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Estrogen receptor beta

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https://www.readbyqxmd.com/read/29772419/duality-of-estrogen-receptor-%C3%AE-action-in-cancer-progression
#1
REVIEW
T C Guillette, Thomas W Jackson, Scott M Belcher
The physiological actions of estrogens are primarily mediated by the nuclear hormone receptors estrogen receptor alpha (ERα) and beta (ERβ). Activities of these nuclear steroid hormone receptors in etiology and progression of many hormone-responsive cancers are well-established, yet the specific role of each receptor, and their various expressed isoforms, in estrogen-responsive cancers remains unclear. Recent advances in nuclear receptor profiling, characterization of expressed splice variants, and the availability of new experimental cancer models, has extended the understanding of the complex interplay between the differentially expressed nuclear estrogen receptors...
May 14, 2018: Current Opinion in Pharmacology
https://www.readbyqxmd.com/read/29769420/stress-urinary-incontinent-women-the-influence-of-age-and-hormonal-status-on-estrogen-receptor-alpha-and-beta-gene-expression-and-protein-immunoexpression-in-paraurethral-tissues
#2
A Adamiak-Godlewska, R Tarkowski, I Winkler, K Romanek-Piva, K Skorupska, A J Jakimiuk, T Rechberger
The underlying cause of stress urinary incontinence (SUI) is an anatomical abnormality associated with paraurethral connective tissue dysfunction. The question as to whether estrogens affect the quality of that tissue remains unexplained. Samples of paraurethral connective tissue from 81 women were examined (the SUI's n = 49; the control's n = 32). In both groups, the patients were subdivided into pre- and postmenopausals. Primary study outcome was comparison of the estrogen receptor alpha (ERα) and the estrogen receptor beta (ERβ) gene and protein in paraurethral tissue between SUI and control group...
February 2018: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29747396/beta-estradiol-regulates-voltage-gated-calcium-channels-and-estrogen-receptors-in-telocytes-from-human-myometrium
#3
Adela Banciu, Daniel Dumitru Banciu, Cosmin Catalin Mustaciosu, Mihai Radu, Dragos Cretoiu, Junjie Xiao, Sanda Maria Cretoiu, Nicolae Suciu, Beatrice Mihaela Radu
Voltage-gated calcium channels and estrogen receptors are essential players in uterine physiology, and their association with different calcium signaling pathways contributes to healthy and pathological conditions of the uterine myometrium. Among the properties of the various cell subtypes present in human uterine myometrium, there is increasing evidence that calcium oscillations in telocytes (TCs) contribute to contractile activity and pregnancy. Our study aimed to evaluate the effects of beta-estradiol on voltage-gated calcium channels and estrogen receptors in TCs from human uterine myometrium and to understand their role in pregnancy...
May 9, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29741891/a-c-estrogens-as-potent-and-selective-estrogen-receptor-beta-agonists-serbas-to-enhance-memory-consolidation-under-low-estrogen-conditions
#4
Alicia M Hanson, K L Iresha Sampathi Perera, Jaekyoon Kim, Rajesh K Pandey, Noreena Sweeney, Xingyun Lu, Andrea Imhoff, Alexander Craig Mackinnon, Adam J Wargolet, Rochelle M Van Hart, Karyn M Frick, William A Donaldson, Daniel S Sem
Estrogen receptor-beta (ERβ) is a drug target for memory consolidation in post-menopausal women. Herein is reported a series of potent and selective ERβ agonists (SERBAs) with in vivo efficacy that are A-C estrogens, lacking the B and D estrogen rings. The most potent and selective A-C estrogen is selective for activating ER relative to seven other nuclear hormone receptors, with a surprising 750-fold selectivity for the beta over alpha isoform, and with EC50's of 20-30 nM in cell-based and direct binding assays...
May 9, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29735694/genomic-integration-of-err%C3%AE-hnf1%C3%AE-regulates-renal-bioenergetics-and-prevents-chronic-kidney-disease
#5
Juanjuan Zhao, Katherine Lupino, Benjamin J Wilkins, Chengxiang Qiu, Jian Liu, Yasuhiro Omura, Amanda L Allred, Caitlin McDonald, Katalin Susztak, Grant D Barish, Liming Pei
Mitochondrial dysfunction is increasingly recognized as a critical determinant of both hereditary and acquired kidney diseases. However, it remains poorly understood how mitochondrial metabolism is regulated to support normal kidney function and how its dysregulation contributes to kidney disease. Here, we show that the nuclear receptor estrogen-related receptor gamma (ERRγ) and hepatocyte nuclear factor 1 beta (HNF1β) link renal mitochondrial and reabsorptive functions through coordinated epigenomic programs...
