, Luis G Hernandez-Abad, Isidre Ferrer, David Quinto-Alemany, Fatima Mesa-Herrera, Carla Ferri, Ricardo A Puertas-Avendano, Mario Diaz, Raquel Marin
The increase in the incidence of Alzheimer's disease (AD) in old women may be attributable to estrogen deficiency, and estrogen replacement therapy may be useful in preventing or delaying the onset of this disease. In neuronal membranes, 17 beta-estradiol interacts with estrogen receptors (mERs) located in lipid raft signalosomes which trigger neuroprotective responses by anchoring to scaffolding caveolin-1 complexed with other proteins. We suggest that mER-signalosome malfunctions in AD and by menopause due to development of aberrations in these microstructures...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27813338/dutasteride-mediated-morphological-changes-in-the-genitourinary-tract-associated-with-altered-expression-patterns-of-the-androgen-and-estrogen-receptors-in-male-rats
#18
N Enatsu, K Chiba, K Sumii, T Fukuda, K Okada, K Matsushita, M Fujisawa
We evaluated the effects of dutasteride on the genitourinary tract using fifteen 8-week-old male Sprague-Dawley rats. Animals were divided into three groups comprising five animals each and treated as follows. Group A was a control group, members of Group B received oral administration of dutasteride 0.1 mg/kg/day from the age of 8 to 16 weeks, and members of Group C were castrated at the age of 8 weeks. All rats were killed at the age of 16 weeks for the sample collection of blood, bladder, prostate, seminal vesicles, and penis...
November 3, 2016: Andrology
https://www.readbyqxmd.com/read/27810901/high-estrogen-receptor-%C3%AE-expression-is-prognostic-among-adjuvant-chemotherapy-treated-patients-results-from-a-population-based-breast-cancer-cohort
#19
Karin Elebro, Signe Borgquist, Ann H Rosendahl, Andrea Markkula, Maria Simonsson, Karin Jirström, Carsten Rose, Christian Ingvar, Helena Jernström
PURPOSE: Isoform-specific tumor estrogen receptor β (ERβ) expression may hold prognostic information in breast cancer, especially among endocrine-treated breast cancer patients. The study's purpose was to evaluate ERβ isoform 1 (ERβ1) expression in relation to tumor characteristics, ESR2 genotypes, and prognosis in different treatment groups. EXPERIMENTAL DESIGN: A population-based prospective cohort of 1,026 patients diagnosed with primary invasive breast cancer in Lund, Sweden, between October 2002 and June 2012 was followed until June 2014 (median 5 years)...
November 3, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/27810492/molecular-initiating-events-of-the-intersex-phenotype-low-dose-exposure-to-17%C3%AE-ethinylestradiol-rapidly-regulates-molecular-networks-associated-with-gonad-differentiation-in-the-adult-fathead-minnow-testis
#20
April Feswick, Jennifer R Loughery, Meghan A Isaacs, Kelly R Munkittrick, Christopher J Martyniuk
Intersex, or the presence of oocytes in the testes, has been documented in fish following exposure to wastewater effluent and estrogenic compounds. However, the molecular networks underlying the intersex condition are not completely known. To address this, we exposed male fathead minnows to a low, environmentally-relevant concentration of 17alpha-ethinylestradiol (EE2) (15ng/L) and measured the transcriptome response in the testis after 96h to identify early molecular initiating events that may proceed the intersex condition...
December 2016: Aquatic Toxicology
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