Jinghong Yuan, Yameng Wang, Yanzhe Huang, Shengqin Li, Xiaowen Zhang, Zhiwen Wu, Wenrui Zhao, Junchao Zhu, Junqiu Zhang, Guowen Huang, Peng Yu, Xigao Cheng, Xinhui Wang, Xijuan Liu, Jingyu Jia
Idiopathic short stature (ISS) is a common childhood condition with largely unknown underlying causes. Recent research highlights the role of circulating exosomes in the pathogenesis of various disorders, but their connection to ISS remains unexplored. In the experiments, human chondrocytes are cocultured with plasma exosomes from ISS patients, leading to impaired chondrocyte growth and bone formation. Elevated levels of a specific long non-coding RNA (lncRNA), ISSRL, are identified as a distinguishing factor in ISS, boasting high specificity and sensitivity...
April 19, 2024: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)