May 7, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29729480/the-anti-androgenic-effect-of-chronic-exposure-to-semicarbazide-on-male-japanese-flounder-paralichthys-olivaceus-and-its-potential-mechanisms
#6
Zonghao Yue, Miao Yu, Xiaona Zhang, Jun Wang, Shaoguo Ru
Semicarbazide (SMC), a new marine pollutant, has anti-estrogenic effects on female Japanese flounder (Paralichthys olivaceus). However, whether SMC also affects the reproductive endocrine system of male marine organisms is currently unclear. In this study, Japanese flounder embryos were exposed to 1, 10, and 100 μg/L SMC for 130 days. Plasma testosterone (T) and 17β-estradiol (E2 ) concentrations were significantly decreased in male flounders after SMC exposure. The expression of genes involved in T and E2 synthesis, including steroidogenic acute regulatory protein, cytochrome P450 11A1, 17α-hydroxylase, 17β-hydroxysteroid dehydrogenase and cytochrome P450 19A, was down-regulated in the gonads, which may explain the decrease in plasma sex hormones levels...
May 2, 2018: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29727907/pancreatic-beta-cell-proliferation-induced-by-estradiol-17%C3%AE-is-foxo1-dependent
#7
Sigal Shaklai, Meital Grafi-Cohen, Orli Sharon, Nadav Sagiv, Gabi Shefer, Dalia Somjen, Naftali Stern
Estradiol-17β (E2) and the Foxo1 transcription factor have each been implicated in the regulation of β-cell proliferation. Interaction between Foxo1and estrogen receptor alpha (ERα), effecting cell cycle, has been demonstrated in breast cancer cells, but has not been studied thus far in β-cells. Using human islets and the INS1-E β-cell line, this study investigated the contribution of Foxo1 to E2-mediated β-cell replication. Foxo1 expression was knocked down in INS1-E cells using siRNA and Foxo1 activity was inhibited in human islets with a specific Foxo1 inhibitor (AS1842856)...
May 4, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29710856/nicotine-alters-estrogen-receptor-beta-regulated-inflammasome-activity-and-exacerbates-ischemic-brain-damage-in-female-rats
#8
Nathan D d'Adesky, Juan Pablo de Rivero Vaccari, Pallab Bhattacharya, Marc Schatz, Miguel A Perez-Pinzon, Helen M Bramlett, Ami P Raval
Smoking is a preventable risk factor for stroke and smoking-derived nicotine exacerbates post-ischemic damage via inhibition of estrogen receptor beta (ER-β) signaling in the brain of female rats. ER-β regulates inflammasome activation in the brain. Therefore, we hypothesized that chronic nicotine exposure activates the inflammasome in the brain, thus exacerbating ischemic brain damage in female rats. To test this hypothesis, adult female Sprague-Dawley rats (6⁻7 months old) were exposed to nicotine (4...
April 30, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29695491/nest-box-exploration-may-stimulate-breeding-physiology-and-alter-mrna-expression-in-the-medial-preoptic-area-of-female-european-starlings
#9
Jeremy A Spool, Melannie D Jay, Lauren V Riters
Environmental resources are proposed to fine-tune the timing of breeding, yet how they may do so remains unclear. In female European starlings ( Sturnus vulgaris ), nest cavities are limited resources that are necessary for breeding. Females that explore nest cavities, compared to those that do not, readily perform sexually-motivated behaviors. We assigned female starlings to aviaries with 1) no nest boxes, 2) nest boxes, or 3) nest boxes, plants, flowing water, insects and berries to test the hypothesis that environmental resources alter neural systems to stimulate mating behavior...
April 25, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29686616/estradiol-activates-pi3k-akt-gsk3-pathway-under-chronic-neurodegenerative-conditions-triggered-by-perinatal-asphyxia
#10
G Ezequiel Saraceno, Maria J Bellini, Luis M Garcia-Segura, Francisco Capani
Perinatal asphyxia (PA) remains as one of the most important causes of short-term mortality, psychiatric and neurological disorders in children, without an effective treatment. In previous studies we have observed that the expression of different neurodegenerative markers increases in CA1 hippocampal area of 4-months-old male rats born by cesarean section and exposed for 19 min to PA. We have also shown that a late treatment with 17β estradiol (daily dose of 250 μg/kg for 3 days) was able to revert the brain alterations observed in those animals...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29684419/recruited-t-cells-promote-the-bladder-cancer-metastasis-via-up-regulation-of-the-estrogen-receptor-%C3%AE-il-1-c-met-signals
#11
Le Tao, Jianxin Qiu, Spencer Slavin, Zhenyu Ou, Zhihong Liu, Jifu Ge, Elizabeth A Guancial, Edward M Messing, Chawnshang Chang, Shuyuan Yeh
Clinical data indicates that T cells can be recruited to bladder cancer (BCa) tumors, yet the impact of T cells on BCa progression remains unclear. In the present study, we found that T cells were recruited more to BCa tissues than to the surrounding normal bladder tissues. Results from an in vitro co-culture system also found that BCa recruited more CD4+ T cells than did normal bladder cells. The recruiting of T cells to BCa tissues may increase the proliferation and invasion of BCa cells. Mechanistic studies revealed that infiltrating T cells stimulate BCa estrogen receptor beta (ERβ) signaling and consequently increase the expression of MET proto-oncogene, receptor tyrosine kinase (c-MET), through either direct binding to its promoter or via modulation of IL-1 expression...
April 20, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29682196/testosterone-metabolites-inhibit-proliferation-of-castration-and-therapy-resistant-prostate-cancer
#12
Felix Bremmer, Hubertus Jarry, Valerie Unterkircher, Silke Kaulfuss, Peter Burfeind, Heinz-Joachim Radzun, Philipp Ströbel, Paul Thelen
Novel treatments for castration-resistant prostate cancer (CRPC) such as abiraterone acetate (AA) or enzalutamide effectively target the androgen pathway to arrest aberrant signalling and cell proliferation. Testosterone is able to inhibit tumour cell growth in CRPC. Estrogen receptor-beta (ERβ) binds the testosterone-metabolites 3β-androstanediol and 3α-androstanediol in parallel to the canonical estradiol. In the prostate it is widely accepted that ERβ regulates estrogen signalling, mediating anti-proliferative effects...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29680290/estrogen-receptor-beta-signaling-inhibits-pdgf-induced-human-airway-smooth-muscle-proliferation
#13
Nilesh Sudhakar Ambhore, Rathnavali Katragadda, Rama Satyanarayana Raju Kalidhindi, Michael A Thompson, Christina M Pabelick, Y S Prakash, Sathish Venkatachalem
Airway smooth muscle (ASM) cell hyperplasia driven by persistent inflammation is a hallmark feature of remodeling in asthma. Sex steroid signaling in the lungs is of considerable interest, given epidemiological data showing more asthma in pre-menopausal women and aging men. Our previous studies demonstrated that estrogen receptor (ER) expression increases in asthmatic human ASM; however, very limited data are available regarding differential roles of ERα vs. ERβ isoforms in human ASM cell proliferation. In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved...
April 19, 2018: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/29674171/a-combinatorial-modulation-of-synaptic-plasticity-in-the-rat-medial-amygdala-by-oxytocin-urocortin3-and-estrogen
#14
Linoy Mia Frankiensztajn, Rotem Gur-Pollack, Shlomo Wagner
The medial nucleus of the amygdala (MeA) plays a pivotal role in a variety of mammalian social behaviors. Specifically, activity of the hypothalamic pro-social neuropeptide oxytocin in the MeA was shown to be crucial for social recognition memory. The MeA is also a hub of neuroendocrine activity and expresses a large number of receptors of neuropeptides and hormones. These include oxytocin receptor, estrogen receptor alpha and corticotropin-releasing factor (CRF) receptor type 2 (CRFR2). In a previous study we found that intracerebroventricular (ICV) oxytocin application to anesthetized rats promotes long-term depression (LTD) of the MeA response to electrical stimulation of its main sensory input, the accessory olfactory bulb (AOB)...
April 11, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29665550/polyfluorinated-iodine-alkanes-regulated-distinct-breast-cancer-cell-progression-through-binding-with-estrogen-receptor-alpha-or-beta-isoforms
#15
Wenting Song, Qian S Liu, Zhendong Sun, Xiaoxi Yang, Qunfang Zhou, Guibin Jiang
Polyfluorinated iodine alkanes (PFIs) are a kind of emerging chemicals with endocrine disrupting effects. Based on the different binding preferences of PFIs to estrogen receptor alpha and beta isoforms (ERα and β), two representative PFIs, dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were selected to evaluate their effects on the proliferation of two kinds of breast cancer cells with different ERα/β expression levels, MCF-7 and T47D. The cell viability assay showed PFHxDI could cause higher cellular toxicity than did PFHxI in both MCF-7 and T47D...
April 14, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29661831/differential-effects-of-estrogen-receptor-beta-isoforms-on-glioblastoma-progression
#16
Jinyou Liu, Gangadhara R Sareddy, Mei Zhou, Suryavathi Viswanadhapalli, Xiaonan Li, Zhao Lai, Rajeshwar R Tekmal, Andrew J Brenner, Ratna K Vadlamudi
The estrogen receptor beta (ERβ) functions as a tumor suppressor in glioblastoma cells (GBM). However, the in vivo significance of endogenous ERβ and the roles of its isoforms in GBM are incompletely understood. Using ERβ isoform-specific PCR screening, we found that GBM cells predominantly express ERβ1 and ERβ5, along with low levels of ERβ2 and ERβ4. We observed greater ERβ5 expression in higher grades of glioma than in lower grades. In CRISPR-based ERβ knockout (KO) cells and ERβ KO cells uniquely expressing ERβ1, ERβ1 significantly reduced proliferation...
April 16, 2018: Cancer Research
https://www.readbyqxmd.com/read/29653158/mice-deficient-in-akap13-brx-develop-compulsive-like-behavior-and-increased-body-weight
#17
K Maravet Baig, Szu-Chi Su, Sunni L Mumford, Emma Giuliani, Sinnie Sin Man Ng, Charles Armstrong, Margaret F Keil, Kamaria Cayton Vaught, Nils Olsen, Elyse Pettiford, Irina Burd, James H Segars
OBJECTIVE: Hormonal contributions to the sex-dependent development of both obsessive-compulsive disorder (OCD) and obesity have been described, but the underlying mechanisms are incompletely understood. A-kinase anchoring protein 13 (AKAP13) significantly augments ligand-dependent activation of estrogen receptors alpha and beta. The hypothalamus and pituitary gland are implicated in the development and exacerbation of OCD and obesity and have strong AKAP13 expression. The AKAP13 localization pattern observed in these key brain regions together with its effects on sex steroid action suggest a potential role for AKAP13 in compulsive-like behaviors...
April 10, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29649968/swimming-exercise-to-control-precocious-maturation-in-male-seabass-dicentrarchus-labrax
#18
Marco Graziano, Raul Benito, Josep V Planas, Arjan P Palstra
BACKGROUND: Male European seabass, already predominant (~ 70%) in cultured stocks, show a high incidence (20-30%) of precocious sexual maturation under current aquaculture practices, leading to important economic losses for the industry. In view of the known modulation of reproductive development by swimming exercise in other teleost species, we aimed at investigating the effects of sustained swimming on reproductive development in seabass males during the first year of life in order to determine if swimming could potentially reduce precocious sexual maturation...
April 12, 2018: BMC Developmental Biology
https://www.readbyqxmd.com/read/29629944/human-endometriosis-tissue-microarray-reveals-site-specific-expression-of-estrogen-receptors-progesterone-receptor-and-ki67
#19
Mariano Colón-Caraballo, Miosotis García, Adalberto Mendoza, Idhaliz Flores
Most available therapies for endometriosis are hormone-based and generally broadly used without taking into consideration the ovarian hormone receptor expression status. This contrasts strikingly with the standard of care for other hormone-based conditions such as breast cancer. We therefore aimed to characterize the expression of ovarian steroid hormone receptors for estrogen alpha (ESR1), estrogen beta (ESR2), and progesterone (PGR) in different types of endometriotic lesions and eutopic endometrium from women with endometriosis and controls using a tissue microarray (TMA)...
April 7, 2018: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29627338/a-comparative-review-on-estrogen-receptors-in-the-reproductive-male-tract-of-non-mammalian-vertebrates
#20
REVIEW
Mariailaria Verderame, Rosaria Scudiero
Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors known to be involved in the regulation of many complex physiological processes in mammals. They are expressed primarily in the reproductive tract of all vertebrates females, thus indicating important and conserved functions in female reproductive success. ERs are also present in physiological different tissues as bone, brain, liver, skin and adipose tissues, in both females and males. In the latter, ERs have been found also in the genital tract, supporting the findings of a complex role for estrogen in spermatogenesis and, more generally, in male reproduction...
June 2018: Steroids
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